Rs7657958

rs7657958 (Asp67Tyr, 199G>T) is a SNP within the UGT2B10 (UDP-glucuronosyltransferase 2B10) gene.

Tyr allele defines haplotype C, significantly associated with lower 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL, a nitrosamine found in tobacco) N-glucuronidation, an 1.8-fold and 12-fold reduction in NNAL-N-glucuronidation was found for one and two haplotype C alleles, respectively

may effect nicotine metabolism