SNX5

Sorting nexin-5 is a is_associated_with::protein that in humans is encoded by the SNX5 is_associated_with::gene.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein is a component of the mammalian is_associated_with::retromer complex, which facilitates cargo retrieval from is_associated_with::endosomes to the trans-Golgi network. It has also been shown to bind to the Fanconi anemia, complementation group A protein. This gene results in two transcript variants encoding the same protein.

Model organisms
is_associated_with::Model organisms have been used in the study of SNX5 function. A conditional is_associated_with::knockout mouse line, called Snx5tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice, however no significant abnormalities were observed.

Interactions
SNX5 has been shown to interact with is_associated_with::FANCA.