ACTR1A

Alpha-centractin (yeast) or ARP1 is a is_associated_with::protein that in humans is encoded by the ACTR1A is_associated_with::gene.

Function
This gene encodes a 42.6 kD subunit of is_associated_with::dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both is_associated_with::microtubules and is_associated_with::cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. ARP1 forms a 37 nm filament-like structure and is the core of the is_associated_with::dynactin complex. It only exists in the dynactin complex in vivo. Highly purified, native Arp1 polymerize rapidly at extremely low concentrations into short filaments in vitro that were similar, but not identical, in length to those in dynactin. With time, these Arp1 filaments appeared to anneal to form longer assemblies but never attained the length of conventional is_associated_with::actin filaments. As for conventional actin, Arp1 can bind and hydrolyze ATP, and Arp1 assembly is accompanied by nucleotide hydrolysis.

It has been reported that Arp1 interacts with other dynactin components including is_associated_with::DCTN1/p150Glued, is_associated_with::DCTN4/p62 and is_associated_with::Actr10/Arp11. Arp1 has been shown as the domain for dynactin binding to membrane vesicles (such as Golgi or is_associated_with::late endosome) through its association with β-is_associated_with::spectrin.

Interactions
ACTR1A has been shown to interact with is_associated_with::SPTBN2.