SFRS7

Serine/arginine-rich splicing factor 7 (SRSF7) also known as splicing factor, arginine/serine-rich 7 (SFRS7) or splicing factor 9G8 is a is_associated_with::protein that in humans is encoded by the SRSF7 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-is_associated_with::mRNA splicing factors, which constitute part of the is_associated_with::spliceosome. Each of these factors contains an is_associated_with::RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in is_associated_with::serine and is_associated_with::arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation.

Model organisms
is_associated_with::Model organisms have been used in the study of SRSF7 function. A conditional is_associated_with::knockout mouse line called Srsf7tm1a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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