Rs11178997

rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission

paper Association with and bipolar disorder in a Northern Swedish, Isolated Population. 182 patients and 364 unrelated control individuals. P = .001

rs11178997 significantly reduced TPH2 transcriptional activity by 22% and 7% in cell lines might have implications for the development and function of the serotonergic system in the brain.

paper Carriers of the A-Allele of rs11178997 showed a decreased cortisol and ACTH stimulation. might be crucial factors for major depression

pdf paper associated with bipolar disorder

Minor allele yielded odds ratio of 1.5 (CI:1.2-1.9) for increased risk for bipolar disorder in a study of 883 Russian patients.

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

Association of brain-specific tryptophan hydroxylase, TPH2, with unipolar and bipolar disorder in a Northern Swedish, isolated population.

Tryptophan hydroxylase 2 gene and alcohol use among college students.

Investigation of the tryptophan hydroxylase 2 gene in bipolar I disorder in the Romanian population.

Alternative splicing and extensive RNA editing of human TPH2 transcripts.

Pharmacogenetics of antidepressant response.

Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.