CD7

CD7 (Cluster of Differentiation 7) is a is_associated_with::protein that in humans is encoded by the CD7 is_associated_with::gene.

Function
This gene encodes a transmembrane protein which is a member of the is_associated_with::immunoglobulin superfamily. This protein is found on is_associated_with::thymocytes and mature is_associated_with::T cells. It plays an essential role in T-cell interactions and also in is_associated_with::T-cell/is_associated_with::B-cell interaction during early is_associated_with::lymphoid development.

Interactions
CD7 has been shown to interact with is_associated_with::PIK3R1.

Clinical significance
CD7 can be aberrantly expressed in refractory anaemia with excess blasts (RAEB) and may confer a worse prognosis. Also, a lack of CD7 expression could insinuate is_associated_with::mycosis fungoides (MF) or is_associated_with::Sezary syndrome (SS).