Rs10088218

rs10088218 is a SNP on chromosome 8q24, >700 kb distal to the CMYC gene in an area termed a 'gene desert'.

A genome-wide association study ultimately including over 10,000 ovarian cancer patients found statistically strong (p = 8 &#215; 10e-15) evidence for slightly reduced risk associated with the rs10088218(A) allele, with an odds ratio of 0.76 (CI: 0.7 &#8211; 0.81) as calculated for the serous subtype (of ovarian cancer).

A large study of over 18,000 patients with epithelial ovarian cancer, including BRCA1 and BRCA2 carriers and a meta-analysis, has also found similar levels of decreased risk for the rs10088218(A) allele.