Interleukin 20

Interleukin 20 is a is_associated_with::protein that in humans is encoded by the IL20 is_associated_with::gene.

Function
The protein encoded by this gene is a cytokine structurally related to is_associated_with::interleukin 10 (IL-10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (is_associated_with::STAT3) in is_associated_with::keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in is_associated_with::psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis.

Interleukin-20 (IL-20) is a protein belonging to the IL-10 family of is_associated_with::cytokines. IL-20 is produced by activated is_associated_with::keratinocytes and is_associated_with::monocytes and transmits an intracellular signal through two distinct cell-surface receptor complexes on keratinocytes and other is_associated_with::epithelial cells. IL-20 regulates proliferation and differentiation of keratinocytes during inflammation, particularly inflammation associated with the skin. In addition, IL-20 also causes cell expansion of multipotential is_associated_with::hematopoietic is_associated_with::progenitor cells.

Anti IL-20
Anti-IL-20 monoclonal antibodies have been researched as clinical candidates for the treatment or prevention of psoriasis, rheumatoid arthritis, atherosclerosis, and stroke.