ACAD10

Acyl-CoA dehydrogenase family, member 10 is a is_associated_with::protein that in humans is encoded by the ACAD10 is_associated_with::gene.

Function
This gene encodes a member of the acyl-CoA dehydrogenase family of enzymes (ACADs), which participate in the beta-oxidation of fatty acids in mitochondria. The encoded enzyme contains a hydrolase domain at the N-terminal portion, a serine/threonine protein kinase catlytic domain in the central region, and a conserved ACAD domain at the C-terminus. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Clinical significance
In is_associated_with::Pima people, ACAD10 has been identified as a gene associated with type 2 diabetes, insulin resistance, and impaired lipid metabolism. Specifically, two is_associated_with::single nucleotide polymorphisms, rs601663 and rs659964, have been significantly correlated with these symptoms in a large population of both the Pima people and is_associated_with::American Indians.

Interactions
Using affinity capture mass spectrometry, an interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. Using this method, ACAD10 has been shown to interact with is_associated_with::P2RY8, is_associated_with::NDUFA10, is_associated_with::NTRK3, is_associated_with::SLC2A12, is_associated_with::LPAR4, is_associated_with::PTH1R, is_associated_with::COLEC10, is_associated_with::APP, is_associated_with::MAS1, is_associated_with::CD79A, is_associated_with::BSG, and is_associated_with::Ubiquitin C.