ERCC8 (gene)

DNA excision repair protein ERCC-8 is a is_associated_with::protein that in humans is encoded by the ERCC8 is_associated_with::gene.

This gene encodes a WD repeat protein, which interacts with the is_associated_with::Cockayne syndrome type B (CSB) and is_associated_with::p44 proteins, the latter being a subunit of the RNA polymerase II is_associated_with::transcription factor II H. Mutations in this gene have been identified in patients with the hereditary disease is_associated_with::Cockayne syndrome (CS). The CS cells are abnormally sensitive to ultraviolet radiation and are defective in the repair of transcriptionally active genes. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Interactions
ERCC8 (gene) has been shown to interact with is_associated_with::XAB2.