OLR1

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a is_associated_with::protein that in humans is encoded by the OLR1 is_associated_with::gene.

Function
LOX-1 is a receptor protein which belongs to the C-type lectin superfamily. Its gene is regulated through the cyclic AMP signaling pathway. The protein binds, internalizes and degrades oxidized low-density is_associated_with::lipoprotein. This protein may be involved in the regulation of Fas-induced is_associated_with::apoptosis. This protein may play a role as a scavenger receptor.

Clinical significance
Mutations of the OLR1 gene have been associated with is_associated_with::atherosclerosis, risk of is_associated_with::myocardial infarction, and may modify the risk of is_associated_with::Alzheimer's disease. is_associated_with::Berberine inhibits ORL1 (LOX-1)with the improvement in is_associated_with::hemoglobin A1c and AGEs in diabetics. Berberine hence protects against endothelial injury and enhances the endothelium-dependent vasodilatation, which is mediated in part through activation of the AMPK signaling cascade.