SRD5A2

3-oxo-5-alpha-steroid 4-dehydrogenase 2 is an is_associated_with::enzyme that in humans is encoded by the SRD5A2 is_associated_with::gene.

Steroid is_associated_with::5-alpha reductase catalyzes the conversion of the male sex hormone is_associated_with::testosterone into the more potent is_associated_with::androgen, is_associated_with::dihydrotestosterone.

This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the is_associated_with::prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor is_associated_with::finasteride. Deficiencies in this gene can result in male is_associated_with::pseudohermaphroditism, specifically is_associated_with::pseudovaginal perineoscrotal hypospadias (PPSH).