Rs12143842

rs12143842 is a SNP within 100kb of the NOS1AP gene.

A study of participants in the Rotterdam Study, a population-based, prospective cohort study of individuals >/=55 years of age, concluded that each rs12143842(T) allele was associated with a QT-interval duration increase of 4.4-ms (p =4.4x10e-28). This SNP is the most strongly associated with QT interval of all known to date (at the time of publication).