ACTL6A

Actin-like protein 6A is a is_associated_with::protein that in humans is encoded by the ACTL6A is_associated_with::gene.

Function
This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

Interactions
ACTL6A has been shown to interact with is_associated_with::SMARCA2,  is_associated_with::Myc, is_associated_with::Transformation/transcription domain-associated protein, is_associated_with::RuvB-like 1 and is_associated_with::SMARCA4.