Addressin

Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a is_associated_with::protein that in humans is encoded by the MADCAM1 is_associated_with::gene.

Addressin is an is_associated_with::extracellular is_associated_with::protein of the is_associated_with::endothelium of is_associated_with::venules. Addressins are the is_associated_with::ligands to the is_associated_with::homing receptors of is_associated_with::lymphocytes. The task of these ligands and their receptors is to determine which tissue the lymphocyte will enter next. They carry carbohydrates in order to be recognized by is_associated_with::L-selectin.

Function
The protein encoded by this gene is an endothelial is_associated_with::cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), is_associated_with::L-selectin, and is_associated_with::VLA-4 (alpha4 / beta1) on myeloid cells to direct is_associated_with::leukocytes into mucosal and inflamed tissues. It is a member of the is_associated_with::immunoglobulin superfamily and is similar to is_associated_with::ICAM-1 and is_associated_with::VCAM-1.