ARFGEF2

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a is_associated_with::protein that in humans is encoded by the ARFGEF2 is_associated_with::gene.

Function
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in is_associated_with::Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.

Interactions
ARFGEF2 has been shown to interact with is_associated_with::ARFGEF1, is_associated_with::PRKAR1A and is_associated_with::PRKAR2A.