Progeroid syndrome

Progeroid syndromes (PSs) is the name of a group of disorders that mimic aging at an early age. Some disorders shows hallmarks of aging, whereas others do not; it can affect one organ or many. Segmental progeroid syndromes are PSs which do not associate with all aspects of physiological aging; examples include Werner syndrome, Hutchinson-Gilford progeria, ataxia telangiectasia, dyskeratosis congenita and Bloom syndrome. Other PSs affects only one organ, and includes familial Alzheimer's disease, familial Parkinson's disease.

PS can be separated into sub-groups corresponding to the cause of the disorder, which includes mutations in the genes encoding for DNA repair, usually DNA helicase, and genes affecting the structure or post-translational maturation of lamin A, a nuclear intermediate filament constituting large parts of the nuclear lamina.