Rs2303067

rs2303067, a SNP in the SPINK5 gene, has been significantly associated with susceptibility to atopic dermatitis.

The risk allele for rs2303067 is (A).

rs2303067 has also been associated with predisposition to asthma,. From this study: "A significant association between rs2303067 and the development of asthma was observed (OR 1.77; 95%CI: 1.02-3.06, P=0.041 for rs2303067(A;A) homozygotes). Atopic carriers of rs2303067 showed an increased risk for asthma and asthma symptoms (OR 2.06; 95%CI: 1.01-4.20, P=0.047). When children with a combination of asthma and atopic dermatitis were compared with normal controls, the rs2303067(A) genotype was more prevalent in the disease group (OR 4.56; 95%CI: 1.370-15.12, P=0.007)."


 * is_associated_with_disease::Netherton syndrome
 * is_associated_with_disease::Atopic dermatitis
 * is_associated_with_disease::Asthma