FBLN1

FBLN1 is the gene encoding fibulin-1, an extracellular matrix and plasma protein.

Function
Fibulin-1 is a secreted is_associated_with::glycoprotein that is found in association with is_associated_with::extracellular matrix structures including is_associated_with::fibronectin-containing fibers, is_associated_with::elastin-containing fibers and is_associated_with::basement membranes. Fibulin-1 binds to a number of extracellular matrix constituents including is_associated_with::fibronectin, nidogen-1, and the is_associated_with::proteoglycan, is_associated_with::versican. Fibulin-1 is also a blood protein capable of binding to is_associated_with::fibrinogen.

Structure
Fibulin-1 has modular domain structure and includes a series of nine is_associated_with::epidermal growth factor-like modules followed by a is_associated_with::fibulin-type module, a module found in all members of the fibulin gene family.

The human fibulin-1 gene, FBLN1, encodes four splice variants designated fibulin-1A, B, C and D, which differ in their carboxy terminal regions. In mouse, chicken and the nematode, C. elegans, only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.

Interactions
FBLN1 has been shown to interact with is_associated_with::entactin,  NOV/CCN3, is_associated_with::amyloid precursor protein, is_associated_with::fibrinogen, and is_associated_with::fibronectin.