Myocyte-specific enhancer factor 2A

Myocyte-specific enhancer factor 2A is a is_associated_with::protein that in humans is encoded by the MEF2A is_associated_with::gene. MEF2A is a is_associated_with::transcription factor in the is_associated_with::Mef2 family. In humans it is located on chromosome 15q26. Certain is_associated_with::mutations in MEF2A cause an is_associated_with::autosomal dominant form of is_associated_with::coronary artery disease and is_associated_with::myocardial infarction.

Function
The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM]

Interactions
Myocyte-specific enhancer factor 2A has been shown to interact with:


 * is_associated_with::ASCL1,
 * is_associated_with::EP300,
 * is_associated_with::HDAC4,
 * is_associated_with::HDAC9,
 * is_associated_with::Histone deacetylase 5,
 * is_associated_with::MAPK14,
 * is_associated_with::MEF2D,
 * is_associated_with::Mothers against decapentaplegic homolog 2, and
 * is_associated_with::Thyroid hormone receptor alpha and