GAS5

Growth arrest-specific 5 is a non-protein coding is_associated_with::RNA that in humans is encoded by the GAS5 is_associated_with::gene.

GAS5 is_associated_with::noncoding RNA, which accumulates in growth arrested cells, acts as a decoy is_associated_with::hormone response element for the is_associated_with::glucocorticoid receptor (GR) and hence blocks the upregulation of gene expression by activated GR.

A number of studies have linked GAS5 to is_associated_with::apoptosis and it may play a role in the progression of some types of is_associated_with::cancer.

The GAS5 introns host several is_associated_with::snoRNA sequences, including SNORD81, SNORD47, SNORD80, SNORD79, SNORD78, SNORD44, SNORD77, SNORD76, SNORD75 and SNORD74. These intronic sequences are more conserved than the exons of the host gene, these sorts of genes are often called "inside-out genes".

It was recently discovered that the nonsense-mediated degradation pathway can regulate the function of the GAS5 in mammalian cells.