Death receptor 5

Death receptor 5 (DR5), also known as TRAIL receptor 2 (TRAILR2) and tumor necrosis factor receptor superfamily member 10B (TNFRSF10B), is a is_associated_with::cell surface receptor of the is_associated_with::TNF-receptor superfamily that binds is_associated_with::TRAIL and mediates is_associated_with::apoptosis.

Function
The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Mice have a homologous gene, tnfrsf10b, that has been essential in the elucidation of the function of this gene in humans. Studies with FADD-deficient mice suggested that FADD, a is_associated_with::death domain containing is_associated_with::adaptor protein, is required for the apoptosis mediated by this protein.

Interactions
DR5 has been shown to interact with:
 * is_associated_with::Caspase 8,
 * is_associated_with::Caspase 10,
 * is_associated_with::FADD,  and
 * is_associated_with::TRAIL.

Cancer therapy
Monoclonal antibodies targeting DR5 have been developed and are currently under clinical trials for patients suffer from a variety of cancer types, see is_associated_with::Tigatuzumab (CS-1008).