STX10

Syntaxin-10 (STX10) is a is_associated_with::SNARE protein that is encoded by the STX10 is_associated_with::gene. This protein is found in most vertebrates (including humans) but is noticeably absent from mice. As with other SNARE proteins, STX10 facilitates is_associated_with::vesicle fusion and thus is important for intracellular trafficking of proteins and other cellular components. More specifically, STX10 has been implicated in is_associated_with::endosome to Golgi trafficking of the is_associated_with::mannose 6-phosphate receptor and glucose transporter type 4.

STX10 has been detected in the trans-Golgi network (TGN) by is_associated_with::immunofluorescence.

Structure and function
Human STX10 is a 249 is_associated_with::amino acid protein that has three N-terminal α-helices and a single SNARE domain followed by a single-pass transmembrane domain. Human STX10 is 60% identical to human is_associated_with::STX6.

STX10 is structurally classified as a Qc-SNARE (contributes a is_associated_with::glutamine (Q) residue in the formation of the assembled core SNARE complex) and is functionally classified as a t-is_associated_with::SNARE (or target-SNARE which is often located in the membranes of target compartments).

Interactions
STX10 is known to interact with the t-SNAREs is_associated_with::VTI1A and is_associated_with::STX16 and with the v-SNAREs is_associated_with::VAMP3 and is_associated_with::VAMP4. The SNARE complex of STX10, is_associated_with::STX16, VTI1A, and VAMP3 are required for late endosome to Golgi trafficking of the is_associated_with::mannose 6-phosphate receptor. Early endosome to Golgi trafficking of Shiga toxin requires the SNARE complex of is_associated_with::STX6, STX16, VTI1A, and VAMP3 or VAMP4.

Thus, STX10 distinguishes early endosome to Golgi trafficking from late endosome to Golgi trafficking.