FASTKD1

FAST kinase domain-containing protein 1 is a is_associated_with::protein that in humans is encoded by the FASTKD1 is_associated_with::gene on chromosome 2. This protein is part of the FASTKD family, which is known for regulating the energy balance of mitochondria under stress. FASTKD1 has been associated with endometrial cancer.

Structure
FASTKD1 shares structural characteristics of the FASTKD family, including an amino terminal mitochondrial targeting domain and three C-terminal domains: two FAST kinase-like domains (FAST_1 and FAST_2) and a RNA-binding domain (RAP). The mitochondrial targeting domain directs FASTKD1 to be imported into the mitochondria. Though the functions of the C-terminal domains are unknown, RAP possibly binds RNA during trans-splicing.

Function
As a member of the FASTKD family, FASTKD1 localizes to the mitochondria to modulate their energy balance, especially under conditions of stress. Though ubiquitously expressed in all tissues, FASTKD1 appears more abundantly in skeletal muscle, heart muscle, and other tissues enriched in mitochondria.

Clinical Significance
FASTKD1 has been identified as a potential biomarker for endometrial cancer (EC), a cancer of the female genital tract.