Dock5

Dock5 ( D edicator o f c yto k inesis 5), also known as DOCK5, is a large (~180 kDa) is_associated_with::protein involved in is_associated_with::intracellular signalling networks. It is a member of the DOCK-A subfamily of the DOCK family of is_associated_with::guanine nucleotide exchange factors (GEFs) which function as activators of small is_associated_with::G proteins. Dock5 is predicted to activate the small G protein Rac.

Function
Dock5 shares significant is_associated_with::sequence identity with Dock180, the archetypal member of the DOCK family. It is therefore predicted to partake in similar interactions although this has yet to be demonstrated. Indeed, the function and signalling properties of Dock5 are poorly understood thus far. Dock5 has been identified as a crucial signalling protein in is_associated_with::osteoclasts, and suppression of Dock5 expression with is_associated_with::shRNA has been shown to inhibit survival and differentiation of osteoclast precursor cells. In addition, a mutation in Dock5 has been associated with the rupture of is_associated_with::murine lens is_associated_with::cataracts. In is_associated_with::zebrafish Dock5 has been implicated in myoblast fusion.