Germ cell nuclear factor

The germ cell nuclear factor (GCNF), also known as RTR (retinoid receptor-related testis-associated receptor) or NR6A1 (nuclear receptor subfamily 6, group A, member 1), is a is_associated_with::protein that in humans is encoded by the NR6A1 is_associated_with::gene. GCNF is a member of the is_associated_with::nuclear receptor family of is_associated_with::intracellular is_associated_with::transcription factors.

In adults, GCNH is expressed mainly in the is_associated_with::germ cells of is_associated_with::gonads and is involved in the regulation of is_associated_with::embryogenesis and germ cell differentiation.

Its expression pattern suggests that it may be involved in neurogenesis and germ cell development. The protein can homodimerize and bind DNA, but in vivo targets have not been identified. The gene expresses three alternatively spliced transcript variants.