ATP6V0C

V-type proton ATPase 16 kDa proteolipid subunit is an is_associated_with::enzyme that in humans is encoded by the ATP6V0C is_associated_with::gene.

Function
This gene encodes a component of is_associated_with::vacuolar is_associated_with::ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of is_associated_with::eukaryotic intracellular is_associated_with::organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated is_associated_with::endocytosis, and is_associated_with::synaptic vesicle proton gradient generation. V-ATPase is composed of a is_associated_with::cytosolic V1 domain and a is_associated_with::transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is part of the V0 domain. This gene had the previous symbols of ATP6C and ATP6L.