UGT2B4

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an is_associated_with::enzyme that in humans is encoded by the UGT2B4 is_associated_with::gene.

Function
UGT2B4 is mainly involved in the is_associated_with::glucuronidation of is_associated_with::hyodeoxycholic acid, a is_associated_with::bile acid, and is_associated_with::catechol-is_associated_with::estrogens, such as 17-is_associated_with::epiestriol and 4-hydroxy-is_associated_with::estrone.

The expression of the UGT2B4 enzyme is upregulated by the is_associated_with::farnesoid X receptor (FXR), a is_associated_with::nuclear receptor which is activated by bile acids. These same bile acids are substrates for the UGT2B4 enzyme. Hence upregulation of UGT2B4 by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.