PLCB2

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2 is an is_associated_with::enzyme that in humans is encoded by the PLCB2 is_associated_with::gene.

Function
The gene codes for the enzyme is_associated_with::phospholipase C β2. The enzyme catalyzes the formation of is_associated_with::inositol 1,4,5-trisphosphate and is_associated_with::diacylglycerol from is_associated_with::phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two is_associated_with::G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.

Interactions
PLCB2 has been shown to interact with is_associated_with::MAP2K3 and is_associated_with::TRPM7.