FZD8

Frizzled-8 is a is_associated_with::protein that in humans is encoded by the FZD8 is_associated_with::gene.

Function
This intronless gene is a member of the is_associated_with::frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.