D1-D2 Dopamine receptor heteromer

The D1-D2 dopamine receptor heteromer is a receptor heteromer consisting of D1 and D2 protomers.

Structure
D1 and D2 receptors interact primarily through discrete amino acids in the cytoplasmic regions of each receptor, with no involvement of transmembrane parts. The intracellular loop 3 of the D2 receptor contains two adjacent arginine residues, while the carboxyl tail of the D1 receptor possesses two adjacent glutamic acid residues. The two receptors can form a heteromer complex via a salt bridge between the guanidine moiety and the carboxylic group.

Ligands

 * SKF-83,959