Rs6123837

rs6123837 ( G(-1211)A ) is a SNP within GNAS (GNAS complex locus - encoding the Gs alpha subunit).

among a group of 110 individuals participating in a randomized placebo-controlled weight loss trial (and under a low calorie diet)...
 * those with GG genotypes lost significantly more weight compared to A allele carriers
 * sibutramine was effective only in A allele carriers for weight loss, however, carriers for two Gs showed the strongest increases in resting heart rate and systolic blood pressure