PRMT1

Protein arginine N-methyltransferase 1 is an is_associated_with::enzyme that in humans is encoded by the PRMT1 is_associated_with::gene.

Function
The HRMT1L2 gene encodes a protein is_associated_with::arginine is_associated_with::methyltransferase that functions as a is_associated_with::histone methyltransferase specific for is_associated_with::histone H4.

Model organisms
is_associated_with::Model organisms have been used in the study of PRMT1 function. A conditional is_associated_with::knockout mouse line, called Prmt1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and thus none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice and females displayed increased circulating is_associated_with::creatinine levels.

Interactions
PRMT1 has been shown to interact with:


 * is_associated_with::BTG1,
 * is_associated_with::BTG2,
 * is_associated_with::DHX9,
 * is_associated_with::FUS,
 * is_associated_with::HNRNPR,
 * is_associated_with::HNRPK,
 * is_associated_with::IFNAR1,
 * is_associated_with::ILF3,
 * is_associated_with::KHDRBS1, and
 * is_associated_with::SUPT5H.