Rs7775

rs7775 (R324G) osteoarthritis at multiple joints (p = 0.07), particularly in the hip in women

associated with osteoarthritis of the hip in females

This is an arg324-to-gly (R324G) substitution

Meta-analysis of 14 studies did not support a significant association between rs7775 and osteoarthritis.

Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females.

Genetic variation in candidate osteoporosis genes, bone mineral density, and fracture risk: the study of osteoporotic fractures.

No association of the polymorphisms of the frizzled-related protein gene with peak bone mineral density in Chinese nuclear families.

Variant alleles of the Wnt antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis.