Anterior cingulate cortex

The anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex, that resembles a "collar" form around the corpus callosum, the fibrous bundle that relays neural signals between the right and left cerebral hemispheres of the brain. It includes both the ventral and dorsal areas of the cingulate cortex, and appears to play a role in a wide variety of autonomic functions, such as regulating blood pressure and heart rate, as well as rational cognitive functions, such as reward anticipation, decision-making, empathy and emotion.



Anatomy
The anterior cingulate cortex can be divided anatomically based on cognitive (dorsal), and emotional (ventral) components. The dorsal part of the ACC is connected with the prefrontal cortex and parietal cortex as well as the motor system and the frontal eye fields making it a central station for processing top-down and bottom-up stimuli and assigning appropriate control to other areas in the brain. By contrast, the ventral part of the ACC is connected with amygdala, nucleus accumbens, hypothalamus, and anterior insula, and is involved in assessing the salience of emotion and motivational information. The ACC seems to be especially involved when effort is needed to carry out a task such as in early learning and problem-solving.

Tasks
A typical task that activates the ACC involves eliciting some form of conflict within the participant that can potentially result in an error. One such task is called the Eriksen flanker task and consists of an arrow pointing to the left or right, which is flanked by two distractor arrows creating either compatible (<<<<<) or incompatible (<<<>>) trials. Another very common conflict-inducing stimulus is the Stroop task (Pardo et al., 1990), which involves naming the color ink of words that are either congruent (RED written in red) or incongruent (RED written in blue). Conflict occurs because people’s reading abilities interfere with their attempt to correctly name the word’s ink color. A variation of this task is the Counting-Stroop, during which people count either neutral stimuli (‘dog’ presented four times) or interfering stimuli (‘three’ presented four times) by pressing a button. Another version of the Stroop task named the Emotional Counting Stroop is identical to the Counting Stroop test, except that it also uses segmented or repeated emotional words such as "murder" during the interference part of the task.

Functions
Many studies attribute functions such as error detection, anticipation of tasks, attention, motivation, and modulation of emotional responses to the ACC.

Error detection and conflict monitoring
The most basic form of ACC theory states that the ACC is involved with error detection. Evidence has been derived from studies involving a Stroop task. However, ACC is also active during correct response and this has been shown using a letter task, whereby participants had to respond to the letter X after an A was presented and ignore all other letter combinations with some letters being more competitive than others. They found that for more competitive stimuli ACC activation was greater.

A similar theory poses that the ACC’s primary function is the monitoring of conflict. In Eriksen flanker task, incompatible trials produce the most conflict and, the most activation by the ACC. Upon detection of a conflict, the ACC then provides cues to other areas in the brain to cope with the conflicting control systems.

Evidence for ACC as having an error detection function comes from observations of error-related negativity (ERN) uniquely generated within the ACC upon error occurrences. A distinction has been made between an ERP following incorrect responses (response ERN) and a signal after subjects receive feedback after erroneous responses (feedback ERN).
 * Evidence from electrical studies

No-one has clearly demonstrated that the ERN comes from the ACC. Related to this it is striking that patients with lateral PFC damage showed reduced ERNs.

Reinforcement learning ERN theory poses that there is a mismatch between actual response execution and appropriate response execution, which results in an ERN discharge. Furthermore, this theory predicts that, when the ACC receives conflicting input from control areas in the brain, it determines and allocates which area should be given control over the motor system. Varying levels of dopamine are believed to influence the optimization of this filter system by providing expectations about the outcomes of an event. The ERN then, serves as a beacon to highlight the violation of an expectation. Research on the occurrence of the feedback ERN shows evidence that this potential has larger amplitudes when violations of expectancy are large. In other words, if an event is not likely to happen the feedback ERN will be larger if no error is detected. Other studies have examined if the ERN is elicited by varying the cost of an error and the evaluation of a response.

In these trials, feedback is given about whether the participant has gained or lost money after a response. Amplitudes of ERN responses with small gains and small losses were similar. No ERN was elicited for any losses as opposed to an ERN for no wins, even though both outcomes are the same. The finding in this paradigm suggests that monitoring for wins and losses is based on the relative expected gains and losses. If you get a different outcome than expected, the ERN will be larger than for expected outcomes. ERN studies have also localized specific functions of the ACC.

The rostral ACC seems to be active after an error commission, indicating an error response function, whereas the dorsal ACC is active after both an error and feedback, suggesting a more evaluative function (for fMRI evidence, see also  ). This evaluation is emotional in nature and highlights the amount of distress associated with a certain error. Summarizing the evidence found by ERN studies it appears to be the case that ACC receives information about a stimulus, selects an appropriate response, monitors the action, and adapts behavior if there is a violation of expectancy.

Studies examining task performance related to error and conflict processes in patients with ACC damage, cast doubt on the necessity of this region for these functions. The error detection and conflict monitoring theories cannot explain some evidence obtained by electrical studies  that demonstrate the effects of giving feedback after responses because the theory describes the ACC as strictly monitoring conflict, not as having evaluative properties.
 * Evidence against error detection and conflict monitoring theory

It has been stated that "The cognitive consequences of anterior cingulate lesions remain rather equivocal, with a number of case reports of intact general neuropsychological and executive function in the presence of large anterior dorsal cingulate lesions. For an alternative view of anterior cingulate, see Rushworth's review (2007).

Reward-based learning theory
A more comprehensive and recent theory describes the ACC as a more active component and poses that it detects and monitors errors, evaluates the degree of the error, and then suggests an appropriate form of action to be implemented by the motor system. Earlier evidence from electrical studies indicate the ACC has an evaluative component, which is indeed confirmed by fMRI studies. The dorsal and rostral areas of the ACC both seem to be affected by rewards and losses associated with errors. During one study, participants received monetary rewards and losses for correct and incorrect responses respectively.

Largest activation in the dACC was shown during loss trials. This stimulus did not elicit any errors, and, thus, error detection and monitoring theories cannot fully explain why this ACC activation would occur. The dorsal part of the ACC seems to play a key role in reward-based decision-making and learning. The rostral part of the ACC, on the other hand, is believed to be more involved with affective responses to errors. In an interesting expansion of the previously described experiment, the effects of rewards and costs on ACC’s activation during error commission was examined. Participants performed a version of the Eriksen flanker task using a set of letters assigned to each response button instead of arrows.

Targets were flanked by either a congruent or an incongruent set of letters. Using an image of a thumb (up, down, or neutral), participants received feedback on how much money they gained or lost. The researchers found greater rostral ACC activation when participants lost money during the trials. The participants reported being frustrated when making mistakes. Because the ACC is intricately involved with error detection and affective responses, it may very well be that this area forms the bases of self-confidence. Taken together, these findings indicate that both the dorsal and rostral areas are involved in evaluating the extent of the error and optimizing subsequent responses. A study confirming this notion explored the functions of both the dorsal and rostral areas of the ACC involved using a saccade task.

Participants were shown a cue that indicated whether they had to make either a pro-saccade or an anti-saccade. An anti-saccade requires suppression of a distracting cue because the target appears in the opposite location causing the conflict. Results showed differing activation for the rostral and dorsal ACC areas. Early correct anti-saccade performance was associated with rostral activation. The dorsal area, on the other hand, was activated when errors were committed, but also for correct responses.

Whenever the dorsal area was active, fewer errors were committed providing more evidence that the ACC is involved with effortful performance. The second finding showed that, during error trials, the ACC activated later than for correct responses, clearly indicating a kind of evaluative function.

Role in consciousness
The ACC area in the brain is associated with many functions which are correlated with conscious experience. Greater ACC activation levels were present in more emotionally-aware female participants when shown short ‘emotional’ video clips. Better emotional awareness is associated with improved recognition of emotional cues or targets, which is reflected by ACC activation.

The idea of awareness being associated with the ACC has some evidence with it, in that it seems to be the case that, when subjects' responses are not congruent with actual responses, a larger ERN is produced.

One study found an ERN even when subjects were not aware of their error. Awareness may not be necessary to elicit an ERN, but it could influence the effect of the amplitude of the feedback ERN. Relating back to the reward-based learning theory, awareness could modulate expectancy violations. Increased awareness could result in decreased violations of expectancies and decreased awareness could achieve the opposite effect. Further research is needed to completely understand the effects of awareness on ACC activation.

Role in registering pain
The ACC registers physical pain as shown in functional MRI studies which showed an increase in signal intensity, typically in the posterior part of area 24 of the ACC, that was correlated with pain intensity. When this pain-related activation was accompanied by attention-demanding cognitive tasks (verbal fluency), the attention-demanding tasks increased signal intensity in a region of the ACC anterior and/or superior to the pain-related activation region.

Role in political orientation
A widely publicized study by the University College London, demonstrated a correlation between larger development of the ACC and left political orientation versus larger development of the amygdala in right political orientation.

Pathology
Stimulation of the anterior cingulate (also known as Area 25) with low dosages of electric current in neurosurgical studies has been shown to improve depression in a portion of test subjects.

Studying the effects of damage to the ACC provides insights into the type of functions it serves in the intact brain. Behavior that is associated with lesions in the ACC includes: inability to detect errors, severe difficulty with resolving stimulus conflict in a Stroop task, emotional instability, inattention, and akinetic mutism. There is evidence that damage to ACC is present in patients with schizophrenia, where studies have shown patients have difficulty in dealing with conflicting spatial locations in a Stroop-like task and having abnormal ERNs. Participants with ADHD were found to have reduced activation in the dorsal area of the ACC when performing the Stroop task. Together these findings corroborate results from imaging and electrical studies about the variety of functions attributed to the ACC.

There is evidence that this area may have a role in obsessive–compulsive disorder due to the fact that what appears to be an unnaturally low level of glutamate activity in this region has been observed in patients with the disorder, in strange contrast to many other brain regions that are thought to have excessive glutamate activity in OCD. Recent SDM meta-analyses of voxel-based morphometry studies comparing people with OCD and healthy controls has found people with OCD to have increased grey matter volumes in bilateral lenticular nuclei, extending to the caudate nuclei, while decreased grey matter volumes in bilateral dorsal medial frontal/anterior cingulate cortex. These findings contrast with those in people with other anxiety disorders, who evince decreased (rather than increased) grey matter volumes in bilateral lenticular / caudate nuclei, while also decreased grey matter volumes in bilateral dorsal medial frontal / anterior cingulate gyri.

Helen S. Mayberg and two collaborators described how they cured 4 of 6 depressed people — individuals virtually catatonic with depression despite years of talk therapy, drugs, even shock therapy — with pacemakerlike electrodes in area 25. A decade earlier, Mayberg had identified area 25 as a key conduit of neural traffic between the "thinking" frontal cortex and the phylogenetically older central limbic region that gives rise to emotion. She subsequently found that area 25 appeared overactive in these depressed people — "like a gate left open," as she puts it — allowing negative emotions to overwhelm thinking and mood. Inserting the electrodes closed this gate and rapidly alleviated the depression of two-thirds of the trial's patients.

It has also been suggested to have possible links with Social Anxiety, along with the amygdala part of the brain, but is still in the early stages of research.

A 2008 study of brain MRIs taken on adults that had previously participated in the Cincinnati Lead Study demonstrated that people that had suffered higher levels of lead poisoning as children had decreased brain size as adults. This effect was most pronounced in the ACC (Cecil et al., 2008) and is thought to relate to the cognitive and behavioral deficits of affected individuals.