E2F1

Transcription factor E2F1 is a is_associated_with::protein that in humans is encoded by the E2F1 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the E2F family of is_associated_with::transcription factors. The E2F family plays a crucial role in the control of is_associated_with::cell cycle and action of is_associated_with::tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a is_associated_with::DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to is_associated_with::retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and is_associated_with::p53-dependent/independent is_associated_with::apoptosis.

Transcription
E2F1 promoter[PAX8] => E2F1 [PMID 21602887]

Interactions
E2F1 has been shown to interact with:


 * is_associated_with::ARID3A,
 * is_associated_with::CUL1,
 * is_associated_with::Cyclin A1,
 * is_associated_with::Cyclin A2,
 * is_associated_with::GTF2H1,
 * is_associated_with::MDM4,
 * is_associated_with::NCOA6,
 * NDN,
 * is_associated_with::NPDC1,
 * is_associated_with::PURA,
 * PHB,
 * RB1,
 * RBL1,
 * is_associated_with::SKP2,
 * SP1,
 * SP2,
 * SP3,
 * SP4,
 * is_associated_with::TFDP1
 * is_associated_with::TOPBP1,
 * is_associated_with::TP53BP1, and
 * UBC.