KDM2B

The human KDM2B is_associated_with::gene encodes the is_associated_with::protein Lysine (K)-specific demethylase 2B.

Function
This gene encodes a member of the is_associated_with::F-box protein family which is characterized by an approximately 40 is_associated_with::amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of is_associated_with::ubiquitin protein is_associated_with::ligase complex called SCFs (SKP1-cullin-F-box), which function in is_associated_with::phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing is_associated_with::leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined.