SOCS2

Suppressor of cytokine signaling 2 is a is_associated_with::protein that in humans is encoded by the SOCS2 is_associated_with::gene.

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as is_associated_with::suppressor of cytokine signalling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including is_associated_with::erythropoietin, GM-CSF, IL10 and is_associated_with::interferon-gamma (IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of is_associated_with::insulin-like growth factor 1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.

Interactions
SOCS2 has been shown to interact with is_associated_with::Insulin-like growth factor 1 receptor and is_associated_with::Erythropoietin receptor.