Rs10033464

Two SNPs from chromosome 4q25, rs2200733 and rs10033464, were found to be associated with atrial fibrillation in a study of both European and Asian populations. The odds ratio associated with one or more copies of either risk allele was ~1.4x.

In 1,661 Icelandic ischemic stroke samples and two large European replication sets combined, rs10033464 was associated with cardioembolic stroke (CES) (odds ratio 1.27, p = 6.1 x 10e-4).

rs2200733 and rs10033464 are strongly associated with AF in four cohorts of European descent.

Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.

Chromosome 4q25 variants and atrial fibrillation recurrence after catheter ablation.

Common variants in KCNN3 are associated with lone atrial fibrillation.

Association of RS2200733 but not RS10033464 on 4q25 with atrial fibrillation based on the recessive model in a Taiwanese population.

The association of the 4q25 susceptibility variant for atrial fibrillation with stroke is limited to stroke of cardioembolic etiology.

Lone AF - etiologic factors and genetic insights into pathophysiolgy.