CAMLG

Calcium signal-modulating cyclophilin ligand is a is_associated_with::protein that in humans is encoded by the CAMLG is_associated_with::gene.

Function
The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of is_associated_with::calcium. This integral is_associated_with::membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin.

Interactions
CAMLG has been shown to interact with is_associated_with::TNFRSF13B.