Heparin cofactor II

Heparin cofactor II (HCII), a protein encoded by the SERPIND1 gene, is a is_associated_with::coagulation factor that inhibits IIa, and is a cofactor for is_associated_with::heparin and is_associated_with::dermatan sulfate ("minor antithrombin").

Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state.