Rs3764028

rs3764028 ( -421C/A ) is a SNP in close proximity to GRIN2B (Glutamate [NMDA] receptor subunit epsilon-2).

significant differences in genotype between the North Chinese sporadic Alzheimer's patients (of which there were 362) and controls (of which there were 334). 34.69-39.79% decreased transcriptional activity (per luciferase reporter assay in SH-SY5Y and HeLa cell lines) noted for the C allele versus the A allele