CLUAP1

Clusterin associated protein 1, also known as CLUAP1, is a human is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of CLUAP1 function. A conditional is_associated_with::knockout mouse line, called Cluap1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; both sexes had decreased IgG1 levels while males also displayed abnormal spine curvature resulting in is_associated_with::kyphosis.