Hydroxyacid oxidase (glycolate oxidase) 1

Hydroxyacid oxidase (glycolate oxidase) 1 is a is_associated_with::protein that in humans is encoded by the HAO1 is_associated_with::gene.

Function
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the is_associated_with::peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on is_associated_with::glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream is_associated_with::polyadenylation site.