CREB1

CAMP responsive element binding protein 1, also known as CREB-1, is a is_associated_with::protein that in humans is encoded by the CREB1 is_associated_with::gene. This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

This protein is a is_associated_with::CREB is_associated_with::transcription factor that is a member of the is_associated_with::leucine zipper family of is_associated_with::DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is is_associated_with::phosphorylated by several is_associated_with::protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. is_associated_with::Alternate splicing of this gene results in two transcript variants encoding different is_associated_with::isoforms.

Interactions
CREB1 has been shown to interact with:
 * PPI::CEBPB,
 * PPI::CREB binding protein,
 * PPI::FHL2,
 * PPI::FHL3,
 * PPI::FHL5.
 * PPI::HTATIP,
 * PPI::P53, and
 * PPI::RPS6KA5.