Rs67608943

rs67608943, also known as Y142X, is a SNP in the PCSK9 gene.

It has been reported in several studies (including ) to be both rare (2% frequency in Africans, 0.1% in Europeans) and as a dominant nonsense mutation a cause of plasma LDL-C levels being up to 40% lower than average. This lowered LDL-C level is thought to be directly associated with very significantly lowered risk for coronary events.


 * is_associated_with_disease::Coronary heart disease