TFCP2

Alpha-globin transcription factor CP2 is a is_associated_with::protein that in humans is encoded by the TFCP2 is_associated_with::gene.

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1. Late SV40 factor (LSF) also acts as an oncogene in is_associated_with::hepatocellular carcinoma. Late SV40 factor (LSF) enhances is_associated_with::angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (is_associated_with::MMP9).

Along with its main is_associated_with::oncogene function in is_associated_with::hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, is_associated_with::epithelial-mesenchymal transition (EMT), allergic response, inflammation and is_associated_with::Alzheimer's disease. The is_associated_with::small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death.

Interactions
TFCP2 has been shown to interact with is_associated_with::APBB1 and is_associated_with::RNF2.