SLC34A3

Sodium-dependent phosphate transport protein 2C is a is_associated_with::protein that in humans is encoded by the SLC34A3 is_associated_with::gene.

Function
SLC34A3 contributes to the maintenance of inorganic phosphate concentration at the is_associated_with::kidney.

Interactions
SLC34A3 has been shown to interact with is_associated_with::PDZK1.

Clinical Correlation
A mutation in the SLC34A3 gene has been known to cause the autosomal recessive condition hereditary hypophophatemic rickets with is_associated_with::hypercalciuria. This gene is correlated closely with is_associated_with::SLC34A1, an analogue sodium phosphate cotransporter protein. Symptoms include renal phosphate wasting in addition to increase levels of 1,25-dihydroxyvitamin D (yields the hypercalcuria).