ACCN1

Amiloride-sensitive cation channel 1, neuronal is a is_associated_with::protein that in is_associated_with::humans is encoded by the ACCN1 is_associated_with::gene. It is also known as an is_associated_with::acid-sensing ion channel, is_associated_with::ASIC2.

Function
This gene encodes a member of the is_associated_with::degenerin/is_associated_with::epithelial is_associated_with::sodium channel (DEG/ENaC) superfamily. The members of this family are is_associated_with::amiloride-sensitive is_associated_with::sodium channels that contain is_associated_with::intracellular N and C termini, 2 is_associated_with::hydrophobic is_associated_with::transmembrane regions, and a large is_associated_with::extracellular loop, which has many is_associated_with::cysteine residues with conserved spacing. The member encoded by this gene may play a role in is_associated_with::neurotransmission. In addition, a is_associated_with::heteromeric association between this member and is_associated_with::ACCN3 (variant 1) has been observed to co-assemble into is_associated_with::proton-gated channels sensitive to is_associated_with::gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct is_associated_with::isoforms, have been identified.