WDR47

WD repeat domain 47 is a is_associated_with::protein that in humans is encoded by the WDR47 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of WDR47 function. A conditional is_associated_with::knockout mouse line, called Wdr47tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty-six tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. Homozygous mutant animals had an absence of is_associated_with::corpus callosum and increased circulating is_associated_with::alkaline phosphatase levels. Male homozygous mice also had abnormal is_associated_with::indirect calorimetry measures.