Rs1693482

rs1693482, also known as Arg272Gln, is a SNP in the alcohol dehydrogenase 1C ADH1C gene. The rs1693482(C) allele is the more common, encoding the amino acid arginine (Arg); the rarer rs1693482(T) allele encodes the variant glutamine (Gln).

A study of 575 Irish alcoholics observed an association between rs1693482 and risk for alcohol dependence.

On it's own, this SNP is also said to explain 8.4% of the variability in the rate at which alcohol is metabolized, based on a study of 250 Spaniards.

More significantly (in a statistical sense), this study concluded that combinations of this SNP and others were shown to affect alcohol metabolism; most of these combinations are represented by the gs211 genoset.

Note that the effects of alcohol are higher in individuals who break down (basically, detoxify) ethanol more slowly.