MIR941-1

MicroRNA 941-1 is a human specific is_associated_with::microRNA that is encoded by the MIR941-1 is_associated_with::gene.

Function
is_associated_with::microRNAs (miRNAs) are short (20-24 nt) non-coding is_associated_with::RNAs that are involved in post-transcriptional regulation of is_associated_with::gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by is_associated_with::RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the is_associated_with::Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a is_associated_with::RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Evolution
The miR-941 gene is only found in humans where it first appeared between one and six million years ago. Its copy number and binding sites have decreased with migration out of Africa. miR-941 regulates genes involved in is_associated_with::cellular differentiation and is_associated_with::neurotransmitter signalling.