Rs7901695

implicated in type-2 diabetes according to this Gene Sherpas post

Extensive blog post theorizing this snp may activate a cryptic exon.

Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in the Amish: replication and evidence for a role in both insulin secretion and insulin resistance.

TCF7L2 polymorphisms are associated with type 2 diabetes in northern Sweden.

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population.

TCF7L2 gene polymorphisms confer an increased risk for early impairment of glucose metabolism and increased height in obese children.

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population.

Variants of the transcription factor 7-like 2 (TCF7L2) gene are associated with type 2 diabetes in an African-American population enriched for nephropathy.

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

Heterogeneity in meta-analyses of genome-wide association investigations.

A variant of the transcription factor 7-like 2 (TCF7L2) gene and the risk of posttransplantation diabetes mellitus in renal allograft recipients.

Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans.

Variation in TCF7L2 and increased risk of colon cancer: the Atherosclerosis Risk in Communities (ARIC) Study.

Common variants of the TCF7L2 gene are associated with increased risk of type 2 diabetes mellitus in a UK-resident South Asian population.

TCF7L2 single nucleotide polymorphisms, cardiovascular disease and all-cause mortality: the Atherosclerosis Risk in Communities (ARIC) study.

Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.

Worldwide population differentiation at disease-associated SNPs.

Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

TCF7L2 variants associate with CKD progression and renal function in population-based cohorts.

Weak or no association of TCF7L2 variants with Type 2 diabetes risk in an Arab population.

Association of variants of the TCF7L2 gene with increases in the risk of type 2 diabetes and the proinsulin:insulin ratio in the Spanish population.

Association studies of 22 candidate SNPs with late-onset Alzheimer's disease.

Single nucleotide transcription factor 7-like 2 (TCF7L2) gene polymorphisms in antiislet autoantibody-negative patients at onset of diabetes.

Loci of TCF7L2, HHEX and IDE on chromosome 10q and the susceptibility of their genetic polymorphisms to type 2 diabetes.

Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

An open access database of genome-wide association results.

Meta-analysis in genome-wide association studies.

Association between TCF7L2 gene polymorphisms and susceptibility to type 2 diabetes mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis.

Genome-wide association studies in type 2 diabetes.

Worldwide patterns of haplotype diversity at 9p21.3, a locus associated with type 2 diabetes and coronary heart disease.

Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

Underlying genetic models of inheritance in established type 2 diabetes associations.

Genome-wide association studies for atherosclerotic vascular disease and its risk factors.

ATRIUM: testing untyped SNPs in case-control association studies with related individuals.

TCF7L2 polymorphism rs7903146 is associated with coronary artery disease severity and mortality.

Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies.

Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

Variants and haplotypes of TCF7L2 are associated with beta-cell function in patients with newly diagnosed type 2 diabetes: the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 1.

Genetic risk profiling for prediction of type 2 diabetes.

Gestational diabetes mellitus is associated with TCF7L2 gene polymorphisms independent of HLA-DQB1*0602 genotypes and islet cell autoantibodies.

Worldwide distribution of type II diabetes-associated TCF7L2 SNPs: evidence for stratification in Europe.

Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.


 * is_associated_with_disease::Alzheimer's disease
 * is_associated_with_disease::Gestational diabetes
 * is_associated_with_disease::Atherosclerosis
 * is_associated_with_disease::Type 2 diabetes mellitus
 * is_associated_with_disease::Coronary heart disease
 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Colon cancer