HDAC1

Histone deacetylase 1 is an is_associated_with::enzyme that in humans is encoded by the HDAC1 is_associated_with::gene.

Function
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of is_associated_with::eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 is_associated_with::MTA2, it deacetylates is_associated_with::p53 and modulates its effect on cell growth and apoptosis.

Model organisms
is_associated_with::Model organisms have been used in the study of HDAC1 function. A conditional is_associated_with::knockout mouse line, called Hdac1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out and two is_associated_with::phenotypes were reported. A reduced number of is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice, and no significant abnormalities were observed in these animals.

Interactions
HDAC1 has been shown to interact with:


 * is_associated_with::Androgen receptor,
 * is_associated_with::BCL6,
 * is_associated_with::BTG2,
 * is_associated_with::BUB1B,
 * is_associated_with::BUB1,
 * is_associated_with::BUB3,
 * is_associated_with::CBFA2T3,
 * is_associated_with::CDC20,
 * CDH1,
 * is_associated_with::CHD3,
 * is_associated_with::CHD4,
 * is_associated_with::COUP-TFII,
 * is_associated_with::CTBP1,
 * is_associated_with::DDX17,
 * is_associated_with::DDX5,
 * is_associated_with::DNMT3A,
 * is_associated_with::DNMT3L,
 * is_associated_with::Death-associated protein 6,
 * is_associated_with::EED,
 * is_associated_with::EVI1,
 * is_associated_with::EZH2,
 * is_associated_with::FKBP3,
 * is_associated_with::GATA1,
 * is_associated_with::HMG20B,
 * is_associated_with::HSPA4,
 * is_associated_with::HUS1,
 * is_associated_with::Histone deacetylase 2,
 * is_associated_with::Homeobox protein TGIF1,
 * is_associated_with::Host cell factor C1,
 * is_associated_with::IFRD1,
 * is_associated_with::IKZF1,
 * is_associated_with::ING1,
 * is_associated_with::MBD3,
 * is_associated_with::MIER1,
 * MLL,
 * is_associated_with::MTA1,
 * is_associated_with::MTA2,
 * is_associated_with::Mad1,
 * is_associated_with::Mdm2,
 * is_associated_with::Methyl-CpG-binding domain protein 2,
 * is_associated_with::Mothers against decapentaplegic homolog 2,
 * is_associated_with::MyoD,
 * is_associated_with::NFKB1,
 * is_associated_with::Nuclear receptor co-repressor 2,
 * is_associated_with::PCNA,
 * is_associated_with::PHF21A,
 * is_associated_with::Prohibitin,
 * is_associated_with::Promyelocytic leukemia protein,
 * is_associated_with::RAD9A,
 * is_associated_with::RBBP4,
 * is_associated_with::RBBP7,
 * is_associated_with::RCOR1,
 * is_associated_with::RELA,
 * is_associated_with::RFC1,
 * is_associated_with::Retinoblastoma protein,
 * is_associated_with::Retinoblastoma-like protein 1,
 * is_associated_with::Retinoblastoma-like protein 2,
 * is_associated_with::SAP30,
 * is_associated_with::SATB1,
 * is_associated_with::SIN3A,
 * is_associated_with::SIN3B,
 * is_associated_with::SPEN,
 * is_associated_with::SUDS3,
 * is_associated_with::SUV39H1,
 * is_associated_with::Sp1 transcription factor,
 * is_associated_with::TOP2A,
 * is_associated_with::TOP2B,  and
 * is_associated_with::Zinc finger and BTB domain-containing protein 16.