Interleukin 24

Interleukin 24 (IL-24) is a is_associated_with::protein that in humans is encoded by the IL24 is_associated_with::gene.

IL-24 is a is_associated_with::cytokine belonging to the IL-10 family of cytokines that signals through two is_associated_with::heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as melanoma differentiation-associated 7 (mda-7) due to its discovery as a is_associated_with::tumour suppressing protein. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular is_associated_with::transcription factors called is_associated_with::STAT1 and is_associated_with::STAT3. This cytokine is predominantly released by activated is_associated_with::monocytes, is_associated_with::macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, is_associated_with::psoriasis and is_associated_with::cancer. Several studies have shown that cell death occurs in cancer cells/cell lines following exposure to IL-24. The gene for IL-24 is located on chromosome 1 in humans.