Centromere protein B

Centromere protein B also known as major centromere autoantigen B is an is_associated_with::autoantigen protein of the is_associated_with::cell nucleus. In humans, centromere protein B is encoded by the CENPB is_associated_with::gene.

Function
Centromere protein B is a highly conserved protein that facilitates is_associated_with::centromere formation. It is a is_associated_with::DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies.

Clinical significance
Centromere protein B is a potential is_associated_with::biomarker of small-cell is_associated_with::lung cancer.