SRPK1

Serine/threonine-protein kinase SRPK1 is an is_associated_with::enzyme that in humans is encoded by the SRPK1 is_associated_with::gene.

Function
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors. The protein localizes to the nucleus and the cytoplasm. It is thought to play a role in regulation of both constitutive and is_associated_with::alternative splicing by regulating intracellular localization of splicing factors. A second alternatively spliced transcript variant for this gene has been described, but its full length nature has not been determined.

Possible anti-cancer target
Some cancers are is_associated_with::VEGF dependant (for is_associated_with::angiogenesis). SRPK1 activates (phosphorylates) is_associated_with::VEGF splicing factor. is_associated_with::SRPK1 inhibitors (e.g. 'SPHINX compounds' ) are being investigated as treatments for prostate cancer.

Interactions
SRPK1 has been shown to interact with:
 * is_associated_with::ASF/SF2  and
 * is_associated_with::SNRP70.
 * is_associated_with::C6orf201