VPS45

Vacuolar protein sorting-associated protein 45 is a is_associated_with::protein that in humans is encoded by the VPS45 is_associated_with::gene.

Function
Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct is_associated_with::organelles. Genetic studies in yeast have identified more than 40 is_associated_with::vacuolar protein sorting (VPS) genes involved in is_associated_with::vesicle transport to vacuoles. This gene is a member of the Sec1 domain family, and shows a high degree of sequence similarity to mouse, rat and yeast Vps45. The exact function of this gene is not known, but its high expression in peripheral blood mononuclear cells suggests a role in trafficking proteins, including inflammatory mediators.