HOXD13

Homeobox protein Hox-D13 is a is_associated_with::protein that in humans is encoded by the HOXD13 is_associated_with::gene.

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in is_associated_with::morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. Mutations in this particular gene cause is_associated_with::synpolydactyly and is_associated_with::Brachydactyly. The product of the mouse Hoxd13 gene plays a role in axial skeleton development and forelimb morphogenesis.