Hippocalcin

Hippocalcin is a is_associated_with::protein that in humans is encoded by the HPCA is_associated_with::gene.

Hippocalcin is a is_associated_with::calcium-binding protein that belongs to the is_associated_with::neuronal calcium sensor (NCS) family of proteins. It is expressed in is_associated_with::mammalian is_associated_with::brains especially in the is_associated_with::hippocampus. It possesses a Ca2+/myristoyl switch.

Processes
Hippocalcin takes part in the following processes:


 * Activation of PLD1 and is_associated_with::PLD2 expression
 * Inhibition of is_associated_with::apoptosis
 * is_associated_with::MAP kinase signalling
 * Involved in long term depression in is_associated_with::hippocampal neuron
 * Required for normal is_associated_with::spatial learning

Interactions
Hippocalcin interacts with following proteins:


 * Neuronal apoptosis inhibitory protein (NAIP)
 * Mixed lineage kinase 2 (MLK2) – MLK2 is myosin light chain kinase 2
 * The b2 adaptin of the AP2 complex
 * Calcium-dependent activator protein for secretion (is_associated_with::CADPS)