ADCYAP1R1

Pituitary adenylate cyclase-activating polypeptide type I receptor also known as PAC1, is a is_associated_with::protein that in humans is encoded by the ADCYAP1R1 is_associated_with::gene. This receptor binds is_associated_with::pituitary adenylate cyclase activating peptide.

PAC1 is a membrane-associated protein and shares significant homology with members of the G-protein coupled class B glucagon/is_associated_with::secretin receptor family. This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. is_associated_with::Alternative splicing of two exons of this gene generates four major splice variants, but their full-length nature has not been determined. PAC1 is expressed in the is_associated_with::adrenal medulla, pancreatic acini, is_associated_with::uterus, is_associated_with::myenteric plexus and is_associated_with::brain. It is also expressed in the trigeminal, otic and superior cervical ganglia (prejunctional) and cerebral arteries (postjunctional).