Sarcolipin

Sarcolipin is a is_associated_with::protein that in humans is encoded by the SLN is_associated_with::gene.

Function
is_associated_with::Sarcoplasmic reticulum Ca2+-is_associated_with::ATPases are transmembrane proteins that catalyze the ATP-dependent transport of Ca2+ from the cytosol into the lumen of the sarcoplasmic reticulum in muscle cells. This gene encodes a small proteolipid that regulates several sarcoplasmic reticulum Ca2+-ATPases. The transmembrane protein interacts with Ca2+-ATPases and reduces the accumulation of Ca2+ in the sarcoplasmic reticulum without affecting the rate of ATP hydrolysis.

Ablation of sarcolipin increases atrial Ca2+ transient amplitudes and enhanced atrial is_associated_with::contractility. Furthermore, atria from sarcolipin-null mice have blunted response to isoproterenol stimulation, implicating sarcolipin as a mediator of beta-adrenergic responses in atria. Recently it has been shown that SLN is an important mediator of muscle based thermogenesis and loss of sarcolipin predisposes mice to diet-induced obesity thus suggesting its role in energy metabolism and regulation of weight gain

Interactions
SLN (gene) has been shown to interact with PLN and is_associated_with::ATP2A1.