Rs25489

rs25489, a SNP also known as Arg280His located in the DNA-repair gene XRCC1, is associated with an increased risk for breast cancer based on a study of 1,100 Cypriot women. The odds ratio for the rs25489(A;A) homozygote is 4.68, CI: 1.01-21.7, p=0.03.

rs25489(A;G) prostate cancer patients being treated by radiation therapy are more likely (67% compared to 24%, p=0.048) to develop erectile dysfunction after irradiation than (G;G) patients, based on a study of 135 patients.

A meta-analysis concludes that this SNP is not associated with risk of gastric cancer.

Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.

Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC1.

DNA repair gene XRCC1 polymorphisms and bladder cancer risk.

Selected base excision repair gene polymorphisms and susceptibility to biliary tract cancer and biliary stones: a population-based case-control study in China.

Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.

Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years.

Polymorphisms in DNA repair genes, smoking, and pancreatic adenocarcinoma risk.

Genotyping panel for assessing response to cancer chemotherapy.

Polygenic model of DNA repair genetic polymorphisms in human breast cancer risk.

Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994.

International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.

Base excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African-Americans.

Thyroid nodules, polymorphic variants in DNA repair and RET-related genes, and interaction with ionizing radiation exposure from nuclear tests in Kazakhstan.

Smoking modifies the relationship between XRCC1 haplotypes and HPV16-negative head and neck squamous cell carcinoma.

Gene-environment interactions between DNA repair polymorphisms and exposure to the carcinogen vinyl chloride.

Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer.

XRCC1 polymorphisms and breast cancer risk from the New York Site of the Breast Cancer Family Registry: A family-based case-control study.

Functional polymorphisms of base excision repair genes XRCC1 and APEX1 predict risk of radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.

Evaluation of the XRCC1 gene as a phenotypic modifier in BRCA1/2 mutation carriers. Results from the consortium of investigators of modifiers of BRCA1/BRCA2.

Polymorphisms in base excision DNA repair genes and association with melanoma risk in a pilot study on Central-South Italian population.