G12/G13 alpha subunits

G12/G13 subunits are alpha units of heterotrimeric G proteins that regulate cell processes through the use of guanine nucleotide exchange factors. These two subunits represent a fourth class of G protein alpha subunits. They are not sensitive to pertussis toxin.

G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells. G13 is also essential for receptor tyrosine kinase-induced migration of fibroblast and endothelial cells.

Genes

 * GNA12 ,