PTPRF

Receptor-type tyrosine-protein phosphatase F is an is_associated_with::enzyme that in humans is encoded by the PTPRF is_associated_with::gene.

The protein encoded by this gene is a member of the is_associated_with::protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including is_associated_with::cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of is_associated_with::neural cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell–cell contacts at is_associated_with::adherens junctions, as well as in the control of is_associated_with::beta-catenin signaling. An increased expression level of this protein was found in the is_associated_with::insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of is_associated_with::insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Interactions
PTPRF has been shown to interact with is_associated_with::Beta-catenin and is_associated_with::liprin-alpha-1.