NOD1

Nucleotide-binding oligomerization domain-containing protein 1 is a is_associated_with::protein receptor that in humans is encoded by the NOD1 is_associated_with::gene. It recognizes bacterial molecules and stimulates an immune reaction.

NOD1 protein contains a is_associated_with::caspase recruitment domain (CARD). NOD1 is a member of is_associated_with::NOD-like receptor protein family and is a close relative of is_associated_with::NOD2. NOD1 is an intracellular is_associated_with::pattern recognition receptor, which is similar in structure to resistant proteins of plants, and mediates innate and acquired immunity by recognizing bacterial molecules containing D-glutamyl-meso-diaminopimelic acid (iE-DAP) moiety. Nod1 interacts with is_associated_with::RIPK2 through the CARDs of both molecules (See the structure of the NOD1 CARD in the right panel). Stimulation of NOD1 by iE-DAP containing molecules results in activation of the transcription factor is_associated_with::NF-κB.