Rs2302254

breast cancer 1,134 breast cancer patients recruited as part of the Shanghai Breast Cancer Study who were followed for a median of 7.1 years. rs2302254 was also associated with breast cancer (HR, 1.3; 95% CI, 1.0-1.6). strong linkage disequilibrium for rs16949646 rs2302254 and rs3760468

Acute myeloid leukemia patients carrying rs2302254(T) alleles are at much higher risk of developing neurotoxic side effects if treated with Ara-C (cytarabine), compared to those not carrying a (T) allele.