Rs2240340

Several studies have all found that rs2240340, a SNP in the PADI4 gene, is associated with risk for developing rheumatoid arthritis (RA). The risk allele in dbSNP orientation is (T).

The largest study involved over 2,000 RA patients, and although implicating PTPN22 SNPs with greater risk, PADI4 SNP rs2240340 was also implicated. The odds ratio varied between the two (European) populations a bit, but when combined, was 1.10 (CI: 1.00 - 1.21) for the risk allele.

Additional studies include:

rs2240340 was modestly associated with rheumatoid arthritisin a study of 950 unrelated Japanese subjects with RA, with an odds ratio of 1.22 (CI: 1.04 - 1.43,p=0.012).

rs2240340 was associated with rheumatoid arthritis with an odds ratio of 1.97 (CI: 1.44 â€“ 2.69), based on 830 cases and 736 controls.


 * is_associated_with_disease::Rheumatoid arthritis
 * is_associated_with_disease::Spondylitis
 * is_associated_with_disease::Ankylosing spondylitis
 * is_associated_with_disease::Diabetes mellitus