U2 small nuclear RNA auxiliary factor 1

Splicing factor U2AF 35 kDa subunit is a is_associated_with::protein that in humans is encoded by the U2AF1 is_associated_with::gene.

Function
This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions
U2 small nuclear RNA auxiliary factor 1 has been shown to interact with:
 * is_associated_with::ASF/SF2,
 * is_associated_with::NXF1,
 * is_associated_with::RP9,
 * is_associated_with::SMNDC1,
 * is_associated_with::U2AF2,  and
 * is_associated_with::ZRANB2.