ANXA11

Annexin A11 is a is_associated_with::protein that in humans is encoded by the ANXA11 is_associated_with::gene.

Function
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain the calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Transcript variants encoding the same isoform have been identified.

Interactions
ANXA11 has been shown to interact with is_associated_with::PDCD6 and is_associated_with::ALG2.

Clinical significance
It is shown that over-expression of the ANXA11 is involved in apoptotic alterations in is_associated_with::schizophrenia and contribute to pathomechanisms of this disorder.