CSNK2B

Casein kinase II subunit beta is an is_associated_with::protein that in humans is encoded by the CSNK2B is_associated_with::gene.

Casein kinase, a ubiquitous, well-conserved is_associated_with::protein kinase involved in cell is_associated_with::metabolism and differentiation, is characterised by its preference for is_associated_with::Serine or is_associated_with::Threonine in acidic stretches of is_associated_with::amino acids. The enzyme is a is_associated_with::tetramer of 2 alpha- and 2 beta-subunits. However, some is_associated_with::species (e.g., mammals) possess 2 related forms of the alpha-subunit (alpha and alpha'), while others (e.g., fungi) possess 2 related beta-subunits (beta and beta'). The alpha-subunit is the catalytic unit and contains regions characteristic of serine/threonine protein kinases. The beta-subunit is believed to be regulatory, possessing an N-terminal auto-phosphorylation site, an internal acidic domain, and a potential metal-binding motif. The beta subunit is a highly conserved protein of about 25kDa that contains, in its central section, a cysteine-rich motif, CX(n)C, that could be involved in binding a metal such as is_associated_with::zinc. The is_associated_with::mammalian beta-subunit is_associated_with::gene promoter shares common features with those of other is_associated_with::mammalian protein kinases and is closely related to the promoter of the regulatory subunit of cAMP-dependent protein kinase.

Interactions
CSNK2B has been shown to interact with is_associated_with::CD163, is_associated_with::CSNK2A2,   is_associated_with::Casein kinase 2, alpha 1,    is_associated_with::FGF1, is_associated_with::TRIB3, is_associated_with::CDC34, is_associated_with::Ribosomal protein L5,   is_associated_with::BTF3, is_associated_with::BRCA1, is_associated_with::RNF7, is_associated_with::P70-S6 Kinase 1 and APC.