TNFRSF13B

Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI (transmembrane activator and CAML interactor), is a transmembrane receptor protein found predominantly on the surface of is_associated_with::B cells, which are an important part of the immune system.

Functions of TACI
TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis.

Medical significance
TACI mutations are associated with immunodeficiency in humans, as a significant proportion of is_associated_with::CVID patients have TACI mutations. People with this condition produce abnormally low amounts of is_associated_with::antibodies, which are needed for protection against infections.

In humans, the gene encoding this protein is located within the Smith-Magenis syndrome region on chromosome 17.

Interactions
TNFRSF13B has been shown to interact with is_associated_with::B-cell activating factor, is_associated_with::TRAF6, is_associated_with::TRAF5, is_associated_with::TNFSF13, is_associated_with::TRAF2 and is_associated_with::CAMLG.