AKT2

RAC-beta serine/threonine-protein kinase is an is_associated_with::enzyme that in humans is encoded by the AKT2 is_associated_with::gene.

Function
This gene is a putative is_associated_with::oncogene encoding a protein belonging to the AKT subfamily of is_associated_with::serine/threonine kinases that contain SH2-like (Src homology 2-like) domains. The encoded protein is a general protein kinase capable of phosphorylating several known proteins.

Clinical significance
The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary is_associated_with::ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal is_associated_with::pancreatic cancers.

Mice lacking Akt2 have a normal body mass, but display a profound diabetic phenotype, indicating that Akt2 plays a key role in is_associated_with::signal transduction downstream of the is_associated_with::insulin receptor. Mice lacking Akt2 show worse outcome in is_associated_with::breast cancer initaited by the is_associated_with::large T antigen as well as the neu oncogene.

Interactions
AKT2 has been shown to interact with:


 * is_associated_with::APPL1,
 * is_associated_with::CHUK,
 * is_associated_with::SH3RF1 and
 * is_associated_with::TCL1A.