Vesicle-associated membrane protein

Vesicle associated membrane proteins (VAMP) are a family of SNARE proteins with similar structure, and are mostly involved in vesicle fusion.


 * VAMP1 and VAMP2 proteins known as synaptobrevins are expressed in brain and are constituents of the synaptic vesicles, where they participate in neuromediator release.


 * VAMP3 (known as cellubrevin) is ubiquitously expressed and participates in regulated and constitutive exocytosis as a constituent of secretory granules and secretory vesicles.


 * VAMP5 and VAMP7 (SYBL1) participate in constitutive exocytosis.
 * VAMP5 is a constituent of secretory vesicles, myotubes and tubulovesicular structures.
 * VAMP7 is found both in secretory granules and endosomes.


 * VAMP8 (known as endobrevin) participates in endocytosis and is found in early endosomes. VAMP8 also participates the regulated exocytosis in pancreatic acinar cells.


 * VAMP4 is involved in transport from the Golgi.