PCSK5

Proprotein convertase subtilisin/kexin type 5 is an is_associated_with::enzyme that in humans is encoded by the PCSK5 is_associated_with::gene, found in chromosome 9q21.3   Two alternatively spliced transcripts are described for this gene but only one has its full length nature known.

Function
The protein encoded by this gene belongs to the is_associated_with::subtilisin-like is_associated_with::proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein mediates posttranslational endoproteolytic processing for several is_associated_with::integrin alpha subunits. It is thought to process prorenin, pro-membrane type-1 is_associated_with::matrix metalloproteinase and HIV-1 glycoprotein is_associated_with::gp160.

Clinical significance
Mutations in this gene have been associated with is_associated_with::Currarino syndrome-like malformations.