Nitric oxide synthase 2 (inducible)

Nitric oxide synthase, inducible is an is_associated_with::enzyme that in humans is encoded by the NOS2 is_associated_with::gene.

is_associated_with::Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in is_associated_with::liver and is inducible by a combination of is_associated_with::lipopolysaccharide and certain is_associated_with::cytokines. Three related is_associated_with::pseudogenes are located within the Smith-Magenis syndrome region on is_associated_with::chromosome 17. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Interactions
Nitric oxide synthase 2A has been shown to interact with is_associated_with::Caveolin 1 and is_associated_with::Rac2.