Rs1010

This SNP, located on chromosome 2 in a gene (VAMP8) associated with platelet activation, may be associated with early onset myocardial infarction (MI). The risk allele for this SNP (in dbSNP orientation) is rs1010(G), with an odds ratio of 1.75 (CI: 1.17â€“2.62).

Furthermore, this SNP is one of the 5 used by Celera's genetic risk score (GRS) for coronary heart disease (CHD).


 * rs20455, in the KIF6 gene
 * rs3900940, in the MYH15 gene
 * rs7439293, in the PALLD gene
 * rs2298566, in the SNX19 gene
 * rs1010, in the VAMP8 gene

For each of the five variants, the GRS was increased by 1 if the subject was homozygous for the risk variant, unchanged if heterozygous, and decreased by 1 if the individual did not carry the variant. Therefore, individuals carrying all 10 possible risk variants (two copies of each of the five SNPs) were assigned a GRS of 5 and those carrying no risk variants a GRS of -5. A high GRS was defined as 3 or higher. Approximately 4% of the white cohort in ARIC was classified as high risk, and the hazard ratio for CHD after adjustment for traditional risk factors was a significant 1.57 (CI: 1.21-2.04; p<0.001). The results did not reproduce for African American participants.