Neuropeptide FF receptor

The neuropeptide FF receptors are members of the G-protein coupled receptor superfamily of integral membrane proteins which bind the pain modulatory neuropeptides AF and FF. These neuropeptides are thought to be involved in modulation of opioid receptor function in the brain and spinal cord, and can either reduce or increase opioid receptor function depending which tissue they are released in, reflecting a complex role for neuropeptide FF in pain responses.

Agonists

 * Neuropeptide AF
 * Neuropeptide FF

Antagonists

 * BIBP-3226 (mixed NPFF1 / NPY1 antagonist)
 * RF-9