CRLF3

Cytokine receptor-like factor 3 is a is_associated_with::protein that in humans is encoded by the CRLF3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of CRLF3 function. A conditional is_associated_with::knockout mouse line, called Crlf3tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and two significant is_associated_with::phenotypes were reported. is_associated_with::Homozygous is_associated_with::mutant female adults had a significant increase in circulating levels of is_associated_with::fructosamine, while mutants of both sexes had decreased is_associated_with::platelet cell numbers.