MED13

Mediator complex subunit 13 is a is_associated_with::protein that in humans is encoded by the MED13 is_associated_with::gene.

Function
This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or is_associated_with::nuclear receptors to induce gene expression, possibly by interacting with is_associated_with::RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with is_associated_with::MED12, is_associated_with::cyclin C, and is_associated_with::CDK8 that can negatively regulate transactivation by mediator.