CBFA2T3

Protein CBFA2T3 is a is_associated_with::protein that in humans is encoded by the CBFA2T3 is_associated_with::gene.

Function
The t(16;21)(q24;q22) translocation is a rare but recurrent chromosomal abnormality associated with therapy-related myeloid malignancies. The translocation produces a chimeric gene made up of the 5'-region of the is_associated_with::AML1 gene fused to the 3'-region of this gene. In addition, this gene is a putative breast tumor suppressor. Two transcript variants encoding different isoforms have been found for this gene, and a is_associated_with::brefeldin A-sensitive association of RII-alpha protein with one of the isoforms has been demonstrated in the is_associated_with::Golgi apparatus.

Interactions
CBFA2T3 has been shown to interact with:


 * is_associated_with::HDAC1,
 * is_associated_with::HDAC3,
 * is_associated_with::LDB1,
 * is_associated_with::PRKAR2A,
 * is_associated_with::RUNX1T1 and
 * is_associated_with::TAL1, and
 * is_associated_with::TCF3.