Sodium–hydrogen antiporter 3

Sodium–hydrogen antiporter 3 also known as sodium–hydrogen exchanger 3 (NHE3) or solute carrier family 9 member 3 (SLC9A3) is a is_associated_with::protein that in humans is encoded by the SLC9A3 is_associated_with::gene.

SLC9A3 is a is_associated_with::sodium–hydrogen antiporter. It is found in the is_associated_with::nephron of the is_associated_with::kidney and in the is_associated_with::apical membrane of is_associated_with::enterocytes of the is_associated_with::intestine. It is primarily responsible for maintaining the balance of is_associated_with::sodium.

Regulation
is_associated_with::Protein kinase C stimulates NHE3, while is_associated_with::protein kinase A inhibits it.

There is a specific protein functioning as an NHE3 regulator, is_associated_with::Sodium-hydrogen antiporter 3 regulator 1.

Inhibitors

 * is_associated_with::Tenapanor

Stimulators

 * is_associated_with::Insulin stimulates NHE3 and thereby proximal tubule sodium absorption.

Interactions
Sodium–hydrogen antiporter 3 has been shown to interact with CHP.