NBPF16

Neuroblastoma Breakpoint Family, Member 16, also known as NBPF16, is a is_associated_with::protein which in humans is encoded by the NBPF16 is_associated_with::gene. The gene is 18762 bp long, with is_associated_with::mRNA that is 3837 bp long. The gene is located on chromosome 1q21.1. Its sub-cellular location is predicted to be in the nucleus and is_associated_with::cytoplasm. It contains what is known as the NBPF repeat, which is a two exon stretch of sequence that is characteristic of all 21 members of the NBPF gene family. The repeat is considered the ancestral exons, and the NBPF family has been linked to primate evolution.

Function
The function of NBPF16 is not fully understood. It is a member of the NBPF family of proteins, which have been linked to possible roles in is_associated_with::oncogenesis and is_associated_with::tumor suppressor genes.

Protein
The protein is composed of 670 is_associated_with::amino acids. The gene contains five domains of unknown function, called DUF1220. DUF1220 domains are found in all members of the NBPF gene family, although the number differs between each member. Repetitive structure with high intergenic and intragenic sequence conservation, both in coding and noncoding regions. Makes it possible for homologous recombination to occur easily between different alleles. The repetitiveness of it, and the other members of the NBPF gene family is thought to have arisen from segmental duplications on chromosome 1.

Predicted properties
Properties of NBPF16 that were predicted using is_associated_with::Bioinformatics tools:
 * Molecular Weight: 76 kD
 * is_associated_with::Isoelectric point: 4.43
 * Post-translational modification: None predicted.
 * No predicted Signal Peptide or signal peptide cleavage site.
 * No interacting proteins or binding partners.

Expression
There is little to no expression data available for the gene, but most indications point to it being ubiquitously expressed throughout the body.

Orthologs
There exists no great is_associated_with::orthologs outside of primates. These orthologs were gathered from BLAT. and BLAST searches

Paralogs
Due to there being 21 other members of the NBPF gene family, there are 21 is_associated_with::paralogs of NBPF16. They all show high conservation and repetitive structures.