MKI67IP

MKI67 FHA domain-interacting nucleolar phosphoprotein is a is_associated_with::protein that in humans is encoded by the MKI67IP is_associated_with::gene.

MKI67 FHA domain-interacting nucleolar phosphoprotein contains an is_associated_with::RNA recognition motif (RRM) near to the is_associated_with::N-terminus and a FHA Ki67 binding domain near to the is_associated_with::C-terminus. There are two is_associated_with::conserved sequence motifs within the FHA Ki67 binding domain: TPVCTP and LERRKS, this domain binds to the is_associated_with::forkhead-associated domain of is_associated_with::human Ki67. High-affinity binding requires sequential is_associated_with::phosphorylation by two is_associated_with::kinases, is_associated_with::CDK1 and is_associated_with::GSK3, yielding pThr238, pThr234 and pSer230. This interaction is involved in is_associated_with::cell cycle regulation.