ACVR2B

Activin receptor type-2B is a is_associated_with::protein that in humans is encoded by the ACVR2B is_associated_with::gene. ACVR2B is an is_associated_with::activin type 2 receptor.

Function
is_associated_with::Activins are dimeric growth and differentiation factors which belong to the is_associated_with::transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with is_associated_with::cysteine-rich region, a is_associated_with::transmembrane domain, and a is_associated_with::cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in is_associated_with::phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.

Interactions
ACVR2B has been shown to interact with is_associated_with::ACVR1B and is_associated_with::SYNJ2BP.