PTPRD

Receptor-type tyrosine-protein phosphatase delta is an is_associated_with::enzyme that in humans is encoded by the PTPRD is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting is_associated_with::neurite growth, and regulating neurons is_associated_with::axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.

Clinical significance
Mutations in the PTPRD gene are associated with is_associated_with::autism, and is_associated_with::breast cancer.

Interactions
PTPRD has been shown to interact with is_associated_with::PTPRS and is_associated_with::liprin-alpha-1.