Interleukin-23 receptor

Interleukin 23 receptor is a is_associated_with::type I cytokine receptor. IL23R is its human is_associated_with::gene.

Clinical significance
Mutations in the IL23R gene were linked to is_associated_with::Crohn's disease.

Model organisms
is_associated_with::Model organisms have been used in the study of IL23R function. A conditional is_associated_with::knockout mouse line called Il23rtm2a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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