PRKCQ

Protein kinase C theta (PKC-θ) is an is_associated_with::enzyme that in humans is encoded by the PRKCQ is_associated_with::gene.

Function
is_associated_with::Protein kinase C (PKC) is a family of serine- and threonine-specific is_associated_with::protein kinases that can be activated by the is_associated_with::second messenger is_associated_with::diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for is_associated_with::phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and is_associated_with::phospholipid-dependent protein kinase. This kinase is important for is_associated_with::T-cell activation. It is required for the activation of the transcription factors is_associated_with::NF-kappaB and AP-1, and may link the is_associated_with::T cell receptor (TCR) signaling complex to the activation of the is_associated_with::transcription factors.

Interactions
PRKCQ has been shown to interact with:
 * is_associated_with::AKT1
 * is_associated_with::FYN,
 * is_associated_with::GLRX3, and
 * is_associated_with::VAV1.

PRKCQ has been shown to phosphorylate is_associated_with::CARD11 as part of the is_associated_with::NF-κB signaling pathway.

Inhibitors

 * (R)-2-((S)-4-(3-Chloro-5-fluoro-6-(1H-pyrazolo[3,4-b]pyridin- 3-yl)pyridin-2-yl)piperazin-2-yl)-3-methylbutan-2-ol