FABP7

Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human is_associated_with::gene.

FABP7 is expressed, during development, in is_associated_with::radial glia by the activation of Notch receptors. is_associated_with::Reelin was shown to induce FABP7 expression in neural is_associated_with::progenitor cells via is_associated_with::Notch-1 activation.

According to one study, FABP7 binds DHA with the highest affinity among all of the FABPs.



Role in pathology
FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.

As of 2008, two studies have been conducted into FABP7 as a possible risk gene for is_associated_with::schizophrenia, with one, that tested for only one SNP, showing negative and another, with seven SNPs, a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak is_associated_with::prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.