CD86

Cluster of Differentiation 86 (also known as CD86 and B7-2) is a is_associated_with::protein expressed on is_associated_with::antigen-presenting cells that provides costimulatory signals necessary for is_associated_with::T cell activation and survival. It is the ligand for two different proteins on the T cell surface: is_associated_with::CD28 (for autoregulation and intercellular association) and is_associated_with::CTLA-4 (for attenuation of regulation and cellular disassociation). CD86 works in tandem with is_associated_with::CD80 to prime T cells.

The CD86 is_associated_with::gene encodes a type I membrane protein that is a member of the is_associated_with::immunoglobulin superfamily. is_associated_with::Alternative splicing results in two transcript variants encoding different isoforms. Additional transcript variants have been described, but their full-length sequences have not been determined.