Rs1052133

rs1052133, also known as Ser326Cys, is a SNP in the oxoguanine glycosylase 1 OGG1 gene, involved in the repair of DNA damage (for example, damage caused by tobacco smoke). The minor (rarer) allele, encoding the cysteine (Cys), is rs1052133(G). Note that associations reported for this SNP are not always replicating in different studies or populations.

A study of 250 Japanese patients with bladder cancer found an adjusted odds ratio of 2.05 (CI: 1.36-3.08; p = 0.01) for (G;G) homozygotes compared to the other genotypes. In addition, if evaluated only in non-smokers, the adjusted odds ratio increased to 2.78 (CI: 1.39-5.60; p < 0.01).

A study of 200 Chinese patients with gallbladder cancer concluded that increased risk was associated with both the (C;G) genotype (odds ratio 1.9, (CI: = 1.0-3.7) and the (G;G) genotype (odds ratio 4.5, CI: 1.1-22.4).

A study of 300 lung cancer patients of various ethnicities found that the (G;G) genotype was associated with an odds ratio of 2.1 (CI: 1.2-3.7), regardless of sex or ethnicity. However, a Danish study of 400 lung cancer patients found no association.