Podocin

Podocin is a protein component of the slit diaphragm of podocytes. Glomerular capillary endothelial cells, the glomerular basement membrane and the slit diaphragms function as the filtration barrier of the kidney glomerulus. Mutations in the podocin gene NPHS2 can cause nephrotic syndrome, such as Focal Segmental Glomerulosclerosis (FSGS) or Minimal Change Disease (MCD).