Serrate RNA effector molecule homolog

Serrate RNA effector molecule homolog (SRRT) also known as arsenite-resistance protein 2 (ARS2) is a is_associated_with::protein that in humans is encoded by the SRRT is_associated_with::gene.

The SRRT gene product plays a role in RNA-mediated is_associated_with::gene silencing (RNAi) by miRNAs. Independently of its activity on miRNAs, it is necessary and sufficient to promote neural is_associated_with::stem cell self-renewal, by directly binding the is_associated_with::SOX2 promoter and positively regulating its transcription.

It does not directly confer arsenite resistance but rather modulates arsenic sensitivity. Diseases associated with SRRT include is_associated_with::spondylocostal dysostosis.