SORL1

Sortilin-related receptor, L(DLR class) A repeats containing is a is_associated_with::protein that in humans is encoded by the SORL1 is_associated_with::gene.

SORL1 (also known as SORLA, SORLA1, or LR11) is a is_associated_with::neuronal is_associated_with::apolipoprotein E receptor, the is_associated_with::gene for which is predominantly expressed in the central nervous system.

Clinical significance
Mutation of the gene for apolipoprotein E (APOE) is predictive of is_associated_with::Alzheimer's disease. Lack of the APOE receptor is suspected to be a contributory factor to Alzheimer's: a significant reduction in SORL1 (LR11) expression has been found in brain tissue of Alzheimer's disease patients. The APOE receptor has also been linked with regulation of is_associated_with::amyloid precursor protein, faulty processing of which is implicated in Alzheimer's. A more recent study by a group of international researchers supports the proposition that SORL1 plays a part in seniors developing Alzheimer's disease, the findings being significant across racial and ethnic strata.