CD226

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a is_associated_with::protein that in humans is encoded by the CD226 is_associated_with::gene which is located on chromosome 18q22.3.

Structure and function
CD226 is a ~65 kDa glycoprotein expressed on the surface of is_associated_with::natural killer cells, is_associated_with::platelets, is_associated_with::monocytes and a subset of is_associated_with::T cells. It is a member of the is_associated_with::immunoglobulin superfamily containing 2 Ig-like domains of the V-set. CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and is_associated_with::CD155, and cross-linking CD226 with antibodies causes cellular activation.