BATF (gene)

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a is_associated_with::protein which in humans is encoded by the BATF is_associated_with::gene.

Function
The protein encoded by this gene is a nuclear basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of is_associated_with::transcription factors. The leucine zipper of this protein mediates dimerization with members of the Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to is_associated_with::multiple sclerosis.

Interactions
BATF (gene) has been shown to interact with is_associated_with::IFI35.