Rs5751876

Variation at this SNP, rs5751876, also referred to as 1976C>T or 1976T>C, appears to influence how an individual responds to moderate levels (150mg) of caffeine.

T/T carriers displaying significantly increased subjective levels of anxiety after consumption.

However a PharmGKB variant annotation suggests it is (C;C) genotypes who are more sensitive to caffeine.

rs5751876 is not associated with how much coffee one drinks, though, nor with risk for Parkinson's disease, based on a study of 1,200 subjects.

"rs2298383 shows functional potential based on in silico analyses and might therefore represent the true underlying causal variant"