NFX1

Transcriptional repressor NF-X1 is a is_associated_with::protein that in humans is encoded by the NFX1 is_associated_with::gene.

is_associated_with::MHC class II gene expression is controlled primarily at the transcriptional level by is_associated_with::transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional is_associated_with::repressor capable of binding to the conserved X box motif of is_associated_with::HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-γ. Three alternative splice variants, each of which encodes a different isoform, have been identified.