PRKCD

Protein kinase C delta type is an is_associated_with::enzyme that in humans is encoded by the PRKCD is_associated_with::gene.

Function
is_associated_with::Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by is_associated_with::calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for is_associated_with::phorbol esters, a class of is_associated_with::tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in is_associated_with::B cell signaling and in the regulation of growth, is_associated_with::apoptosis, and differentiation of a variety of cell types. PKCD is also regulated by phosphorylation on various tyrosine residues including Y311 (by SRC).

Interactions
PRKCD has been shown to interact with:


 * is_associated_with::C1QBP,
 * INSR,
 * is_associated_with::MUC1,
 * MTOR,
 * is_associated_with::PLD2,
 * is_associated_with::PTPN6,
 * is_associated_with::PTPRM,
 * PDPK1,
 * is_associated_with::RASGRP3,
 * is_associated_with::SHC1 and
 * is_associated_with::STAT1.