Thyroglobulin domain

Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.

Human proteins containing this domain
CD74;     IGFBP-4;   IGFBP1;    IGFBP2;    IGFBP3;    IGFBP4;    IGFBP5;    IGFBP6; NID1;     NID2;      SMOC1;     SMOC2;     SPOCK1;    SPOCK2;    SPOCK3;    TACSTD1; TACSTD2;  TG;