CDKN2B

Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4B is a is_associated_with::protein that is encoded by the CDKN2B is_associated_with::gene in humans.

Function
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with is_associated_with::CDK4 or is_associated_with::CDK6, and prevents the activation of the CDK kinases by is_associated_with::cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Interactions
CDKN2B has been shown to interact with is_associated_with::Cyclin-dependent kinase 4.