Ezrin

Ezrin also known as cytovillin or villin-2 is a is_associated_with::protein that in humans is encoded by the EZR is_associated_with::gene.

Structure
The is_associated_with::N-terminus of ezrin contains a is_associated_with::FERM domain which is further subdivided into three subdomains. The is_associated_with::C-terminus contain a ERM domain.

Function
The is_associated_with::cytoplasmic is_associated_with::peripheral membrane protein encoded by this gene functions as a protein-is_associated_with::tyrosine kinase substrate in is_associated_with::microvilli. As a member of the is_associated_with::ERM protein family, this protein serves as an intermediate between the plasma membrane and the is_associated_with::actin is_associated_with::cytoskeleton. It plays a key role in cell surface structure adhesion, migration, and organization.

The N-terminal is_associated_with::FERM domain strongly binds sodium-hydrogen exchanger regulatory factor (is_associated_with::NHERF) proteins (involving long-range is_associated_with::allostery). The C-terminal binds to is_associated_with::actin, phosphatidylinositol(4,5)bis-phosphate (is_associated_with::PIP2) and membrane proteins like is_associated_with::CD44 and is_associated_with::ICAM-2.

Interactions
VIL2 has been shown to interact with:


 * is_associated_with::CD43,
 * FASLG,
 * is_associated_with::ICAM-1,
 * is_associated_with::ICAM2,
 * is_associated_with::ICAM3,
 * Merlin,
 * MSN,
 * is_associated_with::PIK3R1,
 * PALLD
 * is_associated_with::S100P,
 * is_associated_with::SDC2,
 * SLC9A3R1,
 * SLC9A3R2,  and
 * is_associated_with::VCAM-1.