ARL6IP5

PRA1 family protein 3 is a is_associated_with::protein that in humans is encoded by the ARL6IP5 is_associated_with::gene.

Function
Expression of this gene is affected by is_associated_with::vitamin A. The encoded protein of this gene may be associated with the is_associated_with::cytoskeleton. A similar protein in rats may play a role in the regulation of cell differentiation. The rat protein binds and inhibits the cell membrane glutamate transporter is_associated_with::EAAC1. The expression of the rat gene is upregulated by retinoic acid, which results in a specific reduction in EAAC1-mediated glutamate transport. The disruption of the mouse gene results in increased neuronal glutathione content, neuroprotection against oxidative stress and a better performance in motor/spatial learning and memory tests than wild-type mice.

Interactions
ARL6IP5 has been shown to interact with is_associated_with::SLC1A1.