LRIG1

Leucine-rich repeats and immunoglobulin-like domains protein 1 is a is_associated_with::protein that in humans is encoded by the LRIG1 is_associated_with::gene. It encodes a is_associated_with::transmembrane protein that has been shown to interact with receptor tyrosine kinases of the EGFR-family , MET and RET.

Model organisms
is_associated_with::Model organisms have been used in the study of LRIG1 function. A conditional is_associated_with::knockout mouse line, called Lrig1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on homozygous is_associated_with::mutant mice and ten significant abnormalities were observed, including decreased body weight and total body fat, scaly skin, abnormal hair shedding, a moderate degree of is_associated_with::hearing impairment, vertebral fusion, abnormal plasma chemistry and an increased susceptibility to is_associated_with::bacterial infection (with both Salmonella and Citrobacter).