IRGM

Immunity-related GTPase family M protein (IRGM), also known as interferon-inducible protein 1 (IFI1), is an is_associated_with::enyzme that in humans is IRGM is_associated_with::gene.

IRGM is a member of the is_associated_with::interferon-inducible GTPase family. The encoded protein may play a role in the is_associated_with::innate immune response by regulating is_associated_with::autophagy formation in response to intracellular pathogens.

Clinical relevance
Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to is_associated_with::Crohn's disease and is_associated_with::tuberculosis.