DAAM1

Disheveled-associated activator of morphogenesis 1 is a is_associated_with::protein that in humans is encoded by the DAAM1 is_associated_with::gene. Evidence of alternative splicing has been observed for this gene but the full-length nature of these variants has not been determined.

Function
is_associated_with::Cell motility, adhesion, and is_associated_with::cytokinesis, and other functions of the is_associated_with::cell cortex are mediated by the reorganization of the is_associated_with::actin is_associated_with::cytoskeleton and recent evidence suggests a role for formin homology (FH) proteins in these processes. The protein encoded by this gene contains FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. Wnt/Fz signaling activates the small is_associated_with::GTPase Rho, a key regulator of cytoskeleton architecture, to control is_associated_with::cell polarity and movement during development. Activation requires Dvl-Rho complex formation, an assembly mediated by this gene product, which is thought to function as a scaffolding protein.

Clinical significance
The deletion of a single copy of this gene has been associated with is_associated_with::congenital heart defects.