Pyroglutamylated RFamide peptide receptor

Pyroglutamylated RFamide peptide receptor also known as orexigenic neuropeptide QRFP receptor or G-protein coupled receptor 103 (GPR103) is a is_associated_with::protein that in humans is encoded by the QRFPR is_associated_with::gene.

Function
is_associated_with::G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric is_associated_with::G proteins.

A 26-amino acid RF-amide peptide, P518 functions as a high-affinity ligand of GPR103. Both GPR103 and P518 precursor mRNA exhibited highest expression in brain. The 43-amino acid is_associated_with::QRFP peptide, a longer form of the P518 peptide is necessary to exhibit full agonistic activity with GPR103. Intravenous administration QRFP caused release of is_associated_with::aldosterone, suggesting that QRFP and GPR103 regulate is_associated_with::adrenal function.