LPIN1

Lipin-1 is a is_associated_with::protein that in humans is encoded by the LPIN1 is_associated_with::gene.

Function
Lipin-1 has is_associated_with::phosphatidate phosphatase activity.

Clinical significance
This gene represents a candidate gene for human is_associated_with::lipodystrophy, characterized by loss of body fat, fatty liver, is_associated_with::hypertriglyceridemia, and is_associated_with::insulin resistance. Mouse studies suggest that this gene functions during normal adipose tissue development and may also play a role in human triglyceride metabolism.