JAG1

JAG1 is a protein associated with is_associated_with::Alagille syndrome. JAG1 has also been designated as CD339 (is_associated_with::cluster of differentiation 339).

Function
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor is_associated_with::Notch-1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis.

Interactions
JAG1 has been shown to interact with is_associated_with::NOTCH2.