Endothelial protein C receptor

Endothelial protein C receptor (EPCR) also known as activated protein C receptor (APC receptor) is a is_associated_with::protein that in humans is encoded by the PROCR is_associated_with::gene. PROCR has also recently been designated CD201 (is_associated_with::cluster of differentiation 201).

The protein encoded by this gene is a receptor for activated is_associated_with::protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C.

Clinical significance
Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy.

The protein is also involved in is_associated_with::Plasmodium falciparum is_associated_with::malaria as subtypes of the P. falciparum erythrocyte membrane protein 1 (PfEMP1) family use EPCR of the host as a receptor.