Brain-specific angiogenesis inhibitor 1

Brain-specific angiogenesis inhibitor 1 is a is_associated_with::protein that in humans is encoded by the BAI1 is_associated_with::gene. It is a member of the adhesion-GPCR family of receptors.

Function
is_associated_with::Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and is_associated_with::metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype is_associated_with::p53. There are two other brain-specific angiogenesis inhibitor genes, designated is_associated_with::BAI2 and is_associated_with::BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of is_associated_with::glioblastomas.

Interactions
Brain-specific angiogenesis inhibitor 1 has been shown to interact with is_associated_with::BAIAP3 and is_associated_with::MAGI1.

Model organisms
is_associated_with::Model organisms have been used in the study of BAI1 function. A conditional is_associated_with::knockout mouse line called Bai1tm2a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping