SLC22A12

Solute carrier family 22 (organic anion/cation transporter), member 12, also known as SLC22A12 and URAT1, is a is_associated_with::protein which in humans is encoded by the SLC22A12 is_associated_with::gene.

Function
The protein encoded by this gene is a urate transporter and urate-anion exchanger which regulates the level of urate in the blood. This protein is an is_associated_with::integral membrane protein primarily found in kidney. Two transcript variants encoding different isoforms have been found for this gene.

Clinical significance
Numerous is_associated_with::single nucleotide polymorphisms of this gene are significantly associated with altered (increased or decreased) reabsorption of uric acid by the kidneys. Respectively, these altered rates of reabsorption contribute to is_associated_with::hyperuricemia and is_associated_with::hypouricemia.

Interactions
SLC22A12 has been shown to interact with is_associated_with::PDZK1.