SMYD3

SET and MYND domain-containing protein 3 is a is_associated_with::protein that in humans is encoded by the SMYD3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SMYD3 function. A conditional is_associated_with::knockout mouse line, called Smyd3tm2a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice, however no significant abnormalities were observed.

Interactions
SMYD3 has been shown to interact with is_associated_with::Heat shock protein 90kDa alpha (cytosolic), member A1 and is_associated_with::POLR2A.

SMYD3 trimethylates a lysine residue on is_associated_with::MAP3K2, which causes crosstalk into the is_associated_with::MAP kinase signaling pathway in Ras-driven cancers.