ATF3

Cyclic AMP-dependent transcription factor ATF-3 is a is_associated_with::protein that, in humans, is encoded by the ATF3 is_associated_with::gene.

Function
Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (is_associated_with::CREB) protein family of is_associated_with::transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the is_associated_with::leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription, it is presumed, by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Clinical significance
ATF-3 is widely used as a marker for injured dorsal root ganglion neurons in Pain Research.

Interactions
ATF3 has been shown to interact with:
 * is_associated_with::C-jun,
 * DDIT3
 * is_associated_with::JunD,
 * is_associated_with::P53, and
 * SMAD3.