ARG2

Arginase, type II is an is_associated_with::arginase is_associated_with::protein that in humans is encoded by the ARG2 is_associated_with::gene.

Function
is_associated_with::Arginase catalyzes the hydrolysis of is_associated_with::arginine to is_associated_with::ornithine and is_associated_with::urea. At least two isoforms of mammalian arginase exists (types I and II, this enzyme) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in is_associated_with::nitric oxide and is_associated_with::polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative is_associated_with::polyadenylation sites have been described.