Glycine transporter 1

Sodium- and chloride-dependent glycine transporter 1 is a is_associated_with::protein that in humans is encoded by the SLC6A9 is_associated_with::gene.

Selective inhibitors
Elevation of extracellular synaptic is_associated_with::glycine concentration by blockade of GlyT1 has been hypothesized to potentiate is_associated_with::NMDA receptor function in vivo and to represent a rational approach for the treatment of schizophrenia and cognitive disorders. Several drug candidates have reached clinical trials.
 * is_associated_with::ASP2535
 * is_associated_with::Bitopertin (RG1678), which has entered phase II trials for the treatment of schizophrenia
 * is_associated_with::Org 25935
 * PF-03463275 (in phase II trial)