Rs4704397

A study of over 9,000+ individuals indicates that each copy of rs4704397(A) is associated with an increase of 0.13 muIU/ml in serum TSH (thyroid-stimulating hormone).

A separate study of 970 pregnant women at 28 weeks of gestation found that serum TSH was highest for rs4704397(A;A) individuals (median, 2.16, 1.84, and 1.73 mIU/liter for AA, AG, and GG genotypes, respectively; p=0.0004), and more women with the (A;A) genotype had TSH concentrations above 4.21 mIU/liter, the upper limit of the reference range, compared with the (A;G) and (G;G) genotypes (9.6 vs. 3.5%, respectively; p=0.004). However, maternal PDE8B genotype was not associated with offspring birthweight or gestational age at delivery.


 * is_associated_with_disease::Myocardial infarction
 * is_associated_with_disease::Thyroid cancer
 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Hypothyroidism