JARID1A

Lysine-specific demethylase 5A is an is_associated_with::enzyme that in humans is encoded by the KDM5A is_associated_with::gene.

The Drosophila homolog, LID, was found to be an H3K4 histone is_associated_with::demethylase that binds to c-Myc. It was recently renamed to Lysine Demethylase 5A (KDM5A).

Enzymatically can be designated as a is_associated_with::trimethyllysine dioxygenase. (EC 1.14.11.8)

Interactions
JARID1A has been shown to interact with is_associated_with::Estrogen receptor alpha, is_associated_with::LMO2 and is_associated_with::Retinoblastoma protein.

JARID1A is a major component of the circadian clock, the upregulation of which at the end of the sleep phase blocks HDAC1 activity. Blocking HDAC1 activity results in an upregulation of CLOCK and BMAL1 and consequent upregulation of PER proteins. The PSF (polypyrimidine tract-binding protein-associated splicing factor) within the PER complex recruits SIN3A, a scaffold for assembly of transcriptional inhibitory complexes and rhythmically delivers histone deacetylases to the Per1 promoter, which repress Per1 transcription.[PMID 21960634] [PMID 21680841]

Knockdown of JARID1A promoted osteogenic differentiation of human adipose-derived stromal cells in vitro and in vivo and resulted in marked increases of mRNA expression of osteogenesis-associated genes such as alkaline phosphatase (ALP), osteocalcin (OC), and osterix (OSX). RBP2 was shown to occupy the promoters of OSX and OC to maintain the level of the H3K4me3 mark by chromatin immunoprecipitation assays. RBP2 was also physically and functionally associated with RUNX2, an essential transcription factor that governed osteoblastic differentiation. RUNX2 knockdown impaired the repressive activity of RBP2 in osteogenic differentiation of human adipose-derived stromal cells. [PMID 21604327]