HBG2

Hemoglobin subunit gamma-2 is a is_associated_with::protein that in humans is encoded by the HBG2 is_associated_with::gene.

Function
The gamma globin genes (is_associated_with::HBG1 and HBG2, this gene) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some is_associated_with::beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where is_associated_with::glycine is found in the G-gamma product (HBG2) and is_associated_with::alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5' - epsilon – gamma-G – gamma-A – delta – beta - 3'.