Melatonin receptor 1A

Melatonin receptor type 1A is a is_associated_with::protein that in humans is encoded by the MTNR1A is_associated_with::gene.

Function
This gene encodes the MT1 is_associated_with::protein, one of two high-affinity forms of a receptor for is_associated_with::melatonin, the primary hormone secreted by the is_associated_with::pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian is_associated_with::circadian rhythm and reproductive alterations affected by day length. The receptor is an is_associated_with::integral membrane protein that is readily detectable and localized to two specific regions of the brain. The is_associated_with::hypothalamic is_associated_with::suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial is_associated_with::pars tuberalis may be responsible for the is_associated_with::reproductive effects of melatonin.

Ligands

 * 1) is_associated_with::Melatonin – full agonist
 * 2) is_associated_with::Afobazole – agonist