GMP synthase (glutamine—hydrolysing)

Guanosine monophosphate synthetase, (EC 6.3.5.2) also known as GMPS is an is_associated_with::enzyme that converts is_associated_with::xanthosine monophosphate to is_associated_with::guanosine monophosphate.

Enzymology
In is_associated_with::enzymology, a GMP synthetase (glutamine-hydrolysing) is an is_associated_with::enzyme that catalyzes the is_associated_with::chemical reaction


 * ATP + xanthosine 5'-phosphate + L -glutamine + H2O $$\rightleftharpoons$$ AMP + diphosphate + GMP + L -glutamate

The 4 substrates of this enzyme are ATP, is_associated_with::xanthosine 5'-phosphate, L -glutamine, and H2O, whereas its 4 products are AMP, is_associated_with::diphosphate, GMP, and  L -glutamate.

This enzyme belongs to the family of is_associated_with::ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is xanthosine-5'-phosphate: L -glutamine amido-ligase (AMP-forming). Other names in common use include GMP synthetase (glutamine-hydrolysing), guanylate synthetase (glutamine-hydrolyzing), guanosine monophosphate synthetase (glutamine-hydrolyzing), xanthosine 5'-phosphate amidotransferase, and guanosine 5'-monophosphate synthetase. This enzyme participates in is_associated_with::purine metabolism and is_associated_with::glutamate metabolism. At least one compound, is_associated_with::Psicofuranin is known to inhibit this enzyme.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.