HOXC10

Homeobox protein Hox-C10 is a is_associated_with::protein that in humans is encoded by the HOXC10 is_associated_with::gene.

Pathology

 * HOXC10 is overexpressed in is_associated_with::breast cancer and transcriptionally regulated by is_associated_with::estrogen via involvement of is_associated_with::histone methylases is_associated_with::MLL3 and is_associated_with::MLL4.
 * Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to is_associated_with::aromatase inhibitors. This is_associated_with::epigenetic reprogramming of HOXC10 is observed in is_associated_with::endocrine-resistant breast cancer.