FLNB

Filamin B, beta (FLNB), also known as Filamin B, beta (actin binding protein 278), is a is_associated_with::cytoplasmic is_associated_with::protein which in humans is encoded by the FLNB is_associated_with::gene.

FLNB regulates intracellular communication and signalling by cross-linking the protein is_associated_with::actin to allow direct communication between the is_associated_with::cell membrane and cytoskeletal network, to control and guide proper skeletal development.

Mutations in the FLNB gene are involved in several lethal bone dysplasias, including is_associated_with::boomerang dysplasia and is_associated_with::atelosteogenesis type I.

Interactions
FLNB has been shown to interact with is_associated_with::GP1BA, is_associated_with::Filamin, is_associated_with::FBLIM1, is_associated_with::PSEN1, is_associated_with::CD29 and is_associated_with::PSEN2.