NAD(P)H dehydrogenase, quinone 2

NAD(P)H dehydrogenase, quinone 2, also known as NQO2 or QR2, is a human is_associated_with::gene. It is a phase II detoxification enzyme which can carry out two or four electron reductions. Its mechanism of reduction is via a covalently bound zinc ion and a cocrystalized FAD. NQO2 contains two chains homologous in AA sequence but 7% different in structure. As a result, NQO2 contains two similar yet unique active sites. An important function of NQO2 is its activation on NRH. NQO2 can be inhibited by resveratrol.