Rs4970834

rs599839 and rs4970834 explain about 1% of the variation in circulating LDL-cholesterol levels. "When we look at this particular genetic variance, of all the cholesterol variation among the population, 1% of it can be attributed to this particular locus," said Sandhu. "This is equivalent to more established genes for LDL regulation, particularly APOE." rs646776 also linked. rs599839, rs4970834 and rs17228212 associated with non-HDL cholesterol.

Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.

An open access database of genome-wide association results.

Analysis of recently identified dyslipidemia alleles reveals two loci that contribute to risk for carotid artery disease.

Evaluation of genetic risk scores for lipid levels using genome-wide markers in the Framingham Heart Study.

Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.


 * is_associated_with_disease::Atherosclerosis
 * is_associated_with_disease::Carotid artery disease