LIMK1

LIM domain kinase 1 is an is_associated_with::enzyme that in humans is encoded by the LIMK1 is_associated_with::gene.

Function
There are approximately 40 known eukaryotic LIM proteins, so named for the is_associated_with::LIM domains they contain. LIM domains are highly conserved is_associated_with::cysteine-rich structures containing 2 is_associated_with::zinc fingers. Although zinc fingers usually function by binding to is_associated_with::DNA or is_associated_with::RNA, the LIM motif probably mediates is_associated_with::protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 is_associated_with::N-terminal LIM motifs, a central is_associated_with::PDZ domain, and a is_associated_with::C-terminal is_associated_with::protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development.

Clinical signficance
LIMK1 is_associated_with::hemizygosity is implicated in the impaired visuospatial constructive cognition of is_associated_with::Williams syndrome.

Interactions
LIMK1 has been shown to interact with:
 * CFL1,
 * CDKN1C,
 * NRG1,
 * is_associated_with::PAK1,
 * is_associated_with::PAK4, and
 * is_associated_with::YWHAZ.