Carboxylesterase family

Carboxylesterase, type B is a family of evolutionarily related proteins.

Higher eukaryotes have many distinct esterases. The different types include those that act on carboxylic esters. Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. The sequence of a number of type-B carboxylesterases indicates  that the majority are evolutionarily related. As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. This family belongs to the superfamily of proteins with the Alpha/beta hydrolase fold.

Subfamilies

 * Neuroligin
 * Cholinesterase

Examples
Human genes that encode proteins containing the carboxylesterase domain include:


 * ACHE
 * ARACHE
 * BCHE
 * CEL
 * CES1
 * CES2
 * CES3
 * CES4
 * CES7
 * CES8
 * NLGN1
 * NLGN2
 * NLGN3
 * NLGN4X
 * NLGN4Y
 * TG