MAP2K2

Dual specificity mitogen-activated protein kinase kinase 2 is an is_associated_with::enzyme that in humans is encoded by the MAP2K2 is_associated_with::gene.

Function
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates is_associated_with::MAPK1/ERK2 and is_associated_with::MAPK2/ERK3.

The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by is_associated_with::MAP kinase kinase kinases.

The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax.

Interactions
MAP2K2 has been shown to interact with is_associated_with::MAPK3  and is_associated_with::ARAF.