GAS6

Growth arrest-specific 6, also known as GAS6, is a human is_associated_with::gene coding for the Gas6 protein. It is similar to the is_associated_with::Protein S with the same domain organization and 43% amino acid identity. It was originally found as a gene upregulated by growth arrested fibroblasts.

Function
GAS6 is a gamma-carboxyglutamic acid (Gla) domain-containing protein thought to be involved in the stimulation of cell proliferation.

Interactions
GAS6 has been shown to interact with is_associated_with::AXL receptor tyrosine kinase, MerTK and is_associated_with::TYRO3.

The presence of Gla needs a vitamin K-dependent enzymatic reaction that carboxylates the gamma carbon of certain glutamic residues of the protein during its production in the endoplasmic reticulum.