Thyroid hormone receptor beta

Thyroid hormone receptor beta (TR-beta) also known as nuclear receptor subfamily 1, group A, member 2 (NR1A2), is a is_associated_with::nuclear receptor protein that in humans is encoded by the THRB gene.

Function
The protein encoded by this gene is a nuclear hormone receptor for is_associated_with::triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Defects in this gene are known to be a cause of generalized is_associated_with::thyroid hormone resistance (GTHR), a syndrome characterized by is_associated_with::goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated is_associated_with::thyroid stimulating hormone (TSH). Several transcript variants have been observed for this gene, but the full-length nature of only one has been observed so far.

Interactions
Thyroid hormone receptor beta has been shown to interact with:


 * is_associated_with::BRD8,
 * CCND1,
 * NCOA1,
 * is_associated_with::NCOA6,
 * NCOR2,
 * NR2F6,
 * is_associated_with::PPARGC1A, and
 * RXRA.