Rs1975197

rs1975197, a SNP in the motor neuron PTPRD gene, has been linked to restless legs syndrome based on a study of several European populations totaling ~2,500 patients. The odds ratio associated with the rs1975197(T) risk allele is 1.31 (CI: 1.20-1.44, adjusted p = 5 x10e-9).

Note that a nearby SNP, rs4626664, was also shown to independently confer risk for restless legs syndrome in this same study.

Restless Legs Syndrome: Preliminary Research