Rs3218536

rs3218536, a relatively rare SNP also known as Arg188His located in the DNA-repair gene XRCC2, is associated with a lowered risk for breast cancer based on a study of 1,100 Cypriot women. The odds ratio for the His-encoding rs3218536(A) allele carriers is homozygote is 0.79, CI: 0.62-1.00, p=0.05.

rs3218536(A) carriers also appear to be at lower risk for epithelial ovarian cancer. In a study of ~1,600 cases, the odds ratio for rs3218536(A;G) heterozygotes was 0.8 (CI: 0.7-1.0) and for the (quite rare) rs3218536(A;A) homozygotes 0.3 (0.1-0.9).


 * is_associated_with_disease::Lung cancer
 * is_associated_with_disease::Thyroid carcinoma
 * is_associated_with_disease::Breast cancer
 * is_associated_with_disease::Renal cell carcinoma
 * is_associated_with_disease::Cervical cancer
 * is_associated_with_disease::Ovarian cancer
 * is_associated_with_disease::Colorectal cancer
 * is_associated_with_disease::Syndrome
 * is_associated_with_disease::Urinary bladder cancer
 * is_associated_with_disease::Carcinoma
 * is_associated_with_disease::Non-Hodgkin lymphoma
 * is_associated_with_disease::Lynch syndrome