OSBPL9

Oxysterol binding protein-like 9 is a is_associated_with::protein that in humans is encoded by the OSBPL9 is_associated_with::gene.

This gene encodes a member of the is_associated_with::oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal is_associated_with::pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This family member functions as a is_associated_with::cholesterol transfer protein that regulates Golgi structure and function. Multiple transcript variants, most of which encode distinct isoforms, have been identified. Related is_associated_with::pseudogenes have been identified on chromosomes 3, 11 and 12.

Model organisms
is_associated_with::Model organisms have been used in the study of OSBPL9 function. A conditional is_associated_with::knockout mouse line, called Osbpl9tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice, however no significant abnormalities were observed.