CISH

Cytokine-inducible SH2-containing protein is a is_associated_with::protein that in humans is encoded by the CISH is_associated_with::gene. CISH is_associated_with::orthologs have been identified in most is_associated_with::mammals with sequenced genomes. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria.

Model organisms
is_associated_with::Model organisms have been used in the study of CISH function. A conditional is_associated_with::knockout mouse line, called Cishtm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice, however no significant abnormalities were observed.

Interactions
CISH has been shown to interact with is_associated_with::IL2RB and is_associated_with::Growth hormone receptor.