LAIR1

Leukocyte-associated immunoglobulin-like receptor 1 is a is_associated_with::protein that in humans is encoded by the LAIR1 is_associated_with::gene. LAIR1 has also been designated as CD305 (is_associated_with::cluster of differentiation 305).

Function
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Interactions
LAIR1 has been shown to interact with is_associated_with::PTPN11 and is_associated_with::PTPN6.