KCNE3

Potassium voltage-gated channel, Isk-related family, member 3, also known as KCNE3, is a is_associated_with::protein that in humans is encoded by the KCNE3 is_associated_with::gene.

Function
is_associated_with::Voltage-gated potassium channels (Kv) represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating is_associated_with::neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a type I membrane protein, and a beta subunit that assembles with a potassium channel alpha-subunit to modulate the gating kinetics and enhance stability of the multimeric complex. This gene is prominently expressed in the kidney. Mutations in this gene are associated with is_associated_with::hypokalemic periodic paralysis and is_associated_with::Brugada syndrome. KCNE3 is thought to be an accessory protein that serves to inhibit the fast inactivating Kv channel Kv4.3 (the A-current).