APLP2

Amyloid-like protein 2, also known as APLP2, is a is_associated_with::protein that in humans is encoded by the APLP2 is_associated_with::gene. APLP2 along with is_associated_with::APLP1 are important modulators of is_associated_with::glucose and is_associated_with::insulin is_associated_with::homeostasis.

Function
APLP2 associates with antigen presentation molecules like is_associated_with::MHC class I molecules and regulates their surface expression by enhancing is_associated_with::endocytosis.

is_associated_with::APLP1 and APLP2 double knockout mice display is_associated_with::hypoglycemia and is_associated_with::hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis. APLP2 has also been shown to regulate development of the brain by regulating migration and differentiation of neural stem cells.

Interactions
APLP2 has been shown to interact with is_associated_with::APBB1.