MMAB

Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the MMAB is_associated_with::gene.

Function
This gene encodes an enzyme (is_associated_with::cob(I)yrinic acid a,c-diamide adenosyltransferase) that catalyzes the final step in the conversion of vitamin B12 into is_associated_with::adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for is_associated_with::methylmalonyl-CoA mutase.

Clinical significance
Mutations in the gene are the cause of vitamin B12-dependent is_associated_with::methylmalonic aciduria linked to the cblB complementation group.