TLX

Nuclear receptor TLX (homologue of the Drosophila tailless gene) also known as NR2E1 (Nuclear receptor subfamily 2 group E member 1) is a is_associated_with::protein that in humans is encoded by the NR2E1 is_associated_with::gene. TLX is a member of the is_associated_with::nuclear receptor family of is_associated_with::intracellular is_associated_with::transcription factors.

Function
TLX regulates the expression of another nuclear receptor, RAR.

TLX also is essential for normal brain-eye coordination and appears to play a role in control of aggressive behavior.

Adult neural stem cells are nuclear receptor TLX-positive and TLX expression in these cells is crucial in maintaining their undifferentiated state. Furthermore TLX regulates adult neural stem cell proliferation. Removal of TLX from the adult mouse brain resulted in a reduction of stem cell proliferation and spatial learning.

Tlx-positive cells of the is_associated_with::subventricular zone of adult mouse brain are self-renewing stem cells. Mutation of the Tlx gene in adult mouse brain leads to complete loss of is_associated_with::neurogenesis in the subventricular zone. Tlx is also required for transition from radial glial cells to is_associated_with::astrocyte-like neural stem cells.