Arrestin beta 1

Arrestin, beta 1, also known as ARRB1, is a is_associated_with::protein which in humans is encoded by the ARRB1 is_associated_with::gene.

Function
Members of is_associated_with::arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of is_associated_with::G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a is_associated_with::cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known. Beta-arrestin might also play a role as scaffold protein in the GPCR pathways.

Interactions
Arrestin beta 1 has been shown to interact with
 * is_associated_with::Arf6,
 * PTHLH,
 * is_associated_with::DVL2
 * is_associated_with::Mdm2,
 * OPRD1,
 * is_associated_with::PSCD2, and
 * is_associated_with::RALGDS.