MOGAT2

2-Acylglycerol O-acyltransferase 2 also known as acyl-CoA:monoacylglycerol acyltransferase 2 (MGAT2) or Diacylglycerol O-acyltransferase candidate 5 (DC5) is an is_associated_with::enzyme that in humans is encoded by the MOGAT2 is_associated_with::gene.

MOGAT2 and the related is_associated_with::MOGAT3 genes are members of the acylglycerol o-acyltransferase family (DGAT2/MOGAT) and are involved in the synthesis of is_associated_with::diacylglycerol (DAG) and is_associated_with::triacylglycerol (TAG) from is_associated_with::monoacylglycerol (MAG).

MOGAT2 and also MOGAT3 are single copy genes in almost all mammals. However, in is_associated_with::ruminants both genes have undergone tandem gene expansion, indicate of evolving funcionality. MOGAT2 has more than five tandemly duplicated copies in sheep with the first copy expressed in the is_associated_with::duodenum and the last copy expressed in the skin, with no expression of any copy detected in the liver.