FAM134C

Protein FAM134C is a is_associated_with::protein that in humans is encoded by the FAM134C (family with sequence similarity 134, member C) is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of FAM134C function. A conditional is_associated_with::knockout mouse line, called Fam134ctm2a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. Homozygous animals had an abnormal is_associated_with::xyphoid process and eye morphology. Females had increased is_associated_with::indirect calorimetry parameters while males had an increased susceptibility to is_associated_with::bacterial infection.