SAR1B

SAR1 gene homolog B (S. cerevisiae), also known as SAR1B, is a is_associated_with::protein which in humans is encoded by the SAR1B is_associated_with::gene.

Function
SAR1B belongs to the Sar1-is_associated_with::ADP ribosylation factor family of small is_associated_with::GTPases, which govern the intracellular trafficking of proteins in coat protein (COP)-coated vesicles.

Clinical significance
Mutations in the SAR1B gene are associated with is_associated_with::chylomicron retention disease (also known as Anderson disease) which is an autosomal recessive disorder of severe fat malabsorption.