TRADD

Tumor necrosis factor receptor type 1-associated DEATH domain protein is a is_associated_with::protein that in humans is encoded by the TRADD is_associated_with::gene.

TRADD is an is_associated_with::adaptor protein.

Function
The protein encoded by this gene is a is_associated_with::death domain containing adaptor molecule that interacts with is_associated_with::TNFRSF1A/is_associated_with::TNFR1 and mediates is_associated_with::programmed cell death signaling and is_associated_with::NF-kappaB activation. This protein binds adaptor protein is_associated_with::TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein is_associated_with::FADD/MORT1, and is involved in the Fas-induced cell death pathway.



Interactions
TRADD has been shown to interact with:


 * is_associated_with::FADD,
 * is_associated_with::Keratin 18
 * is_associated_with::RIPK1,
 * is_associated_with::STAT1,
 * is_associated_with::TNFRSF1A,
 * is_associated_with::TNFRSF25, and
 * is_associated_with::TRAF2.