Dolichol kinase

In is_associated_with::enzymology, a dolichol kinase is an is_associated_with::enzyme that catalyzes the is_associated_with::chemical reaction


 * CTP + dolichol $$\rightleftharpoons$$ CDP + dolichyl phosphate

Thus, the two substrates of this enzyme are CTP and is_associated_with::dolichol, whereas its two products are CDP and is_associated_with::dolichyl phosphate.

This enzyme belongs to the family of is_associated_with::transferases, to be specific, those transferring phosphorus-containing groups (is_associated_with::phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is CTP:dolichol O-phosphotransferase. This enzyme is also called dolichol phosphokinase. This enzyme participates in is_associated_with::N-glycan biosynthesis.

In humans dolichol kinase is encoded by the DOLK is_associated_with::gene.

Function
Dolichyl monophosphate is an essential is_associated_with::glycosyl carrier lipid for C- and O-mannosylation and N-is_associated_with::glycosylation of proteins and for biosynthesis of is_associated_with::glycosylphosphatidylinositol anchors in is_associated_with::endoplasmic reticulum (ER). Dolichol kinase catalyzes CTP-mediated is_associated_with::phosphorylation of is_associated_with::dolichol, the terminal step in de novo dolichyl monophosphate biosynthesis.

Clinical significance
Mutations in DOLK cause a subtype of the is_associated_with::congenital disorders of glycosylation, DOLK-CDG (CDG-Im).