DOCK (protein)


 * "Zir" redirects here. For other uses, see Zir (disambiguation)

DOCK ( D edicator o f c yto k inesis) is a family of related proteins involved in intracellular signalling networks. Studies to date suggest that this family act as guanine nucleotide exchange factors for small G proteins of the Rho family, such as Rac and Cdc42. DOCK family proteins are categorised into four subfamilies based on their sequence homology:


 * DOCK-A subfamily
 * Dock180 (also known as Dock1)
 * Dock2
 * Dock5
 * DOCK-B subfamily
 * Dock3 (also known as MOCA and PBP)
 * Dock4
 * DOCK-C subfamily (also known as Zir subfamily)
 * Dock6 (also known as Zir1)
 * Dock7 (also known as Zir2)
 * Dock8 (also known as Zir3)
 * DOCK-D subfamily (also known as Zizimin subfamily)
 * Dock9 (also known as Zizimin1)
 * Dock10 (also known as Zizimin3)
 * Dock11 (also known as Zizimin2)