Peroxiredoxin 1

Peroxiredoxin-1 is a is_associated_with::protein that in humans is encoded by the PRDX1 is_associated_with::gene.

Interactions
Peroxiredoxin 1 has been shown to interact with is_associated_with::PRDX4. A chemoproteomic approach has revealed that peroxiredoxin 1 is the main target of theonellasterone.

Clinical Significance
As enzymes that combat is_associated_with::oxidative stress, peroxiredoxins play an important role in health and disease. Peroxiredoxin 1 and peroxiredoxin 2 have been shown to be released by some cells when stimulated by LPS or TNF-alpha. The released peroxiredoxin can then act to produce inflammatory is_associated_with::cytokines. The levels of peroxiredoxin 1 are elevated in pancreatic cancer and it can potentially act as a marker for the diagnosis and prognosis of this disease. In some types of is_associated_with::cancer, peroxiredoxin 1 has been determined to act as a tumor suppressor and other studies show that peroxiredoxin 1 is overexpressed in certain human cancers. A recent study has found that peroxiredoxin 1 may play a role in is_associated_with::tumorigenesis by regulating the mTOR/p70S6K pathway in esophageal squamous cell carcinoma. The expression patterns of peroxiredoxin 1 along with peroxiredoxin 4 are involved in human lung cancer malignancy. It has also been shown that peroxiredoxin 1 may be an important player in the pathogenesis of acute respiratory distress syndrome because of its role in promoting inflammation.