BAZ1A

Bromodomain adjacent to zinc finger domain protein 1A is a is_associated_with::protein that in humans is encoded by the BAZ1A is_associated_with::gene.

Structure
The is_associated_with::protein encoded by this gene belongs to a family of proteins which includes is_associated_with::BAZ1B, is_associated_with::BAZ2A, and is_associated_with::BAZ2B. All family members contain the following domains and is_associated_with::structural motifs:


 * is_associated_with::N-terminus – is_associated_with::PHD finger (C4HC3 is_associated_with::zinc finger)
 * WAKZ motif
 * LH (leucine-rich helical domain) motif
 * is_associated_with::C-terminus – is_associated_with::bromodomain

Function
BAZ1A along with is_associated_with::SMARCA5, is_associated_with::POLE3, and is_associated_with::CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.

The purified CHRAC complex can mobilize is_associated_with::nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent. Furthermore the BAZ1A-SMARCA5 complex enables is_associated_with::DNA replication through highly condensed regions of is_associated_with::chromatin.

Interactions
BAZ1A has been shown to interact with is_associated_with::SMARCA5    and is_associated_with::SATB1.