Vohwinkel syndrome

Vohwinkel syndome (also known as "Keratoderma hereditaria mutilans," "Keratoma hereditaria mutilans," "Mutilating keratoderma of Vohwinkel", "Mutilating palmoplantar keratoderma" ) is a diffuse autosomal dominant keratoderma with onset in early infancy characterized by a honeycombed keratoderma involving the palmoplantar surfaces. Mild to moderate sensorineural hearing loss is often associated.

It has been associated with GJB2.

It was characterized in 1929.