LRRC40

Leucine rich repeat containing 40 (LRRC40) is a is_associated_with::protein that in humans is encoded by the LRRC40 is_associated_with::gene.

Species Distribution
LRRC40 is conserved throughout all of its is_associated_with::orthologs. The entire protein is highly conserved in mammals, while conservation is high within the leucine rich repeats in the rest of the orthologs. Orthologs were found all the way back to the scarlet sea anemone and homologs were found in is_associated_with::bacteria and is_associated_with::Archaea using is_associated_with::BLAST. The following table gives information on the homologs of LRRC40.

Gene
LRRC40 is located on the negative DNA strand (see is_associated_with::Sense (molecular biology)) of is_associated_with::chromosome 1 from 70,611,483- 70,671,223. The gene produces a 2958 is_associated_with::base pair is_associated_with::mRNA. There are 15 predicted is_associated_with::exons in the human gene with four other splice patterns predicted on GeneCards by the Alternative Splice Database.

Gene Neighborhood
LRRC40 is neighbored downstream by is_associated_with::LRRC7 (70,225,888 - 70,587,570) on the positive DNA strand and upstream by is_associated_with::SRSF11 (70,687,320-70,716,488) on the positive DNA strand.

Gene Expression
LRRC40 is expressed between the 50th and 100th percentile in almost every tissue in the body.

Protein
While the exact function of the LRRC40 protein is not yet understood, it is believed to participate in protein-protein interactions because it is a member of the is_associated_with::leucine rich repeat family of proteins which are known to participate in is_associated_with::protein-protein interactions.

Properties
LRRC40 is a 602 amino acid protein with a is_associated_with::molecular weight of 68.254 kDa and an is_associated_with::isoelectric point of 6.04. LRRC40 is expected to localize to the nucleus and has no transmembrane domains to anchor it to the is_associated_with::nuclear membrane. LRRC40 has many predicted is_associated_with::phosphorylation sites. Of the 19 predicted is_associated_with::phosphoserine sites, only two are conserved within the orthologs. These two sites are S38 and S391.

Protein Structure
The is_associated_with::secondary structure of the protein has a pattern within the leucine repeat regions. Each leucine repeat has a is_associated_with::β-sheet and is_associated_with::α-helix. The image to the right shows the particular horseshoe-like structure of a protein with many leucine rich repeats. Depending on the area where the LRRs are located, other proteins can bind within the curve of the horseshoe or attach to the outside of the protein.

Protein Interactions
According to Genecards, LRRC40 has 756 possible is_associated_with::protein interactions. These interactions are based on results in the Molecular Interaction database which provided two possible protein interactions. The two proteins are described in the table below.