TRIM25

Tripartite motif-containing protein 25 is a is_associated_with::protein that in humans is encoded by the TRIM25 is_associated_with::gene.

TRIM25 functions
TRIM25 act in expression of IFN response. It interact with is_associated_with::RIG-I which is a receptor from PRR (Pattern Recognitiion Receptor) family. Two domains of TRIM25 (RING and SPRY) allow an interaction with RIG-I. Thanks to this interaction an ubiquitination of RIG-I by TRIM25 is possible. Its follows an IFN production by an intracellular signaling pathway involving is_associated_with::IRF3.

Viral escape
To avoid IFN production, a viral non structural protein (is_associated_with::NS1) will interact with CCD domain of TRIM25 to block RIG-I ubiquitination. This CCD domain is essential for the binding of NS1 on TRIM25. Some studies have shown that with a deletion of the CCD domain the binding of NS1 was impossible. Without this ubiquitination, there won’t be IFN production.