Rs2297508

rs2297508 is one of several SNPs associated with the SREBF1 gene that show a modest association with type-2 diabetes.

A study of ~2,000 Caucasian patients (and 10,000+ controls) led to an odds ratio of 1.17 (CI: 1.05-1.30, p=0.003) for the minor (risk) allele, rs2297508(C). A meta-analysis included other published studies concluded the odds ratio was 1.08 (CI: 1.03-1.14, p=0.001).

type-2 diabetes rs2297508(C) and rs11868035(C)