Rs9642880

rs9642880 is a SNP located in chromosome region 8q24, a region that has been linked to prostate, breast, and colon cancer.

A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs9642880(T) were at 1.49x increased risk (allele-specific odds ratio = 1.22, p = 9 x 10e-12) for the disease. This SNP was not associated, however, with risk for prostate, breast, or colon cancer.

Another study in Chinese populations found similar results in regard to bladder cancer.

rs9642880(T;T) estimated risk of developing 1.49 times that of noncarriers. 1,803 urinary bladder cancer cases and 34,336 controls. No association with prostate, colorectal and breast cancers.

In contrast to GSTM1 SNPs, the rs9642880(T) was only associated with increased risk for bladder cancer in cases not selected based on exposure to bladder carcinogens such as aromatic amines and polycyclic aromatic hydrocarbons, based on an analysis of 515 bladder cancer cases and 893 controls where the quality and quantity of occupational exposure to bladder carcinogens was documented.


 * is_associated_with_disease::Carcinoma
 * is_associated_with_disease::Colon cancer
 * is_associated_with_disease::Urinary bladder cancer