Fumarylacetoacetate hydrolase

Fumarylacetoacetase is an is_associated_with::enzyme that in humans is encoded by the FAH is_associated_with::gene.

This gene encodes the last enzyme in the is_associated_with::tyrosine is_associated_with::catabolism pathway. FAH deficiency is associated with Type 1 hereditary is_associated_with::tyrosinemia (HT).

Fumarylacetoacetate hydrolase is an is_associated_with::enzyme which catalyzes the is_associated_with::hydrolysis of is_associated_with::4-fumarylacetoacetate into is_associated_with::fumarate and is_associated_with::acetoacetate.

Pathology
Mutations in the FAH gene cause is_associated_with::type I tyrosinemia.