Bromodomain and WD repeat-containing protein 3

Bromodomain and WD repeat-containing protein 3 is a is_associated_with::protein that in humans is encoded by the BRWD3 is_associated_with::gene.

Function
The protein encoded by this gene contains a is_associated_with::bromodomain and several is_associated_with::WD repeats. It is thought to have a is_associated_with::chromatin-modifying function, and may thus play a role in transcription.

Clinical significance
Mutations in this gene can cause mental retardation or permanent paralysis X-linked type 93, which is also referred to as mental retardation X-linked with is_associated_with::macrocephaly. This gene is also associated with translocations in patients with is_associated_with::B-cell chronic lymphocytic leukemia.