PRKAB1

5'-AMP-activated protein kinase subunit beta-1 is an is_associated_with::enzyme that in humans is encoded by the PRKAB1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PRKAB1 function. A conditional is_associated_with::knockout mouse line, called Prkab1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. Homozygous mutant males displayed is_associated_with::impaired glucose tolerance. Animals of both sex had increased circulating is_associated_with::bilirubin levels, increased IgG3 levels, and a number of atypical is_associated_with::haematology parameters.

Interactions
PRKAB1 has been shown to interact with is_associated_with::PRKAG2 and is_associated_with::PRKAG1.

The 5'-AMP-activated protein kinase beta subunit interaction domain (AMPKBI) is a conserved domain found in the beta subunit of the 5-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known.