BRCC3

Lys-63-specific deubiquitinase BRCC36 is an is_associated_with::enzyme that in humans is encoded by the BRCC3 is_associated_with::gene.

Function
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.

Interactions
BRCC3 has been shown to interact with BRE, is_associated_with::BRCA2, is_associated_with::RAD51, is_associated_with::BRCA1, is_associated_with::P53 and is_associated_with::BARD1.