Dipropyltryptamine

Dipropyltryptamine (DPT) is a psychedelic drug belonging to the tryptamine family, first reported in 1973. It is found either as its crystalline hydrochloride salt or as an oily or crystalline base. It has not been found to occur naturally.

Frequent physical effects are nausea, numbness of the tongue or throat, and pupil dilation.

Pharmacology
Studies on rodents have found that the effectiveness with which a selective 5-HT2A receptor antagonist blocks the behavioral actions of this compound strongly suggest that the 5-HT2A receptor receptor is an important site of action for DPT, but the modulatory actions of a 5-HT1A receptor antagonist also imply a 5-HT1A-mediated component to the actions of DPT.

Psychedelic properties
While dipropyltryptamine is chemically similar to dimethyltryptamine, its psychoactive effects are markedly different.

The most prominent features of the DPT experience are increased significance or intensity of music, colors take on a new intensity or appearance, the body may have a buzz or vibratory feeling, a pleasant sensation of warmth, complete ego loss, apparitions of faces.

While seeing other beings under the influence of DPT may occasionally occur, the perspective is more as an observer or watcher, as contrasted to the more personal real-feeling entity contact reported with DMT.

Also sometimes reported is a loss of ego boundary; for example, the boundary between the self and a table may not be easy to distinguish. Difficulty distinguishing other boundaries is common as well. For example, different colors may be difficult to distinguish. Other sensory input may also become blended. This is distinct from synaesthesia.

A user may also encounter the feeling of experiencing the life of someone else, or having had all possible experiences simultaneously. One may have the experience of seeing the universe from different locations in space and time.

Visuals are often geometric, wavy, and/or spiraled. Other visual distortions and hallucinations tend to be experienced in the peripheral vision. The self or the environment may take on a stylized cartoon-like look or feel. Pleasant flashes of light and sparkles are also common.

Dose
Note: These dosages should not be used as a guide for administrating the drug as individual gene polymorphism can cause great variance in effects from the same dose from one person to the next.

Smoked: When smoked, the effects of DPT have an onset in minutes and a duration of less than one hour. Dosage ranges from 30-100 mg.

Insufflation: Average onset for insufflation of DPT is five to fifteen minutes, and typical dosage ranges from 45–225 mg.

Intramuscular: When injected into the muscle, onset ranges from one minute to fifteen minutes. Typical dosage ranges from 20–110 mg.

Intravenous: When injected intravenously, onset ranges from five to fifteen seconds. Typical dosage ranges from 10–75 mg.

Oral Ingestion: DPT is metabolized by the enzyme monoamine oxidase. While DPT is orally active on its own, the combination with a monoamine oxidase inhibitor (MAOI) can increase the length and intensity of the experience. Oral dosages of 150 – 250 mg are commonly reported, with an onset of 20–60 minutes (depending on stomach content).

Religious use
DPT is used as a religious sacrament by the Temple of the True Inner Light, a New York City offshoot of the Native American Church. The Temple believes DPT and other entheogens are physical manifestations of God.