Sodium–hydrogen antiporter 1

The sodium-hydrogen antiporter 1 (NHE-1)  also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of is_associated_with::sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 is_associated_with::gene.

Function
The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug is_associated_with::amiloride and activated by a variety of signals including is_associated_with::growth factors, is_associated_with::mitogens, is_associated_with::neurotransmitters, tumor promoters, and others.

Interactions
Sodium–hydrogen antiporter 1 has been shown to interact with is_associated_with::carbonic anhydrase II and CHP.