Glypican 1

Glypican-1 is a is_associated_with::protein that in humans is encoded by the GPC1 is_associated_with::gene.

Function
Cell surface heparan sulfate is_associated_with::proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the is_associated_with::glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation.

Interactions
Glypican 1 has been shown to interact with is_associated_with::SLIT2.

Clinical significance
This protein is involved in the misfolding of normal is_associated_with::prion proteins in the cell membrane to the infectious prion form.