PCK1

Phosphoenolpyruvate carboxykinase 1 (soluble), also known as PCK1, is an is_associated_with::enzyme which in humans is encoded by the PCK1 is_associated_with::gene.

Function
This enzyme is a main control point for the regulation of is_associated_with::gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of is_associated_with::phosphoenolpyruvate from is_associated_with::oxaloacetate, with the release of is_associated_with::carbon dioxide and GDP. The expression of this gene can be regulated by is_associated_with::insulin, is_associated_with::glucocorticoids, is_associated_with::glucagon, cAMP, and diet. A mitochondrial isozyme of the encoded protein also has been characterized.