ACSL3

Long-chain-fatty-acid—CoA ligase 3 is an is_associated_with::enzyme that in is_associated_with::humans is encoded by the ACSL3 is_associated_with::gene.

Function
The protein encoded by this gene is an is_associated_with::isozyme of the long-chain is_associated_with::fatty-acid-is_associated_with::coenzyme A is_associated_with::ligase family. Although differing in is_associated_with::substrate specificity, is_associated_with::subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA is_associated_with::esters, and thereby play a key role in is_associated_with::lipid is_associated_with::biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes is_associated_with::myristate, is_associated_with::arachidonate, and is_associated_with::eicosapentaenoate as substrates. The is_associated_with::amino acid sequence of this isozyme is 92% identical to that of is_associated_with::rat is_associated_with::homolog. Two transcript variants encoding the same protein have been found for this gene.