PRDX3

Thioredoxin-dependent peroxide reductase, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the PRDX3 is_associated_with::gene.

Function
This gene encodes a protein with is_associated_with::antioxidant function and is localized in the is_associated_with::mitochondrion. This gene shows significant nucleotide sequence similarity to the gene coding for the C22 subunit of is_associated_with::Salmonella typhimurium alkylhydroperoxide reductase. Expression of this gene product in E. coli deficient in the C22-subunit gene rescued resistance of the is_associated_with::bacteria to alkylhydroperoxide. The human and mouse genes are highly conserved, and they map to the regions syntenic between mouse and human chromosomes. Sequence comparisons with recently cloned mammalian homologues suggest that these genes consist of a family that is responsible for regulation of cellular proliferation, differentiation, and antioxidant functions. Two transcript variants encoding two different isoforms have been found for this gene.

Interactions
PRDX3 has been shown to interact with is_associated_with::MAP3K13.

Clinical significance
It has been demonstrated that serum peroxiredoxin 3 can be a valuable is_associated_with::biomarker for the diagnosis and assessment of hepatocellular is_associated_with::carcinoma It has been shown that peroxiredoxin proteins protect MCF-7 breast cancer cells against doxorubicin-mediated toxicity. Additionally, it has been shown that peroxiredoxin 3 is overexpressed in is_associated_with::prostate cancer and promotes cancer cell survival by defending cells against the damages incurred by is_associated_with::oxidative stress.