DLG2

Disks large homolog 2 (DLG2) also known as channel-associated protein of synapse-110 (chapsyn-110) or postsynaptic density protein 93 (PSD-93) is a is_associated_with::protein that in humans is encoded by the DLG2 is_associated_with::gene.

Function
Chapsyn-110/PSD-93 a member of the is_associated_with::membrane-associated guanylate kinase (MAGUK) family. The protein forms a heterodimer with a related family member that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. Alternatively spliced transcript variants encoding distinct isoforms have been described but their full-length nature has yet to be completely determined.

Model organisms
is_associated_with::Model organisms have been used in the study of DLG2 function. A is_associated_with::knockout mouse line, called Dlg2tm1Dsb was generated. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::homozygous is_associated_with::mutant mice and five significant abnormalities were observed. Both sexes had atypical is_associated_with::indirect calorimetry and is_associated_with::DEXA parameters. Females also had decreased body weight, decreased circulating HDL cholesterol levels, and increased susceptibility to is_associated_with::bacterial infection.

Interactions
DLG2 has been shown to interact with is_associated_with::GRIN2B, is_associated_with::KCNJ12.