Rs6918698

rs6918698, a common SNP located in the promoter of the CTGF gene, has been linked to increased risk for systemic sclerosis (scleroderma) based on a study of 500 Caucasian patients. The odds ratio is 2.2 for (G;G) homozygotes (p<0.001). The reason that the (C) allele appears to be protective is thought to be due to decreased CTGF activity.