IKZF3

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a is_associated_with::protein that in humans is encoded by the IKZF3 is_associated_with::gene.

Function
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are is_associated_with::hematopoietic-specific is_associated_with::transcription factors involved in the regulation of is_associated_with::lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in is_associated_with::chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.

Interactions
IKZF3 has been shown to interact with BCL2-like 1 and is_associated_with::HRAS.