PTPRB

Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an is_associated_with::enzyme specifically expressed in endothelial cells that in humans is encoded by the PTPRB is_associated_with::gene.

Function
VEPTP is a member of the classical is_associated_with::protein tyrosine phosphatase (PTP) family. The deletion of the gene in mouse models was shown to be emryonically lethal, thus indicating that it is important for is_associated_with::vasculogenesis and blood vessel development. In addition it was shown to participate in is_associated_with::adherens junctions and regulate is_associated_with::vascular permeability.

Interactions
VE-PTP contains an extracellular domain composed of multiple fibronectin type_III repeats, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to R3 receptor subtype PTPs. The extracellular region was shown to interact with the is_associated_with::angiopoietin receptor is_associated_with::Tie-2. and with the adhesion protein is_associated_with::VE-cadherin.

VE-PTP was also found to interact with is_associated_with::Grb2 and is_associated_with::plakoglobin through its cytoplasmatic domain.