HAPLN2

Hyaluronan and proteoglycan link protein 2 (HAPLN2) also known as brain link protein 1 (BRAL1) is a is_associated_with::protein that in humans is encoded by the HAPLN2 is_associated_with::gene. is_associated_with::HAPLN1 codes for a related link protein that is expressed in is_associated_with::cartilage while Bral1 is expressed in is_associated_with::brain.

Function
Bral1 interacts with is_associated_with::versican and is_associated_with::brevican in is_associated_with::nodes of Ranvier. In mice with reduced Bralp1 expression the is_associated_with::extracellular matrix at nodes of Ranvier is disrupted and is_associated_with::action potential conduction is abnormal.