BHLHE41

"Basic helix-loop-helix family, member e41", or BHLHE41, is a is_associated_with::gene that encodes, as the name implies, a basic helix-loop-helix protein in various tissues of both humans and mice. It also known as DEC2, hDEC2, and SHARP1, and was previously known as "basic helix-loop-helix domain containing, class B, 3", or BHLHB3.

Function
This gene encodes a is_associated_with::transcription factor that belongs to the Hairy/Enhancer of Split subfamily of basic is_associated_with::helix-loop-helix factors. The encoded protein functions as a transcriptional is_associated_with::repressor and as a regulator of molecular clock.

In mice lacking SHARP1 and SHARP2, is_associated_with::IGF-2 is elevated and so is_associated_with::memory consolidation is enhanced.

Clinical significance
Defects in this gene are associated with the short sleep phenotype. A particular genetic variation in the gene affects is_associated_with::sleep duration in humans, and introduction of the human gene into mice also reduces their sleep requirements. This genetic variation was discovered by Ying-Hui Fu's lab.