Downregulated-in-adenoma

The downregulated-in-adenoma (DRA) is a membrane protein in intestinal cells. It is an anion exchanger and a member (SLC26A3) of the sulfate anion transporter (SAT) family. It mediates chloride and bicarbonate exchange and additionally transports sulfate and other anions at the apical membrane, part of the plasma membrane of enterocytes. The congenital absence of this membrane protein results in an autosomal recessive disorder called congenital chloridorrhea or congenital chloride diarrhea (CLD). It is different from the anion exchanger that present in erythrocytes, renal tubule, and several other tissues.