ERCC2

ERCC2, or XPD is a protein involved in transcription-coupled is_associated_with::nucleotide excision repair.

The XPD (ERCC2) gene encodes for a 2.3-kb mRNA containing 22 is_associated_with::exons and 21 is_associated_with::introns. The XPD protein is a 760 is_associated_with::amino acids polypeptide with a size of 87kDa. Defects in this gene can result in three different disorders: the cancer-prone syndrome is_associated_with::xeroderma pigmentosum complementation group D, photosensitive is_associated_with::trichothiodystrophy, and is_associated_with::Cockayne syndrome.

Just like is_associated_with::XPB, XPD is also a part of human transcriptional is_associated_with::initiation factor is_associated_with::TFIIH and has ATP-dependent is_associated_with::helicase activity. It belongs to the RAD3/XPD subfamily of helicases.

XPD is essential for the viability of cells. Deletion of XPD in mice is embryonic lethal.

Interactions
ERCC2 has been shown to interact with is_associated_with::GTF2H2, is_associated_with::GTF2H1,  is_associated_with::ERCC5 and is_associated_with::XPB.