CAPRIN2

caprin family member 2, also known as CAPRIN2, is a human is_associated_with::gene.

The protein encoded by this gene may be involved in the transitioning of is_associated_with::erythroblasts from a highly proliferative state to a terminal phase of differentiation. High level expression of the encoded protein can lead to is_associated_with::apoptosis. Several transcript variants encoding different is_associated_with::isoforms have been found for this gene.

Model organisms
is_associated_with::Model organisms have been used in the study of CAPRIN2 function. A conditional is_associated_with::knockout mouse line, called Caprin2tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::mutant mice, however no significant abnormalities were observed.