FKBPL

FK506-binding protein like, also known as FKBPL, is a is_associated_with::protein that in humans is encoded by the FKBPL is_associated_with::gene.

Function
FKBPL has similarity to the is_associated_with::immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced is_associated_with::radioresistance. Also it appears to have some involvement in the control of the is_associated_with::cell cycle.

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1. It was later reclassified because of its homology to the is_associated_with::FKBP family of proteins and was renamed is_associated_with::FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised is_associated_with::p21 termed it Wisp39.

It is known to interact with is_associated_with::Hsp90, is_associated_with::glucocorticoid receptor and dynamitin and may play a role in signalling, like other is_associated_with::FKBPs.

FKBPL has also been shown to influence is_associated_with::estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug is_associated_with::tamoxifen.