EPH receptor B2

Ephrin type-B receptor 2 is a is_associated_with::protein that in humans is encoded by the EPHB2 is_associated_with::gene.

Function
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the is_associated_with::nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are is_associated_with::transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the is_associated_with::receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Animal studies
EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an is_associated_with::animal model of is_associated_with::Alzheimer's disease.

A is_associated_with::recessive EphB2 gene is responsible for the crested-feather mutation in is_associated_with::pigeons.

Interactions
EPH receptor B2 has been shown to interact with:
 * is_associated_with::Abl gene,
 * is_associated_with::RAS p21 protein activator 1, the and
 * Src.