Steroid sulfatase

Steroid sulfatase (or steryl-sulfatase), formerly known as arylsulfatase C, is a is_associated_with::sulfatase is_associated_with::enzyme involved in the metabolism of is_associated_with::steroids. It is encoded by the STS gene.

Function
The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to the free steroid. This includes sulfated androgens and sulfated estrogens. The encoded protein is found in the is_associated_with::endoplasmic reticulum, where it is present as a homodimer.

Clinical significance
A deficiency is associated with is_associated_with::X-linked ichthyosis, a scaly-skin disease affecting roughly 1 in every 2,000-6,000 males.