KIF3B

Kinesin-like protein KIF3B is a is_associated_with::protein that in humans is encoded by the KIF3B is_associated_with::gene.

Function
The protein encoded by this gene forms a heterotrimeric motor complex with kinesin family member 3A and KAP3 (kinesin accessory protein 3) to drive intra-flagellar transport and possibly to aid in chromosome movement during is_associated_with::mitosis and is_associated_with::meiosis. The encoded protein is a plus end-directed is_associated_with::microtubule motor and can interact with the SMC3 subunit of the cohesin complex. In addition, the encoded protein may be involved in the intracellular movement of membranous is_associated_with::organelles. The heterotrimeric KIF3B/KIF3A/KAP3 motor protein is a member of the kinesin-2 subfamily of the kinesin superfamily.

Interactions
KIF3B has been shown to interact with is_associated_with::RAB4A.

Model organisms
is_associated_with::Model organisms have been used in the study of KIF3B function. A conditional is_associated_with::knockout mouse line called Kif3btm1b(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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