Methyl-CpG-binding domain protein 2

Methyl-CpG-binding domain protein 2 is a is_associated_with::protein that in humans is encoded by the MBD2 is_associated_with::gene.

Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a is_associated_with::methyl-CpG-binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1, and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing if present in promoter regions.

Interactions
Methyl-CpG-binding domain protein 2 has been shown to interact with:


 * is_associated_with::GATAD2B,
 * is_associated_with::HDAC1,
 * is_associated_with::Histone deacetylase 2,
 * is_associated_with::MBD3
 * is_associated_with::MIZF, and
 * is_associated_with::SIN3A.