LETM1

Leucine zipper-EF-hand containing transmembrane protein 1 is a is_associated_with::protein that in humans is encoded by the LETM1 is_associated_with::gene.

Structure
The LETM1 protein has a is_associated_with::transmembrane domain and a is_associated_with::casein kinase 2 and is_associated_with::protein kinase C is_associated_with::phosphorylation site. The LETM1 gene is expressed in the is_associated_with::mitochondria of many eukaryotes indicating that this is a conserved mitochondrial is_associated_with::protein.

Function
LETM1 is a is_associated_with::eukaryotic is_associated_with::protein that is expressed in the inner membrane of mitochondria. Experiments performed with human cells have been interpreted to indicate that it functions as a component of a Ca2+/H+ is_associated_with::antiporter. Experimental results with is_associated_with::yeast cells have been interpreted as suggesting that LETM1 functions as a component of a K+/H+ antiporter. The is_associated_with::Drosophila melanogaster LETM1 protein has been shown to functionally substitute for the K+/H+ antiporter function in yeast cells.

Clinical significance
Deletion of LETM1 is thought to be involved in the development of is_associated_with::Wolf–Hirschhorn syndrome in humans.