USP11

Ubiquitin carboxyl-terminal hydrolase 11 is an is_associated_with::enzyme that in humans is encoded by the USP11 is_associated_with::gene.

Function
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating enzyme which lies in a gene cluster on chromosome Xp11.23

Interactions
USP11 has been shown to interact with is_associated_with::RANBP9.

Model organisms
is_associated_with::Model organisms have been used in the study of USP11 function. A conditional is_associated_with::knockout mouse line called Usp11tm1(KOMP)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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