ADAMTS5

A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an is_associated_with::enzyme that in humans is encoded by the ADAMTS5 is_associated_with::gene.

Function
ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a is_associated_with::metalloproteinase domain, a is_associated_with::disintegrin-like domain, and a is_associated_with::thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as is_associated_with::aggrecanase to cleave is_associated_with::aggrecan, a major is_associated_with::proteoglycan of cartilage.

Clinical significance
Genetically modified mice in which the catalytic domain of ADAMTS5 was deleted are resistant to cartilage destruction in an experimental model of is_associated_with::osteoarthritis. ADAMTS5 is the major aggrecanase in mouse cartilage in a mouse model of inflammatory arthritis.