Rs12994401

23andMe blog citing in an Afro-Caribbean population rs12994401(T;T) had almost 35 times higher odds of primary open-angle glaucoma. This correlation was not found in Japanese, Korean , Chinese , African or Central European  populations. In African-American population correlation was for the reverse allele C. This suggest as yet unidentified causal variant with population dependent linkage to rs12994401 is responsible. South-Indian cohort evaluation suggests rs10202118 as one contributor, while Chinese study  suggests rs1533428 contribution. However, an analysis of extended chromosome locus 2p14-21 did not find such association, and meta-analysis by the Chinese study  showed insignificant association to rs12994401 overall.