Peptidylglycine alpha-amidating monooxygenase

Peptidyl-glycine alpha-amidating monooxygenase is an is_associated_with::enzyme that, in humans, is encoded by the PAM is_associated_with::gene.

Function
This gene encodes a multifunctional protein. It has two enzymatically active domains with catalytic activities - peptidylglycine alpha-hydroxylating monooxygenase (PHM) and peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL). These is_associated_with::catalytic domains work sequentially to catalyze is_associated_with::neuroendocrine is_associated_with::peptides to active alpha-amidated products. Multiple alternatively spliced transcript variants encoding different is_associated_with::isoforms have been described for this gene, but some of their full-length sequences are not yet known.

Interactions
Peptidylglycine alpha-amidating monooxygenase has been shown to interact with is_associated_with::TSC2.