JAM2

Junctional adhesion molecule B is a is_associated_with::protein that in humans is encoded by the JAM2 is_associated_with::gene. JAM2 has also been designated as CD322 (is_associated_with::cluster of differentiation 322).

Function
is_associated_with::Tight junctions represent one mode of cell-to-cell adhesion in is_associated_with::endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of is_associated_with::immune cell types and may play a role in is_associated_with::lymphocyte homing to secondary lymphoid organs.

It is purported to promote lymphocyte transendothelial migration. It might also be involved with endothelial cell polarity, by associating to cell polarity protein PAR-3, together with JAM3.

Interactions
JAM2 has been shown to interact with is_associated_with::PARD3.

It also interacts with α4β1.