Diclofensine

Diclofensine (Ro 8-4650) is a stimulant drug which acts as a triple monoamine reuptake inhibitor, primarily inhibiting the reuptake of dopamine and noradrenaline. It was found to be an effective antidepressant in human trials,  with relatively few side effects, but was ultimately dropped from clinical development, possibly due to concerns about its abuse potential.

Diclofensine is chemically a tetrahydroisoquinoline (THIQ) derivative, as is nomifensine.