POLR1E

DNA-directed RNA polymerase I subunit RPA49 is an is_associated_with::enzyme that in humans is encoded by the POLR1E is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of POLR1E function. A conditional is_associated_with::knockout mouse line, called Polr1etm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.

Interactions
POLR1E has been shown to interact with is_associated_with::CD3EAP and is_associated_with::POLR1C.