RPL23A

60S ribosomal protein L23a is a is_associated_with::protein that in humans is encoded by the RPL23A is_associated_with::gene.

Function
is_associated_with::Ribosomes, the organelles that catalyze protein synthesis, consist of a small is_associated_with::40S subunit and a large is_associated_with::60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L23P family of ribosomal proteins. It is located in the is_associated_with::cytoplasm. The protein may be one of the target molecules involved in mediating growth inhibition by is_associated_with::interferon. In yeast, the corresponding protein binds to a specific site on the 26S rRNA. This gene is co-transcribed with the U42A, U42B, U101A, and U101B small nucleolar RNA genes, which are located in its third, first, second, and fourth is_associated_with::introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed is_associated_with::pseudogenes of this gene dispersed through the genome.

Clinical significance
L23a has been identified as an autoimmune target that causes a form of is_associated_with::rheumatoid arthritis in mice and which also causes a reaction from T cells and autoantibodies from human rheumatoid arthritis patients.