CXorf36

Chromosome X open reading frame 36 (CXorf36) is a is_associated_with::gene that in humans encodes a is_associated_with::protein “hypothetical protein LOC79742”. This protein has a function that is not currently very well understood. Other known aliases are “FLJ14103, DKFZp313K0825, FLJ55198, PRO3743, FLJ55198, hCG1981635, bA435K1.1,” and “4930578C19Rik.”

Gene
The CXorf36 gene is located at Xp11.3. It can be transcribed into 8 different transcript variants, which in turn can produce 6 different is_associated_with::isoforms of the protein. The genomic DNA is 52,529 is_associated_with::base pairs long, while the longest mRNA that it produces is 4,735 bases long.

Gene Neighborhood
CXorf36 is closely surrounded by the following genes on chromosome X: CXorf36 is also surrounded by two other genes on chromosome X that have been implicated in is_associated_with::X-linked mental retardation.
 * DUSP21
 * KDM6A
 * MIR222
 * TBX20
 * is_associated_with::Synaptophysin
 * is_associated_with::CASK

Protein
The longest is_associated_with::protein isoform that is produced by the CXorf36 gene is termed hypothetical protein LOC79742 isoform 1 and is 433 is_associated_with::amino acids long. The protein has a predicated molecular weight of 48.6 kDa and isoelectric point of 8.11.

Domains
The CXorf36 gene protein product contains a region of low complexity from position 16 to position 40.

Post-translational Modification
The CXorf36 protein is predicted to undergo is_associated_with::phosphorylation at several is_associated_with::serines, is_associated_with::threonines, and is_associated_with::tyrosines throughout the structure. However, many of these sites are predicted at serines. There is also a predicted is_associated_with::N-linked glycosylation site at position 100 on the protein product.

Expression
CXorf36 is shown to be expressed ubiquitously at low levels in various tissues throughout the body. It is expressed highly in the is_associated_with::ciliary ganglion, is_associated_with::ovary, and uterus corpus. However, highest expression is seen in the trigeminal ganglion tissue.

Conservation
CXorf36 has one is_associated_with::paralog in humans known as is_associated_with::C3orf58. is_associated_with::Orthologs have been found in all is_associated_with::mammals and through numerous is_associated_with::eukaryotes. However, conservation of the full gene halts past this, most likely a result of duplication from the ancestral gene into CXorf36 and C3orf58. The full list of organisms in which orthologs have been found is given below.


 * is_associated_with::Pongo abelii
 * is_associated_with::Macaca mulatta
 * is_associated_with::Callithrix jacchus
 * is_associated_with::Canis familiaris
 * is_associated_with::Ailuropoda melanoleuca
 * is_associated_with::Equus caballus
 * is_associated_with::Oryctolagus cuniculus
 * is_associated_with::Mus musculus
 * is_associated_with::Rattus norvegicus
 * is_associated_with::Monodelphis domestica
 * is_associated_with::Ornithorhynchus anatinus
 * is_associated_with::Taeniopygia guttata
 * is_associated_with::Gallus gallus
 * is_associated_with::Danio rerio
 * is_associated_with::Bos taurus