Rs5746059

rs5746059 is a SNP in the tumor necrosis factor-alpha receptor 2 TNFRSF1B gene.

A study of ~1,800 subjects from 400 Caucasian families concluded that carriers of a rs5746059(A) allele had a 4.6% higher fat mass and a 2.5% increased percentage fat mass compared to noncarriers; the results were significant after multiple testing correction. This same correlation was also seen in 700 independent Chinese Han adults and 1,000 additional Caucasians. This SNP therefore appears to be associated with risk for obesity.


 * is_associated_with_disease::Obesity