Tenascin X

A member of the is_associated_with::tenascin family, tenascin X (TN-X) also known as hexabrachion-like protein is a is_associated_with::glycoprotein that is expressed in connective tissues including skin, joints and muscles. In humans, tenascin X is encoded by the TNXB is_associated_with::gene.

Gene
This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. The structure of this gene is unusual in that it overlaps the is_associated_with::CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively.

Function
This gene encodes a member of the tenascin family of is_associated_with::extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to is_associated_with::fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing.

Clinical significance
Deficiency causes one of the types of is_associated_with::Ehlers-Danlos syndrome where collagen density is reduced and elastic fibers are fragmentated.