PACS1

Phosphofurin acidic cluster sorting protein 1 also known as PACS-1 is a is_associated_with::protein that in humans is encoded by the PACS1 is_associated_with::gene.

Function
The PACS-1 protein has a putative role in the localization of trans-Golgi network (TGN) membrane proteins. Mouse and rat homologs have been identified and studies of the homologous rat protein indicate a role in directing TGN localization of is_associated_with::furin by binding to the protease's phosphorylated cytosolic domain. In addition, the human protein plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.

Interactions
PACS1 has been shown to interact with is_associated_with::Furin.