CLCN4

H(+)/Cl(-) exchange transporter 4 is a is_associated_with::protein that in humans is encoded by the CLCN4 is_associated_with::gene.

Function
The CLCN family of voltage-dependent is_associated_with::chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved is_associated_with::CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and is_associated_with::OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the is_associated_with::pathogenesis of neuronal disorders.

Clinical significance
Mutations in this gene have been linked to cases of early onset is_associated_with::epilepsy