USP14

Ubiquitin carboxyl-terminal hydrolase 14 is an is_associated_with::enzyme that in humans is encoded by the USP14 is_associated_with::gene.

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a is_associated_with::deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the is_associated_with::cytoplasm and cleaves the is_associated_with::ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions
USP14 has been shown to interact with is_associated_with::CXCR4.