FAM40A

Protein FAM40A is a is_associated_with::protein that is located on is_associated_with::chromosome 1 in humans and is encoded by the FAM40A is_associated_with::gene.

Characteristics and secondary structure
FAM40A has an is_associated_with::isoelectric point of 5.92 and a is_associated_with::molecular weight of 95,575 daltons. It is predicted to have three is_associated_with::transmembrane domains, making it a is_associated_with::transmembrane protein. FAM40A does not contain a is_associated_with::signal peptide and is also predicted to bind to is_associated_with::DNA, possibly making it a is_associated_with::membrane protein in the is_associated_with::nuclear membrane.

The is_associated_with::secondary structure of FAM40A is predicted to contain twenty-six is_associated_with::alpha helices and two is_associated_with::beta sheets. The 5' is_associated_with::untranslated region of FAM40A is predicted to contain one is_associated_with::stem-loop and the 3' untranslated region is predicted to contain eight stem-loop structures. Two is_associated_with::miRNAs are predicted to bind to two of the stem-loop structures present in the 3' UTR region.

Homology
FAM40A has no is_associated_with::paralogs. However, it does have is_associated_with::orthologs stretching all the way back to is_associated_with::yeast. It has been suggested that FAM40A is a is_associated_with::homolog to the yeast gene FAR11, which is involved in the recovery from cell cycle arrest.

The following table represents a small selection of orthologs found using searches in is_associated_with::BLAST and BLAT. This is by no means a comprehensive list, however it does show the vast diversity of species where FAM40A orthologs are found.

Expression
FAM40A is expressed in high levels during the is_associated_with::blastocyst, is_associated_with::eight-cell stage, and is_associated_with::fetal stages of development. FAM40A has also been shown to be expressed in high levels in the is_associated_with::mammary glands, is_associated_with::brain, is_associated_with::thymus, is_associated_with::mouth and the is_associated_with::testes. It has also been shown to be expressed in high levels in is_associated_with::mammary gland tumors, leukemia cells, and is_associated_with::germ cell tumors.



Transcription Regulation
FAM40A is predicted to have a is_associated_with::promoter region 789 base pairs upstream of the start of transcription. The SOX is_associated_with::transcription factors are predicted to bind to the promoter region of the FAM40A gene, possibly indicating a role in sex determination.

Interactions
FAM40A has been shown to interact with is_associated_with::RP6-213H19.1, is_associated_with::STRN, is_associated_with::PDCD10, is_associated_with::TRAF3IP3, is_associated_with::STRN3, is_associated_with::PPP2R1A, is_associated_with::MOBKL3, is_associated_with::CTTNBP2NL, is_associated_with::STK24 and is_associated_with::PPP2CA.