Gadd45

The Growth Arrest and DNA Damage or gadd45 genes, including (originally termed gadd45)  (originally termed MyD118), and  (originally termed CR6), are implicated as stress sensors that modulate the response of mammalian cells to genotoxic/physiological stress, and modulate tumor formation. Gadd45 proteins interact with other proteins implicated in stress responses, including PCNA, p21, Cdc2/CyclinB1, MEKK4, and p38 kinase.

History

 * Gadd45a was discovered and characterized in the laboratory of Dr. Albert Fornace Jr. in 1988.


 * Gadd45b (MyD118) was discovered and characterized in the laboratories of Drs. Dan A. Liebermann and Barbara Hoffman in 1991.


 * Gadd45g (CR6) was discovered and characterized in the laboratories of Drs. Kenneth Smith, Dan A. Liebermann, and Barbara Hoffman in 1993 and 1999.