TGF beta receptor 1

Transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) is a is_associated_with::TGF beta receptor. TGFBR1 is its human is_associated_with::gene.

Function
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS).

Interactions
TGF beta receptor 1 has been shown to interact with:


 * is_associated_with::Caveolin 1,
 * is_associated_with::Endoglin,
 * is_associated_with::FKBP1A,
 * is_associated_with::FNTA,
 * is_associated_with::Heat shock protein 90kDa alpha (cytosolic), member A1
 * is_associated_with::Mothers against decapentaplegic homolog 7,
 * is_associated_with::PPP2R2A,
 * is_associated_with::STRAP,
 * is_associated_with::TGF beta 1,  and
 * is_associated_with::TGF beta receptor 2.

Inhibitors

 * is_associated_with::GW-788,388
 * is_associated_with::LY-2109761
 * is_associated_with::Galunisertib (LY-2157299)
 * is_associated_with::SB-431,542
 * is_associated_with::SB-525,334