QRFP

RF(Arg-Phe)amide family 26 amino acid peptide, also known as P518, is a human is_associated_with::protein.

The 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of is_associated_with::GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of is_associated_with::aldosterone, suggesting that QRFP and GPR103 regulate is_associated_with::adrenal function.