PRIMA1

Proline-rich membrane anchor 1, also known as PRiMA, is a is_associated_with::protein that in humans is encoded by the PRIMA1 is_associated_with::gene.

Function
PRiMA functions to organize is_associated_with::acetylcholinesterase (AChE) into tetramers, and to anchor AChE at neural cell membranes. This is accomplished by the proline rich anchor domain (PRAD) of PRIMA1 which anchors the tetramer of AChE into the plasma membrane of is_associated_with::neural cells and is_associated_with::myocytes. The PRAD interacts with the is_associated_with::C-terminal T-peptide if AChE.

PRiMA plays a role in targeting AChE to the cell surface and, in is_associated_with::neuroblastoma cells, PRiMA the limiting factor of such targeting. In both mice and humans, PRiMA exists as two alternative splice variants that differ in their cytoplasmic regions.

Clinical significance
The severity of neurogenerative diseases, such as Alzheimer’s, can be related to the degradation of AChE.