CUL5

Cullin-5 is a is_associated_with::protein that in humans is encoded by the CUL5 is_associated_with::gene.

Discovery
The mammalian gene product was originally discovered by is_associated_with::expression cloning, due to the protein's ability to mobilize intracellular calcium in response to the peptide hormone is_associated_with::arginine vasopressin. It was first titled VACM-1, for vasopressin-activated, calcium-mobilizing receptor. Since then, VACM-1 has been shown to be homologous to the is_associated_with::Cullin family of proteins, and was subsequently dubbed cul5.

Tissue distribution
Studies have shown that the cul5 protein is expressed at its highest levels in heart and skeletal tissue, and is specifically expressed in vascular is_associated_with::endothelium and renal is_associated_with::collecting tubules.

Function
Cul5 inhibits cellular proliferation, potentially through its involvement in the is_associated_with::SOCS/ BC-box/ eloBC/ cul5/ RING E3 ligase complex, which functions as part of the is_associated_with::ubiquitin system for protein degradation.

One study have shown that Cul5 plays a role in is_associated_with::Reelin signaling cascade, participating in the is_associated_with::DAB1 degradation and thus ensuring the negative feedback mechanism of Reelin signaling during corticogenesis.

Interactions
CUL5 has been shown to interact with is_associated_with::RBX1.