FOXA2

Hepatocyte nuclear factor 3-beta (HNF-3B), also known as forkhead box protein A2 (FOXA2) or transcription factor 3B (TCF-3B) is a is_associated_with::protein that in humans is encoded by the FOXA2 is_associated_with::gene.

Function
Forkhead box protein A2 is a member of the forkhead class of DNA-binding proteins. These is_associated_with::hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as is_associated_with::albumin and is_associated_with::transthyretin, and they also interact with is_associated_with::chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of is_associated_with::maturity onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene.