Tumor necrosis factor receptor 2

Tumor necrosis factor receptor 2 (TNFR2), also known as tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) and CD120b, is a membrane receptor that binds is_associated_with::tumor necrosis factor-alpha (TNFα).

Function
The protein encoded by this gene is a member of the is_associated_with::tumor necrosis factor receptor superfamily, which also contains is_associated_with::TNFRSF1A. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, c-IAP1 and c-IAP2, which possess is_associated_with::E3 ubiquitin ligase activity. The function of IAPs in TNF-receptor signalling is unknown, however, c-IAP1 is thought to potentiate TNF-induced is_associated_with::apoptosis by the is_associated_with::ubiquitination and degradation of TNF-receptor-associated factor 2 (is_associated_with::TRAF2), which mediates anti-apoptotic signals. Knockout studies in mice also suggest a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways.

Interactions
TNFRSF1B has been shown to interact with:
 * is_associated_with::TRAF2,      and
 * is_associated_with::TTRAP.