BCL10

B-cell lymphoma/leukemia 10 is a is_associated_with::protein that in humans is encoded by the BCL10 is_associated_with::gene. Like is_associated_with::BCL2, is_associated_with::BCL3, BCL5, is_associated_with::BCL6, BCL7A, and is_associated_with::BCL9, it has clinical significance in is_associated_with::lymphoma.

Function
This gene was identified by its translocation in a case of is_associated_with::mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate is_associated_with::NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.

Interactions
BCL10 has been shown to interact with:


 * is_associated_with::CARD10,
 * is_associated_with::CARD11,
 * is_associated_with::CARD9
 * is_associated_with::CRADD,
 * is_associated_with::IKBKG,
 * is_associated_with::MALT1, and
 * is_associated_with::TRAF2.