ANAPC2

Anaphase-promoting complex subunit 2 is an is_associated_with::enzyme that in humans is encoded by the ANAPC2 is_associated_with::gene.

A large is_associated_with::protein complex, termed the is_associated_with::anaphase-promoting complex (APC), or the cyclosome, promotes is_associated_with::metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S is_associated_with::proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The product of this gene is a component of the complex and shares sequence similarity with a recently identified family of proteins called is_associated_with::cullins, which may also be involved in is_associated_with::ubiquitin-mediated degradation.

Interactions
ANAPC2 has been shown to interact with is_associated_with::ANAPC1 and is_associated_with::ANAPC11.