Coiled-Coil Domain Containing Protein – 25

The Coiled-Coil Domain Containing Protein – 25 (CCDC25) is a human protein whose function is not presently understood.

Gene
The gene encoding the CCDC25 protein is located at 8p21.1, on the short arm of human is_associated_with::chromosome eight, and is transcribed into an mRNA product approximately 3,583 is_associated_with::nucleotides in length.

General
The protein is highly conserved among is_associated_with::mammals as well as is_associated_with::eukaryotes as diverse as Arabidopsis thaliana. CCDC25 is made up of a single polypeptide chain 208 is_associated_with::amino acids in length and is expressed at a high level, nearly 4.2 times that of a normal is_associated_with::human is_associated_with::protein. Its expression is nearly ubiquitous in human tissues with little indication that its expression level changes drastically in diseased tissues. Despite currently lacking a well understood function, CCDC25 is predicted to localize to the nucleus and was shown by a is_associated_with::microarray experiment to be upregulated in is_associated_with::Metaphase II is_associated_with::oocytes.

Interactions
CCDC25 was shown by a yeast-two-hybrid is_associated_with::assay to interact with is_associated_with::Smad2, a latent is_associated_with::transcription factor that is part of the is_associated_with::TGF-β signaling pathway. The protein is a predicted substrate of is_associated_with::Casein Kinase 1, is_associated_with::Casein Kinase 2, is_associated_with::cGMP-dependent protein kinase, and the is_associated_with::Insulin Receptor; all of which have well defined roles in is_associated_with::cell signaling.