TMEM229B

Transmembrane protein 229b is a is_associated_with::protein that in humans is encoded by the TMEM229b is_associated_with::gene.

Nomenclature
The TMEM229B gene is also known as C14orf83, FLJ33387, Q8NBD8, Hs.509707, Hs.712258, IPR010540, and CN083_HUMAN.

Gene
The TMEM229B gene is located on the is_associated_with::sense strand (-) of chromosome 14 at location 14q24.1 and spans the chromosomal locus 67,936,983—67,982,021. Covering a total of 45,038 is_associated_with::base pairs (bp) along the chromosome, the TMEM229B gene has a total of 3 exons in its primary unspliced transcript is_associated_with::mRNA of 4,068 bp. There are a total of 7 transcript variants for TMEM229B ranging in mRNA size from 519 bp to 5008 bp. The TMEM229B gene is flanked by phosphatidylinotisol glycan anchor class H (is_associated_with::PIGH), a protein associated with the endoplasmic reticulum specifically GPI-anchor biosynthesis, and PLEK2 on its left. See Figure 1.0. The gene is highly conserved in vertebrates, including portions of the approximately 3,000 base pairs of is_associated_with::3'UTR.

Tissue distribution
is_associated_with::Expressed Sequence Tag mapping of TMEM229B gene expression indicates that it is ubiquitously expressed throughout the body. TMEM229B is more heavily expressed in the is_associated_with::parathyroid, skin, and is_associated_with::thyroid tissues, and moderately expressed in bone marrow, trachea, spleen, eye, brain, pancreas, mammary gland, intestine, liver, thymus, lymph node, ovarian, muscle, lung, blood, and kidney tissues.

Protein
The translated TMEM229B protein is a total of 167 amino acids long, with a predicted is_associated_with::molecular weight of 19,531 Daltons. The TMEM229B protein contains a domain of unknown function, part of the domain family DUF1113, spanning from is_associated_with::amino acids 87 to 135.

Based on predicted structure TMEM229b is highly resemblant of a is_associated_with::connexin subunit. A highly conserved phosphorylation site exists at the Threonine-139 position. See multiple sequence alignment below.

Clinical relevance
Expression of the TMEM229B gene increases in several disease states including amelanotic skin melanoma, is_associated_with::B-cell neoplasm, breast carcinoma, is_associated_with::Burkitt’s lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, esophageal carcinoma, gastric carcinoma, glioblastoma, liver carcinoma, lymphoma, melanoma, small cell lung carcinoma, T-cell acute lymphoblastic leukemia, thyroid carcinoma and is_associated_with::Wilms tumor as found in several is_associated_with::microarray experiments. Over-expression of the TMEM229B gene has not been linked as a causal factor in any of these disease states.