DUSP3

Dual specificity protein phosphatase 3 is an is_associated_with::enzyme that in humans is encoded by the DUSP3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of DUSP3 function. A conditional is_associated_with::knockout mouse line, called Dusp3tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. is_associated_with::Homozygous mutants had an increased percent of body fat, abnormal is_associated_with::humerus morphology and an increased susceptibility to is_associated_with::bacterial infection. is_associated_with::Corpus callosum area, hippocampus area and total brain section area was increased, while length of is_associated_with::pyramidal cell layer was reduced.

Interactions
DUSP3 has been shown to interact with is_associated_with::MAPK3 and is_associated_with::MAPK1.