DGUOK

Deoxyguanosine kinase, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the DGUOK is_associated_with::gene.

Function
In mammalian cells, the is_associated_with::phosphorylation of purine is_associated_with::deoxyribonucleosides is mediated predominantly by two deoxyribonucleoside kinases, cytosolic is_associated_with::deoxycytidine kinase and mitochondrial is_associated_with::deoxyguanosine kinase. The protein encoded by this gene is responsible for phosphorylation of purine deoxyribonucleosides in the is_associated_with::mitochondrial matrix. In addition, this protein phosphorylates several purine deoxyribonucleoside analogs used in the treatment of lymphoproliferative disorders, and this phosphorylation is critical for the effectiveness of the analogs. Alternative splice variants encoding different protein isoforms have been described for this gene.