TRPM7

Transient receptor potential cation channel, subfamily M, member 7, also known as TRPM7, is a human is_associated_with::gene encoding a protein of the same name.

Function
TRPs, mammalian homologs of the is_associated_with::Drosophila is_associated_with::transient receptor potential (trp) protein, are is_associated_with::ion channels that are thought to mediate capacitative calcium entry into the cell. TRP-PLIK is a protein that is both an ion channel and a is_associated_with::kinase. As a channel, it conducts calcium and monovalent cations to depolarize cells and increase intracellular calcium. As a kinase, it is capable of phosphorylating itself and other substrates. The kinase activity is necessary for channel function, as shown by its dependence on intracellular ATP and by the kinase mutants.[supplied by OMIM]

Interactions
TRPM7 has been shown to interact with is_associated_with::PLCB1 and is_associated_with::PLCB2.

Clinical relevance
Defects in this gene have been associated to magnesium deficiency in human microvascular endothelial cells.