E2F2

Transcription factor E2F2 is a is_associated_with::protein that in humans is encoded by the E2F2 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the E2F family of is_associated_with::transcription factors. The E2F family plays a crucial role in the control of is_associated_with::cell cycle and action of is_associated_with::tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, is_associated_with::E2F1 and is_associated_with::E2F3, have an additional is_associated_with::cyclin binding domain. This protein binds specifically to is_associated_with::retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.

Interactions
E2F2 has been shown to interact with:
 * is_associated_with::BRD2,
 * is_associated_with::RYBP, and
 * RB1.