Rs17806056

778 Common variable immunodeficiency disorder (CVID) cases compared with 10,999 controls using the Illumina Immunochip; the first non-HLA genome-wide significant risk for CVID locus was found within the CLEC16A gene, namely rs17806056. The minor allele, rs17806056(A), is associated with reduced risk for CVID (odds ratio 0.66, CI: 0.57 - 0.75, p=2.0 × 10e-9).