FGL1

Fibrinogen-like protein 1 (FGL-1) is a is_associated_with::protein that is structurally related to is_associated_with::fibrinogen. In humans, FLG-1 is encoded by the FGL1 is_associated_with::gene. Four splice variants exist for this gene.

Function
Fibrinogen-like protein 1 is a member of the fibrinogen family of proteins, which also includes fibrinogen, fibrinogen-like protein 2, and clotting factors V, VIII, and XIII. FGL-1 is homologous to the is_associated_with::carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved is_associated_with::cysteines of that are common to all members of the fibrinogen family. However, FGL-1 lacks the platelet-binding site, cross-linking region, and is_associated_with::thrombin-sensitive site which allow the other members of the fibrinogen family to aid in fibrin clot formation.

Clinical significance
FGL-1 may play a role in the development of is_associated_with::hepatocellular carcinomas.