STXBP5

Syntaxin-binding protein 5 is a is_associated_with::protein that in humans is encoded by the STXBP5 is_associated_with::gene.

Function
Syntaxin 1 is a component of the 7S and 20S SNARE complexes which are involved in docking and fusion of synaptic vesicles with the presynaptic plasma membrane. This gene encodes a syntaxin 1 binding protein. In rat, a similar protein dissociates syntaxin 1 from the Munc18/n-Sec1/rbSec1 complex to form a 10S complex, an intermediate which can be converted to the 7S SNARE complex. Thus this protein is thought to be involved in neurotransmitter release by stimulating SNARE complex formation. Alternatively spliced variants have been identified, but their biological validity has not been determined.

Interactions
STXBP5 has been shown to interact with is_associated_with::STX4 and is_associated_with::STX1A.