PADI3

Peptidyl arginine deiminase, type III, also known as PADI3, is a is_associated_with::protein which in humans is encoded by the PADI3 is_associated_with::gene.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting is_associated_with::arginine residues into is_associated_with::citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as is_associated_with::filaggrin in the is_associated_with::hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.