Rs7539542

A study of 733 breast cancer cases for 10 SNPs concluded that a rs7539542 genotype was associated with decreased risk (odds ratio 0.51, CI: 0.28-0.92).

After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).

Adiponectin signaling status was assigned as follows:

rs1501299(G,G) + rs2241766(T,T) = low signaler rs1501299(G,T) + rs2241766(T,T) = low signaler rs1501299(G,G) + rs2241766(G,T) = low signaler rs1501299(T,T) + rs2241766(T,T) = intermediate signaler rs1501299(G,T) + rs2241766(G,T) = intermediate signaler rs1501299(G,G) + rs2241766(G,G) = intermediate signaler rs1501299(G,T) + rs2241766(G,G) = high signaler rs1501299(T,T) + rs2241766(G,G) = high signaler rs1501299(T,T) + rs2241766(G,T) = high signaler


 * is_associated_with_disease::Breast cancer