DLGAP5

Disks large-associated protein 5 (DAP-5) also known as discs large homolog 7 (DLG7) or hepatoma up-regulated protein (HURP) is a is_associated_with::protein that in humans is encoded by the DLGAP5 is_associated_with::gene.

DLG7 is a is_associated_with::kinetochore protein that stabilizes is_associated_with::microtubules in vicinity of is_associated_with::chromosomes. DLG7 controls spindle dynamics, promotes interkinetochore tension and efficient kinetochore capture. DGL7 is a part of Ran-dependent complex. Stabilization of DGL7 in cell occurs due to phosphorylation by is_associated_with::Aurora A kinase. Expression of DGL7 is found in cancer and is_associated_with::stem cells.