NOX4

NADPH oxidase 4 is an is_associated_with::enzyme that in humans is encoded by the NOX4 is_associated_with::gene, and is a member of the NOX family of is_associated_with::NADPH oxidases.

Function
Oxygen sensing is essential for is_associated_with::homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of is_associated_with::reactive oxygen species (ROS) in is_associated_with::neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of is_associated_with::erythropoietin in the is_associated_with::renal cortex. Nox4 protects the is_associated_with::vasculature against inflammatory stress. Nox-dependent reactive oxygen species modulation by amino endoperoxides can induce apoptosis in high Nox4-expressing cancer cells.