Paraplegin

Paraplegin is a is_associated_with::protein that in humans is encoded by the SPG7 is_associated_with::gene.

Interactions
Knockdown of spastic paraplegia 7 by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1.

Clinical Significance
It has been shown that an SPG7 variant escapes phosphorylation-regulated processing by AFG3L2 and increases reactive oxygen species generation and is correlated with many clinical phenotypes.