Secretoneurin

Secretoneurin, is a 33-amino acid is_associated_with::neuropeptide derived from secretogranin II (is_associated_with::chromogranin C, CHGC).

Secretoneurin is involved in chemotaxis of monocytes and eosinophils (comparable in potency to IL8) and endothelial cells and in regulation of endothelial cell proliferation. Highest secretoneurin levels are found in anterior pituitary, followed by is_associated_with::adrenal medulla and posterior is_associated_with::pituitary is_associated_with::hypothalamus (2- to 6-fold lower levels in other brain regions investigated). Secretoneurin has been shown to have potent angiogenic activity in vivo in mouse cornea model and in vitro in a 3-dimensional gel. Secretoneurin also stimulates dopamine release from the central striatal neurons and basal ganglia.

Signaling
is_associated_with::PI3 kinase, is_associated_with::phosphodiesterase and is_associated_with::phospholipase D inhibition inhibits its pro-migration effects, but blocking PKC and tyrosine kinases has not been shown to have effect. Downstream to these ERK type MAP kinase and AKT are activated.