GAB1

GRB2-associated-binding protein 1 is a is_associated_with::protein that in humans is encoded by the GAB1 is_associated_with::gene.

Function
The is_associated_with::protein encoded by this is_associated_with::gene is a member of the IRS1-like multisubstrate is_associated_with::docking protein family. The encoded protein is an important mediator of branching tubulogenesis and plays a central role in is_associated_with::cellular growth response, transformation and is_associated_with::apoptosis. Two transcript variants encoding different is_associated_with::isoforms have been found for this gene.

Interactions
GAB1 has been shown to interact with:


 * is_associated_with::CRKL,
 * is_associated_with::Grb2,
 * is_associated_with::MAP3K3,
 * is_associated_with::PIK3R1,
 * is_associated_with::PLCG1 and
 * is_associated_with::PTPN11.

The expression of GAB1 was shown to be regulated by non-coding RNA (miRNA) termed miR-150.