SIRT4

Sirtuin 4, also known as SIRT4 is a is_associated_with::protein which in humans is encoded by the SIRT4 gene.

Function
This gene encodes a member of the is_associated_with::sirtuin family of proteins which are homologs of the Sir2 gene in budding yeast. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been fully determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

SIRT4 is a mitochondrial ADP-ribosyltransferase that inhibits mitochondrial is_associated_with::glutamate dehydrogenase 1 activity, thereby downregulating is_associated_with::insulin secretion in response to amino acids. It has been shown that SIRT4 regulates fatty acid oxidation and mitochondrial gene expression in liver and muscle cells.