KRT83

Keratin 83, also known as KRT83, is a is_associated_with::protein which humans is encoded by the KRT83 gene.

Function
The protein encoded by this gene is a member of the is_associated_with::keratin gene family. As a is_associated_with::type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1 (is_associated_with::KRT81), KRTHB3 (KRT83, this protein), and KRTHB6 (is_associated_with::KRT86), is highly related. The other less-related subfamily includes KRTHB2 (is_associated_with::KRT82), KRTHB4 (is_associated_with::KRT84), and KRTHB5 (is_associated_with::KRT85). All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex.

Clinical significance
Mutations in the KRT83 gene have been associated with is_associated_with::monilethrix.