KIAA1377

Uncharacterized protein KIAA1377 is a is_associated_with::protein that in humans is encoded by the KIAA1377 is_associated_with::gene. Also known as Cep126, the protein has been shown to localize to the is_associated_with::centrosome. Furthermore, it is found at is_associated_with::pericentriolar satellites and the base of the is_associated_with::primary cilium. Depleting Cep126 leads to dispersion of pericentriolar satellites, in turn disrupting is_associated_with::microtubule organization at the is_associated_with::mitotic spindle.

Clinical relevance
Mutations in this gene have been found to cause is_associated_with::monomelic amyotrophy.