Rs2230500

A common SNP only in Asian populations, this SNP (also known as 1425G/A) and a close neighbor also in the PRKCH gene, rs3783799, have been associated with higher risk for subcortical silent brain infarction, a common form of stroke.

In one study of ~1100 Japanese stroke patients, the odds ratio for carriers of the rs2230500(A) risk allele was reported as 1.40 (CI: 1.23-1.59, p=5x10e-7).

A subsequent study reported the odds ratio for carriers of the (A) allele as 1.27 (CI: 1.09-1.48, p=0.0026) compared to individuals homozygous for rs2230500(G), based on studies of ~300 Japanese patients.

rs2230500 (V374I) and rs9943582 were significantly associated with stroke

Genetic association between the PRKCH gene encoding protein kinase Ceta isozyme and rheumatoid arthritis in the Japanese population.

Association of PRKCH gene with lacunar infarction in a local Chinese Han population.

Genome-wide association study for ischemic stroke based on the hisayama study.


 * is_associated_with_disease::Rheumatoid arthritis
 * is_associated_with_disease::Atrophic gastritis
 * is_associated_with_disease::Brain infarction