ANAPC7

Anaphase-promoting complex subunit 7 is an is_associated_with::enzyme that in humans is encoded by the ANAPC7 is_associated_with::gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Function
This gene encodes a is_associated_with::tetratricopeptide repeat containing component of the is_associated_with::anaphase-promoting complex/cyclosome (APC/C), a large is_associated_with::E3 ubiquitin ligase that controls is_associated_with::cell cycle progression by targeting a number of cell cycle regulators such as B-type is_associated_with::cyclins for 26S is_associated_with::proteasome-mediated degradation through is_associated_with::ubiquitination. The encoded protein is required for proper protein ubiquitination function of APC/C and for the interaction of APC/C with certain transcription coactivators.

Interactions
ANAPC7 has been shown to interact with is_associated_with::ANAPC1, is_associated_with::ANAPC4,  is_associated_with::CDC27 and is_associated_with::CDC20.