CLDN16

Claudin-16 is a is_associated_with::protein that in humans is encoded by the CLDN16 is_associated_with::gene. It belongs to the group of is_associated_with::claudins.

Model organisms
is_associated_with::Model organisms have been used in the study of CLDN16 function. A conditional is_associated_with::knockout mouse line, called Cldn16tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on homozygous is_associated_with::mutant animals and one significant abnormality was observed: the mice displayed is_associated_with::urolithiasis.