Neuropeptide S receptor

The neuropeptide S receptor (NPSR) is a member of the is_associated_with::G-protein coupled receptor superfamily of is_associated_with::integral membrane proteins which binds is_associated_with::neuropeptide S (NPS). It was formerly an is_associated_with::orphan receptor, GPR154, until the discovery of neuropeptide S as the endogenous ligand.

In the CNS, activation of the NPSR by NPS promotes is_associated_with::arousal and is_associated_with::anxiolytic-like effects.

In addition, mututations in NPSR have been linked to a susceptibility to is_associated_with::asthma. Hence NPSR has also been called GPRA (G protein-coupled receptor for asthma susceptibility). Activation of NPSR in the airway is_associated_with::epithelium has a number of effects including upregulation of is_associated_with::matrix metalloproteinases which are involved in the is_associated_with::pathogenesis of asthma.