TANK-binding kinase 1

Serine/threonine-protein kinase TBK1 is an is_associated_with::enzyme that in humans is encoded by the TBK1 is_associated_with::gene.

Interactions
TANK-binding kinase 1 has been shown to interact with:


 * is_associated_with::NCK1,
 * TANK, and
 * is_associated_with::TRAF2.

Transcriptional factors activated upon TBK1 activation include IRF3, IRF7 and ZEB1.

Clinical significance
Inhibition of is_associated_with::IκB kinase (IKK) and IKK-related kinases, is_associated_with::IKBKE (IKKε) and TANK-binding kinase 1 (TBK1), has been investigated as a therapeutic option for the treatment of inflammatory diseases and cancer.