GIT2

ARF GTPase-activating protein GIT2 is an is_associated_with::enzyme that in humans is encoded by the GIT2 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of GIT2 function. A conditional is_associated_with::knockout mouse line, called Git2Gt(XG510)Byg was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Mice lacking Git2 had no significant defects in viability or is_associated_with::fertility, so further tests were carried out and four significant is_associated_with::phenotypes were reported:


 * is_associated_with::Mutant mice had differences in their clinical blood chemistry compared to is_associated_with::wildtype control mice.
 * Mutant male mice had a decrease in is_associated_with::white blood cell count.
 * An increased thickness in is_associated_with::hippocampus was observed.
 * Mutant female mice were slower to respond to heat when placed on a is_associated_with::hotplate.

Interactions
GIT2 has been shown to interact with is_associated_with::GIT1.