CCR4

C-C chemokine receptor type 4 is a is_associated_with::protein that in humans is encoded by the CCR4 is_associated_with::gene. CCR4 has also recently been designated CD194 (is_associated_with::cluster of differentiation 194).

The protein encoded by this gene belongs to the is_associated_with::G protein-coupled receptor family. It is a receptor for the following CC chemokines:


 * is_associated_with::CCL2 (MCP-1)
 * is_associated_with::CCL4 (MIP-1)
 * is_associated_with::CCL5 (RANTES)
 * is_associated_with::CCL17 (TARC)
 * is_associated_with::CCL22 (Macrophage-derived chemokine)

is_associated_with::Chemokines are a group of small structurally related proteins that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the is_associated_with::immune system, and they have effects on cells of the is_associated_with::central nervous system as well as on endothelial cells involved in is_associated_with::angiogenesis or is_associated_with::angiostasis.