Rs6454674

risk of the development of substance dependence significantly increased with the number of "G" alleles at rs6454674 and SNP8;T/T genotypes had significant interaction effects (p = .0003 for comorbid DD and AD, .0002 for DD, and .007 for AD). SNP3 and SNP8 together exerted stronger genetic effects on SD than either did individually. The peak delta values among all the markers were seen for SNP3 and SNP8 (rs806368)

rs806377(C) together with rs6454674(G) make up a haplotype associated (p=0.008) with higher risk of ADHD. In addition, the haplotype was more associated (p=0.03) with ADHD in males than in females with the risk haplotype.

Cannabis receptor haplotype associated with fewer cannabis dependence symptoms in adolescents.

No association of CNR1 gene variations with susceptibility to schizophrenia.

Endocannabinoid receptor 1 gene variations increase risk for obesity and modulate body mass index in European populations.

Cannabinoid receptor 1 gene association with nicotine dependence.

Evidence for association between polymorphisms in the cannabinoid receptor 1 (CNR1) gene and cannabis dependence.

Candidate genes for cannabis use disorders: findings, challenges and directions.

The association between cannabinoid receptor 1 gene (CNR1) and cannabis dependence symptoms in adolescents and young adults.

The implication of CNR1 gene's polymorphisms in the modulation of endocannabinoid system effects.

Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

Endocannabinoid type 1 receptor gene (CNR1) polymorphisms (rs806381, rs10485170, rs6454674, rs2023239) and cardiovascular risk factors in postmenopausal women.

Further evidence for association of polymorphisms in the CNR1 gene with cocaine addiction: confirmation in an independent sample and meta-analysis.