Microsomal glutathione S-transferase 1

Microsomal glutathione S-transferase 1 is an is_associated_with::enzyme that in humans is encoded by the MGST1 is_associated_with::gene.

Function
The is_associated_with::MAPEG family (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) consists of six human proteins, two of which are involved in the production of is_associated_with::leukotrienes and is_associated_with::prostaglandin E, important mediators of is_associated_with::inflammation. Other family members, demonstrating is_associated_with::glutathione S-transferase and is_associated_with::peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of is_associated_with::glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the is_associated_with::endoplasmic reticulum and outer is_associated_with::mitochondrial membrane where it is thought to protect these membranes from is_associated_with::oxidative stress. Four is_associated_with::transcript variants of this gene encode one protein isoform.