NEU1

Sialidase 1 (lysosomal sialidase), also known as NEU1 is a mammalian lysosomal is_associated_with::neuraminidase enzyme which in humans is encoded by the NEU1 is_associated_with::gene.

Function
The protein encoded by this gene encodes the lysosomal enzyme, which cleaves terminal is_associated_with::sialic acid residues from substrates such as is_associated_with::glycoproteins and is_associated_with::glycolipids. In the is_associated_with::lysosome, this enzyme is part of a heterotrimeric complex together with beta-galactosidase and cathepsin A (the latter also referred to as 'protective protein'). Mutations in this gene can lead to is_associated_with::sialidosis.

Clinical significance
Deficiencies in the human enzyme NEU1 leads to is_associated_with::sialidosis, a rare is_associated_with::lysosomal storage disease. Sialidase has also been shown to enhance recovery from spinal cord contusion injury when injected in rats.

Interactions
NEU1 has been shown to interact with is_associated_with::Cathepsin A.