GPR119

G protein-coupled receptor 119 also known as GPR119 is a is_associated_with::G protein-coupled receptor that in humans is encoded by the GPR119 is_associated_with::gene.

GPR119, along with is_associated_with::GPR55 and is_associated_with::GPR18, have been implicated as novel is_associated_with::cannabinoid receptors.

Pharmacology
GPR119 is expressed predominantly in the is_associated_with::pancreas and is_associated_with::gastrointestinal tract in rodents and humans, as well as in the is_associated_with::brain in rodents. Activation of the receptor has been shown to cause a reduction in food intake and body weight gain in rats. GPR119 has also been shown to regulate is_associated_with::incretin and is_associated_with::insulin is_associated_with::hormone secretion. As a result, new drugs acting on the receptor have been suggested as novel treatments for is_associated_with::obesity and is_associated_with::diabetes.

Ligands
A number of is_associated_with::endogenous and synthetic is_associated_with::ligands for this receptor have been identified:


 * is_associated_with::2-Oleoylglycerol
 * is_associated_with::Anandamide
 * is_associated_with::AR-231,453
 * is_associated_with::MBX-2982
 * is_associated_with::Oleoylethanolamide (Endogenous Ligand)
 * is_associated_with::PSN-375,963
 * is_associated_with::PSN-632,408