CRKL

Crk-like protein is a is_associated_with::protein that in humans is encoded by the CRKL gene.

Function
v-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. CRKL has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential.

CrkL together with Crk participates in the is_associated_with::Reelin signaling cascade downstream of is_associated_with::DAB1.

Interactions
CRKL has been shown to interact with: CRKL has been shown to interact with:


 * is_associated_with::Abl gene,
 * is_associated_with::BCAR1,
 * is_associated_with::BCR gene,
 * CBLB,
 * is_associated_with::CD117,
 * is_associated_with::CD34,
 * is_associated_with::Cbl gene,
 * is_associated_with::Dock2,
 * EPOR,
 * is_associated_with::GAB1,
 * is_associated_with::GAB2,
 * is_associated_with::INPP5D,
 * is_associated_with::MAP4K1,
 * is_associated_with::MAP4K5,
 * is_associated_with::NEDD9,
 * is_associated_with::PIK3R2,
 * is_associated_with::Paxillin
 * is_associated_with::RAPGEF1,
 * RICS,
 * is_associated_with::STAT5A,
 * is_associated_with::Syk, and
 * WAS.