Rs2267735

An SNP in a putative estrogen response element within the ADCYAP1R1 gene. C is the risk allele - associated with PTSD, hyperarousal in females.

Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. (2011). Predicts Post-traumatic stress disorder diagnoses and symptoms in females only. This may occur due to oestrogen regulation of ADCYAP1R1. Total PTSD symptoms are differentially associated with rs2267735 genotype (CC is high-risk variant) in females (p &#8804; 0.001). Hyperarousal is the most robustly associated symptom with rs2267735 genotype (p = 0.0009). In a dominant/recessive model, even after controlling for childhood trauma, adult trauma, and age, genotype predicts total PTSD symptoms (p &#8804; 0.001) and hyperarousal symptoms (p &#8804; 0.0001). Fear discrimination (CS+ Startle minus CS&#8722; Startle) is impaired in females with rs2267735 &#8216;CC&#8217; genotype. Dark enhanced startle (StartleDark &#8211; StartleLight) is significantly increased in females with rs2267735 &#8216;CC&#8217; genotype.