NEIL3

Nei endonuclease VIII-like 3 (E. coli) is a is_associated_with::protein in is_associated_with::humans that is encoded by the NEIL3 is_associated_with::gene.

NEIL3 belongs to a class of is_associated_with::DNA is_associated_with::glycosylases homologous to the is_associated_with::bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by is_associated_with::reactive oxygen species and introducing a is_associated_with::DNA strand break via the associated lyase reaction.