Interleukin 32

Interleukin 32 is a is_associated_with::protein that in humans is encoded by the IL32 is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative is_associated_with::phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of is_associated_with::T-cells by is_associated_with::mitogens or the activation of is_associated_with::NK cells by IL-2. This protein induces the production of is_associated_with::TNF-alpha from is_associated_with::macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Interleukin 32 (IL-32) is a pro-inflammatory is_associated_with::cytokine that can induce cells of the is_associated_with::immune system (such as is_associated_with::monocytes and is_associated_with::macrophages) to secrete inflammatory cytokines, such as is_associated_with::tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of is_associated_with::chemokines such as IL-8 and MIP-2 / is_associated_with::CXCL2.

IL-32 can also support is_associated_with::osteoclast differentiation but not osteoclast activation by regulating the is_associated_with::MAPK/ERK pathway and the actin cytoskeleton.