KvLQT2

Kv7.2 (KvLQT2) is a is_associated_with::potassium channel is_associated_with::protein coded for by the is_associated_with::gene KCNQ2.

It is associated with is_associated_with::benign familial neonatal epilepsy.

Ligands

 * ICA-069673: channel opener at KCNQ2/Q3, 20-fold selective over KCNQ3/Q5, no measurable activity against a panel of cardiac ion channels (is_associated_with::hERG, is_associated_with::Nav1.5, L type channels, and is_associated_with::KCNQ1) and no activity on GABAA gated channels at 10 μM. A range of related benzamides exhibited activity, of which compound number 40 is shown here.
 * ML252: channel inhibitor, IC50 = 70nM.