SLC4A2

Anion exchange protein 2 (AE2) is a is_associated_with::membrane transport protein that in humans is encoded by the SLC4A2 is_associated_with::gene. AE2 is functionally similar to the is_associated_with::Band 3 Cl−/HCO3− exchange protein.

Mice have been used to explore the function of AE2. AE2 contributes to basolateral membrane HCO3− transport in the is_associated_with::gastrointestinal tract. AE2 is required for is_associated_with::spermiogenesis in mice. AE2 is required for normal is_associated_with::osteoclast function. The activity of AE2 is sensitive to is_associated_with::pH.

AE3 has been suggested as a target for prevention of diabetic vasculopathy.