KCNN4

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human is_associated_with::gene encoding the KCa3.1 is_associated_with::protein.

Function
The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent is_associated_with::potassium channel that is activated by intracellular calcium. Activation is followed by membrane depolarization, which promotes calcium influx. The encoded protein may be part of the predominant is_associated_with::calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.

History
The channel activity was first described in 1958 by is_associated_with::Gyorgi Gardos in human is_associated_with::erythrocytes. The channels is also named Gardos channel because of its discoverer.