ARFGEF1

Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a is_associated_with::protein that in humans is encoded by the ARFGEF1 is_associated_with::gene.

Function
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

Interactions
ARFGEF1 has been shown to interact with is_associated_with::FKBP2, is_associated_with::ARFGEF2 and is_associated_with::PRKAR1A.