HSD17B10

17-β-Hydroxysteroid dehydrogenase X (HSD10) also known as 3-hydroxyacyl-CoA dehydrogenase type-2 is a mitochondrial is_associated_with::enzyme that in humans is encoded by the HSD17B10 (hydroxysteroid (17β) dehydrogenase 10) is_associated_with::gene. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Function
17beta-hydroxysteroid dehydrogenase 10 is a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a is_associated_with::mitochondrial is_associated_with::protein that catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids.

Clinical significance
The protein has also been implicated in the development of Alzheimer's disease. Missense and silent mutations in the gene are the cause of hydroxysteroid (17β) dehydrogenase X (HSD10) deficiency, formerly MHBD deficiency, and X-linked mental retardation, choreoathetosis, and abnormal behavior (MRXS10), respectively.

Interactions
HSD17B10 has been shown to interact with is_associated_with::Amyloid precursor protein.