Translin

Translin is a DNA-binding is_associated_with::protein that in humans is encoded by the TSN is_associated_with::gene. Together with is_associated_with::translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during is_associated_with::microRNA loading into the RNA-induced silencing complex (RISC).

Function
This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in is_associated_with::chromosomal translocation in lymphoid is_associated_with::neoplasms.

Interactions
Translin has been shown to interact with is_associated_with::PPP1R15A.