Janus kinase 1

JAK1 is a human is_associated_with::tyrosine kinase protein essential for signaling for certain type I and type II is_associated_with::cytokines. It interacts with the common gamma chain (γc) of is_associated_with::type I cytokine receptors, to elicit signals from the IL-2 receptor family (e.g. IL-2R, IL-7R, IL-9R and IL-15R), the IL-4 receptor family (e.g. IL-4R and IL-13R), the is_associated_with::gp130 receptor family (e.g. IL-6R, IL-11R, LIF-R, OSM-R, is_associated_with::cardiotrophin-1 receptor (CT-1R), is_associated_with::ciliary neurotrophic factor receptor (CNTF-R), is_associated_with::neurotrophin-1 receptor (NNT-1R) and is_associated_with::Leptin-R). It is also important for transducing a signal by type I (IFN-α/β) and type II (IFN-γ) is_associated_with::interferons, and members of the IL-10 family via is_associated_with::type II cytokine receptors. Jak1 plays a critical role in initiating responses to multiple major cytokine receptor families. Loss of Jak1 is lethal in neonatal mice, possibly due to difficulties suckling. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and is_associated_with::metastasize to other parts of the body.

Interactions
Janus kinase 1 has been shown to interact with:


 * is_associated_with::ELP2,
 * is_associated_with::GNB2L1
 * IL6ST,
 * is_associated_with::Grb2,
 * is_associated_with::IL2RB,
 * is_associated_with::IRS1,
 * IL10RA,
 * is_associated_with::PTPN11,
 * is_associated_with::STAM2,
 * is_associated_with::STAT3,
 * is_associated_with::STAT5A,
 * is_associated_with::STAT5B, and
 * is_associated_with::TNFRSF1A.