NDUFS8

NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial also known as NADH-ubiquinone oxidoreductase 23 kDa subunit is an is_associated_with::enzyme that in humans is encoded by the NDUFS8 is_associated_with::gene.

Function
This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or is_associated_with::Complex I, a multimeric enzyme of the is_associated_with::respiratory chain responsible for is_associated_with::NADH oxidation, is_associated_with::ubiquinone reduction, and the ejection of protons from is_associated_with::mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process.

Clinical significance
Mutations in this gene have been associated with is_associated_with::Leigh syndrome.