NLRC4

NLR family CARD domain-containing protein 4 is a is_associated_with::protein that in humans is encoded by the NLRC4 is_associated_with::gene.

Function
In C. elegans, Ced4 binds and activates Ced3, an is_associated_with::apoptotic initiator caspase, via caspase-associated recruitment domains (CARDs). Human Ced4 homologs include is_associated_with::APAF1, is_associated_with::NOD1 (CARD4), and is_associated_with::NOD2 (CARD15). These proteins have at least 1 is_associated_with::N-terminal CARD domain followed by a centrally located nucleotide-binding domain (NBD or NACHT) and a is_associated_with::C-terminal regulatory domain, found only in mammals, that contains either is_associated_with::WD40 repeats or is_associated_with::leucine-rich repeats (LRRs). CARD12 is a member of the Ced4 family and can induce is_associated_with::apoptosis.

Interactions
NLRC4 has been shown to interact with CASP1 and is_associated_with::NOD2.