OSTalpha

Organic solute transporter alpha, also known as OST-alpha, is a is_associated_with::protein which in humans is encoded by the OSTA is_associated_with::gene.

Function
OST-alpha together with OST-beta is able to transport is_associated_with::estrone sulfate, taurocholate, is_associated_with::digoxin, and is_associated_with::prostaglandin E2 across is_associated_with::cell membranes. The Ost-alpha / Ost-beta heterodimer, but not the individual subunits, stimulates sodium-independent bile acid uptake. The heterodimer furthermore is essential for intestinal bile acid transport.

OST-alpha and OST-alpha have high expression in the testis, colon, liver, small intestine, kidney, ovary, and adrenal gland.