TMEM59

Transmembrane protein 59 is a is_associated_with::protein that in humans is encoded by the TMEM59 is_associated_with::gene.

TMEM59 is a membrane bound protein that is localized to the is_associated_with::Golgi apparatus. The precise function of TMEM59 is not known, however it has been demonstrated that expression of TMEM59 protein inhibits Golgi is_associated_with::glycosylation of is_associated_with::amyloid precursor protein (APP) and blocks APP cleavage by the α- and β-is_associated_with::amyloid precursor protein secretases and therefore inhibits formation of the is_associated_with::beta amyloid peptide that forms  is_associated_with::amyloid plaques in is_associated_with::Alzheimer's disease.