DCTN1

Dynactin subunit 1 is a is_associated_with::protein that in humans is encoded by the DCTN1 is_associated_with::gene.

Function
This gene encodes the largest subunit of is_associated_with::dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both is_associated_with::microtubules and cytoplasmic is_associated_with::dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of is_associated_with::lysosomes and is_associated_with::endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.

Interactions
DCTN1 has been shown to interact with:
 * is_associated_with::BBS4,
 * is_associated_with::Dystonin,
 * is_associated_with::Grb2, and
 * is_associated_with::RAB6A.