Exonuclease 1

Exonuclease 1 is an is_associated_with::enzyme that in humans is encoded by the EXO1 is_associated_with::gene.

This gene encodes a is_associated_with::protein with 5' to 3' exonuclease activity as well as an is_associated_with::RNase H activity (endonuclease activity cleaving RNA on DNA/RNA hybrid). It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in is_associated_with::DNA mismatch repair and is_associated_with::homologous recombination. Alternative splicing of this gene results in three transcript variants encoding two different isoforms.

Interactions
Exonuclease 1 has been shown to interact with is_associated_with::MSH2  and is_associated_with::MLH1.