EXOC7

Exocyst complex component 7 is a is_associated_with::protein that in humans is encoded by the EXOC7 is_associated_with::gene. It was formerly known as Exo70.

It forms one subunit of the is_associated_with::exocyst complex. First discovered in is_associated_with::Saccharomyces cerevisiae, this and other exocyst is_associated_with::proteins have been observed in several other eukaryotes, including humans. In S. cerevisiae, the exocyst complex is involved in the late stages of is_associated_with::exocytosis, and is localised at the tip of the bud, the major site of is_associated_with::exocytosis in yeast. It interacts with the Rho3 is_associated_with::GTPase. This interaction mediates one of the three known functions of Rho3 in is_associated_with::cell polarity: vesicle docking and fusion with the is_associated_with::plasma membrane (the other two functions are is_associated_with::regulation of is_associated_with::actin polarity and is_associated_with::transport of exocytic vesicles from the mother cell to the bud). In humans, the functions of this protein and the exocyst complex are less well characterised: this protein is expressed in several tissues and is thought to also be involved in exocytosis.

Interactions
EXOC7 has been shown to interact with is_associated_with::EXOC4 and is_associated_with::RHOQ.