Rs186996510

rs186996510, also known as c.12C>G or Asp4Glu, is a SNP in the EGLN1 egl-9 family hypoxia-inducible factor 1 gene. The EGLN1 gene encodes prolyl hydroxylase 2 (PHD2) protein.

Along with another SNP seen frequently primarily in Tibetans, rs12097901, this SNP is reported to have arisen ~8,000 years ago as an adaptation protecting Tibetans from hypoxia at the high altitudes they inhabit.