GRB7

Growth factor receptor-bound protein 7, also known as GRB7, is a is_associated_with::protein that in humans is encoded by the GRB7 is_associated_with::gene.

Function
The product of this gene belongs to a small family of is_associated_with::adaptor proteins that are known to interact with a number of is_associated_with::receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with is_associated_with::epidermal growth factor receptor (EGFR) and ephrin receptors. The protein plays a role in the is_associated_with::integrin signaling pathway and cell migration by binding with focal adhesion kinase (FAK). is_associated_with::Alternative splicing results in multiple transcript variants encoding different isoforms, although the full-length natures of only two of the variants have been determined to date.

Clinical significance
GRB7 is an SH2-domain adaptor is_associated_with::protein that binds to is_associated_with::receptor tyrosine kinases and provides the intra-cellular direct link to the Ras is_associated_with::proto-oncogene. Human GRB7 is located on the long arm of chromosome 17, next to the ERBB2 (alias is_associated_with::HER2/neu) proto-oncogene.

These two genes are commonly co-amplified (present in excess copies) in is_associated_with::breast cancers. GRB7 thought to be involved in migration, is well known to be over-expressed in testicular is_associated_with::germ cell tumors, is_associated_with::esophageal cancers, and gastric cancers.

Interactions
GRB7 has been shown to interact with is_associated_with::Insulin receptor, is_associated_with::PTK2, is_associated_with::RET proto-oncogene, is_associated_with::Rnd1 and is_associated_with::EPH receptor B1.

Model organisms
is_associated_with::Model organisms have been used in the study of GRB7 function. A conditional is_associated_with::knockout mouse line called Grb7tm1b(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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