BAG1

BAG family molecular chaperone regulator 1 is a is_associated_with::protein that in humans is encoded by the BAG1 is_associated_with::gene.

Function
The is_associated_with::oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to is_associated_with::apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated is_associated_with::athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this is_associated_with::mRNA through the use of alternative translation initiation sites, including a non-AUG site.

Clinical significance
BAG gene has been implicated in age related neurodegenerative diseases as is_associated_with::Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.

Interactions
BAG1 has been shown to interact with:


 * is_associated_with::Androgen receptor,
 * is_associated_with::C-Raf,
 * is_associated_with::Calcitriol receptor,
 * is_associated_with::Glucocorticoid receptor,
 * is_associated_with::HSPA8,
 * HBEGF,
 * is_associated_with::PPP1R15A,
 * NR1B1, and
 * is_associated_with::SIAH1.