Angiotensin II receptor type 2

Angiotensin II receptor type 2, also known as the AT2 receptor is a is_associated_with::protein that in humans is encoded by the AGTR2 is_associated_with::gene.

Function
is_associated_with::Angiotensin II is a potent pressor is_associated_with::hormone and a primary regulator of is_associated_with::aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors termed AT1 and AT2. AGTR2 belongs to a family 1 of is_associated_with::G protein-coupled receptors. It is an integral membrane protein. It plays a role in the central nervous system and cardiovascular functions that are mediated by the is_associated_with::renin-angiotensin system. This receptor mediates programmed cell death (is_associated_with::apoptosis). In adults, it is highly expressed in is_associated_with::myometrium with lower levels in is_associated_with::adrenal gland and is_associated_with::fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame.

Stimulation of AT2 by the selective agonist CGP 42112A increases mucosal is_associated_with::nitric oxide production.

Model organisms
is_associated_with::Model organisms have been used in the study of AGTR2 function. A conditional is_associated_with::knockout mouse line, called Agtr2tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on is_associated_with::mutant mice, but no significant abnormalities were observed.

Interactions
Angiotensin II receptor type 2 has been shown to interact with is_associated_with::MTUS1.