Pituitary-specific positive transcription factor 1

POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1), also known as POU1F1, is a is_associated_with::transcription factor for is_associated_with::growth hormone.

Function
PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals, and Unc-86 of C. elegans (Herr et al., 1988). PIT1 contains 2 protein domains, termed POU-specific and POU-homeo, which are both necessary for high affinity DNA binding on genes encoding is_associated_with::growth hormone (GH; MIM 139250) and is_associated_with::prolactin (PRL; MIM 176760). PIT1 is also important for regulation of the genes encoding prolactin and is_associated_with::thyroid-stimulating hormone beta subunit (TSHB; MIM 188540) by is_associated_with::thyrotropin-releasing hormone (TRH; MIM 257120) and is_associated_with::cyclic AMP.[supplied by OMIM]

Interactions
Pituitary-specific positive transcription factor 1 has been shown to interact with is_associated_with::GATA2 and is_associated_with::PITX1.