EIF6

Eukaryotic translation initiation factor 6 (EIF6), also known as Integrin beta 4 binding protein (ITGB4BP), is a human is_associated_with::gene.

is_associated_with::Hemidesmosomes are structures which link the is_associated_with::basal lamina to the intermediate filament is_associated_with::cytoskeleton. An important functional component of hemidesmosomes is the integrin beta-4 subunit (is_associated_with::ITGB4), a protein containing two fibronectin type III domains. The protein encoded by this gene binds to the fibronectin type III domains of ITGB4 and may help link ITGB4 to the intermediate filament cytoskeleton. The encoded protein, which is insoluble and found both in the nucleus and in the is_associated_with::cytoplasm, can function as a translation initiation factor and catalyzes the association of the is_associated_with::40S and is_associated_with::60S ribosomal subunits along with eIF5 bound to GTP. Multiple transcript variants encoding several different isoforms have been found for this gene.

Interactions
EIF6 has been shown to interact with is_associated_with::FHL2, is_associated_with::ITGB4 and is_associated_with::GNB2L1.