NRG3

Neuregulin 3 also known as NRG3 is a member of the is_associated_with::neuregulin is_associated_with::protein family which in humans is encoded by the NRG3 is_associated_with::gene.

Function
NRG3 can bind to the extracellular domain of the is_associated_with::ERBB4 receptor tyrosine kinase but not to the related family members is_associated_with::ERBB2 or is_associated_with::ERBB3. NRG3 binding stimulates tyrosine is_associated_with::phosphorylation of ERBB4.

Clinical significance
Variants of the NRG3 gene have been linked to a susceptibility to is_associated_with::schizophrenia.

It has also been linked to is_associated_with::Hirschsprung's disease.