MMP14

Matrix metalloproteinase-14 is an is_associated_with::enzyme that in humans is encoded by the MMP14 is_associated_with::gene.

Function
Proteins of the is_associated_with::matrix metalloproteinase (MMP) family are involved in the breakdown of is_associated_with::extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. "This protein activates is_associated_with::MMP2 protein, and this activity may be involved in is_associated_with::tumor invasion."

Interactions
MMP14 has been shown to interact with is_associated_with::TIMP2.