PUS7L

Pseudouridylate synthase 7 homolog-like protein is an is_associated_with::enzyme that in humans is encoded by the PUS7L is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PUS7L function. A conditional is_associated_with::knockout mouse line, called Pus7ltm2a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::homozygous is_associated_with::mutant mice and one significant abnormality was observed: an increased susceptibility to is_associated_with::bacterial infection.