DYRK1B

Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an is_associated_with::enzyme that in humans is encoded by the DYRK1B is_associated_with::gene.

Function
DYRK1B is a member of the DYRK family of is_associated_with::protein kinases. DYRK1B contains a bipartite nuclear localization signal and is found mainly in muscle and testis. The protein is proposed to be involved in the regulation of nuclear functions. Three isoforms of DYRK1B have been identified differing in the presence of two alternatively spliced exons within the is_associated_with::catalytic domain.

Interactions
DYRK1B has been shown to interact with:
 * is_associated_with::PCBD1 and
 * is_associated_with::RANBP9.

Clinical significance
One lone missense mutation in Dyrk1B gene (R102C) was found associated with an autosomal dominant early onset Coronary Artery Disease, juvenile-onset truncal obesity, severe hypertension, and type II diabetes mellitus - seen in subjects from a nomadic group in Iran.