PLCD3

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an is_associated_with::enzyme that in humans is encoded by the PLCD3 is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::phospholipase C family, which catalyze the hydrolysis of is_associated_with::phosphatidylinositol 4,5-bisphosphate to generate the second messengers is_associated_with::diacylglycerol and is_associated_with::inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing is_associated_with::protein kinase C and increasing cytosolic Ca2+ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by is_associated_with::spermine, is_associated_with::sphingosine, and several is_associated_with::phospholipids.