Cyclin-dependent kinase 7

Cell division protein kinase 7 is an is_associated_with::enzyme that in humans is encoded by the CDK7 is_associated_with::gene.

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of is_associated_with::Saccharomyces cerevisiae is_associated_with::cdc28, and is_associated_with::Schizosaccharomyces pombe is_associated_with::cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with is_associated_with::cyclin H and is_associated_with::MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor is_associated_with::TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

Interactions
Cyclin-dependent kinase 7 has been shown to interact with is_associated_with::XPB,  is_associated_with::Cyclin H,  is_associated_with::P53,  is_associated_with::Androgen receptor, is_associated_with::GTF2H1,  is_associated_with::MNAT1 and is_associated_with::SUPT5H.