REG3G

Regenerating islet-derived protein 3 gamma is a is_associated_with::protein that in humans is encoded by the REG3G is_associated_with::gene.

Intestinal paneth cells produce REG3G (or REG3 gamma) via stimulation of is_associated_with::toll-like receptors (TLRs) by is_associated_with::pathogen-associated molecular patterns (PAMPs). REG3 gamma specifically targets is_associated_with::Gram-positive bacteria because it binds to their surface is_associated_with::peptidoglycan layer. It is one of several antimicrobial peptides produced by is_associated_with::paneth cells.