Rs28942089

rs28942089, also known as His377Tyr or H377Y, is a SNP in the WT1 gene on chromosome 11.

The mutant allele for this SNP is considered causal for Denys-Drash syndrome, based on several reports.

See also OMIM 607102.0012

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.