Rs1121980

rs1121980, a SNP in the FTO gene, showed the strongest association of several SNPs in the region with early onset obesity in a study of ~1,000 Caucasians.

The odds ratio for the rs1121980(T) risk allele was 1.66 (CI: 1.37&#226;&#8364;&#8220;2.01); and the odds ratios for heterozygotes and homozygotes (rs1121980(T;T)) were estimated (with a correct p<0.0001) at 1.67 (CI: 1.22&#226;&#8364;&#8220;2.27) and 2.76 (CI: 1.88&#226;&#8364;&#8220;4.03), respectively.

Note that although rs1121980 showed the strongest association, it is in a block in the FTO gene of at least 5 other SNPs that are in linkage disequilibrium (r2>=0.88 for all). The other 5 SNPs are:
 * rs9939973
 * rs7193144
 * rs9940128
 * rs8050136
 * rs9939609

This SNP is also associated with (severe) obesity in a study of 927 Japanese patients.

obesity and type-2 diabetes
 * rs1121980
 * rs7498665
 * rs4752856
 * rs17782313
 * rs2815752
 * rs10938397