ADCY10

Adenylate cyclase 10 also known as ADCY10 is an is_associated_with::enzyme that, in humans, is encoded by the ADCY10 is_associated_with::gene.

Function
The protein encoded by this gene belongs to a distinct class of mammalian is_associated_with::adenylyl cyclase that is soluble and insensitive to is_associated_with::G protein or is_associated_with::forskolin regulation. It is localized in the is_associated_with::cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in is_associated_with::spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the is_associated_with::acrosome reaction.

Clinical significance
Mutations in the ADCY10 gene are associated with an increased risk of adsorptive is_associated_with::hypercalciuria.