Rs5082

rs5082 is a SNP in the apolipoprotein APOA2 gene, and may influence obesity and heart disease risk.

Individuals homozygous for the -265T>C polymorphism in rs5082, i.e. individuals with the rs5082(C;C) genotype of the Apolipoprotein A-II gene (APOA2) promoter, are associated with increased Body Mass Index and food intake in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study of ~1000 individuals. The odds ratio for obesity in (C;C) individuals compared to rs5082(T) allele carriers was 1.70 (CI: 1.02-2.80, p=0.039). Total energy, total fat, and total protein intake were all significantly higher in (C;C) individuals.

In a separate study, a case-control analysis of 484 Australian male coronary artery disease patients concluded that rs5082(C;C) individuals were at significantly lower risk for that form of heart disease than rs5082(T) allele carriers (odds ratio 0.57, CI: 0.39-0.84, p=0.004).

A meta-analysis of several APOA2 SNPs (including this one) found no association between any APOA2 SNPs studied and type-2 diabetes.

An apolipoprotein A-II polymorphism (-265T/C, rs5082) regulates postprandial response to a saturated fat overload in healthy men.

No evidence for association between BMI and 10 candidate genes at ages 4, 7 and 10 in a large UK sample of twins.

Response to Diet and Exercise