CDC73

Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae), also known as CDC73 and parafibromin, is a is_associated_with::protein which in humans is encoded by the CDC73 is_associated_with::gene.

Function
Parafibromin, is_associated_with::LEO1, is_associated_with::PAF1, and is_associated_with::CTR9 form the PAF protein complex, which associates with the is_associated_with::RNA polymerase II subunit is_associated_with::POLR2A and with a is_associated_with::histone methyltransferase complex.

Clinical significance
Mutations in the CDC73 gene are associated with hyperparathyroidism-jaw tumor syndrome (is_associated_with::HPT-JT) and is_associated_with::parathyroid carcinomas.