Rs10050860

rs10050860 is one of several SNPs in the ERAP1 gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.71 (p=7.7x10e-9).[PMID 17952073, PMID 18037607]

Note that the text description (but not the result) at 23andMe is wrong. It is the uncommon T allele that gives protection.

Association of an ERAP1 ERAP2 haplotype with familial ankylosing spondylitis.

Investigating the genetic association between ERAP1 and ankylosing spondylitis.

Serum cytokine receptors in ankylosing spondylitis: relationship to inflammatory markers and endoplasmic reticulum aminopeptidase polymorphisms.

ERAP1 polymorphisms and haplotypes are associated with ankylosing spondylitis susceptibility and functional severity in a Spanish population.

Associations between ERAP1 polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.