SEC23A

Sec23 homolog A (S. cerevisiae), also known as SEC23A, is a is_associated_with::protein which in humans is encoded by the SEC23A is_associated_with::gene.

Function
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It contains a gelsolin domain. It is part of a protein complex and found in the is_associated_with::ribosome-free transitional face of the is_associated_with::endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of is_associated_with::COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.

SEC23 interacts with both is_associated_with::SEC16A and is_associated_with::SEC16B.

Interactions
SEC23A has been shown to interact with is_associated_with::SEC24C, is_associated_with::Sec16A/p250 and iPLA1β/p125.

Sec23 has also been shown to interact with TRAPPⅠ, Grh1p also known as GRASP65 and Dynactin. Because they are involved in anterograde vesicle transport from ER to Golgi, Sec23 is involved in vesicle transport.