HPN (gene)

Serine protease hepsin is an is_associated_with::enzyme that in humans is encoded by the HPN is_associated_with::gene.

Hepson contains a is_associated_with::peptidase S1 domain and an SRCR domain. The SRCR domain is located in the is_associated_with::extracellular part of the is_associated_with::protein, it is formed primarily by three elements of regular is_associated_with::secondary structure: a 12-residue is_associated_with::alpha helix, a twisted five-stranded antiparallel beta sheet, and a second, two-stranded, antiparallel sheet. The two is_associated_with::beta-sheets lie at roughly right angles to each other, with the is_associated_with::helix nestled between the two, adopting an SRCR fold. The exact function of this domain has not been identified, though it probably may serve to orient the is_associated_with::protease domain or place it in the vicinity of its substrate.