POP1 (gene)

Ribonucleases P/MRP protein subunit POP1 is a is_associated_with::protein that in humans is encoded by the POP1 is_associated_with::gene.

Function
POP1 is a protein subunit of two different small nucleolar is_associated_with::ribonucleoprotein complexes: the is_associated_with::endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. This protein is a is_associated_with::ribonuclease that localizes to the nucleus and functions in pre-RNA processing.

Clinical significance
POP1 is also an autoantigen in patients suffering from connective tissue diseases. Mutations in the POP1 gene result in severe anauxetic is_associated_with::dysplasia.

Interactions
POP1 (gene) has been shown to interact with POP4.