Rs7910977

rs7910977 is a SNP of the IDE gene, which encodes the insulin-degrading enzyme.

Late onset Alzheimer's disease is a neurodegenerative condition in which the brain develops large numbers of extracellular senile plaques composed primarily of aggregated amyloid-B proteins as well as intraneuronal neurofibrillary tangles composed mainly of aggregated tau protein. One notable function of insulin-degrading enzyme is its ability to degrade amyloid-B and therefore to influence the amount of amyloid-B found in the brain.

The rs7910977(T) allele is associated with reduced risk of Alzheimer's disease in one study of ~3,000 patients, and in this study, the conclusion was that it was most likely due to near perfect linkage with rs6583817, a nearby functional variant. rs6583817(T) allele carriers had an odds ratio for late onset Alzheimer's disease of around 0.80 (p<0.03).


 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Alzheimer's disease