Glucagon-like peptide 2 receptor

Glucagon-like peptide 2 receptor (GLP-2R) is a is_associated_with::protein that in human is encoded by the GLP2R is_associated_with::gene located on is_associated_with::chromosome 17.

Function
The GLP2 receptor (GLP2R) is a is_associated_with::G protein-coupled receptor superfamily member closely related to the glucagon receptor (is_associated_with::GLP1 receptor). is_associated_with::Glucagon-like peptide-2 (GLP2) is a 33-amino acid proglucagon-derived peptide produced by intestinal enteroendocrine cells. Like is_associated_with::glucagon-like peptide-1 (GLP1) and glucagon itself, it is derived from the proglucagon peptide encoded by the GCG gene. GLP2 stimulates intestinal growth and upregulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased is_associated_with::enterocyte is_associated_with::apoptosis. Moreover, GLP2 prevents intestinal hypoplasia resulting from total parenteral nutrition. GLP2R, a G protein-coupled receptor superfamily member is expressed in the gut and closely related to the glucagon receptor (GCGR) and the receptor for GLP1 (GLP1R).