SMC1A

Structural maintenance of chromosomes protein 1A is a is_associated_with::protein that in humans is encoded by the SMC1A is_associated_with::gene.

Function
Proper cohesion of is_associated_with::sister chromatids is a prerequisite for the correct segregation of is_associated_with::chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either is_associated_with::SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with is_associated_with::BRCA1 and is is_associated_with::phosphorylated by ATM, indicating a potential role for this protein in is_associated_with::DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the is_associated_with::X-chromosome that escapes is_associated_with::X inactivation.

Interactions
SMC1A has been shown to interact with SMC3   and is_associated_with::Ataxia telangiectasia mutated.