KLF4

Kruppel-like factor 4 (KLF4) is a member of the KLF family of is_associated_with::transcription factors and regulates proliferation, differentiation, is_associated_with::apoptosis and is_associated_with::somatic cell reprogramming. Evidence also suggests that KLF4 is a is_associated_with::tumor suppressor in certain is_associated_with::cancers, including colorectal cancer.

In is_associated_with::embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in is_associated_with::mesenchymal stem cells (MSCs).

In humans, the is_associated_with::protein is encoded by the KLF4 is_associated_with::gene. The KLF4 gene is conserved in chimpanzee, is_associated_with::Rhesus monkey, dog, cow, mouse, rat, chicken, is_associated_with::zebrafish, and frog.

Interactions
KLF4 has been shown to interact with is_associated_with::CREB-binding protein.

It was found that the transcription factor Klf4 present at the promoter of an enzymatic subunit of is_associated_with::telomerase (TERT), where it formed a complex with β-catenin. Klf4 was required for accumulation of β-catenin at the Tert promoter but was unable to stimulate Tert expression in the absence of β-catenin.