ITPR3

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a is_associated_with::protein which in humans is encoded by the ITPR3 is_associated_with::gene. The is_associated_with::protein encoded by this gene is both a receptor for is_associated_with::inositol triphosphate and a is_associated_with::calcium channel.

Function
ITP3 channels serve an important role in the taste transduction pathway of is_associated_with::sweet, bitter and is_associated_with::umami tastes the is_associated_with::gustatory system. ITP3 channels allow the flow of Calcium out of the is_associated_with::endoplasmic reticulum in response to IP3. Calcium cations result in the activation of is_associated_with::TRPM5 which leads to a depolarisation generating potential and an is_associated_with::action potential.