AKT3

RAC-gamma serine/threonine-protein kinase is an is_associated_with::enzyme that in humans is encoded by the AKT3 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the AKT subfamily of is_associated_with::serine/threonine protein kinases. AKT kinases are known to be regulators of cell signaling in response to is_associated_with::insulin and is_associated_with::growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, is_associated_with::apoptosis, is_associated_with::tumorigenesis, as well as is_associated_with::glycogen synthesis and is_associated_with::glucose uptake. This kinase has been shown to be stimulated by is_associated_with::platelet-derived growth factor (PDGF), insulin, and is_associated_with::insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. Mice lacking Akt3 have a normal glucose metabolism (no diabetes), have approximately normal body weight, but have a 25% reduction in brain mass. Incidentally, Akt3 is highly expressed in the brain.

Interactions
AKT3 has been shown to interact with is_associated_with::Protein kinase Mζ.