SNX1

Sorting nexin-1 is a is_associated_with::protein that in humans is encoded by the SNX1 is_associated_with::gene. The protein encoded by this gene is a is_associated_with::sorting nexin. SNX1 is a component of the is_associated_with::retromer complex.

Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of is_associated_with::epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to is_associated_with::lysosomes. This protein may form oligomeric complexes with other family members.