Desmoglein-1

Desmoglein-1 is a is_associated_with::protein that in humans is encoded by the DSG1 is_associated_with::gene.

Function
Desmosomes are cell-cell junctions between is_associated_with::epithelial, is_associated_with::myocardial and certain other cell types. Desmoglein-1 is a calcium-binding is_associated_with::transmembrane is_associated_with::glycoprotein component of is_associated_with::desmosomes in is_associated_with::vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the is_associated_with::cadherin cell adhesion molecule superfamily. These desmoglein is_associated_with::gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been identified as the is_associated_with::autoantigen of the autoimmune skin blistering disease is_associated_with::pemphigus foliaceus.

Interactions
Desmoglein-1 has been shown to interact with is_associated_with::PKP3, is_associated_with::PKP2, and is_associated_with::PTPRT(PTPrho)