CD29

Integrin beta-1 is a is_associated_with::protein that in humans is encoded by the ITGB1 is_associated_with::gene. CD29 is an is_associated_with::integrin unit associated with very late antigen receptors. It is known to conjoin with alpha-3 subunit to create α3β1 complex that reacts to such molecules as netrin-1 and is_associated_with::reelin.

is_associated_with::Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in is_associated_with::mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, is_associated_with::hemostasis, tissue repair, is_associated_with::immune response and metastatic diffusion of tumor cells. The protein encoded by this gene is a beta subunit. Six alternatively spliced variants have been found for this gene which encode five proteins with alternate carboxy termini.

Interactions
CD29 has been shown to interact with is_associated_with::TSPAN4, is_associated_with::CD9, is_associated_with::Filamin,  is_associated_with::FLNB, is_associated_with::CD81, is_associated_with::CD46, is_associated_with::MAP4K4, is_associated_with::FHL2, is_associated_with::NME1, is_associated_with::PKC alpha,  is_associated_with::YWHAB, is_associated_with::ITGB1BP1,  is_associated_with::LGALS8 and is_associated_with::GNB2L1. A neutralizing antibody for CD29 is is_associated_with::AIIB2.