NLRC5

NLRC5, short for is_associated_with::NOD-like receptor family is_associated_with::CARD domain containing 5, is an is_associated_with::intracellular protein that plays a role in the is_associated_with::immune system. NLRC5 is a is_associated_with::pattern recognition receptor implicated in is_associated_with::innate immunity to is_associated_with::viruses potentially by regulating is_associated_with::interferon activity.

Recently, NLRC5 has been suggested to play a positive role in the regulation of Major Histocompatibility Class I (MHCI) molecule expression. This aspect of NLRC5 function was further investigated with the help of Nlrc5-deficient mice, which showed reduced MHCI expression in is_associated_with::lymphocytes (particularly T, NK and NKT lymphocytes). In lymphocytes, NLRC5 localizes to the nucleus and drives MHCI gene expression by occupying H-2D and H-2K gene promoters.

In humans, the NLRC5 is_associated_with::protein is encoded by the NLRC5 is_associated_with::gene. It has also been called NOD27, NOD4, and CLR16.1.