Sphingosine kinase 1

Sphingosine kinase 1 is an is_associated_with::enzyme that in humans is encoded by the SPHK1 is_associated_with::gene.

Sphingosine kinase 1 phosphorylates is_associated_with::sphingosine to is_associated_with::sphingosine-1-phosphate (S1P) SK1 is normally a is_associated_with::cytosolic protein but is recruited to membranes rich in is_associated_with::phosphatidate (PA), a product of is_associated_with::Phospholipase D (PLD)

is_associated_with::Sphingosine-1-phosphate (SPP) is a novel lipid messenger with both intracellular and extracellular functions. Intracellularly, it regulates proliferation and survival, and extracellularly, it is a ligand for is_associated_with::EDG1. Various stimuli increase cellular levels of SPP by activation of is_associated_with::sphingosine kinase (SPHK), the enzyme that catalyzes the is_associated_with::phosphorylation of is_associated_with::sphingosine. Competitive inhibitors of SPHK block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors, including is_associated_with::platelet-derived growth factor and serum.

Interactions
SPHK1 has been shown to interact with is_associated_with::TRAF2.