Sequestosome 1

Sequestosome-1 is a is_associated_with::protein that in humans is encoded by the SQSTM1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SQSTM1 function. A conditional is_associated_with::knockout mouse line, called Sqstm1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::homozygous is_associated_with::mutant mice and one significant abnormality was observed: females had abnormal is_associated_with::complete blood count parameters, including an increased is_associated_with::red blood cell distribution width and increased mean is_associated_with::platelet volume.

Interactions
Sequestosome 1 has been shown to interact with:


 * is_associated_with::MAP1LC3A,
 * is_associated_with::PRKCI,
 * is_associated_with::RAD23A,
 * is_associated_with::RIPK1,
 * is_associated_with::TRAF6
 * is_associated_with::TrkA,    and
 * is_associated_with::TrkB.