CCL19

Chemokine (C-C motif) ligand 19 (CCL19) is a is_associated_with::protein that in humans is encoded by the CCL19 is_associated_with::gene.

Chemokine (C-C motif) ligand 19 (CCL19) is a small is_associated_with::cytokine belonging to the CC is_associated_with::chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in is_associated_with::thymus and is_associated_with::lymph nodes, with moderate levels in trachea and colon and low levels in stomach, is_associated_with::small intestine, is_associated_with::lung, is_associated_with::kidney and is_associated_with::spleen. The gene for CCL19 is located on human is_associated_with::chromosome 9. This chemokine elicits its effects on its target cells by binding to the chemokine receptor is_associated_with::chemokine receptor CCR7. It attracts certain cells of the is_associated_with::immune system, including is_associated_with::dendritic cells and antigen-engaged is_associated_with::B cells, is_associated_with::CCR7+ central-memory T-Cells.