Glycine receptor, alpha 1

Glycine receptor subunit alpha-1 is a is_associated_with::protein that in humans is encoded by the GLRA1 is_associated_with::gene.

Function
The inhibitory is_associated_with::glycine receptor mediates is_associated_with::postsynaptic inhibition in the spinal cord and other regions of the central nervous system. It is a pentameric receptor composed of alpha and beta subunits. The is_associated_with::GLRB gene encodes the beta subunit of the receptor.

Clinical signficance
Mutations in the gene have been associated with is_associated_with::hyperekplexia, a neurologic syndrome associated with an exaggerated startle reaction.