IL2RB

Interleukin-2 receptor subunit beta is a is_associated_with::protein that in humans is encoded by the IL2RB is_associated_with::gene.

Function
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind is_associated_with::interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.

Interactions
IL2RB has been shown to interact with:
 * is_associated_with::CISH,
 * HGS,
 * is_associated_with::Janus kinase 1,     and
 * is_associated_with::SHC1.