ADAMTS8

A disintegrin and metalloproteinase with thrombospondin motifs 8 is an is_associated_with::enzyme that in humans is encoded by the ADAMTS8 is_associated_with::gene.

Function
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a is_associated_with::metalloproteinase domain, a is_associated_with::disintegrin-like domain, and a is_associated_with::thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.

Clinical significance
A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.