Rs7528684

rs7528684 has been reported to be associated with rheumatoid arthritis in a Caucasian population, following reports of a similar association in a Japanese population.

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 0.95 (CI 0.83-1.08), and for homozygotes, 2.30 (CI 1.64-3.23).

In a study of 645 Caucasians from Southern Spain with multiple sclerosis, the rs7528684(G) allele (in dbSNP orientation) was found to be somewhat protective (per allele odds ratio 0.81, CI: 0.70-0.94, p=0.007).

In another report, a summary indicates the following regarding disease and odds ratio (OR)for rs7528684:
 * for rheumatoid arthritis: OR = 2.15 (CI = 1.58&#226;&#8364;&#8220;2.93), from 830 cases and 658 controls;
 * for SLE: OR = 1.49 (CI = 1.16&#226;&#8364;&#8220;1.92), from 564 cases;
 * for Graves' disease : OR = 1.79 (CI = 1.34&#226;&#8364;&#8220;2.39), from 351 cases;
 * for Hashimoto thyroiditis: OR = 1.62 (CI = 1.07&#226;&#8364;&#8220;2.47), from 158 cases.

rs7528684 rs3792876 and rs2268277 failed to showed a statistically significant association with rheumatoid arthritis

rs7528684, rs11264799, rs945635 and rs3761959 were not associated with systemic lupus erythematosus (SLE) in a study of 248 Chinese Han patients.