PRMT3

Protein arginine N-methyltransferase 3 is an is_associated_with::enzyme that in humans is encoded by the PRMT3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PRMT3 function. A conditional is_associated_with::knockout mouse line, called Prmt3tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on is_associated_with::mutant mice and seven significant abnormalities were observed. Fewer than predicted is_associated_with::homozygous is_associated_with::mutant mice survived until is_associated_with::weaning due to is_associated_with::hydrocephaly. The remaining tests were carried out on both is_associated_with::heterozygous and homozygous mutant adult mice. Male heterzygous mice had a decreased is_associated_with::respiratory quotient. Homozygous females had decreased body weight, length and bone mineral density. Homozygous males had abnormal peripheral blood is_associated_with::lymphocyte counts and homozygotes of both sex had eye abnormalities.

Interactions
PRMT3 has been shown to interact with is_associated_with::RPS2.