Liver X receptor alpha

Liver X receptor alpha (LXR-alpha) is a is_associated_with::nuclear receptor protein that in humans is encoded by the NR1H3 is_associated_with::gene (nuclear receptor subfamily 1, group H, member 3).

Expression
miRNA hsa-miR-613 autoregulates the human LXRα gene by targeting the endogenous LXRα through its specific miRNA response element (613MRE) within the LXRα 3′-untranslated region. LXRα autoregulates its own suppression via induction of SREBP1c which upregulates miRNA hsa-miR-613.

Function
The is_associated_with::liver X receptors, LXRα (this protein) and LXRβ, form a subfamily of the nuclear receptor superfamily and are key regulators of is_associated_with::macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRα is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRβ is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with is_associated_with::retinoid X receptors (RXRs) and regulate expression of target genes containing LXR is_associated_with::response elements. Restoration of LXR-alpha expression/function within a psoriatic lesion may help to switch the transition from psoriatic to symptomless skin.

Interactions
Liver X receptor alpha has been shown to interact with is_associated_with::EDF1 and is_associated_with::Small heterodimer partner.