ADAR

Double-stranded RNA-specific adenosine deaminase is an is_associated_with::enzyme that in humans is encoded by the ADAR is_associated_with::gene (which stands for adenosine deaminase acting on RNA).

Model organisms
is_associated_with::Model organisms have been used in the study of ADAR function. A conditional is_associated_with::knockout mouse line, called Adartm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. Few is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice and no abnormalities were observed in these animals.