SLC5A1

Sodium/glucose cotransporter 1 is a is_associated_with::protein that in humans is encoded by the SLC5A1 is_associated_with::gene.

Function
is_associated_with::Glucose transporters are integral is_associated_with::membrane proteins that mediate the transport of is_associated_with::glucose and structurally related substances across cellular membranes. Two families of glucose transporter have been identified: the is_associated_with::facilitated diffusion glucose transporter family (GLUT family), also known as 'is_associated_with::uniporters,' and the is_associated_with::sodium-dependent glucose transporter family (SGLT family), also known as 'is_associated_with::cotransporters' or 'is_associated_with::symporters' (Wright et al., 1994). The SLC5A1 gene encodes a protein that is involved in the active transport of glucose and is_associated_with::galactose into eukaryotic and some prokaryotic cells. [supplied by OMIM]

Cloning
Co-transport proteins of mammalian cell membranes had eluded efforts of purification with classical biochemical methods until the late 1980s. These proteins had proven difficult to isolate because they contain hydrophilic and hydrophobic sequences and exist in membranes only in very low abundance (<0.2% of membrane proteins). The rabbit form of SGLT1 is the first mammalian co-transport protein ever to be cloned and sequenced, and this scientific break-through was reported in 1987. To circumvent the difficulties with traditional isolation methods, Swiss-born biochemist Matthias Hediger and his collaborators at is_associated_with::UCLA used a novel technique of is_associated_with::expression cloning. They size-fractionated large amounts of rabbit intestinal mRNA with a preparative gel electrophoresis device developed by Hediger. These size fractions were then sequentially injected into is_associated_with::Xenopus oocytes to ultimately find the RNA species that induced the expression of sodium-glucose cotransport.

Interactions
SLC5A1 has been shown to interact with is_associated_with::PAWR.