NLRX1

NLRX1 or NLR family member X1, short for nucleotide-binding oligomerization domain, leucine rich repeat containing X1, is an is_associated_with::intracellular protein that plays a role in the is_associated_with::immune system. It is also known as NOD-like receptor X1, NLR family, X1, NOD5, NOD9, and CLR11.3, and is a member of the is_associated_with::NOD-like receptor family of is_associated_with::pattern recognition receptors. NLRX1 was proposed to affect innate immunity to is_associated_with::viruses by interfering with the mitochondrial antiviral signaling protein (MAVS)/retinoic-acid-inducible gene I (is_associated_with::RIG-I) is_associated_with::mitochondrial antiviral pathway., although this was recently questioned.

NLRX1 has a unique protein structure composed of 3 is_associated_with::protein domains: an N-terminal effector domain containing a mitochondrion localization signal; a central is_associated_with::NACHT domain; a C-terminal is_associated_with::leucine-rich repeat (LRR) domain.

In humans, the NLRX1 protein is encoded by the NLRX1 is_associated_with::gene.