Indeloxazine

Indeloxazine (Elen, Noin) is a so-called cerebral activator used in Japan for the treatment of cerebrovascular disease. It was launched in 1988. Indeloxazine acts as a serotonin releasing agent and norepinephrine reuptake inhibitor. It also acts as an NMDA receptor antagonist. It enhances acetylcholine release through indirect activation of the 5-HT4 receptor. Indeloxazine has nootropic,  neuroprotective,    anticonvulsant, and antidepressant effects.