Rs10507391

rs10507391, also known as SG13S114, is an ALOX5AP gene SNP that has been defined as part of a haplotype potentially associated with risk for myocardial infarction or ischemic stroke. Details of this haplotype and several related studies are on the ALOX5AP page.

One study that specifically found association for rs10507391 involved 639 German ischemic stroke patients. The association was statistically significant (only) in males, with an odds ratio of 1.24 (CI: 1.04-1.55, p=0.017).

Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes.

Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis.

Genetics and pharmacogenetics of the leukotriene pathway.

Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study.

ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos.


 * is_associated_with_disease::Myocardial infarction
 * is_associated_with_disease::Cerebral infarction
 * is_associated_with_disease::Asthma
 * is_associated_with_disease::Atherosclerosis
 * is_associated_with_disease::Diabetes mellitus