SMG1 (gene)

Serine/threonine-protein kinase SMG1 is an is_associated_with::enzyme that in humans is encoded by the SMG1 is_associated_with::gene. SMG1 belongs to the is_associated_with::phosphatidylinositol 3-kinase-related kinase protein family.

Function
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.

Interactions
SMG1 (gene) has been shown to interact with is_associated_with::PRKCI and is_associated_with::UPF1.