MAP3K14

Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an is_associated_with::enzyme that in humans is encoded by the MAP3K14 is_associated_with::gene.

Function
This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This kinase binds to is_associated_with::TRAF2 and stimulates is_associated_with::NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.

Interactions
MAP3K14 has been shown to interact with:
 * is_associated_with::CHUK,
 * is_associated_with::IKK2, and
 * is_associated_with::TRAF2.