CHRDL1

Chordin-like 1 is a is_associated_with::protein that in humans is encoded by the CHRDL1 is_associated_with::gene.

Function
This gene encodes an antagonist of is_associated_with::bone morphogenetic protein 4. The encoded protein may play a role in topographic retinotectal projection and in the regulation of retinal is_associated_with::angiogenesis in response to hypoxia. is_associated_with::Alternatively spliced transcript variants encoding different isoforms have been described.

Clinical significance
Mutations in CHRDL1 are associated to Neuhäuser Syndrome,  X-linked megalocornea and  central corneal thickness.