WBP11

Alternative names

 * WW domain binding protein 11 (WBP1)
 * Rsp5
 * WWP domain

Function
WW domain-binding protein 11 is a is_associated_with::protein that in humans, is encoded by the WBP11 is_associated_with::gene. The function of WBP11 is to play a role in the is_associated_with::regulation of pre-mRNA processing. More specifically, this nuclear protein, colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks.

Structure
The WW domain is a short conserved region in a number of unrelated proteins, which folds as a stable, triple stranded is_associated_with::beta-sheet. This short domain of approximately 40 amino acids, may be repeated up to four times in some is_associated_with::proteins. The name WW or WWP derives from the presence of two signature is_associated_with::tryptophan residues that are spaced 20-23 is_associated_with::amino acids apart and are present in most WW domains known to date, as well as that of a conserved is_associated_with::Proline. The WW domain binds to is_associated_with::proteins with particular proline-motifs, [AP]-P-P-[AP]-Y, and/or phosphoserine- phosphothreonine-containing motifs. It is frequently associated with other domains typical for is_associated_with::proteins in is_associated_with::signal transduction processes.

Protein interactions
Wbp11 contains two proline-rich regions that bind to the WW domain of the nuclear protein, Npw38, hence leading to its alternative name, Npw38-binding protein, NpwBP. The Npw38-NpwBP complex functions as a component of an mRNA factory in the nucleus. WBP11 has also been shown to interact with is_associated_with::PQBP1.

Proteins containing Wbp11 domain
A large variety of proteins containing the WW domain are known. These include:
 * is_associated_with::dystrophin, a multidomain is_associated_with::cytoskeletal protein;
 * is_associated_with::utrophin, a dystrophin-like protein of unknown function;
 * is_associated_with::vertebrate YAP protein, substrate of an unknown is_associated_with::serine kinase;
 * Mus musculus (Mouse) NEDD-4, involved in the embryonic development and differentiation of the central nervous system;
 * Saccharomyces cerevisiae (Baker's yeast) RSP5, similar to NEDD-4 in its molecular organisation;
 * Rattus norvegicus (Rat) FE65, a is_associated_with::transcription factor activator expressed preferentially in liver;
 * Nicotiana tabacum (Common tobacco) DB10 protein, amongst others.