PARL

is_associated_with::Presenilins-associated rhomboid-like protein, mitochondrial is a is_associated_with::protein that in humans is encoded by the PARL is_associated_with::gene. It is a member of the rhomboid family of intramembrane serine proteases.

Interactions
PARL has been shown to interact with PINK1.

Clinical Significance
It has been shown that the p.S77N presenilin-associated rhomboid-like protein mutation is not a frequent caus of early-onset Parkinson’s disease. Variation in presenilins-associated rhomboid-like protein (PSARL) sequence and/or expression may be an important new risk factor for type 2 diabetes and other components of the metabolic syndrome.