AATK

Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an is_associated_with::enzyme that in humans is encoded by the (AATK) is_associated_with::gene.

Structure and expression
The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.

Function
The protein contains a is_associated_with::tyrosine kinase domain at the N-terminal end and a is_associated_with::proline-rich domain at the is_associated_with::c-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of is_associated_with::myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells. Its suppressive role on is_associated_with::melanoma development has been reported recently.

AATK is thought to indirectly inhibit the is_associated_with::SPAK/is_associated_with::WNK4 activation of the is_associated_with::Na-K-Cl cotransporter.