FGF15/19

FGF15/19 refers to two orthologous fibroblast growth factors which share 50% aminoacid identity and have similar functions. is_associated_with::FGF15 was described in the mouse; is_associated_with::FGF19 was found in humans and other species. They share physiological functions and so are often referred to as FGF15/19 or as FGF15/FGF19.

They were first described in developing fetal brain. They are now known to be produced in the is_associated_with::ileum, and under certain circumstances in the liver and biliary tree. It is thought their principal function is in response to is_associated_with::bile acid absorption occurring after meals.

FGF15 and FGF19 have similar roles in regulating bile acid synthesis and also is_associated_with::glucose metabolism in the liver.