Apolipoprotein O

Apolipoprotein O also known as protein FAM121B is a is_associated_with::protein that in humans is encoded by the APOO is_associated_with::gene. APOO is a member of the is_associated_with::apolipoprotein family.

The human, apolipoprotein O is a 198 is_associated_with::amino acids protein that contains a 23 is_associated_with::amino acids long is_associated_with::signal peptide. The apoprotein is is_associated_with::secreted by a microsomal is_associated_with::triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from is_associated_with::macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.