ACSS2

Acetyl-coenzyme A synthetase, cytoplasmic is an is_associated_with::enzyme that in is_associated_with::humans is encoded by the ACSS2 is_associated_with::gene.

Function
This gene encodes a is_associated_with::cytosolic is_associated_with::enzyme that catalyzes the activation of is_associated_with::acetate for use in is_associated_with::lipid synthesis and is_associated_with::energy generation. The protein acts as a is_associated_with::monomer and produces is_associated_with::acetyl-CoA from acetate in a reaction that requires ATP. Expression of this gene is regulated by is_associated_with::sterol regulatory element-binding proteins, transcription factors that activate genes required for the synthesis of is_associated_with::cholesterol and unsaturated is_associated_with::fatty acids. Two transcript variants encoding different is_associated_with::isoforms have been found for this gene.