Rs1858830

rs1858830, located in promoter of the MET gene, has been linked to a 2x increase in the risk of autism based on a study of ~700 families.

From OMIM 164860:

"In case-control analysis, the relative risk for autism was 2.27 for the CC genotype and 1.67 for the GC genotype compared to the GG genotype."

The association of rs1858830 in the MET gene with autism failed to replicate in 325 multiplex families and 10 trios of the International Molecular Genetic Study of Autism Consortium (IMGSAC), although another MET SNP did associate with autism (rs38845)


 * is_associated_with_disease::Autistic disorder