Zinc finger FYVE domain-containing protein 9

Zinc finger FYVE domain-containing protein 9 or SARA ( S MAD a nchor for r eceptor a ctivation) is a is_associated_with::protein that in humans is encoded by the ZFYVE9 is_associated_with::gene. SARA contains a double zinc finger (is_associated_with::FYVE domain).

SARA is an anchoring protein involved in TGF beta signaling. It binds to the MH2 domain of the is_associated_with::R-SMADs is_associated_with::SMAD2 and is_associated_with::SMAD3 as well as the type I TGF beta receptors. It facilitates the phosphorylation of the R-SMAD, which subsequently dissociates form SARA and the receptor and binds a coSMAD where they enter the nucleus as is_associated_with::transcription factors.