FHIT

Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an is_associated_with::enzyme that in humans is encoded by the FHIT is_associated_with::gene.

Function
FHIT is also known as human accelerated region 10. It may, therefore, have played a key role in differentiating humans from apes.

This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in is_associated_with::purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where is_associated_with::carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon is_associated_with::carcinomas.

Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies. Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer.

FHIT also acts as a tumor suppressor of is_associated_with::HER2/neu driven breast cancer.

Interactions
FHIT has been shown to interact with is_associated_with::UBE2I.