SALL1

Sal-like 1 (Drosophila), also known as SALL1, is a is_associated_with::protein which in humans is encoded by the SALL1 is_associated_with::gene. As the full name suggests, it is one of the human versions of the spalt (sal) gene known in is_associated_with::Drosophila.

Function
The protein encoded by this gene is a is_associated_with::zinc finger transcriptional repressor and may be part of the NuRD is_associated_with::histone deacetylase (HDAC) complex.

Clinical significance
Defects in this gene are a cause of is_associated_with::Townes–Brocks syndrome (TBS) as well as is_associated_with::branchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene.

Interactions
SALL1 has been shown to interact with is_associated_with::TERF1 and is_associated_with::UBE2I.