NUDCD3

NudC domain-containing protein 3 is a is_associated_with::protein that in humans is encoded by the NUDCD3 is_associated_with::gene.

Function
The product of this gene functions to maintain the stability of is_associated_with::dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from is_associated_with::kinetochores, spindle microtubules, and is_associated_with::spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the is_associated_with::Golgi apparatus during interphase, and levels of the protein increase after the is_associated_with::G1/S transition.