ARHGEF1

Rho guanine nucleotide exchange factor 1 is a is_associated_with::protein that in humans is encoded by the ARHGEF1 is_associated_with::gene.

Function
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.

Interactions
ARHGEF1 has been shown to interact with:
 * is_associated_with::CD44,
 * is_associated_with::GNA12,
 * is_associated_with::GNA13,   and
 * is_associated_with::P110α