Protein arginine methyltransferase 5

Protein arginine N-methyltransferase 5 is an is_associated_with::enzyme that in humans is encoded by the PRMT5 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PRMT5 function. A conditional is_associated_with::knockout mouse line, called Prmt5tm2a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. No is_associated_with::homozygous mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice but no further abnormalities were observed.

Interactions
Protein arginine methyltransferase 5 has been shown to interact with:
 * is_associated_with::CLNS1A,
 * is_associated_with::Janus kinase 2,
 * is_associated_with::SNRPD3,
 * is_associated_with::SUPT5H, and
 * is_associated_with::WD repeat-containing protein 77.