Nav1.9

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated is_associated_with::sodium ion channel protein which in humans is encoded by the SCN11A is_associated_with::gene.

Function
Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the is_associated_with::action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.

Clinical significance
Mutations in this gene have been associated to loss of pain perception.