Cyclin-dependent kinase inhibitor 1C

Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is is_associated_with::protein which in humans is encoded by the CDKN1C imprinted is_associated_with::gene.

Function
Cyclin-dependent kinase inhibitor 1C is a tight-binding inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations of CDKN1C are implicated in sporadic cancers and is_associated_with::Beckwith-Wiedemann syndrome suggesting that it is a tumor suppressor candidate.

CDKN1C is a is_associated_with::tumor suppressor human is_associated_with::gene on is_associated_with::chromosome 11 (11p15) and belongs to the cip/kip gene family. It encodes a is_associated_with::cell cycle inhibitor that binds to G1 is_associated_with::cyclin-CDK complexes. Thus p57KIP2 causes arrest of the cell cycle in is_associated_with::G1 phase.

Clinical significance
A is_associated_with::mutation of this gene may lead to loss of control over the cell cycle leading to uncontrolled cellular proliferation. p57KIP2 has been associated with is_associated_with::Beckwith-Wiedemann syndrome (BWS) which is characterized by increased risk of tumor formation in childhood. Loss-of-function mutations in this gene have also been shown associated to the is_associated_with::IMAGe syndrome (Intrauterine growth restriction, Metaphyseal dysplasia, Adrenal hypoplasia congenita, and Genital anomalies).

Interactions
Cyclin-dependent kinase inhibitor 1C has been shown to interact with is_associated_with::MyoD, is_associated_with::MYBL2, is_associated_with::PCNA and is_associated_with::LIMK1.