Rs11842874

rs11842874 is a SNP in the MCF.2 cell line derived transforming sequence-like MCF2L gene on ch 13.

Based initially on a GWAS study of 3,000 patients of European ancestry with osteoarthritis and then subsequently replicated for a total of 19,000+ cases, the rs11842874(A) allele (major allele) was associated with increased risk, at an odds ratio of 1.17 (CI: 1.11–1.23, p = 2.1 × 10e?8). The authors note that MCF2L regulates a nerve growth factor (NGF), and treatment with a humanized monoclonal antibody against NGF is associated with reduction in pain and improvement in function for knee osteoarthritis patients.