ZEB1

Zinc finger E-box-binding homeobox 1 is a is_associated_with::protein that in humans is encoded by the ZEB1 is_associated_with::gene.

TCF8 encodes a human is_associated_with::zinc finger is_associated_with::transcription factor that represses T-lymphocyte-specific IL2 gene expression by binding to a negative regulatory domain 100 nucleotides 5-prime of the IL2 is_associated_with::transcription start site.

Clinical significance
Mutations of the gene are linked to is_associated_with::posterior polymorphous corneal dystrophy 3. A recent study suggested its contributing role in is_associated_with::lung cancer invasiveness and metastasis development.