Aristaless related homeobox

Aristaless related homeobox is a is_associated_with::protein that in humans is encoded by the ARX is_associated_with::gene.

Function
This gene is a is_associated_with::homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C-peptide (or aristaless domain) and the prd-like class homeobox domain. It is a member of the group-II aristaless-related protein family whose members are expressed primarily in the central and/or peripheral nervous system. This gene is involved in CNS and pancreas development.

Clinical significance
Mutation in the ARX gene are associated with X-linked is_associated_with::intellectual disability, is_associated_with::lissencephaly, as well as is_associated_with::hypoglycemia (in mice).