TERF2

Telomeric repeat-binding factor 2 is a is_associated_with::protein that is also known as TRF2 and TRBF2. It is in humans encoded by the TERF2 is_associated_with::gene.

Function
This gene encodes a telomere specific protein, TERF2, which is a component of the is_associated_with::shelterin nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic.

Interactions
TERF2 has been shown to interact with:


 * is_associated_with::Ku70,
 * is_associated_with::MRE11A,
 * is_associated_with::Nibrin and
 * is_associated_with::Rad50,
 * is_associated_with::TERF2IP,   and
 * is_associated_with::Werner syndrome ATP-dependent helicase.