KIF23

Kinesin-like protein KIF23 is a is_associated_with::protein that in humans is encoded by the KIF23 is_associated_with::gene.

In cell division
KIF23 (also known as Kinesin-6, CHO1/MKLP1, C. elegans ZEN-4 and is_associated_with::Drosophila Pavarotti) is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport is_associated_with::organelles within cells and move chromosomes during is_associated_with::cell division. This protein has been shown to cross-bridge antiparallel is_associated_with::microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in two transcript variants encoding two different isoforms, better known as CHO1, the larger isoform and MKLP1, the smaller isoform. KIF23 is a plus-end directed motor protein expressed in is_associated_with::mitosis, involved in the formation of the cleavage furrow in late is_associated_with::anaphase and in is_associated_with::cytokinesis. KIF23 is part of the is_associated_with::centralspindlin complex that includes is_associated_with::PRC1, is_associated_with::Aurora B and is_associated_with::14-3-3 which cluster together at the is_associated_with::spindle midzone to enable anaphase in dividing cells.

In neurons
In neuronal development KIF23 is involved in the transport of minus-end distal microtubules into is_associated_with::dendrites and is expressed exclusively in cell bodies and dendrites. Knockdown of KIF23 by antisense oligonucleotides and by siRNA both cause a significant increase in axon length and a decrease in dendritic phenotype in neuroblastoma cells and in rat neurons. In differentiating neurons, KIF23 restricts the movement of short microtubules into axons by acting as a "brake" against the driving forces of cytoplasmic dynein. As neurons mature, KIF23 drives minus-end distal microtubules into nascent dendrites contributing to the multi-polar orientation of dendritic microtubules and the formation of their short, fat, tapering morphology.



Interactions
KIF23 has been shown to interact with:
 * is_associated_with::ARF3,
 * AURKB,
 * is_associated_with::BIRC6, and
 * is_associated_with::PRC1.

Mutation and diseases
KIF23 has been implicated in the formation and proliferation of GL261 gliomas in mouse.