Rs10488631

rs10488631, a SNP located 3' of the IRF5 gene, has been reported as a possibly causative SNP for systemic lupus erthymatosus (SLE), based on a study of ~700 Swedish patients. The risk allele is rs10488631(C), with a reported odds ratio of 2.07 (CI: 1.63-2.62, p = 9x10e-10).

The C allele is also associated with primary biliary cirrhosis, with each C increasing the odds about 1.6 times.

Each C allele increases risk of Sj& by 1.7 times.

SLE rs10488631 and rs7582694