MAPK3

Mitogen-activated protein kinase 3 is an is_associated_with::enzyme that in humans is encoded by the MAPK3 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::MAP kinase family. MAP kinases, also known as is_associated_with::extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and is_associated_with::cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it is_associated_with::phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein is_associated_with::isoforms have been described.

Clinical significance
It has been suggested that MAPK3, along with the gene is_associated_with::IRAK1, is turned off by two is_associated_with::microRNAs that were activated after the is_associated_with::influenza A virus had been made to infect human lung cells.

Interactions
MAPK3 has been shown to interact with:


 * is_associated_with::DUSP3,
 * is_associated_with::DUSP6
 * is_associated_with::GTF2I,
 * is_associated_with::HDAC4,
 * is_associated_with::MAP2K1,
 * is_associated_with::MAP2K2,
 * is_associated_with::PTPN7,
 * is_associated_with::RPS6KA2,  and
 * is_associated_with::SPIB.