CLCF1

Cardiotrophin-like cytokine factor 1 (CLCF1), also known as Novel Neurotrophin-1 (NNT-1) or B cell-stimulating factor-3 (BSF-3), is a is_associated_with::protein that in humans is encoded by the CLCF1 is_associated_with::gene.

Function
CLCF1 induces is_associated_with::tyrosine is_associated_with::phosphorylation of the IL-6 receptor common subunit is_associated_with::glycoprotein 130 (gp130), is_associated_with::leukemia inhibitory factor receptor beta, and the transcription factor STAT3. It has been implicated in the induction of IL-1 (via induction of is_associated_with::corticosterone and IL-6) and is_associated_with::serum amyloid A, and in is_associated_with::B cell is_associated_with::hyperplasia. This cytokine is capable of B cell activation via gp130 receptor stimulation.

Structure
CLCF1 is a is_associated_with::cytokine belonging to the is_associated_with::interleukin-6 (IL6) family. It is a secreted protein, found predominantly in is_associated_with::lymph nodes and is_associated_with::spleen, and contains 225 amino acids with a molecular mass of 22 kDa in its mature form. IL6 family members share similarity in gene structure and have a 4-helix bundle in their protein structure. CLCF1 is closely related to other proteins called is_associated_with::cardiotrophin-1 and is_associated_with::ciliary neurotrophic factor.