PSB-10

PSB-10 is a drug which acts as a selective inverse agonist for the adenosine A3 receptor, with high selectivity over the other three adenosine receptor subtypes. It has been shown to produce antiinflammatory effects in animal studies. Simple xanthine derivatives such as caffeine and DPCPX have generally low affinity for the A3 subtype and must be extended by expanding the ring system and adding an aromatic group to give high A3 affinity and selectivity.