Rs1800925

asthma related

This SNP is in the promoter region of the IL-13 gene

PMID: 17615386 IL-13 is involved in pulmonary inflammation, remodeling and susceptibility to chronic obstructive pulmonary disease (COPD). This IL13 promoter polymorphism may modulate the adverse effects of cigarette smoking on pulmonary function in long-term cigarette smokers. Every 20 pack-year increment in smoking was associated with a 2.4% reduction in mean ppFEV1(forced expiratory volume in 1 second, a measure used to assess lung disease, like COPD) in the common homozygous (CC) or heterozygous (CT) promoter genotypes, and an 8.2% reduction in mean ppFEV1 in minor allele homozygotes (TT, recessive model).
 * pack-year= packs per day x years smoked

rs1800925 and/or rs11568506 related to psoriasis and/or Crohn's disease ?

rs324013 and rs1800925 influence transcription factor binding. These results are consistent with the Th2 cytokine pathway enhancing resistance to schistosome infection.

Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria


 * is_associated_with_disease::Rheumatoid arthritis
 * is_associated_with_disease::Schistosomiasis
 * is_associated_with_disease::Systemic scleroderma
 * is_associated_with_disease::Hypersensitivity reaction type I disease
 * is_associated_with_disease::Esophageal cancer
 * is_associated_with_disease::Glioblastoma
 * is_associated_with_disease::Lung cancer
 * is_associated_with_disease::Crohn's disease
 * is_associated_with_disease::Non-Hodgkin lymphoma
 * is_associated_with_disease::Asthma
 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Psoriasis
 * is_associated_with_disease::Breast cancer
 * is_associated_with_disease::Cervical cancer
 * is_associated_with_disease::Malaria
 * is_associated_with_disease::Allergic rhinitis
 * is_associated_with_disease::Chronic obstructive pulmonary disease
 * is_associated_with_disease::Psoriatic arthritis