CCR10

C-C chemokine receptor type 10 is a is_associated_with::protein that in humans is encoded by the CCR10 is_associated_with::gene.

Function
is_associated_with::Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of is_associated_with::leukocytes through interactions with a subset of 7-transmembrane, is_associated_with::G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the is_associated_with::immune system, and they have effects on cells of the central nervous system as well as on is_associated_with::endothelial cells involved in is_associated_with::angiogenesis or is_associated_with::angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.

CCR10 is a is_associated_with::chemokine receptor. Its ligands are is_associated_with::CCL27 and is_associated_with::CCL28. This receptor is normally expressed by melanocytes, plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of is_associated_with::lymph node is_associated_with::metastasis in mice after inoculation in the skin, suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.