Rs1049225

778 Common variable immunodeficiency disorder (CVID) cases compared with 10,999 controls using the Illumina Immunochip; confirming the previously reported human leukocyte antigen (HLA) associations on chromosome 6p21. The minor allele, rs1049225(T) as represented on the minus strand, is associated with reduced risk for CVID (odds ratio 0.56, CI: 0.49 - 0.64, p=4.8 × 10e-16).