PCP4

Purkinje cell protein 4 is a is_associated_with::protein that in humans is encoded by the PCP4 is_associated_with::gene. Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to is_associated_with::calmodulin (CaM). PCP4 is abundant in is_associated_with::Purkinje cells of the is_associated_with::cerebellum, and plays an important role in synaptic plasticity.

Function
PCP4 is_associated_with::knockout mice have been reported to exhibit impaired locomotor learning and markedly altered is_associated_with::synaptic plasticity in cerebellar is_associated_with::Purkinje neurons. PCP4 accelerates both the association and dissociation of calcium (Ca2+) with is_associated_with::calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).