TRPV3

Transient receptor potential cation channel, subfamily V, member 3, also known as TRPV3, is a human is_associated_with::gene encoding the is_associated_with::protein of the same name.

Physiology of TRPV3 channel
The TRPV3 channel is widely expressed in the human body, especially in the is_associated_with::skin in is_associated_with::keratinocytes, but also in the is_associated_with::brain. It functions as a molecular sensor for innocuous warm temperatures. Mice lacking these protein are unable to sense elevated temperatures (>33 °C) but are able to sense cold and noxious heat. In addition to thermosensation TRPV3 channels seem to play a role in hair growth because mutations in the TRPV3 gene cause hair loss in mice. The role of TRPV3 channels in the brain is unclear, but researchers found that they play a role in mood regulation, and that a protective effects of Incensole acetate were partially mediated by TRPV3 channels.

Modulation
The TRPV3 channel is directly activated by various natural compounds like is_associated_with::carvacrol, is_associated_with::thymol and is_associated_with::eugenol. Several other monoterpenoids which cause either feeling of warmth or are is_associated_with::skin sensitizers can also open the channel. Monoterpenoids also induce agonist-specific desensitization of TRPV3 channels in a calcium-independent manner.