Elongation factor P

In molecular biology, elongation factor P is a prokaryotic protein translation factor required for efficient peptide bond synthesis on 70S ribosomes from fMet-tRNAfMet. It probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.

Elongation factor P consists of three domains:
 * An N-terminal KOW-like domain
 * A central OB domain, which forms an oligonucleotide-binding fold. It is not clear if this region is involved in binding nucleic acids
 * A C-terminal domain which adopts an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology