PTTG1

Securin is a is_associated_with::protein that in humans is encoded by the PTTG1 is_associated_with::gene.

Interactions
PTTG1 has been shown to interact with is_associated_with::RPS10, is_associated_with::PTTG1IP, is_associated_with::DNAJA1, is_associated_with::Ku70 and is_associated_with::P53.

Regulation
During Mitosis CDK1 phosphorylate PTTG1 at Ser-165. PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase inhibitor PHA-848125.