MIS18BP1

MIS18 binding protein 1 is a is_associated_with::protein that in humans is encoded by the MIS18BP1 is_associated_with::gene. The gene is also known as LKNL2, M18BP1, C14orf106, and HSA242977.

Model organisms
is_associated_with::Model organisms have been used in the study of MIS18BP1 function. A conditional is_associated_with::knockout mouse line, called Mis18bp1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. Few is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice and an abnormal tail morphology was observed in female animals.