M6PRBP1

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a is_associated_with::protein which in humans is encoded by the M6PRBP1 is_associated_with::gene. Its gene product, as well as the gene itself, is commonly known as TIP47.

Function
is_associated_with::Mannose 6-phosphate receptors (MPRs) deliver lysosomal is_associated_with::hydrolase from the Golgi to is_associated_with::endosomes and then return to the Golgi complex. The protein encoded by this gene interacts with the cytoplasmic domains of both cation-independent and cation-dependent MPRs, and is required for endosome-to-Golgi transport. This protein also binds directly to the GTPase RAB9 (is_associated_with::RAB9A), a member of the RAS oncogene family. The interaction with RAB9 has been shown to increase the affinity of this protein for its cargo.

The mannose-6-phosphate receptor-binding properties of TIP47 are disputed, despite the designation of M6PRBP1 as TIP47's gene symbol. TIP47 protein is most commonly described in the scientific literature as a coat protein for is_associated_with::lipid droplets.

TIP47 belongs to the peripilin protein family and shares significant homology with the other genes of this family, including is_associated_with::perilipin and adipophilin.

Interactions
M6PRBP1 has been shown to interact with both is_associated_with::Mannose 6-phosphate receptors.