Decoy receptor 3

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the is_associated_with::tumor necrosis factor receptor superfamily which inhibits is_associated_with::Fas ligand-induced is_associated_with::apoptosis.

Discovery
Dcr3 was identified in 1998 by the search of genes with homology to the TNFR gene superfamily in expressed sequence tag (EST) database.

Structure
The open reading frame of TNFRSF6B encodes 300 amino acids with a 29-residue signal sequence and four tandem cystein-rich repeats. Two transcript variants encoding the same isoform, but differing in the 5' UTR, have been observed for this gene. Unlike most of the other members of TNFR superfamily, TNFRSF6 is a soluble protein which contains no transmembrane domain.

Function
This gene belongs to the is_associated_with::tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with is_associated_with::death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing is_associated_with::FasL- and LIGHT-mediated cell death and T cell activation as well as to induce is_associated_with::angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.

Interactions
TNFRSF6B has been shown to interact with:
 * is_associated_with::TNFSF14
 * is_associated_with::Fas ligand.