GSK3B

Glycogen synthase kinase 3 beta, also known as GSK3B, is an is_associated_with::enzyme that in humans is encoded by the GSK3B is_associated_with::gene. In mice, the enzyme is encoded by the GSK-3β gene.

Function
Glycogen synthase kinase-3 (is_associated_with::GSK-3) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and an inactivating agent of is_associated_with::glycogen synthase. Two isoforms, alpha (is_associated_with::GSK3A) and beta, show a high degree of amino acid homology. GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.

Loss of function mutations
is_associated_with::Homozygous disruption of the GSK-3β locus in mice results in embryonic lethality during mid-gestation. This lethality phenotype could be rescued by inhibition of is_associated_with::tumor necrosis factor.

Interactions
GSK3B has been shown to interact with:


 * is_associated_with::AKAP11,
 * is_associated_with::AXIN1,
 * is_associated_with::AXIN2,
 * AR,
 * CTNNB1,
 * is_associated_with::DNM1L,
 * is_associated_with::MACF1
 * is_associated_with::MUC1,
 * SMAD3
 * is_associated_with::NOTCH1,
 * is_associated_with::NOTCH2,
 * is_associated_with::P53,
 * is_associated_with::PRKAR2A,
 * is_associated_with::SGK3, and
 * is_associated_with::TSC2.