ROR2

Tyrosine-protein kinase transmembrane receptor ROR2 also known as neurotrophic tyrosine kinase, receptor-related 2, is a is_associated_with::protein that in humans is encoded by the ROR2 is_associated_with::gene located on position 9 of the long arm of chromosome 9. This protein is responsible for aspects of is_associated_with::bone and is_associated_with::cartilage growth. It is involved in is_associated_with::Robinow syndrome and autosomal dominant is_associated_with::brachydactyly type B. ROR2 is a member of the is_associated_with::receptor tyrosine kinase-like orphan receptor (ROR) family.

Function
The protein encoded by this gene is a is_associated_with::receptor tyrosine kinase and type I is_associated_with::transmembrane protein that belongs to the ROR subfamily of cell surface receptors. The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development.

Clinical significance
Mutations in this gene can cause is_associated_with::brachydactyly type B, a skeletal disorder characterized by is_associated_with::hypoplasia/is_associated_with::aplasia of distal is_associated_with::phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of is_associated_with::Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, is_associated_with::brachydactyly, and a dysmorphic facial appearance.