TRAFD1

TRAF-type zinc finger domain-containing protein 1 is a is_associated_with::protein that in humans is encoded by the TRAFD1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of TRAFD1 function. A conditional is_associated_with::knockout mouse line, called Trafd1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty eight tests were carried out on is_associated_with::homozygous is_associated_with::mutant mice and two significant abnormalities were observed: abnormal spine curvature and atypical peripheral blood is_associated_with::lymphocyte parameters.