MDA5

MDA5 (Melanoma Differentiation-Associated protein 5) is a is_associated_with::RIG-I-like receptor dsRNA is_associated_with::helicase is_associated_with::enzyme that in humans is encoded by the IFIH1 is_associated_with::gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes is_associated_with::RIG-I and is_associated_with::LGP2, and functions as a is_associated_with::pattern recognition receptor (recognizing dsRNA) that is a sensor for is_associated_with::viruses. MDA5 typically recognizes dsRNA that is over 2000nts in length. For many viruses, effective MDA5-mediated antiviral responses are dependent on functionally active LGP2. The signaling cascades in MDA5 is initiated via CARD domain.

Clinical significance
Mutations in IFIH1/MDA5 are associated to Singleton-Merten Syndrome.