Amfepramone

Amfepramone (INN, other names diethylcathinone and diethylpropion, trade names Anorex, Linea, Nobesine, Prefamone, Regenon, Tepanil, Tenuate), is a stimulant drug of the phenethylamine, amphetamine, and cathinone chemical classes that is used as an appetite suppressant.

Pharmacology
Amfepramone itself lacks any affinity for the monoamine transporters and instead functions as a prodrug to ethcathinone. Ethcathinone (and therefore amfepramone as well) is a very weak dopaminergic and serotonergic, and is approximately 10x and 20x stronger on norepinephrine in comparison, respectively. As a result, ethcathinone and amfepramone can essentially be considered selective norepinephrine releasing agents (NRAs).

Abuse
Amfepramone is believed to have relatively low abuse potential.

Legality
Amfepramone is classified as a Schedule IV controlled substance in the United States. In the UK Amfepramone is a class C drug.

Chemistry

 * 1) Propiophenone is brominated to produce α-bromopropiophenone.
 * 2) This is reacted with diethylamine to yield the product, diethylpropion.

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