TRIM33

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human is_associated_with::gene.

The is_associated_with::protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few is_associated_with::transcription factors such as is_associated_with::Smad4 that interact with TIF1-γ have been identified.

Structure
The protein is a member of the is_associated_with::tripartite motif family. This motif includes three zinc-binding domains: and a coiled-coil region.
 * RING
 * B-box type 1 zinc finger
 * B-box type 2 zinc finger

Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

Interactions
TRIM33 has been shown to interact with is_associated_with::TRIM24.

Role in cancer
TRIM33 acts as a is_associated_with::tumor suppressor gene preventing the development chronic myelomonocytic leukemia. TRIM33 acts as an is_associated_with::oncogene by preventing is_associated_with::apoptosis in B-cell leukemias.