MAP3K7IP2

Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 is an is_associated_with::enzyme that in humans is encoded by the MAP3K7IP2 is_associated_with::gene.

The is_associated_with::protein encoded by this gene is an activator of is_associated_with::MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and is_associated_with::MAPK8/is_associated_with::JNK. This protein forms a kinase complex with is_associated_with::TRAF6, is_associated_with::MAP3K7 and TAB1, thus serves as an adaptor linking is_associated_with::MAP3K7 and is_associated_with::TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by is_associated_with::TNFSF11/is_associated_with::RANKL through the activation of the receptor activator of NF-kappB (is_associated_with::TNFRSF11A/is_associated_with::RANK), which may regulate the development and function of is_associated_with::osteoclasts. Mutations in MAP3K7IP2 have been associated with human congenital heart defects.

Interactions
MAP3K7IP2 has been shown to interact with:


 * is_associated_with::HDAC3,
 * is_associated_with::MAP3K7IP1,
 * is_associated_with::MAP3K7IP3,
 * is_associated_with::MAP3K7,
 * is_associated_with::NFKB1,
 * is_associated_with::NUMBL,
 * is_associated_with::Nuclear receptor co-repressor 1,
 * is_associated_with::TRAF2,  and
 * is_associated_with::TRAF6.