CXCL11

Chemokine (C-X-C motif) ligand 11 (CXCL11) is a small is_associated_with::cytokine belonging to the CXC is_associated_with::chemokine family that is also called Interferon-inducible T-cell alpha is_associated_with::chemoattractant (I-TAC) and Interferon-gamma-inducible protein 9 (IP-9). It is highly expressed in peripheral blood is_associated_with::leukocytes, is_associated_with::pancreas and is_associated_with::liver, with moderate levels in is_associated_with::thymus, is_associated_with::spleen and is_associated_with::lung and low expression levels were in is_associated_with::small intestine, is_associated_with::placenta and is_associated_with::prostate. Gene expression of CXCL11 is strongly induced by IFN-γ and IFN-β, and weakly induced by IFN-α. This chemokine elicits its effects on its target cells by interacting with the cell surface is_associated_with::chemokine receptor CXCR3, with a higher affinity than do the other ligands for this receptor, is_associated_with::CXCL9 and is_associated_with::CXCL10. CXCL11 is is_associated_with::chemotactic for activated is_associated_with::T cells. Its gene is located on human is_associated_with::chromosome 4 along with many other members of the CXC chemokine family.