Rs3184504

rs3184504 is a nonsynonymous SNP in the SH2B3 gene, and it is also known as R262W.

In a recent (2008) study of non-HLA SNP associations of 1600+ celiac disease patients, this SNP was considered one of the most significant. The odds ratio for the minor allele was 1.19 (CI:1.10-1.30, p=1.33x10e-7). rs653178, another SNP in strong linkage disequilibrium (r2>0.99) with rs3184504, was also associated with celiac disease.

associated with type-1 diabetes

23andMe blog coronary artery disease and heart attack

SNP 	Risk Version 	Effect
 * rs646776 	T 	1.19
 * rs17465637 	C 	1.14
 * rs1746048 	C 	1.17
 * rs6725887 	C 	1.17
 * rs11206510 	T 	1.15
 * rs3184504 	T 	1.13
 * rs2306374 	C 	1.15
 * rs3782886 	C 	1.44

23andMe blog blood pressure

Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations?

Determinants of platelet count in humans.

The carriage of the type 1 diabetes-associated R262W variant of human LNK correlates with increased proliferation of peripheral blood monocytes in diabetic patients.

Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.

Genetics of coronary artery disease: focus on genome-wide association studies.

Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.

Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

Genetic evidence for a role of IL33 in nasal polyposis.

Signals of recent positive selection in a worldwide sample of human populations.

Type 1 diabetes in the BB rat: a polygenic disease.

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

The expanding genetic overlap between multiple sclerosis and type I diabetes.

Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

Translational mini-review series on the immunogenetics of gut disease: immunogenetics of coeliac disease.

Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).

On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants.