Metabotropic glutamate receptor 6

Glutamate receptor, metabotropic 6, also known as GRM6, is a is_associated_with::protein which in humans is encoded by the GRM6 is_associated_with::gene.

Function
L-is_associated_with::glutamate is the major excitatory is_associated_with::neurotransmitter in the is_associated_with::central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The is_associated_with::metabotropic glutamate receptors are a family of is_associated_with::G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes is_associated_with::GRM1 and is_associated_with::GRM5 and these receptors have been shown to activate is_associated_with::phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the is_associated_with::cyclic AMP cascade but differ in their agonist selectivities.