DTNA

Dystrobrevin alpha is a is_associated_with::protein that in humans is encoded by the DTNA is_associated_with::gene.

Function
The protein encoded by this gene belongs to the is_associated_with::dystrobrevin subfamily and the is_associated_with::dystrophin family. This protein is a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including is_associated_with::dystroglycans, is_associated_with::sarcoglycans, is_associated_with::syntrophins and alpha- and beta-dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of is_associated_with::muscular dystrophy. This protein may be involved in the formation and stability of is_associated_with::synapses as well as the clustering of is_associated_with::nicotinic acetylcholine receptors. Multiple is_associated_with::alternatively spliced transcript variants encoding different isoforms have been identified.

Clinical significance
Mutations in DTNA are associated to Meniere's disease.

Interactions
DTNA has been shown to interact with is_associated_with::dystrophin.