MRNA (guanine-N7-)-methyltransferase

In is_associated_with::enzymology, a mRNA (guanine-N7-)-methyltransferase also known as mRNA cap guanine-N7 methyltransferase is an is_associated_with::enzyme that catalyzes the is_associated_with::chemical reaction


 * S-adenosyl-L-methionine + G(5')pppR-RNA $$\rightleftharpoons$$ S-adenosyl-L-homocysteine + m7G(5')pppR-RNA (mRNA containing an N7-methylguanine cap)

Thus, the two substrates of this enzyme are S-adenosyl methionine and is_associated_with::G(5')pppR-RNA, whereas its two products are is_associated_with::S-adenosylhomocysteine and is_associated_with::m7G(5')pppR-RNA. This enzyme belongs to the family of is_associated_with::transferases, specifically those transferring one-carbon group methyltransferases.

In humans, mRNA cap guanine-N7 methyltransferase is encoded by the RNMT is_associated_with::gene.

Nomenclature
The systematic name of this enzyme class is S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase. Other names in common use include:
 * messenger ribonucleate guanine 7-methyltransferase,
 * guanine-7-methyltransferase,
 * messenger RNA guanine 7-methyltransferase, and
 * S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase.