Alpha-taxilin

Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a is_associated_with::protein that in humans is encoded by the TXLNA is_associated_with::gene.

Interleukin-14 is a is_associated_with::cytokine that controls the growth and proliferation of both normal and cancerous B cells. This molecule was also recently designated taxilin. IL-14 induces B-cell proliferation, inhibits is_associated_with::antibody secretion, and expands selected B-cell subgroups. This is_associated_with::interleukin is produced mainly by is_associated_with::T cells and certain is_associated_with::malignant B cells.

Gene
In murine models, two distinct transcripts are produced from opposite strands of the il14 is_associated_with::gene that are called IL-14α and IL-14β. The il14 locus is near the gene for LCK on is_associated_with::chromosome 1 in humans.