PIP5K1C

Phosphatidylinositol-4-phosphate 5-kinase type-1 gamma is an is_associated_with::enzyme that in humans is encoded by the PIP5K1C is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PIP5K1C function. A conditional is_associated_with::knockout mouse line, called Pip5k1ctm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. Fewer than expected is_associated_with::homozygous mutant embryos were identified during gestation, and none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice and no further phenotypes were observed.