Rs3918396

rs3918396, also known as Ile710Val or S-1, is a SNP in the ADAM metallopeptidase domain 33 ADAM33 gene.

A study of ~600 non-Hispanic white males who smoked concluded that rs3918396(G;G) carriers, i.e. those homozygous for the most common allele, were more likely (p< 0.0026, after Bonferroni correction) to develop chronic obstructive pulmonary disease (COPD) than carriers of one or two rs3918396(A) alleles.