ACACA

Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an is_associated_with::enzyme that in humans is encoded by the ACACA is_associated_with::gene.

Function
is_associated_with::Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a is_associated_with::biotin-containing enzyme which catalyzes the is_associated_with::carboxylation of is_associated_with::acetyl-CoA to is_associated_with::malonyl-CoA, the rate-limiting step in is_associated_with::fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.