HNRPA2B1

Heterogeneous nuclear ribonucleoproteins A2/B1 is a is_associated_with::protein that in humans is encoded by the HNRNPA2B1 is_associated_with::gene.

Function
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. HnRNPA2B1 is an autoantigen in autoimmune diseases such as is_associated_with::rheumatoid arthritis, is_associated_with::systemic lupus erythematosus and is_associated_with::mixed connective tissue disease. When referred to as an is_associated_with::autoantigen, hnRNPA2B1 is also known as is_associated_with::RA33.

Interactions
HNRPA2B1 has been shown to interact with is_associated_with::Casein kinase 2, alpha 1.