STUB1

STUB1 ( ST IP1 homology and U - B ox containing protein 1 ), also known as CHIP ( C terminus of H SC70- I nteracting P rotein), is a human is_associated_with::gene.

Function
The CHIP protein encoded by this gene binds to and inhibits the is_associated_with::ATPase activity of the chaperone proteins HSC70 and HSP70 and blocks the forward reaction of the HSC70-HSP70 substrate-binding cycle. In addition, CHIP possesses E3 ubiquitin ligase activity and promotes is_associated_with::ubiquitylation. CHIP enhances HSP70 induction during acute stress and also mediates its turnover during the stress recovery process. Hence CHIP appears to maintain protein homeostasis by controlling chaperone levels during stress and recovery.

Mutations in STUB1 cause ataxia.

Interactions
STUB1 has been shown to interact with is_associated_with::C-Raf, is_associated_with::Parkin (ligase), is_associated_with::DNAJB1, is_associated_with::HSPA8, is_associated_with::RUNX2, is_associated_with::HSPA1A and is_associated_with::HSPA4.