ATG12

Autophagy-related protein 12 is a is_associated_with::protein that in humans is encoded by the ATG12 is_associated_with::gene.

is_associated_with::Autophagy requires the covalent attachment of the protein Atg12 to is_associated_with::ATG5 through a is_associated_with::ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of is_associated_with::ATG8 to the lipid is_associated_with::phosphatidylethanolamine.

Atg12 was found to be involved in is_associated_with::apoptosis. This protein promotes apoptosis through an interaction with anti-apoptotic members of the is_associated_with::Bcl-2 family.