TTRAP

TRAF and TNF receptor-associated protein is a is_associated_with::protein that in humans is encoded by the TTRAP is_associated_with::gene.

Function
This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors.

Interactions
TTRAP has been shown to interact with is_associated_with::ETS1, is_associated_with::TNFRSF1B and CD40.