PARD6A

Partitioning defective 6 homolog alpha is a is_associated_with::protein that in humans is encoded by the PARD6A is_associated_with::gene.

Function
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions
PARD6A has been shown to interact with:
 * is_associated_with::CDC42,
 * is_associated_with::ECT2
 * is_associated_with::Protein kinase Mζ, and
 * is_associated_with::RAC1.