Prostaglandin F receptor

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.

It is a member of the is_associated_with::G-protein coupled receptor family. Activation of FP Receptor results in activation of G-protein subunit Gq, increasing IP3 and DAG.

Two transcript variants encoding different isoforms have been found for this gene.

Functions
Main effects of prostaglandin binding to the receptor are:
 * is_associated_with::uterine contraction
 * is_associated_with::bronchoconstriction

Via activation of this receptor, PGF2-alpha mediates is_associated_with::luteolysis, and may also be involved in modulating is_associated_with::intraocular pressure and smooth muscle contraction in is_associated_with::uterus and is_associated_with::gastrointestinal tract is_associated_with::sphincters.

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition.