PVT1

Pvt1 oncogene (non-protein coding), also known as PVT1, is a is_associated_with::long non-coding RNA is_associated_with::gene. In is_associated_with::mice, this gene was identified as a breakpoint site in is_associated_with::chromosome 6;15 translocations. These translocations are associated with murine is_associated_with::plasmacytomas. The equivalent translocation in humans is t(2;8), which is associated with a rare variant of is_associated_with::Burkitt's lymphoma. In is_associated_with::rats, this breakpoint was shown to be a common site of proviral integration in retrovirally induced T lymphomas. Transcription of PVT1 is regulated by is_associated_with::Myc.