RIPK1

Receptor-interacting serine/threonine-protein kinase 1 is an is_associated_with::enzyme that in humans is encoded by the RIPK1 is_associated_with::gene. RIPK1 is known to have function in a variety of cellular pathways including the is_associated_with::NF-κB pathway and programmed necrotic cell death (necroptosis).

Function
Although, RIPK1 has been primarily studied in the context of is_associated_with::TNFR signaling, RIPk1 is also activated in response to diverse stimuli.

The kinase domain, while important for necroptotic (programmed necrotic) functions, it appears dispensable for pro-survival roles. Kinase activity of RIPK1 is also required for RIPK1-dependent apoptosis in conditions of IAP1/2 depletion, TAK1inhibition/depletion, RIPK3 depletion or MLKL depletion. Also, is_associated_with::proteolytic processing of RIPk1, through both is_associated_with::caspase-dependent and -independent mechanisms, triggers lethality that is dependent on the generation of one or more specific is_associated_with::C-terminal cleavage product(s) of RIPk1 upon stress.

Interactions
RIPK1 has been shown to interact with:
 * is_associated_with::BIRC2,
 * BIRC3,
 * is_associated_with::CA11,
 * CASP8,
 * is_associated_with::CFLAR,
 * is_associated_with::CRADD,
 * is_associated_with::RIPK3,
 * is_associated_with::RNF11,
 * is_associated_with::RNF216,
 * SQSTM1,
 * is_associated_with::TNFRSF1A,
 * is_associated_with::TRADD,
 * is_associated_with::TRAF2,  and
 * UBC.