TMPRSS3

Transmembrane protease, serine 3 is an is_associated_with::enzyme that in humans is encoded by the TMPRSS3 is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::serine protease family. The encoded protein contains a serine protease domain, a is_associated_with::transmembrane domain, an is_associated_with::LDL receptor-like domain, and a is_associated_with::scavenger receptor is_associated_with::cysteine-rich domain. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified by its association with both congenital and childhood onset is_associated_with::autosomal recessive deafness. This gene is expressed in fetal is_associated_with::cochlea and many other tissues, and is thought to be involved in the development and maintenance of the is_associated_with::inner ear or the contents of the is_associated_with::perilymph and is_associated_with::endolymph. This gene was also identified as a is_associated_with::tumor associated gene that is overexpressed in ovarian tumors. Four is_associated_with::alternatively spliced variants have been described, two of which encode identical products.