Rs4646284

rs4646284 is a prostate cancer susceptibility indel at 6q25.3 (risk allele: "G" insertion) ascertained in a University of California, San Francisco and Kaiser Permanente RPGEH GWAS of KP health plan members. Hoffmann, Witte, and colleagues report in the journal Cancer Discovery a fixed effects p-value of 1.0E-19 when meta-analyzing across multiple ethnic subpopulations within a diverse study cohort as well multiple replication cohorts. The rs4646284 indel significant exhibited cis-eQTL activity with adjacent genes at 6q25.3, with the strongest association being with the expression of SLC22A1 (p=1.3E-23) and SLC22A3 (p=3.2E-52).