Liver X receptor beta

Liver X receptor beta (LXR-β) is a member of the is_associated_with::nuclear receptor family of is_associated_with::transcription factors. LXR-β is encoded by the gene (nuclear receptor subfamily 1, group H, member 2).

Function
The is_associated_with::liver X receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with is_associated_with::retinoid X receptor and bind to specific is_associated_with::response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA) and beta, are known to encode LXR proteins.

Structure
Crystal structure of human liver X receptor β(LXRβ) forming heterodimer with its partner retinoid X receptor α(RXRα) on its cognate element, an AGGTCA direct repeat spaced by 4 nt shows an extended X-shaped arrangement, with DNA- and ligand-binding domains crossed. The LXRβ core binds DNA via canonical contacts and auxiliary DNA contacts that enhance affinity for the response element.

Interactions
Liver X receptor beta has been shown to interact with is_associated_with::NCOA6 and is_associated_with::Retinoid X receptor alpha.