WNT16

Protein Wnt-16 is a is_associated_with::protein that in humans is encoded by the WNT16 is_associated_with::gene. It has been proposed that stimulation of WNT16 expression in nearby normal cells is responsible for the development of is_associated_with::chemotherapy-resistance in is_associated_with::cancer cells.

WNT16B expression is regulated by nuclear factor of κ light polypeptide gene enhancer in is_associated_with::B cells 1 (NF-κB) after DNA damage, as can occur to normal cels during radiation or chemotherapy. Subsequently WNT16B signals in a paracrine manner to activate the Wnt expression program in tumor cells. The expression of WNT16B in the tumor microenvironment attenuates the effects of cytotoxic chemotherapy in vivo, promoting tumor cell survival and disease progression. This implies a mechanism by which cycles of genotoxic therapy might enhance subsequent treatment resistance in the tumor microenvironment.

Model organisms
is_associated_with::Model organisms have been used in the study of WNT16 function. A conditional is_associated_with::knockout mouse line called Wnt16tm2b(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

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