Rs926103

Rs926103 is located within the SH2D2A gene on Chromosome 1. SH2D2A encodes an adapter protein thought to function in T-cell signal transduction.

A study in the Journal for Neuroimmunology reported that 16 repeats repeat of GA after the (A;A) allele at this SNP is associated with multiple sclerosis in Norwegian, Danish and Swedish sample sets.

The study concludes that the SH2D2A gene may contribute to susceptibility to MS.

This study has yet to be verified or reproduced in any subsequent research.

The T cell regulator gene SH2D2A contributes to the genetic susceptibility of multiple sclerosis

rs926103 and a GA repeat polymorphism forming a risk haplotype for Multiple sclerosis

The fact that this is a mixture of a snp and a repeat makes this an interesting test case for Promethease


 * is_associated_with_disease::Multiple sclerosis