Herpesvirus entry mediator

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human is_associated_with::cell surface receptor of the is_associated_with::TNF-receptor superfamily.

Nomenclature
This protein was originally known as herpesvirus entry mediator A (HveA); is_associated_with::HveB and is_associated_with::HveC are structurally unrelated proteins of the immunoglobulin superfamily. It is also known as CD270 in the is_associated_with::cluster of differentiation classification. Moreover it is also referred to as ATAR (another TRAF-associated receptor).

Interactions
TNFRSF14 has been shown to interact with is_associated_with::TRAF2, is_associated_with::TNFSF14  and is_associated_with::TRAF5.

Clinical relevance
Mutations in this gene have been recurrently been associated to cases of is_associated_with::diffuse large B-cell lymphoma.