TAP2

TAP2 is a is_associated_with::gene in humans that encodes the is_associated_with::protein Antigen peptide transporter 2.

Function
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various is_associated_with::molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 (is_associated_with::TAP1). The protein encoded by this gene is involved in is_associated_with::antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the is_associated_with::cytoplasm to the is_associated_with::endoplasmic reticulum. Mutations in this gene may be associated with is_associated_with::ankylosing spondylitis, insulin-dependent is_associated_with::diabetes mellitus, is_associated_with::schizophrenia, and is_associated_with::celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.