Rs7538876

2 SNPs located in different regions of chromosome 1 are likely to be associated with increased risk for basal cell carcinoma (BCC), the most common form of skin cancer.


 * each A at rs7538876 yields a 1.28x increased risk of developing BCC (p = 4.4 x 10e-12)
 * each G at rs801114 also yields a 1.28x increased odds of developing BCC (p = 5.9 x 10e-12)
 * 2.68x increased risk of BCC for homozygous carriers of both SNPs

This study was based on an analysis of ~2,000 Icelandic and Eastern European skin cancer patients (as well as a large number of controls). The authors estimate that approximately 1.6% of all individuals of European ancestry are homozygous for both risk alleles, and thus that percentage of the population is at 2.68x higher risk for BCC compared to individuals who are rs7538876(G;G) and rs801114(T;T).

See also:23andMe blog