Sortilin 1

Sortilin (Sort1) is a is_associated_with::protein that in humans is encoded by the SORT1 is_associated_with::gene. The SORT1 locus shows the strongest association with serum is_associated_with::lipoproteins of any genetic locus in the genome. In is_associated_with::hepatocytes, sortilin participates in the presecretory degradation of nascent is_associated_with::VLDL particles.

Function
This gene encodes a protein that is a multi-ligand type-1 receptor with similarity to the yeast carboxypeptidase Y sorting receptor Vps10 protein. The encoded protein, a trans-Golgi network (TGN) transmembrane protein, binds a number of unrelated ligands that participate in a wide range of cellular processes; however, it lacks the typical features of a signalling receptor. In the TGN, furin mediates the activation of the mature binding form. The encoded protein consists of a large luminal domain, a single transmembrane segment and short C-terminal cytoplasmic tail. The luminal domain contains a cysteine-rich region similar to two corresponding segments in the yeast Vps10p; the cytoplasmic tail is similar to the corresponding segment of the cation-independent mannose 6-phosphate receptor and the tail also interacts with the VHS domains of GGA (Golgi-associated, gamma-adaptin homologous, ARF-interacting) proteins.

In melanocytic cells SORT1 gene expression may be regulated by MITF.

Interactions
Sortilin 1 has been shown to interact with is_associated_with::GGA1 and is_associated_with::GGA2.