NEAT1

Nuclear Enriched Abundant Transcript 1 (NEAT1) is a ~3.2 kb novel nuclear is_associated_with::long non-coding RNA (RIKEN cDNA 2310043N10Rik). It is also known as is_associated_with::Virus Inducible NonCoding is_associated_with::RNA (VINC) or MEN epsilon RNA. It is transcribed from the multiple endocrine neoplasia locus.

Expression of NEAT1 is induced in is_associated_with::mouse is_associated_with::brains during infection by Japanese is_associated_with::encephalitis virus and is_associated_with::rabies virus. NEAT1 is constitutively expressed in a number of non-neuronal tissues and is_associated_with::cell lines.

NEAT1 localizes to specific nuclear structures called is_associated_with::paraspeckles. NEAT1 RNA interacts with a paraspeckle is_associated_with::protein known as P54nrb or is_associated_with::NONO and it is essential for paraspeckle formation. Some studies demonstrate that NEAT1 RNA is essential for the formation and maintenance of paraspeckles. Thus, this novel noncoding RNA appears to have an important structural role in the nuclear paraspeckles.