PRKCE

Protein kinase C epsilon type is an is_associated_with::enzyme that in humans is encoded by the PRKCE is_associated_with::gene.

Function
is_associated_with::Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger is_associated_with::diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for is_associated_with::phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as is_associated_with::apoptosis, cardioprotection from is_associated_with::ischemia, is_associated_with::heat shock response, as well as insulin is_associated_with::exocytosis.

Clinical significance
Knockout and molecular studies in mice suggest that this kinase is important for regulating behavioural response to morphine and alcohol. It also plays a role lipopolysaccharide (LPS)-mediated signaling in activated macrophages and in controlling anxiety-like behavior.

Substrates and interactions
PKC-epsilon has a wide variety of substrates, including is_associated_with::ion channels, other signalling molecules and is_associated_with::cytoskeletal proteins.

PKC-epsilon has been shown to interact with:
 * ACTA1,
 * is_associated_with::COPB2,
 * CFTR,
 * KRT1,
 * is_associated_with::GNB2L1,
 * is_associated_with::MYH9,
 * is_associated_with::VDAC1, and
 * is_associated_with::YWHAZ.