CD49b

CD49b (cluster of differentiation 49b) is a is_associated_with::protein which in humans is encoded by the CD49b is_associated_with::gene.

The CD49b protein is an is_associated_with::integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane is_associated_with::glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including, is_associated_with::T cells (the NKT cells), NK cells, is_associated_with::fibroblasts and is_associated_with::platelets. Integrins are involved in is_associated_with::cell adhesion and also participate in cell-surface mediated signalling.

DX5 is a monoclonal antibody which binds to CD49b.

Interactions
CD49b has been shown to interact with is_associated_with::MMP1.