Beta-3 adrenergic receptor

The beta-3 adrenergic receptor (β3 adrenoreceptor), also known as ADRB3, is a is_associated_with::beta-adrenergic receptor, and also denotes the human is_associated_with::gene encoding it.

Function
Actions of the β3 receptor include:
 * Enhancement of is_associated_with::lipolysis in is_associated_with::adipose tissue.
 * is_associated_with::Thermogenesis in is_associated_with::skeletal muscle

It is located mainly in is_associated_with::adipose tissue and is involved in the regulation of lipolysis and is_associated_with::thermogenesis. Some β3 is_associated_with::agonists have demonstrated is_associated_with::antistress effects in animal studies, suggesting it also has a role in the central nervous system (CNS). Beta3-Receptors are found in the gallbladder, urinary bladder, and in is_associated_with::brown adipose tissue. Their role in gallbladder physiology is unknown, but they are thought to play a role in lipolysis and thermogenesis in brown fat. In the urinary bladder it is thought to cause relaxation of the bladder and prevention of urination.

Mechanism of action
Beta adrenergic receptors are involved in the is_associated_with::epinephrine- and is_associated_with::norepinephrine-induced activation of is_associated_with::adenylate cyclase through the action of the is_associated_with::G proteins of the type Gs.

Agonists

 * is_associated_with::Amibegron (SR-58611A)
 * CL-316,243
 * L-742,791
 * L-796,568
 * LY-368,842
 * is_associated_with::Mirabegron (YM-178), approved for treatment of overactive bladder in Japan, United States, UK, Canada, China and India.
 * Ro40-2148
 * is_associated_with::Solabegron (GW-427,353)

A selective β3 is_associated_with::agonist has potential weight loss effects through modulation of lipolysis.

Antagonists

 * L-748,328
 * L-748,337
 * is_associated_with::SR 59230A was thought to be a selective β3 antagonist but later found to also be an antagonist of the α1 receptor.

Interactions
Beta-3 adrenergic receptor has been shown to interact with Src.