CXCL3

Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small is_associated_with::cytokine belonging to the CXC is_associated_with::chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of is_associated_with::monocytes and mediates its effects on its target cell by interacting with a cell surface is_associated_with::chemokine receptor called CXCR2. More recently, it has been shown that Cxcl3 regulates cell autonomously the migration of the precursors of cerebellar granule neurons toward the internal layers of cerebellum, during the morphogenesis of is_associated_with::cerebellum. Moreover, if the expression of Cxcl3 is reduced in cerebellar granule neuron precursors, this highly enhances the frequency of the medulloblastoma, the tumor of cerebellum. In fact, the reduced expression of Cxcl3 forces the cerebellar granule neuron precursors to remain at the surface of the cerebellum, where they highly proliferate under the stimulus of is_associated_with::Sonic hedgehog, becoming target of transforming insults. Remarkably, the treatment with CXCL3 reduces the area of medulloblastoma lesions in a mouse model of medulloblastoma. Thus, CXCL3 is a potential target for medulloblastoma therapy. Cxcl3 is directly regulated transcriptionally by is_associated_with::BTG2

The gene for CXCL3 is located on is_associated_with::chromosome 4 in a cluster of other CXC chemokines.