NFKBIE

Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon, also known as NFKBIE, is a is_associated_with::protein which in humans is encoded by the NFKBIE is_associated_with::gene.

Function
NFKBIE protein expression is up-regulated following is_associated_with::NF-κB activation and during is_associated_with::myelopoiesis. NFKBIE is able to inhibit NF-κB-directed is_associated_with::transactivation via cytoplasmic retention of is_associated_with::REL proteins.

is_associated_with::NFKB1 or is_associated_with::NFKB2 is bound to is_associated_with::REL, is_associated_with::RELA, or is_associated_with::RELB to form the NF-κB is_associated_with::transcription factor complex. The NF-κB complex is inhibited by I-kappa-B proteins (is_associated_with::NFKBIA or is_associated_with::NFKBIB), which inactivate NF-kappa-B by trapping it in the is_associated_with::cytoplasm. is_associated_with::Phosphorylation of serine residues on the I-kappa-B proteins by kinases (is_associated_with::IKBKA, or is_associated_with::IKBKB) marks them for destruction via the is_associated_with::ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NF-κB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine). For some genes, activation requires NF-κB interaction with other transcription factors, such as STAT (see is_associated_with::STAT6), AP-1 (JUN), and NFAT (see is_associated_with::NFATC1).

Interactions
NFKBIE has been shown to interact with is_associated_with::NFKB2, is_associated_with::RELA, is_associated_with::NFKB1 and is_associated_with::REL.