Rs646776

rs599839 and rs4970834 explain about 1% of the variation in circulating LDL-cholesterol levels. "When we look at this particular genetic variance, of all the cholesterol variation among the population, 1% of it can be attributed to this particular locus," said Sandhu. "This is equivalent to more established genes for LDL regulation, particularly APOE." rs646776 also linked.

Pharmacogenetic meta-analysis of genome-wide association studies of LDL &#8203;cholesterol response to statins found each minor allele to increase statin effectiveness by 1.3% (rs646776, &#946;=&#8722;0.013, s.e.=0.002, P=1.05 &#215; 10&#8722;9 and rs12740374, &#946;=&#8722;0.013, s.e.=0.002, P=1.05 &#215; 10&#8722;9).

23andMe blog coronary artery disease and heart attack

SNP 	Risk Version 	Effect
 * rs646776 	T 	1.19
 * rs17465637 	C 	1.14
 * rs1746048 	C 	1.17
 * rs6725887 	C 	1.17
 * rs11206510 	T 	1.15
 * rs3184504 	T 	1.13
 * rs2306374 	C 	1.15
 * rs3782886 	C 	1.44