TRPC6

Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a is_associated_with::human is_associated_with::gene encoding a is_associated_with::protein of the same name. TRPC6 is a is_associated_with::transient receptor potential is_associated_with::ion channel. It has been associated with depression and is_associated_with::anxiety (see below), as well as with is_associated_with::focal segmental glomerulosclerosis (FSGS).

Interactions
TRPC6 has been shown to interact with:
 * is_associated_with::FYN,
 * is_associated_with::TRPC2, and
 * is_associated_with::TRPC3.

Ligands
Two of the primary is_associated_with::active constituents responsible for the is_associated_with::antidepressant and is_associated_with::anxiolytic benefits of is_associated_with::Hypericum perforatum, also known as St. John's Wort, are is_associated_with::hyperforin and is_associated_with::adhyperforin. These compounds are inhibitors of the is_associated_with::reuptake of is_associated_with::serotonin, is_associated_with::norepinephrine and is_associated_with::epinephrine, is_associated_with::dopamine, is_associated_with::γ-aminobutyric acid, and is_associated_with::glutamate, and they exert these effects by binding to and activating TRPC6. Activation of TRPC6 induces the entry of Ca2+ and Na+ into the cell, which results in the inhibition of reuptake.