Rs1800588

rs1800588, also known as the -514C/T polymorphism of the LIPC gene, may influence the levels of the "good" cholestorols, the high density lipoprotein (HDL) cholesterols. Generally, the (T) allele (as published) is considered to lead to higher HDL levels.

However, high HDL cholesterol, at least when combined with another HDL raising SNP (rs708272), doesn't appear to actually protect individuals from coronary artery disease, at least based on one study of ~800 Caucasian male patients.

Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adults.

A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study.

Low-density lipoprotein and high-density lipoprotein cholesterol levels in relation to genetic polymorphisms and menopausal status: the Atherosclerosis Risk in Communities (ARIC) Study.

New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.

A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

Genetic differences between the determinants of lipid profile phenotypes in African and European Americans: the Jackson Heart Study.

Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.

Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Development of a fingerprinting panel using medically relevant polymorphisms.

Common lipid-altering gene variants are associated with therapeutic intervention thresholds of lipid levels in older people.

beta-Carotene conversion products and their effects on adipose tissue.

Polymorphisms in the hepatic lipase gene affect plasma HDL-cholesterol levels in a Turkish population.

Genetic loci associated with plasma concentration of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, apolipoprotein A1, and Apolipoprotein B among 6382 white women in genome-wide analysis with replication.

Molecular interactions between HNF4a, FOXA2 and GABP identified at regulatory DNA elements through ChIP-sequencing.

Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

Using a latent growth curve model for an integrative assessment of the effects of genetic and environmental factors on multiple phenotypes.

Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project.

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

Genetic polymorphisms in fatty acid metabolism genes and colorectal cancer.