5-HT1D receptor

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a is_associated_with::5-HT receptor, but also denotes the human is_associated_with::gene encoding it. 5-HT1D acts on the is_associated_with::central nervous system, and affects locomotion and is_associated_with::anxiety. It also induces vascular is_associated_with::vasoconstriction in the brain.

Agonists

 * is_associated_with::5-(Nonyloxy)tryptamine,
 * is_associated_with::sumatriptan (is_associated_with::vasoconstrictor in is_associated_with::migraine)
 * is_associated_with::5-Carboxamidotryptamine (5-CT)
 * 5-(t-Butyl)-N-methyltryptamine
 * is_associated_with::CP-135,807
 * CP-286,601
 * PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
 * PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
 * GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
 * L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
 * L-772,405

Antagonists

 * is_associated_with::Ziprasidone (is_associated_with::atypical antipsychotic)
 * is_associated_with::methiothepin (is_associated_with::antipsychotic)
 * is_associated_with::yohimbine (is_associated_with::aphrodisiac)
 * is_associated_with::metergoline
 * is_associated_with::ergotamine (is_associated_with::vasoconstrictor in is_associated_with::migraine)
 * is_associated_with::BRL-15572
 * is_associated_with::Vortioxetine (is_associated_with::antidepressant)
 * GR-127,935 (mixed 5-HT1B/1D antagonist)
 * is_associated_with::LY-310,762
 * LY-367,642
 * LY-456,219
 * LY-456,220