MEP1A

Meprin A subunit alpha also known as endopeptidase-2 or PABA peptide hydrolase is the alpha subunit of the is_associated_with::meprin A is_associated_with::enzyme that in humans is encoded by the MEP1A is_associated_with::gene. The MEP1A locus is on chromosome 6p in humans and on chromosome 17 in mice.

Function
The meprin alpha subunit product of the MEP1A gene is processed in the is_associated_with::endoplasmic reticulum during intracellular transport, and is secreted as homomeric meprin A. Meprin alpha subunits may self-associate, and once secreted, form very large multimers, with a molecular mass of over 1 million daltons. In cells concurrently expressing is_associated_with::MEP1B, the meprin alpha and meprin beta subunits form disulfide dimers that interact to form membrane bound heterotetrameric is_associated_with::meprin A.