ALAS1

Delta-aminolevulinate synthase 1 also known as ALAS1 is a is_associated_with::protein that in humans is encoded by the ALAS1 gene. ALAS1 is an is_associated_with::aminolevulinic acid synthase.

Delta-aminolevulinate synthase catalyzes the condensation of is_associated_with::glycine with is_associated_with::succinyl-CoA to form is_associated_with::delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by is_associated_with::ALAS2.