TOPBP1

DNA topoisomerase 2-binding protein 1 is an is_associated_with::enzyme that in humans is encoded by the TOPBP1 is_associated_with::gene.

Interactions
TOPBP1 has been shown to interact with is_associated_with::RAD9A, is_associated_with::E2F1, is_associated_with::Promyelocytic leukemia protein, is_associated_with::ZBTB17 and is_associated_with::UBR5.

Clinical relevance
This gene may be involved in the development of ovarian and breast cancer.

Mutations in TOPBP1 cause Idiopathic pulmonary arterial hypertension.