Nuclear receptor coactivator 3

The nuclear receptor coactivator 3 also known as NCOA3 is a is_associated_with::protein that, in humans, is encoded by the NCOA3 is_associated_with::gene. NCOA3 is also frequently called 'amplified in breast 1' (AIB1), steroid receptor coactivator-3 (SRC-3), or thyroid hormone receptor activator molecule 1 (TRAM-1).

Function
NCOA3 is a transcriptional coactivator protein that contains several is_associated_with::nuclear receptor interacting domains and an intrinsic is_associated_with::histone acetyltransferase activity. NCOA3 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA3, in turn, acylates is_associated_with::histones, which makes downstream DNA more accessible to transcription. Hence, NCOA3 assists is_associated_with::nuclear receptors in the upregulation of gene expression.

Clinical significance
The ratio of is_associated_with::PAX2 to AIB-1 protein expression may be predictive of the effectiveness of is_associated_with::tamoxifen in is_associated_with::breast cancer treatment.

Interactions
Nuclear receptor coactivator 3 has been shown to interact with:


 * is_associated_with::Androgen receptor,
 * is_associated_with::CHUK and
 * is_associated_with::CREB-binding protein,
 * is_associated_with::DDX17,
 * is_associated_with::DDX5,
 * is_associated_with::Estrogen receptor alpha,
 * is_associated_with::Estrogen receptor beta,
 * is_associated_with::Glucocorticoid receptor,
 * is_associated_with::IKBKG,
 * is_associated_with::IKK2,
 * is_associated_with::Peroxisome proliferator-activated receptor gamma, and
 * is_associated_with::Retinoid X receptor alpha.