MYH9

Myosin, heavy chain 9, non-muscle is a is_associated_with::protein which in humans is encoded by the MYH9 is_associated_with::gene.

Clinical significance
MYH9 polymorphisms have been shown to associate with is_associated_with::glomerulosclerosis and non-diabetic end stage renal disease in African Americans and in Hispanic Americans, though it was later shown that two independent variants in the nearby is_associated_with::APOL1 gene were responsible for the increased risk of disease.

Model organisms
is_associated_with::Model organisms have been used in the study of MYH9 function. A conditional is_associated_with::knockout mouse line, called Myh9tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.

Interactions
MYH9 has been shown to interact with is_associated_with::PRKCE.