Thyrotropin receptor

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to is_associated_with::thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of is_associated_with::thyroxine (T4) and is_associated_with::triiodothyronine (T3). The TSH receptor is a member of the is_associated_with::G protein-coupled receptor superfamily of is_associated_with::integral membrane proteins and is coupled to the Gs protein.

It is primarily found on the surface of the is_associated_with::thyroid epithelial cells.

Function
Upon binding circulating is_associated_with::thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; is_associated_with::thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.