Hepatic lipase

Hepatic lipase, also called hepatic triglyceride lipase (HTGL) or LIPC (for "lipase, hepatic"), is a form of is_associated_with::lipase, catalyzing the is_associated_with::hydrolysis of is_associated_with::fats. It is expressed in the is_associated_with::liver and is_associated_with::adrenal glands.

One of the principal functions of hepatic lipase is to convert is_associated_with::intermediate-density lipoprotein (IDL) to is_associated_with::low-density lipoprotein (LDL).

Clinical significance
Hepatic lipase deficiency is a rare, autosomal recessive disorder that results in elevated is_associated_with::high density lipoprotein (HDL) cholesterol due to a mutation in the hepatic lipase gene. Clinical features are not well understood and there are no characteristic is_associated_with::xanthomas. There is an association with a delay in is_associated_with::atherosclerosis in an animal model.