EHMT1

Euchromatic histone-lysine N-methyltransferase 1, also known as G9a-like protein (GLP), is a is_associated_with::protein that in humans is encoded by the EHMT1 is_associated_with::gene.

Function
The protein encoded by this gene is a is_associated_with::histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of is_associated_with::histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of is_associated_with::MYC- and is_associated_with::E2F-responsive genes and therefore could play a role in the G0/G1 is_associated_with::cell cycle transition.

Clinical significance
Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome).