YWHAZ

14-3-3 protein zeta/delta is a is_associated_with::protein that in humans is encoded by the YWHAZ is_associated_with::gene.

Function
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for this gene.

Interactions
YWHAZ has been shown to interact with:


 * is_associated_with::AKT1,
 * is_associated_with::BCAR1,
 * BAD,
 * is_associated_with::C-Raf,
 * is_associated_with::CDC25B,
 * is_associated_with::GP1BA,
 * is_associated_with::GP1BB,
 * is_associated_with::HMGN1,
 * IL9R,
 * is_associated_with::LIMK1,
 * is_associated_with::P53,
 * is_associated_with::PRKCE
 * PRKCZ,
 * is_associated_with::TNFAIP3,
 * is_associated_with::TSC2,
 * is_associated_with::Tau protein, and
 * VIM.