GDF15

Growth differentiation factor 15 (GDF15) is a protein belonging to the is_associated_with::transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB. GDF15 mRNA is most abundant in the liver, with lower levels seen in some other tissues. Its expression in liver can be significantly up-regulated in during injury of organs such as is_associated_with::liver, is_associated_with::kidney, is_associated_with::heart and is_associated_with::lung.