PYCARD

Apoptosis-associated speck-like protein containing a CARD or ASC is a is_associated_with::protein that in humans is encoded by the PYCARD is_associated_with::gene.

Function
This gene encodes an adaptor protein that is composed of two protein–protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of is_associated_with::caspase. In normal cells, this protein is localized to the is_associated_with::cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.

Interactions
PYCARD has been shown to interact with is_associated_with::MEFV.