DNM1

Dynamin-1 is a is_associated_with::protein that in humans is encoded by the DNM1 is_associated_with::gene.

Function
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.

Interactions
DNM1 has been shown to interact with:


 * AMPH,
 * is_associated_with::FNBP1,
 * is_associated_with::Grb2
 * is_associated_with::NCK1,
 * is_associated_with::PACSIN1, and
 * is_associated_with::SH3GL2.