Phosphoglycerate dehydrogenase

In is_associated_with::enzymology, a D-3-phosphoglycerate dehydrogenase is an is_associated_with::enzyme that catalyzes the is_associated_with::chemical reactions


 * 3-phospho-D-glycerate + NAD+ $$\rightleftharpoons$$ 3-phosphonooxypyruvate + NADH + H+
 * 2-hydroxyglutarate + NAD+ $$\rightleftharpoons$$ 2-oxoglutarate + NADH + H+

Thus, in the first case, the two substrates of this enzyme are is_associated_with::3-phospho-D-glycerate and NAD+, whereas its 3 products are is_associated_with::3-phosphohydroxypyruvate, NADH, and H+; in the second case, the two substrates of this enzyme are is_associated_with::2-hydroxyglutarate and NAD+, whereas its 3 products are is_associated_with::2-oxoglutarate, NADH, and H+.

This enzyme belongs to the family of is_associated_with::oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor.

In humans, this enzyme is encoded by the PHGDH is_associated_with::gene.

Certain breast cancers are dependent on the overexpression of PHGDH.

Clinical aspect
Homozygous or compound heterozygous mutations in PHGDH cause is_associated_with::Neu-Laxova syndrome and Phosphoglycerate dehydrogenase deficiency.