Information Hyperlinked over Proteins

Information Hyperlinked over Proteins (or iHOP) is an online service that provides a gene-guided network to access PubMed abstracts. By using genes and proteins as hyperlinks between sentences and abstracts, the information in PubMed can be converted into one navigable resource. Navigating across interrelated sentences within this network rather than the use of conventional keyword searches allows for stepwise and controlled acquisition of information. Moreover, this literature network can be superimposed upon experimental interaction data to facilitate the simultaneous analysis of novel and existing knowledge. The network presented in iHOP currently contains 12 million sentences and 80000 genes from over 1,500 organisms, including Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Danio rerio, Arabidopsis thaliana, Saccharomyces cerevisiae and Escherichia coli.

The system was published in Nature Genetics 36, 664 (2004) as 'A gene network for navigating the literature'.