BCL3

B-cell lymphoma 3-encoded protein is a is_associated_with::protein that in humans is encoded by the BCL3 is_associated_with::gene.

This gene is a proto-is_associated_with::oncogene candidate. It is identified by its translocation into the is_associated_with::immunoglobulin alpha-locus in some cases of is_associated_with::B-cell leukemia. The protein encoded by this gene contains seven is_associated_with::ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.

Like is_associated_with::BCL2, BCL5, is_associated_with::BCL6, BCL7A, is_associated_with::BCL9, and is_associated_with::BCL10, it has clinical significance in is_associated_with::lymphoma.

Interactions
BCL3 has been shown to interact with:


 * is_associated_with::BARD1,
 * is_associated_with::C-Fos,
 * is_associated_with::C-jun,
 * is_associated_with::C22orf25,
 * COPS5,
 * is_associated_with::EP300,
 * is_associated_with::HTATIP,
 * is_associated_with::NFKB1,
 * is_associated_with::NFKB2,
 * PIR, and
 * NR2B1.