ATP1A2

ATPase, Na+/K+ transporting, alpha 2 (+) polypeptide, also known as ATP1A2, is a is_associated_with::protein which in humans is encoded by the ATP1A2 is_associated_with::gene.

Function
The is_associated_with::protein encoded by this gene belongs to the family of P-type cation transport is_associated_with::ATPases, and to the subfamily of Na+/K+-ATPases. Na+/K+-ATPase is an integral is_associated_with::membrane protein responsible for establishing and maintaining the is_associated_with::electrochemical gradients of Na and K is_associated_with::ions across the is_associated_with::plasma membrane. These gradients are essential for is_associated_with::osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of is_associated_with::nerve and is_associated_with::muscle. This is_associated_with::enzyme is composed of two subunits, a large is_associated_with::catalytic subunit (alpha) and a smaller is_associated_with::glycoprotein subunit (beta). The catalytic subunit of Na+/K+-ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit.

Clinical significance
Mutations in the ATP1A2 gene has been implicated in the familial form of is_associated_with::alternating hemiplegia of childhood.