Rs2427837

rs2427837 is a SNP in the gene encoding the alpha chain of the high affinity receptor for IgE (FCER1A) on chromosome 1q23. High levels of serum IgE are associated with allergies, and are mediators of autoimmune diseases.

An examination of over 11,000 Germans led to the conclusion that rs2427837 (and one other FCER1A SNP, the tightly linked rs2251746) were strongly associated with high levels of serum IgE. The more common (G) allele was associated with higher serum IgE, and the effect appeared to be additive. Therefore, homozygous rs2251746(G;G) individuals may be at higher risk for atopic eczema and asthma than carriers of one or two (A) alleles.


 * is_associated_with_disease::Asthma
 * is_associated_with_disease::Atopic dermatitis