CHD4

Chromodomain-helicase-DNA-binding protein 4 is an is_associated_with::enzyme that in humans is encoded by the CHD4 is_associated_with::gene.

Function
The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein.

Interactions
CHD4 has been shown to interact with is_associated_with::HDAC1,  is_associated_with::Histone deacetylase 2,  is_associated_with::MTA2, is_associated_with::SATB1 and is_associated_with::Ataxia telangiectasia and Rad3 related.