CCBE1

Collagen and calcium-binding EGF domain-containing protein 1 is a is_associated_with::protein that in humans is encoded by the CCBE1 is_associated_with::gene.

Function
This gene is thought to function in is_associated_with::extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary is_associated_with::carcinomas, suggesting its role as a tumor suppressor.

Clinical significance
Mutation in the CCBE1 gene may be associated with is_associated_with::Hennekam syndrome, a generalized lymphatic dysplasia in humans.