F2RL2

Protease activated receptor 3 (PAR-3) also known as coagulation factor II receptor-like 2 (F2RL2) and thrombin receptor-like 2, is a is_associated_with::protein that in humans is encoded by the F2RL2 is_associated_with::gene.

Function
Coagulation factor II (thrombin) receptor-like 2 (F2RL2) is a member of the large family of 7-transmembrane receptors that couple to is_associated_with::G proteins. F2RL2 is also a member of the is_associated_with::protease-activated receptor family and activated by thrombin. F2RL2 is activated by is_associated_with::proteolytic cleavage of its extracellular is_associated_with::amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL2 is a cofactor for F2RL3 activation by is_associated_with::thrombin. It mediates thrombin-triggered is_associated_with::phosphoinositide hydrolysis and is expressed in a variety of tissues.