USO1

General vesicular transport factor p115 is a is_associated_with::protein that in humans is encoded by the USO1 is_associated_with::gene.

Function
The protein encoded by this gene is a peripheral membrane protein which recycles between the is_associated_with::cytosol and the is_associated_with::Golgi apparatus during is_associated_with::interphase. It is regulated by is_associated_with::phosphorylation: dephosphorylated protein associates with the Golgi membrane and dissociates from the membrane upon phosphorylation. Ras-associated protein 1 recruits this protein to coat protein complex II (is_associated_with::COPII) vesicles during budding from the is_associated_with::endoplasmic reticulum (ER), where it interacts with a set of COPII vesicle-associated is_associated_with::SNAREs to form a cis-SNARE complex that promotes targeting to the Golgi apparatus. Transport from the ER to the cis/medial Golgi compartments requires the action of this gene product, is_associated_with::GOLGA2, and giantin in a sequential manner.

Interactions
USO1 has been shown to interact with:
 * is_associated_with::GOSR1,
 * is_associated_with::GOSR2,
 * is_associated_with::SCFD1, and
 * is_associated_with::STX5.