BOP1

Ribosome biogenesis protein BOP1 is a is_associated_with::protein that in humans is encoded by the BOP1 is_associated_with::gene.

Function
It is a is_associated_with::WD40 repeat-containing nucleolar protein involved in rRNA processing, thereby controlling the cell cycle. It is required for the maturation of the 25S and 5.8S ribosomal RNAs. It may serve as an essential factor in is_associated_with::ribosome formation that coordinates processing of the spacer regions in pre-rRNA. The Pes1-Bop1 complex has several components: BOP1, is_associated_with::GRWD1, is_associated_with::PES1, is_associated_with::ORC6L, and is_associated_with::RPL3 and is involved in ribosome is_associated_with::biogenesis and altered is_associated_with::chromosome segregation. The overexpression of BOP1 increases the percentage of is_associated_with::multipolar spindles in is_associated_with::human cells. Deregulation of the BOP1 pathway may contribute to colorectal tumourigenesis in humans. Elevated levels of Bop1 induces Bop1/WDR12 and Bop1/Pes1 subcomplexes and the assembly and integrity of the PeBoW complex is highly sensitive to changes in Bop1 protein levels.

Nop7p-Erb1p-Ytm1p, found in yeast, is potentially the homologous complex of Pes1-Bop1-WDR12 as it is involved in the control of ribosome biogenesis and is_associated_with::S phase entry. The integrity of the PeBoW complex is required for ribosome biogenesis and cell proliferation in mammalian cells. In Giardia, the is_associated_with::species specific is_associated_with::cytoskeleton protein, beta-giardin, interacts with Bop1.

Structure
BOP1 contains a conserved is_associated_with::N-terminal domain, BOP1NT.