Macrophage-capping protein

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a is_associated_with::protein that in humans is encoded by the CAPG is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::gelsolin/is_associated_with::villin family of is_associated_with::actin-regulatory proteins. The encoded protein reversibly blocks the barbed ends of is_associated_with::F-actin filaments in a is_associated_with::Ca2+ and is_associated_with::phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based is_associated_with::motility in non-muscle cells. Alternatively spliced is_associated_with::transcript variants have been observed, but have not been fully described.