AFF3

AF4/FMR2 family member 3 is a is_associated_with::protein that in humans is encoded by the AFF3 is_associated_with::gene.

Function
This gene encodes a tissue-restricted nuclear is_associated_with::transcriptional activator that is preferentially expressed in is_associated_with::lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear is_associated_with::transcription factors that may function in lymphoid development and is_associated_with::oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.