N-Arachidonoyl dopamine

N-Arachidonoyl dopamine (NADA) is an endocannabinoid which acts as an agonist of the CB1 receptor and the transient receptor potential V1 (TRPV1) ion channel. Its discovery was described in 2002 by an academic research group from Italy and the USA. It was found in the brain of rats, with especially high concentrations in the hippocampus, cerebellum and striatum. It activates the TRPV1 channel with an EC50 of approximately of 50nM. The high potency makes it the putative endogenous TRPV1 agonist.