Rs27072

rs27072, a SNP in the dopamine transporter SLC6A3 gene, has been associated with more severe symptoms upon alcohol withdrawal, such as seizures, in a study of 250 Caucasian alcohol-dependent patients. Two haplotypes appear to be tagged by this SNP and a neighbor, rs27048. The rs27072 polymorphism has been shown to be significantly associated with ADHD in clinical samples of Canadian children aged 6 to 16 [Feng et al., 2005] and the significant association was also reported by Ouellet-Morin et al. in a Canadian twin study, 2008 (Am. J. of Medical Genetics Part B, 147B:1442-1449 (2008).

The interaction between the dopamine transporter gene and age at onset in relation to tobacco and alcohol use among 19-year-olds.

Association of promoter variants of human dopamine transporter gene with schizophrenia in Han Chinese.

Dopamine Transporter Gene Variant Affecting Expression in Human Brain is Associated with Bipolar Disorder.

Sequence variation in the 3'-untranslated region of the dopamine transporter gene and attention-deficit hyperactivity disorder (ADHD).

Association of the dopamine transporter gene and ADHD symptoms in a Canadian population-based sample of same-age twins.

Candidate gene studies of ADHD: a meta-analytic review.

Association between polymorphism of the dopamine transporter gene and early smoking onset: an interaction risk on nicotine dependence.

Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers.

Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene.

Haplotypes of dopamine and serotonin transporter genes are associated with antisocial personality disorder in alcoholics.

Pharacogenetic effects of dopamine transporter gene polymorphisms on response to chlorpromazine and clozapine and on extrapyramidal syndrome in schizophrenia.

The role of dopamine transporter (SLC6A3) and dopamine D2 receptor/ankyrin repeat and kinase domain containing 1 (DRD2/ANKK1) gene polymorphisms in personality traits.

Alcohol Dependence