NOS1AP

Nitric oxide synthase 1 adaptor protein (NOS1AP) also known as carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (CAPON) is a is_associated_with::protein that in humans is encoded by the NOS1AP is_associated_with::gene.

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal is_associated_with::phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an is_associated_with::adapter protein linking nNOS to specific targets, such as Dexras1 and the is_associated_with::synapsins. NOS1AP polymorphisms has been associated with the is_associated_with::QT interval length.

Interactions
NOS1AP has been shown to interact with:
 * is_associated_with::LRP1,
 * is_associated_with::LRP2,
 * is_associated_with::NOS1,
 * is_associated_with::RASD1,
 * is_associated_with::SYN1