NFE2L3

Nuclear factor erythroid 2-related factor 3, also known as NF-E2-related factor 3 or Nrf3, is a is_associated_with::transcription factor that in humans is encoded by the NFE2L3 is_associated_with::gene.

Function
This gene encodes a member of the cap 'n' collar basic-region leucine zipper (bZIP) family of transcription factors. The encoded protein is_associated_with::heterodimerizes with small musculoaponeurotic fibrosarcoma factors (MAF) to bind antioxidant is_associated_with::response elements in target genes. This protein is a membrane bound is_associated_with::glycoprotein that is targeted to the is_associated_with::endoplasmic reticulum and the is_associated_with::nuclear envelope.