Zona pellucida-like domain

Zona pellucida-like domain  (ZP domain / ZP-like domain) is a family of evolutionarily related proteins.

A large domain, containing around 260 amino acids, has been recognised in a variety of receptor-like eukaryotic glycoproteins. All of these proteins are mosaic proteins composed of various domains and that all have a large extracellular region followed by either a transmembrane region and a very short cytoplasmic region or by a GPI-anchor. The domain common to all these proteins is a bipartite protein polymerization module that is located in the C-terminal portion of the extracellular region and contains 8 or 10 conserved Cys residues involved in disulfide bonds.

Examples
Humans genes encoding proteins containing this domain include:


 * CUZD1
 * DMBT1
 * ENG
 * GP2
 * OIT3
 * POMZP3
 * TECTA, TECTB, TGFBR3
 * UMOD, UMODL1
 * ZP1, ZP2, ZP3, ZP4, ZPLD1