CRSP3

Mediator of RNA polymerase II transcription subunit 23 is an is_associated_with::enzyme that in humans is encoded by the MED23 is_associated_with::gene.

Function
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a is_associated_with::metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions
CRSP3 has been shown to interact with is_associated_with::Estrogen receptor alpha, is_associated_with::CEBPB and is_associated_with::Cyclin-dependent kinase 8.