KLRC4

NKG2-F type II integral membrane protein is a is_associated_with::protein that in humans is encoded by the KLRC4 is_associated_with::gene.

Natural killer (NK) cells are is_associated_with::lymphocytes that can mediate is_associated_with::lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and is_associated_with::cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) is_associated_with::lectins, which have been implicated in the regulation of NK cell function. KLRC4 is a member of the is_associated_with::NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of is_associated_with::transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. The 3' end of the KLRC4 transcript includes the first non-coding exon found at the 5' end of the adjacent D12S2489E gene transcript.