Rs1024611

rs1024611, also known as the -2578A>G SNP due to its position in the promoter of the monocyte chemoattractant protein-1 MCP-1 CCL2 gene, influences the production of its corresponding protein, a chemokine involved in inflammatory responses.

In a study focusing on 679 apparently healthy siblings of people with premature heart disease, investigators found that carriers of an rs1024611(C) allele - oriented as in dbSNP, not as published - independently predicted the risk of exercise induced ischemia in general. The odds ratio was reported to be 1.86 (CI: 1.14-3.04, p=0.014), regardless of race, age, sex and other factors. However, it is not clear if this risk carries over to individuals who lack siblings with heart disease.

discussed in the 23andMe blog as being relevant to HIV

rs1024611 is not associated with systemic sclerosis in a multicenter study of 345 European patients

tuberculosis

Association study of functional genetic variants of innate immunity related genes in celiac disease.

Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation.

Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

Polymorphisms within inflammatory genes and colorectal cancer.

Association of the -2510A/G chemokine (C-C motif) ligand 2 polymorphism with knee osteoarthritis in a Korean population.

The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility.

Genome-wide association with select biomarker traits in the Framingham Heart Study.

A genome-wide association study identifies protein quantitative trait loci (pQTLs).

Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

MCP-1 promoter variant -362C associated with protection from pulmonary tuberculosis in Ghana, West Africa.

Analysis of inflammation- and atherosclerosis-related gene polymorphisms in branch retinal vein occlusion.

Common variants of inflammatory cytokine genes are associated with risk of nephropathy in type 2 diabetes among Asian Indians.

Single nucleotide polymorphisms in monocyte chemoattractant protein-1 and its receptor act synergistically to increase the risk of carotid atherosclerosis.

Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.

Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.

The -A2518G polymorphism of monocyte chemoattractant protein-1 is associated with Crohn's disease.

Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage.

Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.

CCL3 genotype and current depression increase risk of HIV-associated dementia.

Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

Monocyte chemoattractant protein-1 in schizophrenia: -2518A/G genetic variant and protein levels in Armenian population.