Gastricsin

Gastricsin also known as pepsinogen C is an is_associated_with::enzyme that in humans is encoded by the PGC is_associated_with::gene.

Function
Gastricsin is an is_associated_with::aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself.

Clinical significance
Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including is_associated_with::Helicobacter pylori related is_associated_with::gastritis.