PRDM9

PR domain zinc finger protein 9 is a is_associated_with::protein that in humans is encoded by the Prdm9 is_associated_with::gene. The protein has is_associated_with::histone H3K4 trimethyltransferase activity, a KRAB domain, and a is_associated_with::DNA-binding domain consisting of multiple tandem C2H2 is_associated_with::zinc finger (ZF) domains. PRDM9 specifically trimethylates lysine 4 of histone H3 during meiotic prophase and is essential for proper meiotic progression, but does not have the ability to mono- and dimethylate lysine 4 of histone H3. H3K4 methylation represents a specific tag for epigenetic transcriptional activation which plays a central role in the transcriptional activation of genes during early meiotic prophase.

Function
PRDM9 is thought to mediate the process of meiotic homologous recombination.