KLF13

Kruppel-like factor 13, also known as KLF13, is a is_associated_with::protein that in humans is encoded by the KLF13 is_associated_with::gene.

Function
KLF13 belongs to a family of is_associated_with::transcription factors that contain 3 classical is_associated_with::zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.

KLF13 was first described as the is_associated_with::RANTES factor of late activated is_associated_with::T lymphocytes (RFLAT)-1. It regulates the expression of the is_associated_with::chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of is_associated_with::Bcl-xL expression.

Interactions
KLF13 has been shown to interact with is_associated_with::CREB-binding protein, is_associated_with::Heat shock protein 47 and is_associated_with::PCAF.