Rs121908027

rs121908027, also known as 652delGGT, G197del, among other terms, is a mutation in the LDLR gene on chromosome 19. This mutation is known as FH Lithuania, since it appears to be a founder mutation for familial hypercholesterolemia originating in the 14th century. It is reported to the be most common FH mutation in Ashkenazi Jews, found in up to 35% of FH families in Israel.

rs121908027 is named i4000356 in 23andMe data.