Trefoil factor 2

Trefoil factor 2 is a is_associated_with::protein that in humans is encoded by the TFF2 is_associated_with::gene.

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved is_associated_with::disulfides. They are stable secretory is_associated_with::proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the is_associated_with::epithelium. The encoded protein inhibits is_associated_with::gastric acid secretion. This is_associated_with::gene and two other related trefoil family member genes are found in a cluster on chromosome 21.