DDX42

ATP-dependent RNA helicase DDX42 is an is_associated_with::enzyme that in humans is encoded by the DDX42 is_associated_with::gene.

Function
This gene encodes a member of the Asp-Glu-Ala-Asp (DEAD) box protein family. Members of this protein family are putative RNA helicases, and are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. Two transcript variants encoding the same protein have been identified for this gene.

Interactions
DDX42 has been shown to interact with is_associated_with::SF3B1.

Model organisms
is_associated_with::Model organisms have been used in the study of DDX42 function. A conditional is_associated_with::knockout mouse line called Ddx42tm1b(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping .