MTRF1L

Mitochondrial translational release factor 1-like is a is_associated_with::protein that in humans is encoded by the MTRF1L is_associated_with::gene.

Mitochondrial DNA encodes 13 proteins that play essential roles in the respiratory chain, while all proteins involved in mitochondrial translation are encoded by nuclear genes that are imported from the cytoplasm. MTRF1L is a nuclear-encoded protein that functions as a releasing factor that recognizes termination codons and releases mitochondrial ribosomes from the synthesized protein (summary by Nozaki et al., 2008 [PubMed 18429816]).[supplied by OMIM].

Model organisms
is_associated_with::Model organisms have been used in the study of MTRF1L function. A conditional is_associated_with::knockout mouse line, called Mtrf1ltm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. No is_associated_with::homozygous mutant embryos were recorded during gestation and, in a separate study, no homozygous animals were observed at is_associated_with::weaning. The remaining tests were carried out on adult is_associated_with::heterozygous mutant animals and males displayed an increased circulating is_associated_with::free fatty acid level.