NCDN

Neurochondrin (also known as its murine homologue, Norbin) is a is_associated_with::protein that in humans is encoded by the NCDN is_associated_with::gene.

This gene encodes a is_associated_with::leucine-rich cytoplasmic is_associated_with::protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent is_associated_with::protein kinase II phosphorylation and may be essential for spatial is_associated_with::learning processes. Several alternatively spliced transcript variants of this is_associated_with::gene have been described.

Norbin can modulate signaling activity and expression of is_associated_with::metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of is_associated_with::schizophrenia, including disruptions in is_associated_with::prepulse inhibition.