ATF6

Activating transcription factor 6, also known as ATF6, is a is_associated_with::protein that, in humans, is encoded by the ATF6 is_associated_with::gene   and is involved in the is_associated_with::unfolded protein response.

Function
ATF6 is an is_associated_with::endoplasmic reticulum (ER) stress-regulated transmembrane is_associated_with::transcription factor that activates the transcription of ER molecules. Accumulation of misfolded proteins in the Endoplasmic Reticulum results in the proteolytic cleavage of ATF6. The cytosolic portion of ATF6 will move to the nucleus and act as a transcription factor to cause the transcription of ER chaperones.

Interactions
ATF6 has been shown to interact with is_associated_with::YY1 and is_associated_with::Serum response factor.