Rs679620

A study of 1418 African-American women and men from the Genetic Epidemiology Network of Arteriopathy study found a significant sex-specific interaction effect between rs679620, a SNP in the metallopeptidase 3 MMP3 gene and body mass index (BMI) in African-American women but not men (p = 0.0009). rs679620 appears to have a protective effect on diastolic blood pressure in women with high BMI, but surprisingly, it had the opposite effect on women with low BMI, resulting in higher diastolic BP.

A relatively small study (~100 patients) found associations between risk for Achilles tendinopathy and SNPs in the MMP3 gene. For rs679620, the (G;G) genotype had an odds ratio of 2.5 (CI: 1.2 - 4.90, p = 0.010). An interaction resulting in increased risk for Achilles tendinopathy was also reported between the rs679620(G) and COL5A1 rs12722(T) alleles (p = 0.006).


 * is_associated_with_disease::Rheumatoid arthritis
 * is_associated_with_disease::Endometrial cancer
 * is_associated_with_disease::Hepatitis B
 * is_associated_with_disease::Lymphoma
 * is_associated_with_disease::Vascular disease
 * is_associated_with_disease::Alzheimer's disease
 * is_associated_with_disease::Kidney disease
 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Hepatitis
 * is_associated_with_disease::Skin cancer
 * is_associated_with_disease::Renal cell carcinoma
 * is_associated_with_disease::Breast cancer
 * is_associated_with_disease::Carcinoma