Rs28941779

rs28941779, also known as Phe392Leu or F392L, is a SNP in the WT1 gene on chromosome 11.

A report links a mutation at this SNP to the rare disease known as Frasier syndrome, which has similarities to Denys-Drash syndrome, no doubt in part since both are based on mutations in the WT1 gene.

See also OMIM 607102.0025

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.