PITX1

paired-like homeodomain 1 is a is_associated_with::protein that in humans is encoded by the PITX1 is_associated_with::gene.

{{PBB_Summary
 * section_title =
 * summary_text = This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. According to an October 2008 press release by the is_associated_with::Washington University School of Medicine, the gene is the first gene thought to be involved with is_associated_with::clubfoot. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.

Clinical relevance
Mutations in this gene have been associated with is_associated_with::autism }} and polydactyly in humans.

Genomic rearrangements at the PITX1 locus are associated with is_associated_with::Liebenberg syndrome

Interactions
PITX1 has been shown to interact with is_associated_with::Pituitary-specific positive transcription factor 1.