Rs8067378

rs8067378 is the strongest associating SNP from a region of chromosome 17q21 found in a large (ultimately over 7,000 patients in 3 populations) genome-wide association study of childhood asthma.

Since the associated SNPs were also strongly associated (p < 10-22) in cis with transcript levels of from the ORMDL3 gene, the authors concluded that genetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma.

Assessing the reproducibility of asthma candidate gene associations, using genome-wide data.

Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.

Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.

Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.

Asthma-susceptibility variants identified using probands in case-control and family-based analyses.