PDGFRB

Beta-type platelet-derived growth factor receptor is a is_associated_with::protein that in humans is encoded by the PDGFRB is_associated_with::gene.

Function
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5q- syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

Interactions
PDGFRB has been shown to interact with:


 * CRK,
 * is_associated_with::Caveolin 1,
 * is_associated_with::Grb2,
 * is_associated_with::NCK1,
 * is_associated_with::NCK2,
 * is_associated_with::PDGFRA,
 * is_associated_with::PTPN11,
 * is_associated_with::RAS p21 protein activator 1,
 * is_associated_with::SHC1 and
 * is_associated_with::Sodium-hydrogen antiporter 3 regulator 1.