Alpha-1-microglobulin

Alpha-1 microglobulin (A1M, α1-microglobulin, sometimes also called Protein HC ) is a microglobulin, a small globular protein. It is found in all vertebrates, including humans, and is distributed in blood plasma and extravascular tissues of all organs. It is synthesized in most cells of the body, but mainly in the liver from a gene that codes for the alpha-1-microglobulin/bikunin precursor.

It can be used as an indicator of proteinuria. The test can be regarded as positive when the ratio of alpha-1 microglobulin (in milligram) and creatinine in millimoles in the urine is over 0.7 mg/mmol.