Rs727428

rs727428 is a SNP in the sex-hormone binding globulin SHBG gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable.

Based on a study of 758 women in 430 families, rs727428 is associated with levels of that sex-hormone binding globulin hormone, independent of the effects of insulin resistance and obesity. Specifically, levels of SHBG were decreased approximately 13% in (A;G) heterozygotes and 27% in (A;A) homozygotes compared with (G;G) homozygotes. [Note: designation of alleles is as shown in dbSNP.]

Haplotype analysis suggested that rs858518, rs727428, or a variant in linkage disequilibrium with them acts to decrease SHBG levels but that this effect is neutralized by rs6259.

This SNP was previously associated with risk of type 2 diabetes mellitus.


 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Type 2 diabetes mellitus
 * is_associated_with_disease::Cancer