LYK5

Protein kinase LYK5, also known as LYK5 or STRADα, is a human is_associated_with::protein and also denotes the is_associated_with::gene encoding it.

Function
Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in is_associated_with::phosphorylation of both partners. Removal of endogenous LYK5 by is_associated_with::small interfering RNA abrogates LKB1-induced is_associated_with::G1 phase arrest. STRADα stabilizes LKB1 protein both in vivo and in vitro, and is capable of eliciting multiple axons in mouse embryonic cortical cultured neurons when overexpressed with LKB1. STRADα is highly spliced in vivo, and this is both developmentally regulated and tissue-specific, but the unique functions of the splice variants are not yet understood.

Disease linkage
Mutations in the LYK5/STRADα gene are associated with is_associated_with::polyhydramnios, is_associated_with::megalencephaly and symptomatic is_associated_with::epilepsy (collectively known as the PMSE syndrome).

Interactions
STRADα has been shown to interact with is_associated_with::LKB1 and is_associated_with::MO25.