Interleukin 19

Interleukin 19 is a is_associated_with::protein that in humans is encoded by the IL19 is_associated_with::gene.

Function
The protein encoded by this gene is a cytokine that belongs to the IL-10 cytokine subfamily. This cytokine is found to be preferentially expressed in is_associated_with::monocytes. It can bind the is_associated_with::interleukin-20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (is_associated_with::STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and is_associated_with::TNF-alpha and induce is_associated_with::apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.

Interleukin-19 is a is_associated_with::cytokine that belongs to the IL-10 family of cytokines along with several other is_associated_with::interleukins including IL-10, IL-20, IL-22, IL-24, IL-26, and several is_associated_with::virus-encoded cytokines. It signals through the same cell surface receptor (IL-20R) that is used by IL-20 and IL-24. The IL-19 is_associated_with::gene is expressed in resting is_associated_with::monocytes and is_associated_with::B cells. It is up-regulated in monocytes following stimulation with is_associated_with::granulocyte-macrophage colony-stimulating factor (GM-CSF) or is_associated_with::lipopolysaccharide.