TRAPPC2

Trafficking protein particle complex subunit 2 (TRAPPC2) also known as MBP-1-interacting protein 2A (MIP-2A) is a is_associated_with::protein that in humans is encoded by the TRAPPC2 is_associated_with::gene. A processed pseudogene of this gene is located on chromosome 19, and other pseuodogenes of it are found on chromosome 8 and the Y chromosome. Two transcript variants encoding the same protein have been found for this gene.

Function
Trafficking protein particle complex subunit 2 is thought to be part of a large multisubunit complex involved in the targeting and fusion of is_associated_with::endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind MBP1 and block its transcriptional repression capability.

Genetic Location
The TRAPPC2 gene is located on the is_associated_with::X-chromosome at position 22 between base-pairs 13,712,241 to 13,734,634.

Clinical significance
Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT).

Interactions
TRAPPC2 has been shown to interact with is_associated_with::Alpha-enolase and is_associated_with::CLIC1.