ARF6

ADP-ribosylation factor 6 (ARF6) is a member of the is_associated_with::ADP ribosylation factor family of is_associated_with::GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of is_associated_with::biological membranes and is_associated_with::transmembrane protein cargo. ARF6 has specifically been implicated in is_associated_with::endocytosis of is_associated_with::plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

Function
This gene encodes a member of the human ARF gene family, which is part of the RAS superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.

ARF6 can interact with βis_associated_with::arrestin upon receptor activation.

Interactions
Arf6 has been shown to interact with:
 * ARRB1,
 * is_associated_with::ARFIP2,
 * CHRM3
 * is_associated_with::EXOC5,
 * is_associated_with::KIAA0090, and
 * is_associated_with::Rac1.