BUB1B

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an is_associated_with::enzyme that in humans is encoded by the BUB1B is_associated_with::gene.

Function
This gene encodes a is_associated_with::kinase involved in is_associated_with::spindle checkpoint function. The protein has been localized to the is_associated_with::kinetochore and plays a role in the inhibition of the is_associated_with::anaphase-promoting complex/is_associated_with::cyclosome (APC/C), delaying the onset of is_associated_with::anaphase and ensuring proper is_associated_with::chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.

Increased expression of BubR1 in mice extends a healthy lifespan.

Interactions
BUB1B has been shown to interact with:


 * is_associated_with::AP2B1,
 * is_associated_with::BRCA2
 * is_associated_with::BUB3,
 * is_associated_with::CDC20,
 * is_associated_with::HDAC1,
 * is_associated_with::MAD2L1, and
 * SNCG.