HESX1

Homeobox expressed in ES cells 1, also known as homeobox protein ANF, is a is_associated_with::homeobox is_associated_with::protein that in humans is encoded by the HESX1 is_associated_with::gene.

Expression of HEX1 and HESX1 marks the is_associated_with::anterior visceral endoderm of the embryo. The AVE is an extra-embryonic tissue, key to the establishment of the anterior-posterior body axis.

Clinical significance
Mutations in the HESX1 gene are associated with some cases of is_associated_with::septo-optic dysplasia or Pickardt-Fahlbusch syndrome.