SIRT2

NAD-dependent deacetylase sirtuin-2 is an is_associated_with::enzyme that in humans is encoded by the SIRT2 is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Two transcript variants result from alternative splicing of this gene.

Model organisms
The functions of human sirtuins have not yet been determined; however, is_associated_with::model organisms have been used in the study of SIRT2 function. is_associated_with::Yeast sirtuin proteins are known to regulate is_associated_with::epigenetic gene silencing and suppress recombination of rDNA. A conditional is_associated_with::knockout mouse line, called Sirt2tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice, however no significant abnormalities were observed.

Inhibitors

 * Benzamide compound # 64
 * (S)-2-Pentyl-6-chloro,8-bromo-chroman-4-one: IC50 of 1.5 μM, highly selective over SIRT2 and is_associated_with::SIRT3
 * 3′-Phenethyloxy-2-anilinobenzamide (33i): IC50 of 0.57 μM