UBQLN1

Ubiquilin-1 is a is_associated_with::protein that in humans is encoded by the UBQLN1 is_associated_with::gene. Ubiquilins contain a N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both is_associated_with::proteasomes and ubiquitin is_associated_with::ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to effect in vivo protein degradation.

Possible Role In Preventing Alzheimers Disease
Ubiquilin has also been shown to modulate accumulation of presenilin proteins, and is found in lesions associated with is_associated_with::Alzheimer's and is_associated_with::Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.

Higher levels of ubiquilin-1 in the brain decreased malformation of the APP molecule which plays a key role in triggering Alzheimers disease. Conversely, lower levels of ubiquilin-1 in the brain were associated with increased malformation of APP.

Similarity to Other Proteins
Human UBQLN1 shares a high degree of similarity with related ubiquilins including is_associated_with::UBQLN2 and is_associated_with::UBQLN4.

Interactions
UBQLN1 has been shown to interact with


 * is_associated_with::HERPUD1,
 * MTOR,
 * is_associated_with::P4HB,
 * is_associated_with::PSEN1
 * is_associated_with::PSEN2, and
 * is_associated_with::UBE3A.
 * is_associated_with::TMCO6,