Rs4730751

rs4730751 is a SNP in the gene for CAV1, a protein that is involved in tissue fibrosis as well as vascular proliferation.

In a study of 785 white kidney transplant donors and their respective recipients, kidneys from rs4730751(A;A) donors were significantly more likely to fail the transplant, compared with those from donors carrying one or two of the more common rs4730751(C) alleles. The hazard ratio was 1.97 (CI: 1.29-3.16, p = 0.002). Overall, the graft failure rate for donor kidneys with the (A;A) genotype was 38.6%, compared with ~22% for donor genotypes (A;C) or (C;C).