Rs145999145

rs145999145, also known as Val232Met is a SNP in the phospholipase D family, member 3 PLD3 gene on chromosome 19. The rs145999145(G) allele encodes the Val; the (A) allele the Met.

A relatively rare variant in this SNP has been linked to a doubling of risk for Alzheimer's disease based on seven independent case-control series with a total of more than 11,000 cases and controls of European descent. Other rare variants in the PLD3 gene may also influence disease risk.