Rs2288774

rs2288774 has been associated with hypertension. In genotypic combination with rs4149601 it was associated with systolic blood pressure (SBP) (p=0.01), DBP (p=0.04), and progression of both SBP (p=0.03) and DBP (p=0.05) over time.

European population substructure: clustering of northern and southern populations.

Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.