MCAT (gene)

Malonyl CoA-acyl carrier protein transacylase, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the MCAT is_associated_with::gene.

Function
The protein encoded by this gene is found exclusively in the is_associated_with::mitochondrion, where it catalyzes the transfer of a is_associated_with::malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a is_associated_with::fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Two transcript variants encoding different isoforms have been found for this gene.

Clinical significance
The enzyme encoded by the MCAT gene, along with other enzymes that regulate is_associated_with::Malonyl-CoA concentration, have been shown to regulate levels such that malonyl-CoA concentration decreases in human muscle tissue when under exercise training. This enzyme specifically has increased activity under these conditions, as it is known to catabolize malonyl-CoA.

Interactions
The human Malonyl CoA-acel carrier protein is_associated_with::transacylase in human mitochondria associates with respiratory complex one, such that it interacts functionally with a mitochondrial is_associated_with::malonyltransferase. Both species are encoded by nuclear genes, and their translocation into mitochondria is dependent on the presence of an is_associated_with::N-terminal targeting sequence.