MMP10

Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an is_associated_with::enzyme that in humans is encoded by the MMP10 is_associated_with::gene.

Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of is_associated_with::extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades is_associated_with::proteoglycans and is_associated_with::fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

MMP10 has been linked to cancer stem cell vitality and metastasis