MCL1

Induced myeloid leukemia cell differentiation protein Mcl-1 is a is_associated_with::protein that in humans is encoded by the MCL1 is_associated_with::gene.

Function
The protein encoded by this gene belongs to the is_associated_with::Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The longer gene product (isoform 1) enhances cell survival by inhibiting is_associated_with::apoptosis while the alternatively spliced shorter gene product (isoform 2) promotes apoptosis and is death-inducing.

Clinical significance
is_associated_with::Omacetaxine mepesuccinate and is_associated_with::Seliciclib as an investigational treatment for is_associated_with::chronic myelogenous leukemia (CML) and is_associated_with::multiple myeloma respectively, act by inhibiting synthesis of Mcl-1.

Interactions
MCL1 has been shown to interact with:
 * is_associated_with::BAK1,
 * is_associated_with::BCL2L11,
 * BID,
 * BAD,
 * is_associated_with::DAD1,
 * PMAIP1,
 * is_associated_with::PCNA, and
 * is_associated_with::TNKS