AFG3L2

AFG3 ATPase family gene 3-like 2 (is_associated_with::S. cerevisiae) is a is_associated_with::protein that in humans is encoded by the AFG3L2 is_associated_with::gene.

This gene encodes a protein localized in is_associated_with::mitochondria and closely related to is_associated_with::paraplegin. The paraplegin gene is responsible for an autosomal recessive form of hereditary spastic paraplegia. This gene is a candidate gene for other hereditary spastic paraplegias or neurodegenerative disorders as well as spastic ataxia-neuropathy syndrome.