DAD1

Dolichyl-diphosphooligosaccharide—protein glycosyltransferase subunit DAD1 is an is_associated_with::enzyme that in humans is encoded by the DAD1 is_associated_with::gene.

Function
DAD1, the defender against is_associated_with::apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of is_associated_with::oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes.

Interactions
DAD1 has been shown to interact with is_associated_with::MCL1.