LGALS3BP

Galectin-3-binding protein is a is_associated_with::protein that in humans is encoded by the LGALS3BP is_associated_with::gene.

Function
The is_associated_with::galectins are a family of is_associated_with::beta-galactoside-binding proteins implicated in modulating cell–cell and cell–matrix interactions. Using fluorescence in–situ hybridization, the full length 90K cDNA has been localized to chromosome 17q25. The native protein binds specifically to a human macrophage-associated lectin known as Mac-2 and also binds to galectin 1.

Clinical significance
LGALS3BP has been found elevated in the serum of patients with cancer and in those infected by the human immunodeficiency virus (is_associated_with::HIV). It appears to be implicated in immune response associated with is_associated_with::natural killer (NK) and lymphokine-activated killer (LAK) cell cytotoxicity.

Interactions
LGALS3BP has been shown to interact with is_associated_with::LGALS3.