Proteinase 3

Proteinase 3 also known as PRTN3 is an is_associated_with::enzyme that in humans is encoded by the PRTN3 is_associated_with::gene.

Function
PRTN3 is a is_associated_with::serine protease is_associated_with::enzyme expressed mainly in is_associated_with::neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown, but, in human neutrophils, proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the is_associated_with::epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the is_associated_with::c-ANCA (is_associated_with::cytoplasmic subtype) class, a type of antibody frequently found in the disease is_associated_with::granulomatosis with polyangiitis (formerly known as "Wegener's granulomatosis").