POM121

Nuclear envelope pore membrane protein POM 121 is a is_associated_with::protein that in humans is encoded by the POM121 is_associated_with::gene. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.

Function
The is_associated_with::nuclear envelope creates distinct nuclear and is_associated_with::cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by is_associated_with::nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the is_associated_with::nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an is_associated_with::integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope.

Antibodies against this protein can be used to identify the nuclear envelope in is_associated_with::immunofluorescence experiments.