Rs7566605

rs7566605 was initially reported as being associated in at least 4 independent populations as being associated with obesity however replications are inconsistent, and a recent (2009) large meta-analysis comprising 34 studies (and over 70,000 subjects) has concluded that there is no evidence for overall association of the rs7566605 polymorphism with obesity. See also: Poster

At least one population has since been reported in which this association was not seen. Furthermore, a study of 18,000 Danish subjects also failed to find any direct role for this SNP in the development of obesity, except that among physically inactive subjects, (C)-allele carriers tended to have a higher body mass index (by O.5 kg/m2) than (G)-allele carriers.

On the other hand, a report has also been published indicating that obese children who are rs7566605(C;C) homozygotes find it harder to lose weight in clinical intervention programs than (C;G) heterozygotes or (G;G) homozygotes, which supports the association of SNP rs7566605 with obesity.

associated with the prevalence of hypercholesterolemia, but not with obesity, in Japanese American women. In Japanese American women, rs7566605(C;C) individuals had a 0.43-fold decreased risk (CI: 0.24 - 0.80) for hypercholesterolemia compared with the (G;G) homozygotes after adjustment for age and other factors. No significant differences in BMI, waist girth and percentage body fat according to the genotype in each of the four groups, which was divided by population and sex. The rs7566605(C;C) genotype is suggested to be a protective genetic factor against the progression of hypercholesterolemia on a high-fat diet, especially in Japanese female subjects.

rs9939609 and rs7566605 linked to obesity

underlies variation in subcutaneous adiposity in young adult women and suppresses the positive effects of resistance training on men.

does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors

rs7566605 is not associated with obesity-related traits and lipids in the ~2,00 person European Youth Heart Study.

rs7566605 near the INSIG2 gene does not influence BMI and is not associated directly with CAD/MI or indirectly through cardiovascular risk factors in a study of ~7,000 German adults.

Obesity: Preliminary Research


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