Rs4570625

rs4570625, also known as G-703T, is a SNP in the tryptophan hydroxylase 2 TPH2 gene. This SNP has been linked to several psychiatric and/or behavioural phenomena, including:


 * rs4570625 and rs4565946 linked to the pathogenesis of early-onset obsessive compulsive disorder


 * rs4570625 and rs11178997 in TPH2's regulatory region display preferential transmission


 * rs4570625(G;G) homozygosity was a significant predictor of clinical placebo response, being associated with greater improvement in anxiety symptoms.

g2b2mh is rs4570625(G;G) is a significant predictor of clinical placebo response? maybe not

panic disorder with a possible gender-dependent effect

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.

Association between a polymorphism in the promoter region of the TPH2 gene and the personality trait of harm avoidance.

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1.

Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons.

Genetic variation of serotonin function and cognitive control.

Tryptophan hydroxylase 2 gene and alcohol use among college students.

Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response.

TPH2 gene variants and anxiety during alcohol detoxification outcome.

Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

Alternative splicing and extensive RNA editing of human TPH2 transcripts.

Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population.

Pharmacogenetics of antidepressant response.

Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants.

Emotion appraisal and the tryptophan hydroxylase 2 (TPH2) gene.

Common variants in the TPH2 promoter confer susceptibility to paranoid schizophrenia.