Rs28934577

rs28934577, also known as Leu257Gln or L257Q, is a SNP in the p53 TP53 tumor suppressor gene.

The rare rs28934577(A) allele is associated with predisposition to cancer in the form of Li-Fraumeni syndrome 1.

ClinVar annotates this as both pathogenic, and, "likely pathogenic"; see also OMIM 191170.0028

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.