SMS (gene)

Spermine synthase is an is_associated_with::enzyme that in humans is encoded by the SMS is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SMS function. A conditional is_associated_with::knockout mouse line, called Smstm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::mutant mice and six significant abnormalities were observed. is_associated_with::Hemizygous males were infertile and thus it was not possible to produce is_associated_with::homozygous mutant female mice. The remaining tests were therefore carried out on is_associated_with::heterozygous mutant females and hemizygous males. Both displayed decreased grip strength while the males also had decreased body weight, length, bone mineral content and atypical peripheral blood is_associated_with::lymphocyte counts.