CRMP1

Collapsin response mediator protein 1, encoded by the CRMP1 gene, is a human is_associated_with::protein of the CRMP family.

This gene encodes a member of a family of is_associated_with::cytosolic is_associated_with::phosphoproteins expressed exclusively in the is_associated_with::nervous system. The encoded protein is thought to be a part of the is_associated_with::semaphorin signal transduction pathway implicated in semaphorin-induced is_associated_with::growth cone collapse during is_associated_with::neural development. is_associated_with::Alternative splicing results in multiple transcript variants.

CRMP1 mediates is_associated_with::reelin signaling in cortical neuronal migration. Mice deficient in CRMP1 exhibit impaired is_associated_with::long-term potentiation and impaired spatial is_associated_with::learning and is_associated_with::memory.

CRMP1 gene overlaps with another gene called EVC.

Interactions
CRMP1 has been shown to interact with is_associated_with::DPYSL2.