TMPRSS2

Transmembrane protease, serine 2 is an is_associated_with::enzyme that in humans is encoded by the TMPRSS2 is_associated_with::gene.

ERG gene fusion
TMPRSS2 protein's function in prostate carcinogenesis relies on overexpression of ETS transcription factors, such as ERG and is_associated_with::ETV1, through is_associated_with::gene fusion. TMPRSS2-ERG fusion gene is the most frequent, present in 40% - 80% of prostate cancers in humans. ERG overexpression contributes to development of androgen-independence in prostate cancer through disruption of is_associated_with::androgen receptor signaling.