ARL4D

ADP-ribosylation factor-like protein 4D is a is_associated_with::protein that in humans is encoded by the ARL4D is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of ARL4D function. A conditional is_associated_with::knockout mouse line, called Arl4dtm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and significant abnormalities were observed. is_associated_with::Homozygous mutant females had decreased bone mineral content, heart weight, lean body mass and CD8-positive, alpha-beta memory is_associated_with::T cell number. Males had abnormal rib morphology with vertebral transformation. Both sexes displayed a reduction in dorsal is_associated_with::third ventricle area and is_associated_with::hippocampal area.