Derlin-1

Derlin-1 also known as degradation in endoplasmic reticulum protein 1 is a is_associated_with::protein that in humans is encoded by the DERL1 is_associated_with::gene. It is a member of the rhomboid-like clan of polytopic membrane proteins.

Function
Derlin-1 is part of a complex (that includes VIMP, is_associated_with::SEL1, HRD1, and HERP) that mediates endoplasmic-reticulum-associated degradation (ERAD) that detects misfolded proteins in the is_associated_with::endoplasmic reticulum and targets them for destruction.

Clinical significance
Derlin 1 (DERL1) is up-regulated in metastatic canine mammary tumors as part of the unfolded protein response.