Vesicular acetylcholine transporter

The Vesicular acetylcholine transporter (VAChT) is a is_associated_with::neurotransmitter transporter which is responsible for loading is_associated_with::acetylcholine (ACh) into secretory organelles in neurons making acetylcholine available for secretion. It is encoded by Solute carrier family 18, member 3 (SLC18A3) is_associated_with::gene. VAChT is able to transport ACh into vesicles by relying on an exchange between protons that were previously pumped into the vesicle diffusing out. ACh molecules are then carried into the cell by the action of exiting protons. Acetylcholine transport utilizes a proton gradient established by a is_associated_with::vacuolar ATPase. This gene is located within the first intron of the is_associated_with::choline acetyltransferase gene.

is_associated_with::Radiolabeled compounds
PET imaging of the VAChT may provide insights into early diagnosis of is_associated_with::Alzheimer's disease.


 * (−)-trans-2-Hydroxy-3-(4-(4- [ 18F ] fluorobenzoyl)piperidino)tetralin; racemate: Ki = 2.70 nM for VAChT, 191 nM for σ1, and 251 nM for σ2