Annexin A2

Annexin A2 also known as annexin II is a is_associated_with::protein that in humans is encoded by the ANXA2 is_associated_with::gene.

Annexin 2 is involved in diverse cellular processes such as is_associated_with::cell motility (especially that of the is_associated_with::epithelial cells), linkage of membrane-associated protein complexes to the actin is_associated_with::cytoskeleton, is_associated_with::endocytosis, fibrinolysis, is_associated_with::ion channel formation, and cell matrix interactions. It is a calcium-dependent phospholipid-binding protein whose function is to help organize is_associated_with::exocytosis of intracellular proteins to the extracellular domain. Annexin II is a is_associated_with::pleiotropic protein meaning that its function is dependent on place and time in the body.

Gene
The ANXA2 gene, located at 15q22.2, has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Function
This protein is a member of the is_associated_with::annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption.

Annexin A2 has been proposed to function inside the cell in sorting of is_associated_with::endosomes and outside the cell in is_associated_with::anticoagulant reactions.

Interactions
Annexin A2 has been shown to interact with is_associated_with::Prohibitin, is_associated_with::CEACAM1, is_associated_with::S100A10, is_associated_with::PCNA and complement is_associated_with::Factor H