Endothelin 1

Endothelin 1, also known as preproendothelin-1 (PPET1), is a is_associated_with::protein that in humans is encoded by the EDN1 is_associated_with::gene. The protein encoded by this gene is proteolytically processed to release a secreted peptide termed endothelin 1. This peptide is a potent is_associated_with::vasoconstrictor and is produced by vascular is_associated_with::endothelial cells. Endothelin 1 is one of three is_associated_with::isoforms of human is_associated_with::endothelin (ET-1).

Preproendothelin is precursor of the peptide ET-1. is_associated_with::Endothelial cells convert preproendothelin to proendothelin and subsequently to mature endothelin, which the cells release.

Endothelin-1 receptor antagonists (is_associated_with::Bosentan) are used in the treatment of is_associated_with::pulmonary hypertension. Inhibition of these receptors prevents pulmonary vasculature constriction and thus decreases pulmonary vascular resistance.