POLR2A

DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an is_associated_with::enzyme that in humans is encoded by the POLR2A is_associated_with::gene.

Function
This gene encodes the largest subunit of is_associated_with::RNA polymerase II, the polymerase responsible for synthesizing is_associated_with::messenger RNA in is_associated_with::eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for is_associated_with::polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing is_associated_with::RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA-binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA.

Interactions
POLR2A has been shown to interact with:


 * is_associated_with::BRCA1,
 * CREBBP,
 * is_associated_with::CTDP1,
 * CDK8,
 * GTF2B,
 * is_associated_with::GTF2F1,
 * is_associated_with::GTF2H4,
 * is_associated_with::MED21,
 * is_associated_with::MED26,
 * is_associated_with::PCAF,
 * is_associated_with::POLR2C,
 * is_associated_with::POLR2E,
 * is_associated_with::POLR2H,
 * is_associated_with::POLR2L,
 * is_associated_with::PQBP1,
 * is_associated_with::SMARCA2,
 * is_associated_with::SMARCA4
 * is_associated_with::SMARCB1,
 * is_associated_with::SMYD3,
 * is_associated_with::SND1,
 * is_associated_with::SUPT5H,
 * is_associated_with::TAF11,
 * TBP,
 * is_associated_with::TCEA1,
 * TCERG1, and
 * is_associated_with::ZNF74.