Rs1466785

Minor allele increases risk of breast cancer in BRCA2 mutation carriers in a study size of 23,463 carriers. The study considers rs804276 and rs804271 more likely causal variants, but they're not tested by standard beadchips. All are thought to affect NEIL2, which removes oxidized bases from transcribing genes.

Preferential repair of oxidized base damage in the transcribed genes of mammalian cells


 * is_associated_with_disease::Hereditary breast ovarian cancer
 * is_associated_with_disease::Breast cancer