Nuclear receptor co-repressor 2

The nuclear receptor co-repressor 2 is a transcriptional coregulatory protein that contains several is_associated_with::nuclear receptor-interacting domains. In addition, NCOR2 appears to recruit is_associated_with::histone deacetylases to DNA promoter regions. Hence NCOR2 assists nuclear receptors in the down regulation of target gene expression. NCOR2 is also referred to as a silencing mediator for retinoid or thyroid-hormone receptors (SMRT) or T3 receptor-associating cofactor 1 (TRAC-1).

Function
NCOR2/SMRT is a transcriptional coregulatory protein that contains several modulatory functional domains including multiple autonomous repression domains as well as two or three C-terminal nuclear receptor-interacting domains. NCOR2/SMRT serves as a repressive coregulatory factor (corepressor) for multiple is_associated_with::transcription factor pathways. In this regard, NCOR2/SMRT functions as a platform protein, facilitating the recruitment of is_associated_with::histone deacetylases to the DNA promoters bound by its interacting transcription factors.

Discovery
SMRT was initially cloned and characterized in the laboratory of Dr. is_associated_with::Ronald M. Evans at the Salk Institute for Biological Studies. In another early investigation into this molecule, similar findings were reported in a variant referred to as TRAC-1.

Interactions
Nuclear receptor co-repressor 2 has been shown to interact with:


 * AR,
 * is_associated_with::BCL6,
 * is_associated_with::C-Fos,
 * is_associated_with::C-jun,
 * is_associated_with::HDAC1,
 * is_associated_with::HDAC3,
 * is_associated_with::HDAC4,
 * HDAC5,
 * is_associated_with::HDAC10,
 * is_associated_with::MeCP2,
 * NR4A1,
 * is_associated_with::POU2F1,
 * PPARD,
 * PGR,
 * PML
 * is_associated_with::RBPJ,
 * is_associated_with::RELA,
 * is_associated_with::RUNX1T1,
 * RARA,
 * is_associated_with::SIN3A,
 * is_associated_with::SNW1,
 * is_associated_with::SPEN,
 * SRF,
 * is_associated_with::TBL1X,
 * THRB,
 * VDR, and
 * ZBTB16.