PAK1

Serine/threonine-protein kinase PAK 1 is an is_associated_with::enzyme that in humans is encoded by the PAK1 is_associated_with::gene.

Function
PAK proteins are critical effectors that link the is_associated_with::Rho_family_of_GTPases (Rho GTPases) to is_associated_with::cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activated is_associated_with::kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined.

Interactions
PAK1 has been shown to interact with:


 * is_associated_with::ARHGEF2,
 * is_associated_with::ARPC1B,
 * BMX,
 * is_associated_with::C-Raf,
 * is_associated_with::CDC42,
 * is_associated_with::Cyclin-dependent kinase 5,
 * is_associated_with::DYNLL1,
 * is_associated_with::LIMK1,
 * is_associated_with::NCK1,
 * is_associated_with::PAK1IP1 and
 * is_associated_with::RAC1.