CLDN3

Claudin 3, also known as CLDN3, is a is_associated_with::protein which in humans is encoded by the CLDN3 is_associated_with::gene. It is a member of the is_associated_with::claudin protein family.

is_associated_with::Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing is_associated_with::cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this is_associated_with::intron-less gene, a member of the is_associated_with::claudin family, is an is_associated_with::integral membrane protein and a component of is_associated_with::tight junction strands. It is also a low-affinity receptor for is_associated_with::Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.

Interactions
CLDN3 has been shown to interact with is_associated_with::CLDN1 and is_associated_with::CLDN5.