BEST2

Bestrophin-2 is a is_associated_with::protein that in humans is encoded by the BEST2 is_associated_with::gene.

Function
This gene is a member of the bestrophin gene family of anion channels. Bestrophin genes share a similar gene structure with highly conserved exon-intron boundaries, but with distinct 3' ends. Bestrophins are transmembrane proteins that contain a homologous region rich in aromatic residues, including an invariant arg-phe-pro motif. Mutation in one of the family members (is_associated_with::bestrophin 1) is associated with is_associated_with::vitelliform macular dystrophy. The bestrophin 2 gene is mainly expressed in the non-pigmented ciliary epithelium and colon.