Rs201617272

rs201617272, also known as 5913G>A, Asp4Asn or D4N, is a SNP of the cytochrome c oxidase subunit 1 of respiratory complex IV gene, located in the mitochondrial genome.

It has been linked in Caucasian populations to hypertension based on a study of the Framingham cohort. Individuals with the rare rs201617272(A) allele had, on average, 7 mm Hg higher systolic blood pressure (BP) at baseline (p = 0.05) and 17 mg/dL higher mean FBG over 25 years of follow up (p = 0.009).