PDIA3

Protein disulfide-isomerase A3 (PDIA3) also known as glucose-regulated protein, 58-kD (GRP58) is an is_associated_with::isomerase is_associated_with::enzyme.

Function
The PDIA3 protein has is_associated_with::protein disulfide isomerase activity. PDIA3 is also part of the is_associated_with::major histocompatibility complex (MHC) class I is_associated_with::peptide-loading complex, which is essential for formation of the final antigen conformation and export from the is_associated_with::endoplasmic reticulum to the cell surface. This protein of the endoplasmic reticulum interacts with lectin chaperones such as calreticulin and calnexin in order to modulate the folding of proteins that are newly synthesized. It is believed that PDIA3 plays a role in protein folding by promoting the formation of disulfide bonds.

Interactions
It has been demonstrated that PDIA3 interacts with is_associated_with::BACE1, CRT and CNX.

Clinical significance
It has been demonstrated that the downregulation of ERp57 expression is correlated with poor prognosis in early-stage cervical is_associated_with::cancer. It has also been demonstrated that ERp57/PDIA3 binds specific DNA fragments in a melanoma cell line.