H6PD

GDH/6PGL endoplasmic bifunctional protein is a is_associated_with::protein that in humans is encoded by the H6PD is_associated_with::gene.

Function
There are two forms of is_associated_with::glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially is_associated_with::galactose-6-phosphate, whereas the G form is specific for is_associated_with::glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells.

Hexose-6-phosphate dehydrogenase has been shown to regulate the reaction direction of is_associated_with::11β-hydroxysteroid dehydrogenase type 1, a bidirectional enzyme able to catalyze the interconversion of the is_associated_with::glucocorticoids is_associated_with::cortisol and is_associated_with::cortisone.