Phospholipase D1

Phospholipase D1 is an is_associated_with::enzyme that in humans is encoded by the PLD1 is_associated_with::gene.

Function
Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995).[supplied by OMIM]

Interactions
Phospholipase D1 has been shown to interact with:


 * is_associated_with::Alpha-synuclein,
 * is_associated_with::Amphiphysin,
 * is_associated_with::BIN1,
 * is_associated_with::CDC42,
 * is_associated_with::PEA15,
 * is_associated_with::Protein kinase N1
 * is_associated_with::RALA,  and
 * is_associated_with::RHOA.

Inhibitors

 * VU-0359595: 1,700-fold selective versus phospholipase D2, IC50 = 3.7nM.