TGF beta receptor 2

Transforming growth factor, beta receptor II (70/80kDa) is a is_associated_with::TGF beta receptor. TGFBR2 is its human is_associated_with::gene.

It is a is_associated_with::tumor suppressor gene.

Interactions
TGF beta receptor 2 has been shown to interact with is_associated_with::Cyclin B2, is_associated_with::TGF beta receptor 1, is_associated_with::Transforming growth factor, beta 3,    is_associated_with::AP2B1, is_associated_with::Endoglin, is_associated_with::Heat shock protein 90kDa alpha (cytosolic), member A1 and is_associated_with::STRAP.

Domain architecture
TGF beta receptor 2 consists of a is_associated_with::C-terminal is_associated_with::protein kinase domain and an is_associated_with::N-terminal ectodomain. The ectodomain consists of a compact fold containing nine beta-strands and a single helix stabilised by a network of six intra strand is_associated_with::disulphide bonds. The folding topology includes a central five-stranded antiparallel beta-sheet, eight-residues long at its centre, covered by a second layer consisting of two segments of two-stranded antiparallel is_associated_with::beta-sheets (beta1-beta4, beta3-beta9).