Cyclin A1

Cyclin-A1 is a is_associated_with::protein that in humans is encoded by the CCNA1 is_associated_with::gene.

Function
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell division cycle. Cyclins function as activating subunits of enzymatic complex together with cyclin-dependent kinases (CDKs). Different cyclins exhibit distinct expression and degradation patterns that contribute to the temporal coordination of cell cycle events. Cyclin A1 was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of is_associated_with::meiosis. This cyclin binds both is_associated_with::Cdk1 and is_associated_with::Cdk2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor is_associated_with::E2F1, and the Kip/Cip family of CDK-inhibitor proteins.

Interactions
Cyclin-A1 interacts with:


 * is_associated_with::CDC20,
 * is_associated_with::Cyclin-dependent kinase 2,
 * is_associated_with::E2F1,
 * is_associated_with::GNB2L1,
 * GPS2,
 * is_associated_with::MYBL2, and
 * is_associated_with::Retinoblastoma protein.