PPP1R15A

Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a is_associated_with::protein that in humans is encoded by the PPP1R15A is_associated_with::gene.

The Gadd34/MyD116 gene was originally discovered as a member in a set of gadd and MyD mammalian genes encoding acidic proteins that synergistically suppress cell growth. Later on it has been characterized as a gene playing a role in ER stress-induced cell death, being a target of is_associated_with::ATF4 that plays a role in ER-mediated cell death via promoting protein is_associated_with::dephosphorylation of elF2α and reversing translational inhibition.

Function
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of is_associated_with::p53 status, and its protein response is correlated with apoptosis following ionizing radiation.

Interactions
PPP1R15A has been shown to interact with:
 * is_associated_with::BAG1
 * is_associated_with::LYN,
 * MLL,
 * is_associated_with::PPP1CA,
 * is_associated_with::PPP1CB,
 * is_associated_with::PPP1CC,
 * is_associated_with::SMARCB1, and
 * TSN.