MALAT1

MALAT 1 (metastasis associated lung adenocarcinoma transcript 1) also known as NEAT2 (noncoding nuclear-enriched abundant transcript 2) is a large, infrequently spliced is_associated_with::non-coding RNA, which is highly conserved amongst is_associated_with::mammals and highly expressed in the nucleus. It regulates the expression of is_associated_with::metastasis-associated is_associated_with::genes. It also positively regulates cell motility via the transcriptional and/or post-transcriptional regulation of motility-related genes. MALAT1 may play a role in is_associated_with::temperature-dependent sex determination in the Red-eared slider turtle (is_associated_with::Trachemys scripta).

Expression in alcoholic brains
Transcripts of MALAT1 are significantly increased in the is_associated_with::cerebellum of human alcoholics, as well as in similar regions of rat brains after the withdrawal of ethanol vapours. This alcohol-induced upregulation of MALAT1 may be responsible for differential expression of a number of proteins which contribute to ethanol tolerance and dependency in humans.