ITGA11

Integrin alpha-11 is a is_associated_with::protein that, in humans, is encoded by the ITGA11 is_associated_with::gene.

This gene encodes an alpha is_associated_with::integrin. Integrins are heterodimeric is_associated_with::integral membrane is_associated_with::proteins composed of an alpha chain and a beta chain. This protein contains an I domain, is expressed in is_associated_with::muscle tissue, dimerizes with beta 1 integrin in vitro, and appears to bind is_associated_with::collagen in this form. Therefore, the protein may be involved in attaching muscle tissue to the is_associated_with::extracellular matrix. Alternative transcriptional splice variants have been found for this gene, but their biological validity is not determined.

According to one study, ITGA11 expression is increased in the anterior stroma of is_associated_with::corneal buttons excised from the eyes affected by is_associated_with::keratoconus.