ABCC6

Multidrug resistance-associated protein 6 (MRP6) also known as ATP-binding cassette sub-family C member 6 (ABCC6) and multi-specific organic anion transporter E (MOAT-E) is a is_associated_with::protein that in humans is encoded by the ABCC6 is_associated_with::gene. The protein encoded by the ABCC6 gene is a member of the superfamily of ATP-binding cassette (ABC) transporters.

ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in is_associated_with::multidrug resistance.

Pathology
Mutations in this protein cause is_associated_with::pseudoxanthoma elasticum (PXE). The most common mutations, R1141X and 23-29del, account for about 25% of the found mutations.

Premature is_associated_with::atherosclerosis is also associated with mutations in the ABCC6 gene, even in those without PXE.