PTK6

Tyrosine-protein kinase 6 is an is_associated_with::enzyme that in humans is encoded by the PTK6 is_associated_with::gene.

Function
Tyrosine-protein kinase 6 (also known as Breast Tumor Kinase, Brk) is a cytoplasmic non-receptor is_associated_with::protein kinase which may function as an intracellular signal transducer in epithelial tissues. The encoded protein has been shown to undergo autophosphorylation.

Clinical significance
Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue.

Interactions
PTK6 has been shown to interact with is_associated_with::STAP2 and is_associated_with::KHDRBS1.