IMP dehydrogenase

IMP dehydrogenase is an enzyme that converts inosine monophosphate to xanthosine monophosphate:


 * inosine 5'-phosphate + NAD+ + H2O —–> xanthosine 5'-phosphate + NADH + H+

The structure of this enzyme is composed of a TIM barrel domain with two CBS domains inserted within a loop.

It is inhibited by Mycophenolic acid.

Examples
Humans express the following two IMP dehydrogenase isozymes: