RHOBTB3

Rho-related BTB domain-containing protein 3 is a is_associated_with::protein that in humans is encoded by the RHOBTB3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of RHOBTB3 function. A conditional is_associated_with::knockout mouse line, called Rhobtb3tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. Homozygote is_associated_with::mutant males had a decreased body weight and abnormal tooth morphology; females had decreased forepaw grip strength and both sexes had a decreased body length.