Rs12708716

rs12708716 has been reported in a large study to be associated with type-1 diabetes.

The risk allele (oriented to the dbSNP entry) is (A); the odds ratio associated with heterozygotes is 1.19 (CI 0.97-1.45), and for homozygotes, 1.55 (CI 1.27-1.89).

In an expanded follow-up study of >6,000 controls and 6,000 patients, the heterozygote odds ratio for this SNP was recalculated to be 0.81 (CI 0.77-0.86).

Tested in a large multiple sclerosis data set consisting of 2369 trio families, 5737 cases and 10 296 unrelated controls, SNP rs12708716 was associated with disease risk (p = 1.6 x 10e-16)


 * is_associated_with_disease::Multiple sclerosis
 * is_associated_with_disease::Systemic lupus erythematosus
 * is_associated_with_disease::Celiac disease
 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Vasculitis
 * is_associated_with_disease::Juvenile rheumatoid arthritis