Rs4762

rs4762, a SNP in the angiotensin II AGT gene, has been reported to be associated with increased risk for developing pre-eclampsia, based on a study of ~180 French-Canadian women. The odds ratio associated with the rs4762(T) allele (encoding methionine) was 1.9 (CI:1.2â€“2.9, p=0.0033).

Note that rs4762 is commonly referred to in the literature as "T174M" or "Thr174Met"; however, databases now indicate that the amino acid that varies is #207 (not 174), as the protein is currently numbered.

rs4762 was also reported to play the major role in the 2.1 fold increased risk (CI: 1.4-3.4, p=0.0008) for pre-eclampsia of the rs3889728(A)-rs4762(T)-rs699(C) haplotype.

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