EIF3D

Eukaryotic translation initiation factor 3 subunit D is a is_associated_with::protein that in humans is encoded by the EIF3D is_associated_with::gene.

Function
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a is_associated_with::multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the is_associated_with::ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.

Interactions
EIF3D has been shown to interact with is_associated_with::PHLDA1 and is_associated_with::EIF3A.