PCSK6

Proprotein convertase subtilisin/kexin type 6 is an is_associated_with::enzyme that in humans is encoded by the PCSK6 is_associated_with::gene. PCSK6 is a protease that cleaves is_associated_with::NODAL into an active form to help trigger the development of left/right (LR) asymmetry. It may also be involved in left and right is_associated_with::handedness in humans.

Function
The protein encoded by this gene belongs to the is_associated_with::subtilisin-like is_associated_with::proprotein convertase family. The members of this family are proprotein convertases that process latent precursor proteins into their biologically active products. This encoded protein is a calcium-dependent serine is_associated_with::endoprotease that can cleave precursor protein at their paired basic amino acid processing sites. Some of its substrates are - is_associated_with::transforming growth factor beta related proteins, proalbumin, and is_associated_with::von Willebrand factor. Alternatively spliced transcript variants encoding different isoforms have been identified.

Clinical significance
This gene is thought to play a role in tumor progression.