Rs1143634

rs1143634, also known as +3954, is a SNP in the IL-1 beta IL1B gene.

A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1143634(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers.

rs1143634 increases susceptibility to Alopecia Areata 2.67 times for heterozygotes (CT) and 1.13 times for homozygotes (TT)

rs1143634 increases susceptibility to Alzheimer's disease 2.33 times for homozygotes (TT)

rs1143634 increases susceptibility to Cervical lesions, low-grade squamous intraepithelial lesions 4.29 times for heterozygotes (CT) and 3.57 times for homozygotes (TT)

rs1143634 increases susceptibility to Duodenal ulcer 1.14 times for carriers of the T allele

rs1143634 increases susceptibility to Inflammatory bowel disease 7.32 times for carriers of the T allele

rs1143634 increases susceptibility to Joint destruction in Rheumatoid Arthritis 1.70 times for carriers of the T allele

rs1143634 increases susceptibility to Myasthenia gravis 1.29 times for heterozygotes (CT) and 4.63 times for homozygotes (TT)

rs1143634 increases susceptibility to Nephropathy in Type I Diabetes 2.03 times for heterozygotes (CT) and 5.01 times for homozygotes (TT)

rs1143634 increases susceptibility to Peptic ulcer disease 1.06 times for carriers of the T allele

rs1143634 increases susceptibility to Periodontitis 2.85 times for heterozygotes (CT) and 4.89 times for homozygotes (TT)

rs1143634 increases susceptibility to Periodontitis 3.33 times for carriers of the T allele

rs1143634 increases susceptibility to Survival in pancreatic cancer for carriers of the T allele

rs1143634 increases susceptibility to Ulcerative colitis 1.89 times for heterozygotes (CT) and 1.59 times for homozygotes (TT)