WASF1

Wiskott-Aldrich syndrome protein family member 1 is a is_associated_with::protein that in humans is encoded by the WASF1 is_associated_with::gene.

Function
The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP) family, plays a critical role downstream of Rac, a Rho-family small is_associated_with::GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an is_associated_with::actin nucleation core is_associated_with::Arp2/3 complex while enhancing actin polymerization in vitro.

Clinical significance
is_associated_with::Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of is_associated_with::actin is_associated_with::cytoskeleton.

Interactions
WASF1 has been shown to interact with is_associated_with::BAIAP2 and is_associated_with::Profilin 1.