PLCE1

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 is an is_associated_with::enzyme that in humans is encoded by the PLCE1 is_associated_with::gene.

Function
PLCE1 belongs to the phospholipase family that catalyzes the hydrolysis of polyphosphoinositides such as phosphatidylinositol-4,5-bisphosphate (PtdIns(4,5)P2) to generate the second messengers Ins(1,4,5)P3 and diacylglycerol. These products initiate a cascade of intracellular responses that result in cell growth and differentiation and gene expression.[supplied by OMIM]