HVCN1

Voltage-gated hydrogen channel 1 is a is_associated_with::protein that in humans is encoded by the HVCN1 is_associated_with::gene.

Voltage-gated hydrogen channel 1 is a is_associated_with::voltage-gated proton channel that has been shown to allow proton transport into is_associated_with::phagosomes and out of many types of cells including  is_associated_with::spermatozoa, electrically excitable cells and respiratory epithelial cells. The proton-conducting HVCN1 channel has only transmembrane domains corresponding to the S1-S4 voltage sensing domains (VSD) of is_associated_with::voltage-gated potassium channels and voltage-gated sodium channels. Molecular simulation is consistent with a water-filled pore that can function as a "water wire" for allowing hydrogen bonded H+ to cross the membrane. The HVCN1 protein has been shown to exist as a dimer with two functioning pores. Like other VSD channels, HVCN1 channels conduct ions about 1000-fold slower than channels formed by tetrameric S5-S6 central pores.

As a drug target
is_associated_with::Small molecule inhibitors of the HVCN1 channel are being developed as is_associated_with::chemotherapeutics and is_associated_with::anti-inflammatory agents.