CLDN2

Claudin-2 is a is_associated_with::protein that in humans is encoded by the CLDN2 is_associated_with::gene. It belongs to the group of is_associated_with::claudins.

Function
Claudin-2 is expressed in cation-leaky epithelia such as that of the is_associated_with::kidney proximal tubule. Mice that are deficient in claudin-2 have reduced is_associated_with::reabsorption of Na+ in the proximal tubule, consistent with a role in is_associated_with::paracellular transport. Similar results have been obtained with cultured cells.