SUPV3L1

ATP-dependent RNA helicase SUPV3L1, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the SUPV3L1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SUPV3L1 function. A conditional is_associated_with::knockout mouse line, called Supv3l1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and three significant is_associated_with::phenotypes were reported. All is_associated_with::homozygous is_associated_with::mutant animals died prior to birth, and therefore none were observed at is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant mice and is_associated_with::radiography showed female animals had defects in their is_associated_with::transverse processes.