Rs1447295

rs1447295 is a SNP on chromosome 8q24, associated with increased risk for prostate cancer in several studies.

In a study of over 3,600 Caucasians with prostate cancer, rs1447295 is one of five SNPs used (with family history as a sixth factor) to cumulatively predict overall risk. On their own, the rs1447295(A;A) and (A;C) risk genotypes yield an odds ratio for developing prostate cancer of 1.22 (CI: 1.06-1.40, p=5.3x10-3) and may account for 5.4% of population attributable risk.

The rs1447295 location could be responsible for about seven percent of prostate cancer cases in white men of north European descent. Thus, taken together with rs6983267, these two genetic changes could account for as much as one quarter of prostate cancer cases in white men. The increased risk was observed for all age groups studied.

Another study, in this case of 1,563 patients of European ancestry, found 4 SNPs (including rs1447295) in this region of chromosome 8q24 (termed "locus 1") to be strongly linked and associated with prostate cancer. The other 3 SNPs are rs4242382, rs7017300, and rs7837688. The odds ratio for having a risk genotype at locus 1 is 1.70 (CI: 1.39-2.07), and increases if risk genotypes are present at "locus 2" (rs6983267) or "locus 3" (rs10086908).

A meta-analysis of 10+ studies comprising over 15,000 prostate cancer patients concluded that the odds ratio for rs1447295(A) allele carriers is 1.42 (CI: 1.40-1.44).

The allele of higher risk for prostate cancer is rs1447295(A).

In a study of Japanese men, the rs1447295(A) allele was associated with susceptibility to prostate cancer (PC vs. non-PC: p = 0.041, OR 1.28, CI: 1.01-1.61), and was more significantly associated with disease in aggressive PC (aggressive PC vs. normal controls, p = 0.013, OR 1.43, CI: 1.08-1.90).

rs1447295 was found to be associated with prostate cancer based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.

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