XPC (gene)

Xeroderma pigmentosum, complementation group C, also known as XPC, is a is_associated_with::protein which in humans is encoded by the XPC is_associated_with::gene. XPC is involved in the recognition of bulky DNA adducts in is_associated_with::nucleotide excision repair. It is located on chromosome 3.

Function
This gene encodes a component of the is_associated_with::nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including is_associated_with::Xeroderma pigmentosum (XP) A-G and V, is_associated_with::Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation.

Clinical significance
Mutations in this gene or some other NER components result in is_associated_with::Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age.

Interactions
XPC (gene) has been shown to interact with is_associated_with::ABCA1, is_associated_with::CETN2 and is_associated_with::XPB.