ATG5

Autophagy protein 5 is a is_associated_with::protein that in humans is encoded by the ATG5 is_associated_with::gene. It is an E3 is_associated_with::ubiquitin is_associated_with::ligase which is necessary for is_associated_with::autophagy due to its role in is_associated_with::autophagosome elongation. It is activated by is_associated_with::ATG7 and forms a complex with is_associated_with::ATG12 and is_associated_with::ATG16L1. This complex is necessary for LC3-1 conjugation to PE to form LC3-II.