CEP170

Centrosomal protein 170kDa, also known as CEP170, is a is_associated_with::protein that in humans is encoded by the CEP170 is_associated_with::gene.

Function
The product of this gene is a component of the is_associated_with::centrosome, a non-membraneous organelle that functions as the major is_associated_with::microtubule-organizing center in animal cells. During is_associated_with::interphase, the encoded protein localizes to the sub-distal appendages of mature is_associated_with::centrioles, which are microtubule-based structures thought to help organize is_associated_with::centrosomes. During is_associated_with::mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (is_associated_with::IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 (phosphorylated_by::Cdk1) and polo-like kinase 1 (phosphorylated_by::PLK1), and functions in maintaining is_associated_with::Microtubule organization, cell morphology and is_associated_with::cilium stability.

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.