ARVCF

Armadillo repeat protein deleted in velo-cardio-facial syndrome is a is_associated_with::protein that in humans is encoded by the ARVCF is_associated_with::gene.

Function
is_associated_with::Armadillo repeat gene deleted in Velo-Cardio-Facial syndrome (ARVCF) is a member of the is_associated_with::catenin family which play an important role in the formation of is_associated_with::adherens junction complexes, which are thought to facilitate communication between the inside and outside environments of a cell. ARVCF gene was isolated in the search for the genetic defect responsible for the autosomal dominant Velo-Cardio-Facial syndrome (VCFS) a relatively common human disorder with phenotypic features including cleft palate, conotruncal heart defects and facial dysmorphology. ARVCF gene encodes a protein containing two motifs, a is_associated_with::coiled coil domain in the is_associated_with::N-terminus and a 10 is_associated_with::armadillo repeat sequence in the midregion. Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In addition, ARVCF contains a predicted nuclear-targeting sequence suggesting that it may have a function as a nuclear protein.

Interactions
ARVCF has been shown to interact with is_associated_with::CDH15.