REL

The proto-oncogene c-Rel is a is_associated_with::protein that in humans is encoded by the REL is_associated_with::gene. The c-Rel protein is a member of the is_associated_with::NF-κB family of is_associated_with::transcription factors and contains a Rel homology domain (RHD) at its is_associated_with::N-terminus and two is_associated_with::C-terminal transactivation domains. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human is_associated_with::B-cell lymphomas, including is_associated_with::diffuse large B-cell lymphoma and is_associated_with::Hodgkin's lymphoma.