MAGI2

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 also known as membrane-associated guanylate kinase inverted 2 (MAGI-2) and atrophin-1-interacting protein 1 (AIP-1) is an is_associated_with::enzyme that in humans is encoded by the MAGI2 is_associated_with::gene.

Function
The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for is_associated_with::dentatorubral-pallidoluysian atrophy. This encoded protein is characterized by two is_associated_with::WW domains, a is_associated_with::guanylate kinase-like domain, and multiple is_associated_with::PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family.

Interactions
MAGI2 has been shown to interact with is_associated_with::ATN1 and is_associated_with::PTEN (gene).