T-box

T-box refers to a group of transcription factors involved in limb and heart development. In humans and some other animals, defects in the TBX5 gene expression can lead to finger-like thumbs and ventricular septal defects in which there is no separation between the left and right ventricle of the heart and are responsible for Holt-Oram syndrome.

Genes encoding T-box proteins include:
 * TBR1 )
 * TBX1
 * TBX2
 * TBX3
 * TBX4
 * TBX5
 * TBX6
 * TBX10
 * TBX15
 * TBX18
 * TBX19
 * TBX20
 * TBX21
 * TBX22