Zinc finger and BTB domain-containing protein 16

Zinc finger and BTB domain-containing protein 16 is a is_associated_with::protein that in humans is encoded by the ZBTB16 is_associated_with::gene.

Function
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a is_associated_with::zinc finger is_associated_with::transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in is_associated_with::cell cycle progression, and interacts with a is_associated_with::histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with is_associated_with::acute promyelocytic leukemia (APL) and physiological roles have been identified in mouse is_associated_with::Natural Killer T cells and gamma-delta T cells. Alternate transcriptional splice variants have been characterized in human.

Interactions
Zinc finger and BTB domain-containing protein 16 has been shown to interact with:


 * is_associated_with::Angiotensin II receptor type 1,
 * is_associated_with::BCL6,
 * is_associated_with::BMI1,
 * is_associated_with::Calcitriol receptor,
 * is_associated_with::FHL2,
 * is_associated_with::GATA1,
 * is_associated_with::GATA2,
 * is_associated_with::HDAC1,
 * is_associated_with::HDAC4,
 * is_associated_with::HDAC6,
 * is_associated_with::Heparin-binding EGF-like growth factor,
 * is_associated_with::Histone deacetylase 5,
 * is_associated_with::Nuclear receptor co-repressor 2,
 * is_associated_with::Promyelocytic leukemia protein
 * is_associated_with::RUNX1T1,
 * is_associated_with::Retinoic acid receptor alpha,
 * is_associated_with::SIN3A,
 * is_associated_with::SIN3B, and
 * is_associated_with::ZBTB32.