RGMB

RGM domain family, member B, also known as RGMB, is a is_associated_with::protein that in humans is encoded by the RGMB is_associated_with::gene.

Function
RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the is_associated_with::repulsive guidance molecule family (see also is_associated_with::RGMA and RGMC) and contributes to the patterning of the developing nervous system.

There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate is_associated_with::bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in is_associated_with::breast cancer and is_associated_with::prostate cancer through BMP signalling. Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.