F2RL3

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a is_associated_with::protein that in humans is encoded by the F2RL3 is_associated_with::gene.

Function
Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the is_associated_with::protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular is_associated_with::amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by is_associated_with::thrombin and is_associated_with::trypsin.