Rs2373115

Conflicting reports of possible small increase in Alzheimer's risk. Currently dubious at best.

rs2373115 is one of several SNPs in the GAB2 gene indicating an increased risk (OR 4.1) of late-onset Alzheimer's disease, but apparently only in individuals also carrying ApoE4 alleles, i.e. rs429358(C) alleles

rs2373115 marker does not modify the risk of Alzheimer's disease in Spanish APOE e4 carriers.

rs2373115(G) is the risk allele.

(p = 9 x 10(-11)) was associated with an odds ratio of 4.06 (confidence interval 2.81-14.69)

However, a separate study of 1,749 Alzheimer patients concluded that this GAB2 SNP is "at best a minor genetic determinant" since the authors of this study observed only a slight tendency for an increase of the (G;G) genotype (odds ratio of 1.3 vs (G;T) and (T;T), CI:1.0-1.6, p=0.09) and for an increase in the G allele frequency (odds ratio 1.3, CI:1.0-1.6, p=0.05) in ApoE4-carriers.

A new (Dec 2008) meta-analysis concludes that, yes, indeed, rs2373115 is associated with increased risk for Alzheimer's disease among ApoE4 carriers, with an odds ratio of 1.58 (CI: 1.17 - 2.14, p = 3 x 10e-3), but only among carriers. This meta-analysis pooled published studies with a new study of 443 AD cases.

A study of 579 Italian Alzheimer's patients saw this association, but only in ApoE4 non-carriers, suggesting it might be an independent risk factor for the disease.


 * is_associated_with_disease::Alzheimer's disease