Rs2304256

rs2304256 is a SNP in the TYK2 gene on chromosome 19. The most common allele, rs2304256(C), has been associated with increased risk for systemic lupus erythematosus (SLE), with an odds ratio of 1.6 (CI: 1.3-1.9).

No association was seen between this SNP and SLE in a study of 411 Japanese SLE patients.

Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

Replication of recently identified systemic lupus erythematosus genetic associations: a case-control study.

Evidence for genetic association and interaction between the TYK2 and IRF5 genes in systemic lupus erythematosus.

Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

Tyrosine kinase 2 and interferon regulatory factor 5 polymorphisms are associated with discoid and subacute cutaneous lupus erythematosus.