IL18RAP

Interleukin 18 receptor accessory protein, also known as IL18RAP and CDw218b (is_associated_with::cluster of differentiation w218b), is a human is_associated_with::gene.

Function
The is_associated_with::protein encoded by this gene is an accessory subunit of the heterodimeric receptor for IL18. This protein enhances the IL18 binding activity of is_associated_with::IL18R1 (IL1RRP), a ligand binding subunit of IL18 receptor. The coexpression of IL18R1 and this protein is required for the activation of is_associated_with::NF-κB and is_associated_with::MAPK8 (JNK) in response to IL18.

Disease association
Variants at IL18RAP have been linked to susceptibility to is_associated_with::Coeliac disease.