RFC1

Replication factor C subunit 1 is a is_associated_with::protein that in humans is encoded by the RFC1 is_associated_with::gene.

Function
The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit is_associated_with::DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.

Interactions
RFC1 has been shown to interact with:
 * is_associated_with::BRD4,
 * is_associated_with::HDAC1,
 * is_associated_with::PCNA,
 * is_associated_with::RELA and
 * is_associated_with::RFC3.