SETMAR

Histone-lysine N-methyltransferase SETMAR is an is_associated_with::enzyme that in humans is encoded by the SETMAR is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SETMAR function. A conditional is_associated_with::knockout mouse line, called Setmartm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. Homozygous mutant animals of both sex had abnormal retinal is_associated_with::pigmentation and morphology, while males also had atypical is_associated_with::peripheral blood lymphocyte parameters.