ACACB

Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an is_associated_with::enzyme that in humans is encoded by the ACACB is_associated_with::gene.

Function
is_associated_with::Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a is_associated_with::biotin-containing enzyme which catalyzes the is_associated_with::carboxylation of is_associated_with::acetyl-CoA to is_associated_with::malonyl-CoA, the rate-limiting step in is_associated_with::fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit is_associated_with::carnitine palmitoyltransferase I, the rate-limiting step in fatty acid uptake and oxidation by is_associated_with::mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis.

Clinical implications
Human acetyl-CoA carboxylase has recently become a target in the design of new anti-obesity drugs. However when the gene for ACC2 was knocked out in mice, no change in body weight was observed relative to normal mice. This result suggests inhibition of ACC2 by drugs may be an ineffective method of treating obesity.