Cofactor of BRCA1

Cofactor of BRCA1, also known as COBRA1, is a human is_associated_with::gene that encodes NELF-B.

Function
NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (is_associated_with::WHSC2; MIM 606026), either NELF-C or NELF-D (TH1L; MIM 605297), and NELF-E (is_associated_with::RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (is_associated_with::DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of is_associated_with::RNA polymerase II (see MIM 180660). COBRA1 was initially identified in a yeast two-hybrid screen using the BRCT1 domain of is_associated_with::BRCA1 as bait.

Interactions
Cofactor of BRCA1 has been shown to interact with:
 * is_associated_with::BRCA1
 * is_associated_with::C-Fos,
 * is_associated_with::C-jun,
 * is_associated_with::Estrogen receptor alpha,
 * is_associated_with::RDBP, and
 * is_associated_with::TH1L.