SPOP


 * Disambiguation: For the animated series see She-Ra: Princess of Power.

Speckle-type POZ protein is a is_associated_with::protein that in humans is encoded by the SPOP is_associated_with::gene.

This gene encodes a is_associated_with::protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with is_associated_with::histone deacetylase, core is_associated_with::histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative is_associated_with::leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. is_associated_with::Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Clinical relevance
Mutations in SPOP lead to a type of prostate tumor thought to be involved in about 15% of all is_associated_with::prostate cancers.