Rs28941778

rs28941778, also known as Asp396Asn or D396N, is a SNP in the WT1 gene on chromosome 11.

This SNP is considered pathogenic (causal) for Denys-Drash syndrome, and may also be associated with nephrotic syndrome, type IV.

See also OMIM 607102.0006

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.