MAPK1

Mitogen-activated protein kinase 1, also known as MAPK1, p42MAPK, and ERK2, is an is_associated_with::enzyme that in humans is encoded by the MAPK1 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::MAP kinase family. is_associated_with::MAP kinases, also known as is_associated_with::extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this is_associated_with::kinase requires its is_associated_with::phosphorylation by upstream is_associated_with::kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Model organisms
is_associated_with::Model organisms have been used in the study of MAPK1 function. A conditional is_associated_with::knockout mouse line, called Mapk1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice and males had decreased circulating is_associated_with::amylase levels.

Interactions
MAPK1 has been shown to interact with:


 * is_associated_with::ADAM17,
 * is_associated_with::CIITA,
 * is_associated_with::DUSP1,
 * is_associated_with::DUSP22,
 * is_associated_with::DUSP3,
 * is_associated_with::ELK1,
 * is_associated_with::FHL2,
 * is_associated_with::HDAC4,
 * is_associated_with::MAP2K1,
 * is_associated_with::MAP3K1
 * is_associated_with::MAPK14,
 * is_associated_with::MKNK1,
 * is_associated_with::MKNK2,
 * is_associated_with::Myc,
 * is_associated_with::NEK2,
 * is_associated_with::PEA15,
 * is_associated_with::PTPN7,
 * is_associated_with::Phosphatidylethanolamine binding protein 1,
 * is_associated_with::RPS6KA1,
 * is_associated_with::RPS6KA2,
 * is_associated_with::RPS6KA3,
 * is_associated_with::SORBS3,
 * is_associated_with::STAT5A,
 * is_associated_with::TNIP1,
 * is_associated_with::TOB1,
 * is_associated_with::TSC2,
 * is_associated_with::UBR5, and
 * is_associated_with::VAV1.