SIAH1

E3 ubiquitin-protein ligase SIAH1 is an is_associated_with::enzyme that in humans is encoded by the SIAH1 is_associated_with::gene.

Function
This gene encodes for a polypeptide structure that is a member of the seven in absentia homolog (SIAH) family. The protein is an is_associated_with::E3 ligase and is involved in is_associated_with::ubiquitination and is_associated_with::proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in the development of certain forms of is_associated_with::Parkinson's disease, the regulation of the cellular response to hypoxia and induction of is_associated_with::apoptosis. is_associated_with::Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Interactions
SIAH1 has been shown to interact with:


 * APC,
 * is_associated_with::BAG1,
 * is_associated_with::CACYBP,
 * is_associated_with::KHDRBS3,
 * is_associated_with::KIF22,
 * NUMB,
 * is_associated_with::PEG10,
 * is_associated_with::PEG3
 * is_associated_with::POU2AF1,
 * is_associated_with::RBBP8, and
 * is_associated_with::TRIB3.