Lecithin retinol acyltransferase

Lecithin retinol acyltransferase is an is_associated_with::enzyme that in humans is encoded by the LRAT is_associated_with::gene.

Function
Lecithin retinol acyltransferase is a microsomal enzyme that catalyzes the esterification of all-trans-is_associated_with::retinol into all-trans-retinyl ester during is_associated_with::phototransduction, an essential reaction for the retinoid cycle in visual system and is_associated_with::vitamin A status in liver.

Clinical significance
Mutations in this gene have been associated with early-onset severe retinal dystrophy.

LRAT was overexpressed in colorectal cancer cells compared to normal colonic epithelium. Strong LRAT expression was associated with a poor prognosis in patients with colorectal cancer.