G6PC3

Glucose-6-phosphatase 3, also known as glucose-6-phosphatase beta, is an is_associated_with::enzyme that in humans is encoded by the G6PC3 is_associated_with::gene.

Function
This gene encodes the catalytic subunit of is_associated_with::glucose 6-phosphatase (G6Pase). G6Pase is located in the is_associated_with::endoplasmic reticulum (ER) and catalyzes the hydrolysis of is_associated_with::glucose 6-phosphate to glucose and phosphate in the last step of the gluconeogenic and glycogenolytic pathways.

Clinical significance
Mutations in this gene result in autosomal recessive severe congenital is_associated_with::neutropenia.