CREB-binding protein

CREB-binding protein, also known as CREBBP or CBP, is a is_associated_with::protein that in humans is encoded by the CREBBP is_associated_with::gene. The CREB protein carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains: the is_associated_with::nuclear receptor interaction domain (RID), the is_associated_with::CREB and MYB interaction domain (KIX), the is_associated_with::cysteine/is_associated_with::histidine regions (TAZ1/CH1 and TAZ2/CH3) and the is_associated_with::interferon response binding domain (IBiD). The CREB protein domains, KIX, TAZ1 and TAZ2, each bind tightly to a sequence spanning both transactivation domains 9aaTADs of transcription factor p53.

Function
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different is_associated_with::transcription factors. First isolated as a nuclear protein that binds to cAMP-response element-binding protein (is_associated_with::CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic is_associated_with::histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high-sequence similarity with protein is_associated_with::EP300 in its is_associated_with::bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Recent results suggest that novel CBP-mediated post-translational N-glycosylation activity alters the conformation of CBP-interacting proteins, leading to regulation of gene expression, cell growth and differentiation,

Clinical significance
Mutations in this gene cause is_associated_with::Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with is_associated_with::acute myeloid leukemia. Hypothalamic expression of this gene in mice correlates with mouse lifespan, and when CBP is inhibited in is_associated_with::C. elegans by is_associated_with::RNAi, there is a proportional fold-change decrease in lifespan.

Interactions
CREB-binding protein has been shown to interact with:


 * TF2,
 * AR,
 * AIRE,
 * is_associated_with::BRCA1,
 * is_associated_with::C-jun,
 * CSK,
 * is_associated_with::Ccaat-enhancer-binding proteins,
 * is_associated_with::CDX2,
 * is_associated_with::CREB1,
 * is_associated_with::CSNK2A2,
 * is_associated_with::CUTL1,
 * CSNK2A1,
 * CDK8,
 * is_associated_with::EBF1,
 * is_associated_with::EVI1,
 * ESR1,
 * is_associated_with::FOXO1,
 * is_associated_with::GLI3,
 * GTF2B,
 * is_associated_with::HIF1A,
 * is_associated_with::HIPK2,
 * is_associated_with::HNF1A,
 * is_associated_with::HOXB7,
 * HNF4A,
 * is_associated_with::ING1,
 * is_associated_with::KHDRBS1,
 * is_associated_with::KLF13,
 * is_associated_with::KLF4,
 * is_associated_with::Ku70,
 * MAF,
 * MLL,
 * is_associated_with::MSX1,
 * is_associated_with::MYBL2,
 * MYB,
 * is_associated_with::MyoD,
 * NCOA1,
 * NCOA3,
 * is_associated_with::NCOA6,
 * is_associated_with::NEUROG1,
 * is_associated_with::NFATC4,
 * is_associated_with::NFE2L2,
 * is_associated_with::NFE2,
 * NR3C1,
 * is_associated_with::NUP98,
 * is_associated_with::P53,
 * is_associated_with::PCAF,
 * is_associated_with::POLR2A,
 * is_associated_with::PPARGC1A,
 * is_associated_with::PTMA,
 * PML,
 * is_associated_with::RBBP4,
 * is_associated_with::RELA,
 * is_associated_with::RPS6KA3,
 * is_associated_with::SERTAD1,
 * is_associated_with::SMARCA4,
 * SMAD1,
 * is_associated_with::SMARCB1
 * is_associated_with::SREBF1,
 * is_associated_with::SREBF2,
 * is_associated_with::SS18L1,
 * is_associated_with::STAT1,
 * is_associated_with::STAT2,
 * is_associated_with::STAT6,
 * SRF,
 * is_associated_with::TCF3,
 * is_associated_with::TGS1,
 * is_associated_with::TRERF1,
 * TDG, and
 * is_associated_with::Zif268.