Rs12722489

The (G) allele of rs12722489, located in the first intron of the IL2RA gene, is associated with a slight increase (25%) in risk of developing multiple sclerosis. [PMID tbd; NEJM 357, 29 July 2007, DA Hafler et al.]

Note that the (G) allele is the most common at this position in all known populations.

blog post giving perspective on the significance of this snp

plos rs12722489 and rs2104286 influence multiple sclerosis and type-1 diabetes

Haplotypic analysis of Wellcome Trust Case Control Consortium data.

IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations.

The complex genetics of multiple sclerosis: pitfalls and prospects.

Refining genetic associations in multiple sclerosis.

IL2RA genetic heterogeneity in multiple sclerosis and type 1 diabetes susceptibility and soluble interleukin-2 receptor production.

IL2RA/CD25 gene polymorphisms: uneven association with multiple sclerosis (MS) and type 1 diabetes (T1D).

Soluble IL-2RA levels in multiple sclerosis subjects and the effect of soluble IL-2RA on immune responses.

Comprehensive follow-up of the first genome-wide association study of multiple sclerosis identifies KIF21B and TMEM39A as susceptibility loci.

The genetic aspects of multiple sclerosis.

The effect of single nucleotide polymorphisms from genome wide association studies in multiple sclerosis on gene expression.

IL2RA gene polymorphism rs2104286 A>G seen in multiple sclerosis is associated with intermediate uveitis: possible parallel pathways?