EPRS

Bifunctional aminoacyl-tRNA synthetase is an is_associated_with::enzyme that in humans is encoded by the EPRS is_associated_with::gene.

Gene
Alternative splicing has been observed for this gene, but the full-length nature and biological validity of the variant have not been determined.

Function
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a multifunctional aminoacyl-tRNA synthetase that catalyzes the aminoacylation of glutamic acid and proline tRNA species.

Phosphorylation of EPRS is reported to be essential for the formation of GAIT (Gamma-interferon Activated Inhibitor of Translation) complex that regulates the translation of multiple genes in is_associated_with::monocytes and is_associated_with::macrophages.

Interactions
EPRS has been shown to interact with is_associated_with::POU2F1, is_associated_with::Heat shock protein 90kDa alpha (cytosolic), member A1 and is_associated_with::IARS.