GRAP

GRB2-related adapter protein is a is_associated_with::protein that in humans is encoded by the GRAP is_associated_with::gene.

This gene encodes a member of the GRB2/Sem5 (C. elegans homolog)/Drk (is_associated_with::Drosophila homolog) family. This member functions as a is_associated_with::cytoplasmic signaling protein which contains an is_associated_with::SH2 domain flanked by two is_associated_with::SH3 domains. The SH2 domain interacts with is_associated_with::ligand-activated receptors for is_associated_with::stem cell factor and is_associated_with::erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL is_associated_with::oncoprotein. This protein also associates with the Ras is_associated_with::guanine is_associated_with::nucleotide exchange factor is_associated_with::SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain.

Interactions
GRAP has been shown to interact with is_associated_with::Linker of activated T cells.