Rs2952768

Genome-wide association study identifies a potent locus associated with human opioid sensitivity

rs2952768(C) was associated with more analgesic requirements ... exhibited less vulnerability to severe methamphetamine or alcohol dependence, fewer eating disorders, and a lower ‘Reward Dependence’ score on a personality questionnaire. The (C;C) genotype was significantly associated with the elevated expression of a neighboring gene, CREB. SNPs in this locus are the most potent genetic factors associated with human opioid sensitivity known to date, affecting both the efficacy of opioid analgesics and liability to severe substance dependence.

Our findings provide valuable information for the personalized treatment of pain and drug dependence.


 * is_associated_with_disease::Drug dependence