GSTP1

Glutathione S-transferase P is an is_associated_with::enzyme that in humans is encoded by the GSTP1 is_associated_with::gene.

Function
is_associated_with::Glutathione S-transferases (GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many is_associated_with::hydrophobic and electrophilic compounds with reduced is_associated_with::glutathione. Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into 4 main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function in is_associated_with::xenobiotic metabolism and play a role in susceptibility to is_associated_with::cancer, and other diseases.

Interactions
GSTP1 has been shown to interact with is_associated_with::Fanconi anemia, complementation group C and is_associated_with::MAPK8.

GST-Pi is expressed in many human tissues, particularly in the biliary tree and renal distal convoluted tubules.