SMC3

Structural maintenance of chromosomes 3, also known as SMC3, is a human gene.

Function
This is_associated_with::gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein.

Model organisms
is_associated_with::Model organisms have been used in the study of SMC3 function. A conditional is_associated_with::knockout mouse line, called Smc3tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::mutant mice and six significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and thus none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice. Females had a higher than normal incidence of pre-wean death in their offspring, and also had a decreased body weight. Males heterozygotes displayed a shortened, upturned is_associated_with::snout.

Interactions
SMC3 (gene) has been shown to interact with:


 * is_associated_with::KIFAP3,
 * is_associated_with::MXD1,
 * is_associated_with::MXI1,
 * is_associated_with::REC8, and
 * is_associated_with::SMC1A.