Rs138326449

rs138326449, also known as IVS2+1G>A, is a rare variant in the apolipoprotein C3 APOC3 gene.

As reported in two large studies published in 2014, rs138326449 is one of several loss of function mutations in the APOC3 gene associated with a >40% lower average triglyceride level in individuals carrying one rs138326449(A) allele and a corresponding decrease in coronary artery disease.