PEA15

Astrocytic phosphoprotein PEA-15 is a is_associated_with::protein that in humans is encoded by the PEA15 is_associated_with::gene.

PEA15 is a death effector domain (DED)-containing protein predominantly expressed in the is_associated_with::central nervous system, particularly in is_associated_with::astrocytes.

PEA-15 promotes autophagy in glioma cells in a JNK-dependent manner.

Interactions
PEA15 has been shown to interact with:
 * is_associated_with::Caspase 8,
 * is_associated_with::FADD, and
 * is_associated_with::MAPK1,
 * is_associated_with::Phospholipase D1, and
 * is_associated_with::RPS6KA3.