FZD6

Frizzled-6 is a is_associated_with::protein that in humans is encoded by the FZD6 is_associated_with::gene.

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for WNT signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other FZD family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. The FZD6 protein is believed to be the receptor for the WNT4 ligand.

Interactions
FZD6 has been shown to interact with is_associated_with::Secreted frizzled-related protein 1.

Model organisms
is_associated_with::Model organisms have been used in the study of FXYD3 function. In 2004, researchers at the Howard Hughes Medical Institute showed that FZD6 controls hair patterning in mice, and its human is_associated_with::homologue is understood to play a part in the formation of is_associated_with::hair whorls and is_associated_with::cowlicks. A conditional is_associated_with::knockout mouse line called Fxyd3tm1a(KOMP)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

''