TSPAN32

Tetraspanin-32 is a is_associated_with::protein that in humans is encoded by the TSPAN32 is_associated_with::gene.

Function
This gene is described as a member of the is_associated_with::tetraspanin superfamily whose expression is confined to is_associated_with::hematopoietic tissues.

Clinical significance
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important is_associated_with::tumor suppressor gene region. Alterations in this region have been associated with the is_associated_with::Beckwith-Wiedemann syndrome, is_associated_with::Wilms tumor, is_associated_with::rhabdomyosarcoma, is_associated_with::adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function.