NBPF10

Neuroblastoma breakpoint family member 10 is a is_associated_with::protein that in is_associated_with::Homo sapiens is encoded by the NBPF10 is_associated_with::gene.

The full gene is 75,313 bp, with the major isoform of is_associated_with::mRNA being 10,697 bp long. The gene is located at 1q21.1. NBPF contains what is known as the is_associated_with::DUF1220 repeats. The highly conserved, repeated region is believed to be originated from is_associated_with::MGC8902. The NBPF family has been linked to primate evolution. It is assumed to be related to the is_associated_with::1q21.1 deletion syndrome and is_associated_with::1q21.1 duplication syndrome.

Homology
Paralogs of NBPF10 includes other NBPF family members. Orthologs of NBPF10 are found in other primates; distant orthologs are found in bovine, equine, and canine



Functional role
Although NBPF10's function is unknown, there is reason to believe that NBPF10 is an important is_associated_with::biomarker for the is_associated_with::Odontoblast is_associated_with::Phenotype

Gene Neighborhood
is_associated_with::NOTCH2NL, is_associated_with::SEC22B, HFE2, is_associated_with::TXNIP are close neighbors of NBPF10. All of these neighboring genes are well studied in their own right.



Post-translational modification
NBPF10 has extremely low is_associated_with::threonine content which may make the protein less susceptible to is_associated_with::post-translational modification.