SKAP1

Src kinase-associated phosphoprotein 1 is an is_associated_with::adapter protein that in humans is encoded by the SKAP1 is_associated_with::gene.

The demonstration that SKAP1 regulates is_associated_with::LFA-1 adhesion was made by retroviral infection and by the SKAP1 deficient mouse. Additional work has implicated SKAP1 in binding to the exchange factor RasGRP1 and in regulating ERK activation in T-cells.

Interactions
SKAP1 has been shown to interact with is_associated_with::FYN,  is_associated_with::PTPRC and is_associated_with::FYB.