MTHFD1

C-1-tetrahydrofolate synthase, cytoplasmic also known as C1-THF synthase is an is_associated_with::enzyme that in humans is encoded by the MTHFD1 (methylenetetrahydrofolate dehydrogenase 1) is_associated_with::gene.

Function
This gene encodes a protein that possesses three distinct enzymatic activities, methylenetetrahydrofolate dehydrogenase (1.5.1.5), is_associated_with::methenyltetrahydrofolate cyclohydrolase (3.5.4.9) and is_associated_with::formate–tetrahydrofolate ligase (6.3.4.3). Each of these activities catalyzes one of three sequential reactions in the interconversion of 1-carbon derivatives of tetrahydrofolate, which are substrates for is_associated_with::methionine, thymidylate, and de novo is_associated_with::purine syntheses. The trifunctional enzymatic activities are conferred by two major domains, an aminoterminal portion containing the dehydrogenase and cyclohydrolase activities and a larger synthetase domain.