PTRF

Polymerase I and transcript release factor, also known as PTRF, is a is_associated_with::protein which in humans is encoded by the PTRF is_associated_with::gene.

Function
Termination of is_associated_with::RNA polymerase I catalyzed transcription is a 2-step process that involves pausing of transcription elongation and release of both the pre-is_associated_with::ribosomal RNA and Pol I from the is_associated_with::DNA template. The pausing is mediated by TTF1 and PTRF.

PTRF is a soluble protein containing putative is_associated_with::leucine zipper, is_associated_with::nuclear localization signal, and PEST domains.

Interactions
PTRF has been shown to interact with is_associated_with::ZNF148.