RACGAP1

Rac GTPase-activating protein 1 is an is_associated_with::enzyme that in humans is encoded by the RACGAP1 is_associated_with::gene.

Function
Rho GTPases control a variety of cellular processes. There are 3 subtypes of Rho GTPases in the Ras superfamily of small G proteins: RHO (see MIM 165370), RAC (see is_associated_with::RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also serve as effector molecules and play a role in signaling downstream of Rho and other Ras-like GTPases.[supplied by OMIM]

Interactions
RACGAP1 has been shown to interact with is_associated_with::Rnd2 and is_associated_with::SLC26A8.

During cytokinesis, RACGAP1 has been shown to interact with is_associated_with::KIF23 to form the is_associated_with::centralspindlin complex.