Sp3 transcription factor

Sp3 transcription factor, also known as SP3, refers to both a is_associated_with::protein and the is_associated_with::gene it is encoded by.

This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. This protein contains a zinc finger is_associated_with::DNA-binding domain and several transactivation domains, and has been reported to function as a bifunctional is_associated_with::transcription factor that either stimulates or represses the transcription of numerous genes. Transcript variants encoding different is_associated_with::isoforms have been described for this gene, and one has been reported to initiate translation from a non-AUG (AUA) is_associated_with::start codon. Additional isoforms, resulting from the use of alternate downstream translation initiation sites, have also been noted.

Interactions
Sp3 transcription factor has been shown to interact with is_associated_with::Histone deacetylase 2, is_associated_with::PIAS1, is_associated_with::E2F1 and is_associated_with::GABPA.