NRG4

Neuregulin 4 also known as NRG4 is a member of the is_associated_with::neuregulin is_associated_with::protein family which in humans is encoded by the NRG4 is_associated_with::gene.

Function
The neuregulins, including NRG4, activate type-1 growth factor receptors (EGFR) to initiating cell-to-cell signaling through tyrosine phosphorylation.

Clinical significance
Loss of expression of NRG4 is frequently seen in advanced is_associated_with::bladder cancer while increased NRG4 expression correlates to better survival.