SLC1A1

Excitatory amino-acid transporter 3 (EAAT3) also known as the high affinity glutamate transporter is a is_associated_with::protein that in humans is encoded by the SLC1A1 is_associated_with::gene.

Function
The Excitatory amino-acid transporter 3 member of the high-affinity is_associated_with::glutamate transporters that play an essential role in transporting is_associated_with::glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the is_associated_with::neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports is_associated_with::aspartate, and mutations in this gene are thought to cause is_associated_with::dicarboxylic aminoaciduria, also known as glutamate-aspartate transport defect.

Interactions
SLC1A1 has been shown to interact with is_associated_with::ARL6IP5.