Rs855791

rs855791, also known as V736A, is a SNP in the transmembrane protease, serine 6 TMPRSS6 gene.

2 studies totaling over 17,000 individuals have linked this SNP to various blood parameters, including iron status, erythrocyte volume, and hemoglobin levels.[PMID 19820699, PMID 19820698]

23andMe blog each rs855791(T) and each rs198846(G) led to an approximately 0.1 gram per deciliter (g/dL) decrease in hemoglobin levels. rs1799945(C) is a proxy for rs198846(G).

Genetics and genomics of human ageing.

Association of TMPRSS6 polymorphisms with ferritin, hemoglobin, and type 2 diabetes risk in a Chinese Han population.

TMPRSS6, but not TF, TFR2 or BMP2 variants are associated with increased risk of iron-deficiency anemia.