JAM3

Junctional adhesion molecule C is a is_associated_with::protein that in humans is encoded by the JAM3 is_associated_with::gene.

Gene
This gene is located on the long arm of is_associated_with::chromosome 11 (11q25) on the Watson strand. It is 83,077 bases in length. The encoded protein is 310 is_associated_with::amino acids long with a predicted is_associated_with::molecular weight of 35.02 kiloDaltons.

Function
is_associated_with::Tight junctions represent one mode of cell-to-cell adhesion in is_associated_with::epithelial or is_associated_with::endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the is_associated_with::paracellular space. The protein encoded by this is_associated_with::immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. Unlike other proteins in this family, this protein is unable to adhere to is_associated_with::leukocyte cell lines and only forms weak homotypic interactions. The encoded protein is a member of the junctional adhesion molecule protein family and acts as a receptor for another member of this family.

Interactions
JAM3 has been shown to interact with is_associated_with::PARD3.

Clinical significance
Mutations in this gene have been associated with a rare syndrome - autosomal recessive hemorrhagic destruction of the brain, subependymal calcification and congenital cataracts.