Interleukin 8 receptor, beta

Interleukin 8 receptor, beta is a is_associated_with::chemokine receptor. IL8RB is also known as CXCR2, and CXCR2 is now the is_associated_with::IUPHAR Committee on Receptor Nomenclature and Drug classification-recommended name.

Function
The is_associated_with::protein encoded by this gene is a member of the is_associated_with::G-protein-coupled receptor family. This protein is a receptor for is_associated_with::interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein-activated second messenger system (Gi/o-coupled ). This receptor also binds to chemokine (C-X-C motif) ligand 1 (is_associated_with::CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. In addition, it binds ligands is_associated_with::CXCL2, is_associated_with::CXCL3, and is_associated_with::CXCL5.

This receptor mediates is_associated_with::neutrophil migration to sites of inflammation. The is_associated_with::angiogenic effects of IL8 in intestinal microvascular is_associated_with::endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of is_associated_with::oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, and IL8RBP, a is_associated_with::pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36.

Mutations in CXCR2 cause hematological traits.

Senescence
Knock-down studies involving the chemokine receptor CXCR2 alleviates both replicative and oncogene-induced is_associated_with::senescence (OIS) and diminishes the DNA-damage response. Also, is_associated_with::ectopic expression of CXCR2 results in premature senescence via a is_associated_with::p53-dependent mechanism.