CDS2

Phosphatidate cytidylyltransferase 2 is an is_associated_with::enzyme that in humans is encoded by the CDS2 is_associated_with::gene.

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many is_associated_with::G protein-coupled receptors and is_associated_with::tyrosine kinases regulating cell growth, calcium metabolism, and is_associated_with::protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of is_associated_with::phosphatidic acid to CDP-is_associated_with::diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and is_associated_with::cardiolipin. and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (CDS1) and a second (this gene) to 20p13.

Model organisms
is_associated_with::Model organisms have been used in the study of CDS2 function. A conditional is_associated_with::knockout mouse line, called Cds2tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and two is_associated_with::phenotypes were reported. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no significant abnormalities were observed in these animals.