MXD3

MAX dimerization protein 3 is a is_associated_with::protein that in humans is encoded by the MXD3 is_associated_with::gene located on Chromosome 5.

MXD3 is a is_associated_with::basic helix-loop-helix protein belonging to a subfamily of MAX-interacting proteins. This protein competes with is_associated_with::MYC for binding to MAX to form a sequence-specific DNA-binding complex. MXD3 is a transcriptional repressor that is specifically expressed during S phase of the is_associated_with::cell cycle. The protein is implicated in both normal neural development and in the development of brain cancer. In is_associated_with::medulloblastoma cells, MXD3 binds is_associated_with::E-box sequences, leading to increased cell proliferation at moderate MXD3 levels but increased cell death and is_associated_with::apoptosis at higher expression levels.