DLGAP1

Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP), is a is_associated_with::protein that in humans is encoded by the DLGAP1 is_associated_with::gene. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the is_associated_with::post synaptic density.

Function
This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the is_associated_with::SHANK and is_associated_with::PSD-95 proteins, facilitating the assembly of the post synaptic density of neurons. Dlgap1 has five 14-amino-acid repeats and three Pro-rich portions.

Interactions
DLGAP1 has been shown to interact with:
 * is_associated_with::DLG1,
 * is_associated_with::DLG4,
 * is_associated_with::DYNLL1,
 * is_associated_with::DYNLL2, and
 * is_associated_with::SHANK2 and

The interaction with PSD95 and S-SCAM is mediated by the GUK domain and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.