OTUB1

Ubiquitin thioesterase OTUB1 also known as otubain-1 is an is_associated_with::enzyme that in humans is encoded by the OTUB1 is_associated_with::gene. Alternative splicing results in multiple transcript variants.

Function
Otubain-1 is a member of the OTU (ovarian tumor) superfamily of predicted is_associated_with::cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves is_associated_with::ubiquitin from branched poly-ubiquitin chains, being specific for lysine48 -linked polyubiquitin but not lysine63 -linked polyubiquitin. It interacts with another ubiquitin protease and an E3 is_associated_with::ubiquitin ligase that inhibits is_associated_with::cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth.

Interactions
OTUB1 has been shown to interact with is_associated_with::RNF128 and is_associated_with::GNB2L1.