NOL1

Putative ribosomal RNA methyltransferase NOP2 is an is_associated_with::enzyme that in humans is encoded by the NOP2 is_associated_with::gene.

The is_associated_with::protein encoded by this gene is a nucleolar is_associated_with::antigen expressed in proliferating cells. It is not detectable in non-proliferating normal tissue but is detectable in many human tumors.

Overexpression of p120 leads to is_associated_with::malignant transformation of is_associated_with::3T3 cells while treatment with is_associated_with::antisense p120 is_associated_with::mRNA causes the transformed cells to revert to their original non-malignant is_associated_with::phenotype. The p120 protein displays a dramatic increase in expression at the is_associated_with::G1/S transition suggesting that p120 regulates the is_associated_with::cell cycle and nucleolar activity that is required for cell proliferation.

Interactions
NOL1 has been shown to interact with is_associated_with::MCRS1.