PLCB1

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 is an is_associated_with::enzyme that in humans is encoded by the PLCB1 is_associated_with::gene.

Function
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

Interactions
PLCB1 has been shown to interact with is_associated_with::TRPM7.

Pathology
Homozygous PLCB1 deletion is associated with malignant migrating partial is_associated_with::seizures in infancy.