Glycine transporter 2

Glycine transporter 2 (GlyT2) also known as the sodium- and chloride-dependent glycine transporter 2 or solute carrier family 6 member 5 is a is_associated_with::protein that in humans is encoded by the SLC6A5 is_associated_with::gene.

The glycine transporter 2 is a membrane protein which recaptures is_associated_with::glycine, a major inhibitory transmitter in the is_associated_with::spinal cord and is_associated_with::brainstem. GlyT2 is a specific marker of glycinergic neurons and a member of the Na+ and Cl−-coupled transporter family SLC6. Glycine uptake mediated by GlyT2 is electrogenic, coupled to three Na+ and one Cl− (i.e. two positive charges per glycine). In humans, GlyT2 is encoded by the SLC6A5 is_associated_with::gene. Inactivation of GlyT2 in is_associated_with::knockout mice is lethal during the second post-natal week as the absence of GlyT2 disrupts inhibitory transmission by reducing glycine release. Mutations in SLC6A5 gene are responsible for a presynaptic form of is_associated_with::hyperekplexia, a genetic disease causing increased is_associated_with::startle reflex. GlyT2 main physiological role is to recapture glycine released in the synaptic cleft and to maintain high glycine concentration in the presynaptic neuron. Therefore chronic inhibition of GlyT2 will deplete intracellular storage of glycine and limit its accumulation in synaptic vesicles.