ACY1

Aminoacylase-1 is an is_associated_with::enzyme that in is_associated_with::humans is encoded by the ACY1 is_associated_with::gene.

Function
Aminoacylase-1 is a is_associated_with::cytosolic, is_associated_with::homodimeric, is_associated_with::zinc-binding enzyme that catalyzes the is_associated_with::hydrolysis of acylated L-is_associated_with::amino acids to L-amino acids and is_associated_with::acyl group, and has been postulated to function in the is_associated_with::catabolism and salvage of acylated amino acids. ACY1 has been assigned to is_associated_with::chromosome 3p21.1, a region reduced to is_associated_with::homozygosity in is_associated_with::small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and is_associated_with::tumors. The amino acid sequence of human is_associated_with::aminoacylase-1 is highly is_associated_with::homologous to the is_associated_with::porcine counterpart, and ACY1 is the first member of a new family of zinc-binding enzymes.