Calcitonin receptor

The calcitonin receptor (CT) is a is_associated_with::G protein-coupled receptor that binds the peptide hormone is_associated_with::calcitonin and is involved in maintenance of is_associated_with::calcium is_associated_with::homeostasis, particularly with respect to bone formation and metabolism.

CT works by activating the is_associated_with::G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. It may also affect the ovaries in women and the testes in men.

The function of the CT receptor protein is modified through its interaction with is_associated_with::Receptor activity-modifying proteins (RAMPs), forming the multimeric is_associated_with::amylin receptors AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), and AMY3 (CT+ RAMP3).

Interactions
Calcitonin receptor has been shown to interact with is_associated_with::Apolipoprotein B and is_associated_with::LRP1.