Rs713598

rs713598 is one of three SNPs that form the main haplotypes behind the ability to perceive as bitter the taste of the compound phenylthiocarbamide (PTC) and similar molecules in foods (like cabbage and raw broccoli) or drinks (like coffee and dark beers).

The rs713598(G) allele, in the orientation shown in dbSNP, is the "tasting" allele, and it is dominant to the "non-tasting" allele rs713598(C), so having one copy is enough to have the bitter tasting ability. If you are a "taster", you're also likely to carry at least one rs10246939(C) and one rs1726866(C) allele since, along with rs713598(G), these three SNPs form the most common tasting haplotype. If you lack these alleles, you're quite likely (~80%) to be a non-taster of bitterness, meaning that foods that may taste bitter to others taste far less bitter to you.

TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study.

Prevalence of common disease-associated variants in Asian Indians.

A combinatorial approach to detecting gene-gene and gene-environment interactions in family studies.

Bitter taste receptors influence glucose homeostasis.

A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women.

Sex differences in the effects of inherited bitter thiourea sensitivity on body weight in 4-6-year-old children.

Implication of the G145C polymorphism (rs713598) of the TAS2r38 gene on food consumption by Brazilian older women.

Bitter Taste Perception