TOLLIP

Toll interacting protein, also known as TOLLIP, is an inhibitory is_associated_with::adaptor protein that in humans is encoded by the TOLLIP is_associated_with::gene.

Function
It is an inhibitory adaptor protein within is_associated_with::Toll-like receptors (TLR). The TLR pathway is a part of the is_associated_with::innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.

Clinical significance
Polymorphisms in TLR genes have been implicated in various diseases like is_associated_with::atopic dermatitis. Recently, variations in the TOLLIP gene have been associated with tuberculosis and idiopathic pulmonary fibrosis.

Interactions
TOLLIP has been shown to interact with is_associated_with::TOM1, is_associated_with::TLR 2, is_associated_with::TLR 4 and is_associated_with::IL1RAP.