CTCFL

Transcriptional repressor CTCFL also known as BORIS (Brother of Regulator of Imprinted Sites) is a is_associated_with::protein that in humans is encoded by the CTCFL is_associated_with::gene.

Function
CCCTC-binding factor (is_associated_with::CTCF), an 11-is_associated_with::zinc finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. Transcriptional repressor CTCFL (this protein) is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of is_associated_with::spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and CTCFL are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation.