EFNB3

Ephrin-B3 is a is_associated_with::protein that in humans is encoded by the EFNB3 is_associated_with::gene.

EphrinB3 has been implicated in mediating various developmental events, particularly in the is_associated_with::nervous system. EphrinB3 reverse signaling is important for axon pruning and synapse and spine formation during postnatal development of the nervous system. Previous work has also shown that signaling through this ligand is important for radial migration during cortical development. Moreover, levels of EFNB3 expression are particularly high in several is_associated_with::forebrain subregions compared to other brain subregions, and may play a pivotal role in forebrain function. It has been suggested that ephrinB3 signaling is necessary for is_associated_with::synaptic plasticity to occur in the is_associated_with::hippocampus; this implicates ephrinB3 as a major player in learning and memory. More recently, ephrinB3 has been shown to regulate proliferation of is_associated_with::neural stem cells in the adult is_associated_with::subventricular zone (SVZ).