Rs10895068

rs10895068, also known as +331G/A, is a SNP in the progesterone receptor PGR gene.

A study of 1,664 postmenopausal breast cancer cases and 2,391 controls led to two conclusions. First, women with at least one rs10895068(A) allele had a 1.3x (CI: 1.04-1.65) increased risk of developing breast cancer. Second, such carriers were at 2.57x (CI: 1.64-4.02) increased risk for breast cancer if they were never postmenopausal hormone users.

2013 meta-analysis suggested association of weak effect with female reproductive (breast, endometrial and ovarian) cancer for A allele (A: OR = 1.063, 95% CI = 1.001-1.129; AA+AG: OR = 1.067, 95% CI = 1.002-1.136). A 2014 meta-analysis that looked only for association with ovarian cancer specifically found no significant association between rs10895068 and ovarian cancer - despite the study title claiming otherwise.

Progesterone receptor PROGINS and +331G/A polymorphisms confer susceptibility to ovarian cancer: a meta-analysis based on 17 studies.

Association of +331G/A PgR polymorphism with susceptibility to female reproductive cancer: evidence from a meta-analysis.