XPO1

Exportin 1 (XPO1), also known as chromosomal maintenance 1 (CRM1), is an eukaryotic protein that mediates the nuclear export of proteins, is_associated_with::rRNA and is_associated_with::snRNA.

Function
Exportin 1 mediates leucine-rich nuclear export signal (is_associated_with::NES)-dependent protein transport. Exportin 1 specifically inhibits the nuclear export of Rev and U is_associated_with::snRNAs. It is involved in the control of several cellular processes by controlling the localization of is_associated_with::cyclin B, is_associated_with::MPAK, and MAPKAP kinase 2. This protein also regulates is_associated_with::NFAT and AP-1.

Interactions
XPO1 has been shown to interact with:


 * APC,
 * is_associated_with::CDKN1B,
 * is_associated_with::CIITA,
 * is_associated_with::NMD3,
 * is_associated_with::Nucleoporin 62,
 * is_associated_with::RANBP1,
 * is_associated_with::RANBP3,
 * Ran,
 * is_associated_with::SMARCB1, and
 * is_associated_with::p53.