TIMP3

Metalloproteinase inhibitor 3 is an is_associated_with::protein that in humans is encoded by the TIMP3 is_associated_with::gene.

This gene belongs to the is_associated_with::tissue inhibitor of metalloproteinases gene family. The proteins encoded by this gene family are inhibitors of the is_associated_with::matrix metalloproteinases, a group of peptidases involved in degradation of the is_associated_with::extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this is_associated_with::netrin domain-containing protein is localized to the ECM. Mutations in this is_associated_with::gene have been associated with the is_associated_with::autosomal dominant disorder is_associated_with::Sorsby's fundus dystrophy.