Rs5911

rs5911, also known as Ile874Ser or Ile843Ser, is a SNP in the ITGA2B gene on chromosome 17. In the context of the plus strand nomenclature used by dbSNP, rs5911(A) encodes the Ile, and rs5911(G) the Ser. The rs5911(C) allele gives rise to the platelet-specific alloantigen known as BAK.

Of some historic interest in the field of platelet transfusion, the BAK alloantigen (rs5911(C;C) homozygotes) has more recently been reported in a small study of healthy Chinese males to be associated with decreased ex vivo antiplatelet activity of ticagrelor.