KIAA1958

Protein KIAA1958 is a is_associated_with::protein that in humans is encoded by the KIAA1958 is_associated_with::gene. Orthologs of KIAA1958 go as far back in evolution to is_associated_with::chordates, although, it is closer in homology to is_associated_with::primates than any other orthologs. KIAA1958 has no known is_associated_with::paralogs.

Gene
KIAA1958 is located on the long arm of chromosome 9 (9.q32) in humans on the plus strand from 115249248 to 115427597. Its mRNA has 2683 bp. The gene has these neighbors on chromosome 9:



HSDL2: Hydroxysteroid dehydrogenase-like protein 2 plays a role in is_associated_with::nucleotide binding, is_associated_with::oxidoreductase activity, and is_associated_with::sterol binding.

C9orf147: Chromosome 9 open reading frame 147 has an unknown function.

C9orf80: Chromosome 9 open reading frame 80 is a component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote is_associated_with::DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular is_associated_with::DNA damage response including is_associated_with::cell cycle checkpoint activation, is_associated_with::recombinational repair and maintenance of genomic stability.

SNX30: Sorting nexin-30 may be linked to is_associated_with::phosphatidylinositol binding.

Expression
KIAA1958 is expressed in the highest quantities in the is_associated_with::larynx as proposed by EST. The highest expression in developmental stage is the is_associated_with::blastocyst and for health state, it is most found in uterine tumors. Data from NCBI GEO Profile shows that KIAA1958 expression includes many of the tissue types in the human body. Using EMBL-EBI, KIAA1958 was found to be overexpressed in is_associated_with::pseudopod RNA during the migration of the is_associated_with::metastatic cancer cells. KIAA1958 was also overexpressed in Stat5/ab and stat 3 which are transcription factors reported to be critical for the growth and viability of prostate cancer cells and both the is_associated_with::embryonic stem cell and the is_associated_with::pluripotent stem cell.

Protein
KIAA1958 is composed of 716 is_associated_with::amino acids and weighs 79212 Da with an iso-electric point of 6.375. Although not much is known about the KIAA1958 protein, scientific predictions have been made using supercomputers for predictions of KIAA1958's structure and function. KIAA1958 undergoes is_associated_with::post-translational modifications. The most interesting modification is is_associated_with::phosphorylation. In comparison to other proteins, KIAA1958 has a substantially significant amount of serines phosphorylated during post-translational modification. 36 serines are predicted to be phosphorylated.

Structure
PELE on SDSC Biology WorkBench is supercomputer that is able to predict secondary structure of the KIAA1958 protein. According to this tool, the protein's secondary structure is a combination of alpha helices and beta sheets, in almost equal amount and spread out almost evenly throughout the protein.

Interactions
There is no known proof that KIAA1958 interacts with any other proteins at this time.