P70-S6 Kinase 1

Ribosomal protein S6 kinase beta-1 is an is_associated_with::enzyme that in humans is encoded by the RPS6KB1 is_associated_with::gene.

Function
This gene encodes a member of the RSK (is_associated_with::ribosomal s6 kinase) family of serine/threonine kinases. This kinase phosphorylates several residues of the S6 ribosomal protein. The kinase activity of this protein leads to an increase in is_associated_with::protein synthesis and is_associated_with::cell proliferation.

Clinical significance
Inhibition of the S6K1 protein, or a lack of it, slows the production of adipose (fat) cells by disrupting and retarding the initial "commitment stage" of their formation. The study could have implications for the treatment of obesity.

Amplification of the region of DNA encoding this gene and overexpression of this kinase are seen in some is_associated_with::breast cancer cell lines.

Another pathway for which P70 has proposed involvement is in muscle lengthening and growing. P70 is is_associated_with::phosphorylated by passive stretch in the is_associated_with::soleus muscle. This may be one of many protein kinases involved in muscle building.

Interactions
P70-S6 Kinase 1 has been shown to interact with:


 * is_associated_with::COASY,
 * is_associated_with::CSNK2B,
 * is_associated_with::EIF3B,
 * is_associated_with::KIAA1303,
 * MTOR,
 * is_associated_with::POLDIP3,
 * is_associated_with::PPP2R2A,
 * is_associated_with::RBX1, and
 * UBC.