Interleukin 8 receptor, alpha

Interleukin 8 receptor, alpha is a is_associated_with::chemokine receptor. IL8RA is its human is_associated_with::gene. IL8RA has also been designated CD181 (is_associated_with::cluster of differentiation 181), and CXCR1. CXCR1 is now the is_associated_with::IUPHAR Committee on Receptor Nomenclature and Drug Classification recommended name.

Function
The protein encoded by this gene is a member of the is_associated_with::G-protein-coupled receptor family. This protein is a receptor for is_associated_with::interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic is_associated_with::oligodendrocyte precursor migration in developing spinal cord. This gene, is_associated_with::IL8RB, a gene encoding another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Stimulation of CXCR1 in is_associated_with::neutrophils by its primary ligand, is_associated_with::Interleukin 8, leads to neutrophil is_associated_with::chemotaxis and activation.

Clinical significance
Blocking CXCR1 (e.g., with is_associated_with::repertaxin ) inhibits some human breast cancer stem cells (in vitro and in mice).

CXCR1 can be cleaved and inactivated by Neutrophil Derived Serine Proteases (NSPs), leading to neutrophil dysfunction and impaired bacterial killing in is_associated_with::Cystic Fibrosis lung disease.

Interactions
Interleukin 8 receptor, alpha has been shown to interact with is_associated_with::GNAI2.