SPTBN4

Spectrin, beta, non-erythrocytic 4, also known as SPTBN4, is a is_associated_with::protein that in humans is encoded by the SPTBN4 is_associated_with::gene.

Spectrin is an is_associated_with::actin crosslinking and molecular scaffold protein that links the is_associated_with::cell membrane to the actin is_associated_with::cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of is_associated_with::organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the is_associated_with::nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene.

Interactions
SPTBN4 has been shown to interact with is_associated_with::PTPRN and is_associated_with::DISC1.