SAP18

Histone deacetylase complex subunit SAP18 is an is_associated_with::enzyme that in humans is encoded by the SAP18 is_associated_with::gene.

Function
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. Additionally, SAP18s splice variants are implicated in apoptotic cycles.

Interactions
SAP18 has been shown to interact with
 * is_associated_with::POLE2, and
 * is_associated_with::RGS10.