Aryl hydrocarbon receptor nuclear translocator

The ARNT is_associated_with::gene encodes the aryl hydrocarbon receptor nuclear translocator is_associated_with::protein that forms a complex with ligand-bound is_associated_with::aryl hydrocarbon receptor (AhR), and is required for receptor function. The encoded protein has also been identified as the beta subunit of a heterodimeric transcription factor, is_associated_with::hypoxia-inducible factor 1 (HIF1). A t(1;12)(q21;p13) translocation, which results in a TEL-ARNT is_associated_with::fusion protein, is associated with acute myeloblastic leukemia. Three alternatively spliced variants encoding different isoforms have been described for this gene.

The aryl hydrocarbon receptor (AhR) is involved in the induction of several is_associated_with::enzymes that participate in is_associated_with::xenobiotic metabolism. The ligand-free, is_associated_with::cytosolic form of the is_associated_with::aryl hydrocarbon receptor is complexed to heat shock protein 90. Binding of ligand, which includes dioxin and polycyclic is_associated_with::aromatic hydrocarbons, results in translocation of the ligand-binding subunit only to the nucleus. Induction of enzymes involved in xenobiotic metabolism occurs through binding of the ligand-bound AhR to xenobiotic responsive elements in the promoters of genes for these enzymes.

Interactions
Aryl hydrocarbon receptor nuclear translocator has been shown to interact with:


 * AIP,
 * AHR,
 * is_associated_with::EPAS1,
 * is_associated_with::HIF1A,
 * NCOA2,
 * is_associated_with::SIM1, and
 * is_associated_with::SIM2.