Microsomal triglyceride transfer protein

Microsomal triglyceride transfer protein large subunit is a is_associated_with::protein that in humans is encoded by the MTTP is_associated_with::gene.

Apoprotein B48 on chylomicra and Apoprotein B100 on LDL, IDL, and VLDL are important for MTP binding.

Pharmacology
Drugs that inhibit MTTP prevent the assembly of apo B-containing lipoproteins thus inhibiting the synthesis of chylomicrons and is_associated_with::VLDL and leading to decrease in plasma levels of LDL-C.
 * is_associated_with::Lomitapide (Juxtapid) was approved by the US FDA for adjunctive treatment of homozygous is_associated_with::familial hypercholesterolemia.
 * is_associated_with::Dirlotapide (Slentrol) and is_associated_with::mitratapide (Yarvitan) are veterinary drugs for the management of obesity in dogs.