Coagulation factor II receptor

Proteinase-activated receptor 1 (PAR1) also known as the coagulation factor II (thrombin) receptor is a is_associated_with::protein that in humans is encoded by the F2R is_associated_with::gene. PAR1 is a is_associated_with::G protein-coupled receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor.

Ligands
Several selective antagonists for the PAR1 receptor have been developed, for use as anti-clotting agents for the treatment of heart disease.


 * is_associated_with::SCH-530,348