Rs63750666

rs63750666, also known as T430M or Thr430Met, is a SNP in the presenilin 2 PSEN2 gene.

Acting as an autosomal dominant, the rare rs63750666(T) allele has been suggested to lead to early-onset Alzheimer's disease. However, a sibling who shared this mutation with an Alzheimer's patient did not show signs of early-onset disease, so this mutation may have reduced penetrance.