RNase III

RNase III enzymes specifically bind to and cleave double-stranded RNA (dsRNA). There are three subdivisions, known as Class 1, 2, and 3.

Prokaryotic ribonuclease III (gene rnc) is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs.


 * Class 1 RNases III are largely found in bacteria, bacteriophage, and some fungi. Among the RNases III in the class are the rnc from E. coli, Pac1p from S. pombe, and Rnt1p from S. cerevisiae. Class 1 RNases III process precursors to ribosomal RNA, and in the case of fungi, process precursors to small nuclear RNA (snRNA) and small nucleolar RNA (snoRNA).


 * Class 2 RNases III include the Drosha family of enzymes known to function in maturation of precursors to rRNA.


 * Class 3 RNases III include the Dicer family of enzymes known to function in RNA interference (RNAi).

Human proteins containing this domain
DICER1;   MRPL44;    RNASEN;