UBE1C

NEDD8-activating enzyme E1 catalytic subunit is a is_associated_with::protein that in humans is encoded by the UBA3 is_associated_with::gene.

This enzyme contains an E2 binding domain, which resembles is_associated_with::ubiquitin, and recruits the is_associated_with::catalytic core of the E2 enzyme is_associated_with::UBE2M (Ubc12) in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains.

Interactions
UBE1C has been shown to interact with is_associated_with::NEDD8, is_associated_with::APPBP1 and is_associated_with::UBE2M.