CALCRL

Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human is_associated_with::protein.

Function
The protein encoded by the CALCRL gene is a is_associated_with::G protein-coupled receptor related to the is_associated_with::calcitonin receptor. CALCRL is linked to one of three single transmembrane domain is_associated_with::receptor activity-modifying proteins (RAMPs) that are essential for functional activity.

The association of CALCRL with different RAMP proteins produces different receptors:
 * with is_associated_with::RAMP1: produces a is_associated_with::CGRP receptor
 * with is_associated_with::RAMP2: produces an is_associated_with::adrenomedullin (AM) receptor, designated AM1
 * with is_associated_with::RAMP3: produces a dual CGRP/AM receptor designated AM2

These receptors are linked to the is_associated_with::G protein Gs, which activates is_associated_with::adenylate cyclase and activation results in the generation of is_associated_with::intracellular is_associated_with::cyclic adenosine monophosphate (cAMP).

Structure
CALCRL associated with RAMP 1 produces the CGRP receptor which is a trans-membrane protein receptor that is made up of four chains. Two of the four chains contain unique sequences. It is a heterodimer protein composed of two polypeptide chains differing in composition of their amino acid residues. The sequence reveals multiple hydrophobic and hydrophilic regions throughout the four chains in the protein. These G-protein coupled receptor (GPCRs) proteins play an important role in pharmaceutical targets. Many drugs used today alter the GPCR signaling pathways.