SUV39H1

Histone-lysine N-methyltransferase SUV39H1 is an is_associated_with::enzyme that in humans is encoded by the SUV39H1 is_associated_with::gene.

Function
This gene is a member of the suppressor of variegation 3-9 homolog family and encodes a protein with a is_associated_with::chromodomain and a C-terminal SET domain. This nuclear protein moves to the centromeres during mitosis and functions as a histone methyltransferase, methylating Lys-9 of histone H3. Overall, it plays a vital role in heterochromatin organization, chromosome segregation, and mitotic progression.

Interactions
SUV39H1 has been shown to interact with:


 * is_associated_with::CBX1,
 * CBX5,
 * is_associated_with::DNMT3A,
 * is_associated_with::HDAC1,
 * is_associated_with::HDAC3,
 * is_associated_with::HDAC9,
 * is_associated_with::Histone deacetylase 2,
 * is_associated_with::MBD1,
 * is_associated_with::RUNX1,
 * is_associated_with::Retinoblastoma protein,  and
 * is_associated_with::SBF1.