Proglucagon

Proglucagon is a protein that in humans is encoded by the GCG gene.

Proglucagon is a precursor of glucagon, and several other components. It is generated in the alpha cells of the pancreas and in the intestinal L cells in the distant ileum and colon. It is cleaved into the following components:


 * Glicentin
 * Glicentin-related pancreatic polypeptide (GRPP)
 * Oxyntomodulin (OXY or OXM)
 * Glucagon
 * Glucagon-like peptide 1 (GLP-1)
 * Glucagon-like peptide 2 (GLP-2)