WWC1

Protein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a is_associated_with::protein that in humans is encoded by the WWC1 is_associated_with::gene.

A single nucleotide polymorphism (is_associated_with::rs17070145) in the gene has been association with is_associated_with::human memory performance in one 2006 study. No significant support for association with memory was found in a study with 584 subjects. However it was replicated in a smaller study of the elderly. A subsequent study in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.

Studies have also begun to investigate the role of KIBRA in is_associated_with::Alzheimer's disease.

Interactions
KIBRA has at least 10 interaction partners, including is_associated_with::synaptopodin, is_associated_with::PKCζ and is_associated_with::Dendrin, most of which modify synaptic plasticity. For instance, Dendrin is a post-synaptic protein with expression regulated by sleep deprivation. KIBRA has been shown to interact with is_associated_with::Protein kinase Mζ.