Rs3095870

rs3095870 is a SNP in the promoter region of the NKX2.5 gene; it is also known as -1192C>T.

rs3095870 has been linked to increased risk for systemic lupus erythematosus (SLE) in two independent Japanese case-control samples (p=0.0037 with odds ratio of 1.74, CI:1.19-2.55). Individuals with risk genotypes of both rs3748079 and rs3095870, in the ITPR3 and NKX2.5 genes, respectively, have even high risk for SLE (odds ratio 5.77, CI: 3.17-10.1).

Note that the orientation of this SNP as published is reversed compared to the dbSNP entry.


 * is_associated_with_disease::Systemic lupus erythematosus