EIF4E3

Eukaryotic translation initiation factor 4E family member 3 is a is_associated_with::protein that in humans is encoded by the EIF4E3 is_associated_with::gene.

EIF4E3 belongs to the EIF4E family of translational initiation factors that interact with the 5-prime cap structure of mRNA and recruit mRNA to the ribosome.

Model organisms
is_associated_with::Model organisms have been used in the study of EIF4E3 function. A conditional is_associated_with::knockout mouse line, called Eif4e3tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice but no significant abnormalities were observed.