Prostacyclin receptor

Prostacyclin receptor ( or prostaglandin I2 receptor, IP1) is a receptor for is_associated_with::prostacyclin.

Transduction
When binding a is_associated_with::prostacyclin-molecule, the receptor changes conformation and activates Gs, with its activation of cAMP and increase in is_associated_with::protein kinase A (PKA) activity.

In vasodilation
In is_associated_with::vasodilation, the PKA activity causes phosphorylation of MLCK, decreasing its activity, resulting in dephosphorylation of MLC of is_associated_with::myosin. The smooth muscle relaxation leads to vasodilation.

Gene
The receptor is encoded by the human gene PTGIR.