Rs3851179

rs3851179 is a SNP upstream of the PICALM gene.

A study of over 5,000 Alzheimer's disease patients (and over 10,000 controls) found a slight protective effect of the (A) allele of this SNP. rs3851179(A) carriers had a slightly decreased risk for Alzheimer's disease, with an odds ratio of 0.85 (CI: 0.8-0.9, p=1.9x10e-8).

The association of this SNP and late-onset Alzheimer's disease was replicated over a total of another 1829 cases (and 2576 controls).