CD49c

Integrin alpha-3 is a is_associated_with::protein that in humans is encoded by the ITGA3 is_associated_with::gene. ITGA3 is an is_associated_with::integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and is_associated_with::corticogenesis, acted upon by such factors as netrin-1 and is_associated_with::reelin.

ITGA3 encodes the is_associated_with::integrin alpha 3 chain. Integrins are heterodimeric integral membrane is_associated_with::proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield is_associated_with::disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many is_associated_with::extracellular matrix proteins.

Alternative names
The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 ('VLA-3'), very common antigen 2 ('VCA-2'), extracellular matrix receptor 1 ('ECMR1'), and galactoprotein b3 ('GAPB3').

Interactions
CD49c has been shown to interact with:
 * is_associated_with::CD9
 * is_associated_with::FHL2,
 * is_associated_with::LGALS8, and
 * is_associated_with::TSPAN4.