IMPDH2

Inosine-5'-monophosphate dehydrogenase 2, also known as IMP dehydrogenase 2, is an is_associated_with::enzyme that in humans is encoded by the IMPDH2 is_associated_with::gene.

Function
IMP dehydrogenase 2 is the rate-limiting enzyme in the de novo is_associated_with::guanine is_associated_with::nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. IMPDH2 catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate.

Clinical significance
This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.