NLRP1

NACHT, LRR and PYD domains-containing protein 1 is a is_associated_with::protein that in humans is encoded by the NLRP1 is_associated_with::gene.

Function
This gene encodes a member of the Ced-4 family of is_associated_with::apoptosis proteins. Ced-family members contain a is_associated_with::caspase recruitment domain (CARD) and are known to be key mediators of is_associated_with::programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in is_associated_with::protein-protein interactions. The NLRP1 protein interacts strongly with is_associated_with::caspase 2 and weakly with is_associated_with::caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.

Interactions
NLRP1 has been shown to interact with is_associated_with::caspase 9 and is_associated_with::APAF1.