Nuclear receptor co-repressor 1

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a is_associated_with::protein that in humans is encoded by the NCOR1 is_associated_with::gene.

NCOR1 is a transcriptional coregulatory protein which contains several is_associated_with::nuclear receptor interacting domains. In addition, NCOR1 appears to recruit is_associated_with::histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

Loss of function of this protein significantly increases the strength and power of mouse muscles.

Interactions
Nuclear receptor co-repressor 1 has been shown to interact with:


 * is_associated_with::Androgen receptor,
 * is_associated_with::CHD1,
 * is_associated_with::Calcitriol receptor
 * GPS2,
 * is_associated_with::Glucocorticoid receptor,
 * is_associated_with::HDAC3,
 * is_associated_with::HDAC4,
 * is_associated_with::HDAC7A,
 * is_associated_with::HDAC9,
 * is_associated_with::HEY2,
 * is_associated_with::Histone deacetylase 5,
 * is_associated_with::MAP3K7IP2,
 * is_associated_with::MECP2,
 * is_associated_with::Peroxisome proliferator-activated receptor alpha,
 * is_associated_with::Promyelocytic leukemia protein,
 * is_associated_with::RUNX1T1,
 * is_associated_with::Retinoic acid receptor alpha,
 * is_associated_with::Retinoic acid receptor gamma,
 * is_associated_with::SAP30,
 * is_associated_with::TBL1XR1,
 * is_associated_with::TBL1X,   and
 * is_associated_with::ZBTB33.