Rs5743551

excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis

G allele of TLR1-7202A/G (rs5743551)

associations with death, organ dysfunction

associated with elevated TLR1-mediated cytokine production (P < 2x10(-20))

predicted worse organ dysfunction and death (OR 1.82, 95% CI 1.07-3.09).

sepsis-related ALI (OR 3.40, 95% CI 1.59-7.27)

and gram-positive infection in sepsis.