TMC6

Transmembrane channel-like protein 6 is a is_associated_with::protein that in humans is encoded by the TMC6 is_associated_with::gene. In vivo, TMC6 and its homolog is_associated_with::TMC8, interact and form a complex with the zinc transporter 1 (is_associated_with::SLC30A1) and localize mostly to the is_associated_with::endoplasmic reticulum, but also to the is_associated_with::nuclear membrane and is_associated_with::Golgi apparatus.

Inactivating mutations in TMC6 or TMC8 have been implicated as the genetic cause of the rare skin disorder is_associated_with::epidermodysplasia verruciformis, which is characterized by abnormal susceptibility to human papillomaviruses (HPVs) of the skin resulting in the growth of scaly is_associated_with::macules and is_associated_with::papules, particularly on the hands and feet.