ATG16L1

Autophagy-related protein 16-1 is a is_associated_with::protein that in humans is encoded by the ATG16L1 is_associated_with::gene.

Function
is_associated_with::Autophagy is the major intracellular degradation system delivering is_associated_with::cytoplasmic components to is_associated_with::lysosomes, and it accounts for degradation of most long-lived proteins and some is_associated_with::organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.

Clinical significance
Mutations in the ATG16L1 gene may be linked to is_associated_with::Crohn's disease.