GCLC

Glutamate—cysteine ligase catalytic subunit is an is_associated_with::enzyme that in humans is encoded by the GCLC is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of GCLC function. A conditional is_associated_with::knockout mouse line, called Gclctm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice, however no significant abnormalities were observed.