CDK2AP1

Cyclin-dependent kinase 2-associated protein 1 is an is_associated_with::enzyme that in humans is encoded by the CDK2AP1 is_associated_with::gene.

Function
The protein encoded by this gene is a specific is_associated_with::CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for is_associated_with::proteolysis. This protein was found to also interact with DNA polymerase alpha/is_associated_with::primase and mediate the is_associated_with::phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during is_associated_with::S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal is_associated_with::keratinocytes.

Interactions
CDK2AP1 has been shown to interact with is_associated_with::Cyclin-dependent kinase 2.

It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.