RHBDF2

Rhomboid family member 2 is a is_associated_with::protein that in humans is encoded by the RHBDF2 is_associated_with::gene. The alternative name iRhom2 has been proposed, in order to clarify that it is a catalytically inactive member of the rhomboid family of intramembrane is_associated_with::serine proteases.

The RHBDF2 gene is located at on the long arm of is_associated_with::chromosome 17 (17q25.1) on the Crick (minus) strand. It is 30.534 kilobases in length and encodes a protein of 856 amino acids with a predicted molecular weight of 96.686 kiloDaltons.

The RHBDF2 protein plays plays an important role in the secretion of is_associated_with::tumor necrosis factor alpha,  and has also been implicated in familial esophageal cancer.

It is involved in the regulation of the secretion of several ligands of the is_associated_with::epidermal growth factor receptor.