TXN2

Thioredoxin, mitochondrial also known as thioredoxin-2 is a is_associated_with::protein that in humans is encoded by the TXN2 is_associated_with::gene.

Function
This nuclear gene encodes a mitochondrial member of the is_associated_with::thioredoxin family, a group of small multifunctional is_associated_with::redox-active proteins. The encoded protein may play important roles in the regulation of the mitochondrial is_associated_with::membrane potential and in protection against oxidant-induced is_associated_with::apoptosis. It has been shown that TGF-beta-mediated induction of HMGA2 was weakened by the expression of TXN2.

Clinical Significance
It has been demonstrated that genetic polymorphisms in the TXN2 gene may be associated with the risk of is_associated_with::spina bifida.