Rs2735839

A study of ~1,800 Caucasian prostate cancer patients concludes that the rs2735839(A) allele is associated with aggressive prostate cancer in general, and more specifically, in Gleason score 7 patients, it is more often associated with being GS 4 + 3 rather than GS 3 + 4 (odd ratio 1.85, CI: 1.31-2.61).

cancer-genetics these snps influence genetic risk for prostate cancer
 * the haplotype rs6983267 rs1016343 rs4242384
 * rs7501939
 * rs1859962
 * rs2660753
 * rs9364554
 * rs6465657
 * rs10993994
 * rs7931342
 * rs2735839
 * rs5945619
 * rs10993994

Genotyping 13 SNPs (including this one) in 1,308 Caucasian prostate cancer patients led to the conclusion that while none of the SNP associations were as significant as having a first-degree family history of the disease, they did replicate. And in fact, for rs2735839, the risk estimate varied by family history.

Prostate-Specific Antigen