Growth hormone receptor

Growth hormone receptor is a is_associated_with::protein that in humans is encoded by the GHR is_associated_with::gene. GHR is_associated_with::orthologs have been identified in most is_associated_with::mammals.

Interactions
Growth hormone receptor has been shown to interact with is_associated_with::SGTA, is_associated_with::PTPN11, is_associated_with::Janus kinase 2,   is_associated_with::Suppressor of cytokine signaling 1 and is_associated_with::CISH.

Evolution
The GHR gene is used in animals as a is_associated_with::nuclear DNA phylogenetic marker. The exon 10 has first been experienced to explore the phylogeny of the major groups of is_associated_with::Rodentia. GHR has also proven useful at lower is_associated_with::taxonomic levels, e.g., in octodontoid, arvicoline, muroid, murine, and peromyscine rodents, in arctoid and is_associated_with::felid carnivores, and in is_associated_with::dermopterans. Note that the GHR intron 9 has also been used to investigate the is_associated_with::mustelid and hyaenid is_associated_with::carnivores phylogenetics.

Antagonists
Growth hormone receptor antagonists such as is_associated_with::pegvisomant (trade name Somavert) are used in the treatment of is_associated_with::acromegaly. They are used if the tumor of the is_associated_with::pituitary gland causing the acromegaly cannot be controlled with surgery or radiation, and the use of is_associated_with::somatostatin analogues is unsuccessful. Pegvisomant is delivered as a powder that is mixed with water and injected under the skin.