SPRY2

Sprouty homolog 2 (Drosophila), also known as SPRY2, is a is_associated_with::protein which in humans is encoded by the SPRY2 is_associated_with::gene.

Function
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal is_associated_with::cysteine-rich domain essential for the inhibitory activity on is_associated_with::receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein.

SPRY2 is a is_associated_with::negative feedback regulator of multiple is_associated_with::receptor tyrosine kinases (RTK's) including receptors for is_associated_with::fibroblast growth factor (FGF), is_associated_with::epidermal growth factor (EGF), and is_associated_with::hepatocyte growth factor (HGF). Antagonization of is_associated_with::growth factor mediated pathways, is_associated_with::cell migration, and is_associated_with::cellular differentiation occurs through the ERK pathway. Spry2 can also enhance EGFR signaling by sequestering CBL. Spry is_associated_with::gene expression has been reported silenced or repressed in cancer of the breast, liver, lung, prostate, and in lymphoma. Human spry2 expression is localized to the is_associated_with::microtubules in unstimulated cells. All sprouty is_associated_with::isoforms inhibit the ERK pathway by themselves, but can also form is_associated_with::heterodimers and is_associated_with::homodimers which have enhanced inhibition.

Interactions
SPRY2 has been shown to interact with is_associated_with::Cbl gene.