Retinoid X receptor gamma

Retinoic acid receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a is_associated_with::nuclear receptor that in humans is encoded by the RXRG is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of is_associated_with::retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions
Retinoid X receptor gamma has been shown to interact with is_associated_with::ITGB3BP.