Prostaglandin E receptor 3

Prostaglandin E receptor 3, also known as EP3, is a is_associated_with::prostaglandin receptor, encoded by the PTGER3 is_associated_with::gene.

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Receptor
The receptor is a member of the G-protein coupled receptor family. It works through the is_associated_with::G protein Gi, leading to a decrease in is_associated_with::cytosolic is_associated_with::cyclic AMP (cAMP). It is one of four receptors identified for is_associated_with::prostaglandin E2 (PGE2). This receptor may have many biological functions, which involve is_associated_with::digestion, nervous system, kidney reabsorption, and uterine contraction activities. In the stomach, it inhibits is_associated_with::gastric acid secretions.

Studies of the mouse counterpart suggest that this receptor may also mediate is_associated_with::adrenocorticotropic hormone response as well as is_associated_with::fever generation in response to exogenous and endogenous stimuli.

Variations
Multiple alternatively spliced transcript variants encoding eight distinct isoforms have been reported. }}