CYP2C8

Cytochrome P4502C8 (abbreviated CYP2C8), a member of the is_associated_with::cytochrome P450 mixed-function oxidase system, is involved in the metabolism of is_associated_with::xenobiotics in the body.

CYP2C8 Ligands
Following is a table of selected substrates, inducers and inhibitors of 2C8.

Inhibitors of CYP2C8 can be classified by their potency, such as:
 * Strong inhibitor being one that causes at least a five-fold increase in the plasma AUC values, or more than 80% decrease in clearance.
 * Moderate inhibitor being one that causes at least a two-fold increase in the plasma AUC values, or 50-80% decrease in clearance.
 * Weak inhibitor being one that causes at least a 1.25-fold but less than two-fold increase in the plasma AUC values, or 20-50% decrease in clearance.

Where classes of agents are listed, there may be exceptions within the class.