HIP2

Ubiquitin-conjugating enzyme E2 K is a is_associated_with::protein that in humans is encoded by the UBE2K is_associated_with::gene.

The protein encoded by this gene belongs to the is_associated_with::ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of is_associated_with::huntingtin. This interaction is not influenced by the length of the huntingtin is_associated_with::polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of is_associated_with::apoptosis.

Interactions
HIP2 has been shown to interact with is_associated_with::Huntingtin and is_associated_with::RNF2.