API5

The human is_associated_with::gene API5 encodes the is_associated_with::protein Apoptosis inhibitor 5.

This gene encodes an is_associated_with::apoptosis inhibitory protein whose expression prevents apoptosis after is_associated_with::growth factor deprivation. This protein suppresses the is_associated_with::transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates acinus, a nuclear factor involved in apoptotic is_associated_with::DNA fragmentation. Its depletion enhances the cytotoxic action of chemotherapeutic drugs.

Diseases associated with API5 include colon is_associated_with::adenocarcinoma, and is_associated_with::cervical cancer.