ACVR1C

The activin A receptor also known as ACVR1C or ALK-7 is a protein that in humans is encoded by the ACVR1C is_associated_with::gene. ACVR1C is a type I receptor for the is_associated_with::TGFB family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD family is_associated_with::transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors.

ACVR1C transduces signals of Nodal. Nodal binds to is_associated_with::ACVR2B and then forms a complex with ACR1C. These go on to recruit the is_associated_with::R-SMADs is_associated_with::SMAD2 or is_associated_with::SMAD3.