EGF-like domain

EGF-like domain  is an evolutionary conserved protein domain, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (except in prostaglandin H/G synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in three disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.

family is very similar, but has 8 instead of 6 conserved cysteines.

This family includes some cytokine receptors.

Proteins containing this domain
Below is a list of human proteins containing the EGF-like domain:


 * AGC1; AGRIN; AREG; ATRN; ATRNL1;
 * BCAN; BMP1; BTC;
 * C1S; CASPR4; CD248; CD93; CELSR1; CELSR2; CELSR3; CNTNAP1; CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; COMP; COX-2; CRB1; CRB2; CSPG3; CUBN;
 * DLK1; DLL1; DLL3; DLL4; DNER;
 * EDIL3; EGF; EGFL11; EGFL8; EGFL9; EGFLAM; EPGN; EREG;
 * F7; F9; F10; F12; FAT; FAT2; FAT4; FBN1; FBN2; FBN3;
 * GAS6;
 * HABP2; HBEGF; HEG1; HGFAC; HMCN1; HSPG2;
 * ITGB5;
 * JAG1; JAG2;
 * LDLR; LRP1; LRP10; LRP1B; LRP2; LRP4; LRP5; LRP6; LRP8; LTBP1; LTBP2; LTBP3; LTBP4;
 * MATN1; MATN2; MATN3; MATN4; MEGF12; MEGF6; MEP1A; MEP1B; MFGE8; MMRN1; MMRN1; MUC4;
 * NAGPA; NID1; NID2; NOTCH1; NOTCH2; NOTCH2NL; NOTCH3; NOTCH4; NRG1; NRG2; NRG3; NRG4; NRXN1; NRXN2; NRXN3; NTNG2;
 * ODZ1; ODZ2; OIT3;
 * PLAT; PP187; PROC; PROS1; PROZ; PTGS1; PTGS2;
 * RAMP;
 * SCUBE1; SCUBE2; SCUBE3; SEL-OB; SELE; SELL; SELP; SLIT1; SLIT2; SLIT3; SNED1; STAB1; STAB2; SVEP1;
 * TECTA; TGFA; THBD; THBS1; THBS2; THBS4; TIE1; TLL1; TLL2; TMEFF1; TMEFF2; TNC; TNXB;
 * UMOD;
 * VASN; VCAN; VLDLR; VWA2;
 * WIF1;
 * ZAN;