NPLOC4

Nuclear protein localization protein 4 homolog is a is_associated_with::protein that in humans is encoded by the NPLOC4 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of NPLOC4 function. A conditional is_associated_with::knockout mouse line, called Nploc4tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and two is_associated_with::phenotypes were reported. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no significant abnormalities were observed in these animals.

Interactions
NPLOC4 has been shown to interact with is_associated_with::UFD1L.