Rs28934875

rs28934875, also known as Ala138Pro or A138P, is a SNP in the p53 TP53 tumor suppressor gene.

The rare rs28934875(C) allele is associated with predisposition to cancer in the form of Li-Fraumeni syndrome 1.

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.