LHX3

LIM/homeobox protein Lhx3 is a is_associated_with::protein that in humans is encoded by the LHX3 is_associated_with::gene.

Function
LHX3 encodes a protein of a large protein family, members of which carry the is_associated_with::LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for is_associated_with::pituitary development and is_associated_with::motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.

Clinical significance
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.

Interactions
LHX3 has been shown to interact with is_associated_with::Ldb1.