NME8

Thioredoxin domain-containing protein 3 (TXNDC3), also known as spermatid-specific thioredoxin-2 (Sptrx-2), is a is_associated_with::protein that in humans is encoded by the NME8 is_associated_with::gene (also known as the TXNDC3 gene) on is_associated_with::chromosome 7.

Function
This gene encodes a protein with an N-terminal is_associated_with::thioredoxin domain and three C-terminal nucleoside diphosphate kinase (NDK) domains, but the NDK domains are thought to be catalytically inactive. The sea urchin ortholog of this gene encodes a component of sperm outer is_associated_with::dynein arms, and the protein is implicated in ciliary function.

Clinical significance
Mutations in the TXNDC3 gene are associated with is_associated_with::primary ciliary dyskinesia.