CYP24A1

1,25-dihydroxyvitamin D3 24-hydroxylase, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the CYP24A1 is_associated_with::gene.

This gene encodes a member of the is_associated_with::cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Function
This mitochondrial protein initiates the degradation of 1,25-dihydroxyvitamin D3, the physiologically active form of vitamin D3, by hydroxylation of the side chain to form is_associated_with::calcitroic acid.

In regulating the level of vitamin D3, this enzyme plays a role in calcium homeostasis and the vitamin D endocrine system.

CYP24A1 could play a role in Severe Infantile Hypercalcemia.