UGT1A5

UDP-glucuronosyltransferase 1-5 is an is_associated_with::enzyme that in humans is encoded by the UGT1A5 is_associated_with::gene.

Function
This gene encodes a is_associated_with::UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small is_associated_with::lipophilic molecules, such as is_associated_with::steroids, is_associated_with::bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first is_associated_with::exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.