Carboxypeptidase A6

Carboxypeptidase A6 (CPA6) is an is_associated_with::metallocarboxypeptidase is_associated_with::enzyme that in humans is encoded by the CPA6 is_associated_with::gene. It is highly expressed in the adult mouse is_associated_with::olfactory bulb and is broadly expressed in the is_associated_with::embryonic is_associated_with::brain and other tissues.

The is_associated_with::protein encoded by this gene belongs to the family of is_associated_with::carboxypeptidases, which catalyze the release of C-terminal is_associated_with::amino acid, and have functions ranging from digestion of food to selective is_associated_with::biosynthesis of is_associated_with::neuroendocrine is_associated_with::peptides. is_associated_with::Polymorphic variants and a is_associated_with::reciprocal translocation t(6;8)(q26;q13) involving this gene, have been associated with is_associated_with::Duane retraction syndrome.

CPA6 processes several is_associated_with::neuropeptides, including [Met]- and [Leu]enkephalin, is_associated_with::angiotensin I, and is_associated_with::neurotensin in vitro. Whereas CPA6 is capable of converting the is_associated_with::enkephalins and neurotensin into inactive forms, it can convert the inactive is_associated_with::angiotensin I into the active is_associated_with::angiotensin II. CPA6 may have additional roles in processing peptides and proteins in vivo, but the nature of these substrates and the effects of these cleavages are currently unknown.