ID4

DNA-binding protein inhibitor ID-4 is a is_associated_with::protein that in humans is encoded by the ID4 is_associated_with::gene.

Function
Transcription factors containing a is_associated_with::basic helix-loop-helix (bHLH) motif regulate expression of tissue-specific genes in a number of mammalian and insect systems. DNA-binding activity of the bHLH proteins is dependent on formation of homo- and/or heterodimers. Dominant-negative (antimorph) HLH proteins encoded by Id-related genes, such as ID4, also contain the HLH-dimerization domain but lack the DNA-binding basic domain. Consequently, Id proteins inhibit binding to DNA and transcriptional is_associated_with::transactivation by heterodimerization with bHLH proteins.