VAV1

Proto-oncogene vav is a is_associated_with::protein that in humans is encoded by the VAV1 is_associated_with::gene.

Function
The protein encoded by this is_associated_with::proto-oncogene is a member of the Dbl family of is_associated_with::guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in is_associated_with::hematopoiesis, playing a role in is_associated_with::T-cell and is_associated_with::B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from is_associated_with::HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.

Interactions
VAV1 has been shown to interact with:


 * is_associated_with::ARHGDIB,
 * is_associated_with::Abl gene,
 * is_associated_with::Cbl gene
 * is_associated_with::EZH2,
 * is_associated_with::Grb2,
 * JAK2,
 * is_associated_with::Ku70,
 * LAT,
 * LCP2,
 * is_associated_with::MAPK1,
 * is_associated_with::PIK3R1,
 * is_associated_with::PLCG1,
 * is_associated_with::PRKCQ,
 * is_associated_with::S100B,
 * SHB,
 * is_associated_with::SIAH2, and
 * is_associated_with::Syk.