CCHCR1

Coiled-coil alpha-helical rod protein 1, also known as CCHCR1, is a is_associated_with::protein which in humans is encoded by the CCHCR1 is_associated_with::gene.

Gene
The Human CCHCR1 gene is located at 6p21.33. It is also known as Coiled-Coil Alphahelical Rod Protein 1, C6orf18, Putative Gene 8 Protein, SBP, HCR (A-Helix Coiled-Coil Rod Homologue), pg8, StAR-Binding Protein, and Pg8.

Homology
Homologes for CCHCR1 are conserved through is_associated_with::tetrapods.

Orthologs
CCHCR1 has orthologs throughout vertebrates.

Phylogeny
Phylogenetic analysis with ClustalW indicated that CCHCR1

The CCHCR1 gene has

Structure
The structure of CCHCR1 is primarily composed of is_associated_with::alpha-helices, is_associated_with::coils, and a small amount of is_associated_with::beta sheets, according to PELE.

Interacting Proteins
CCHCR1 has been shown to interact with is_associated_with::POLR2C, KRT17 , is_associated_with::TOP3B, is_associated_with::Steroidogenic acute regulatory protein, is_associated_with::TRAF4, is_associated_with::HLA-C, is_associated_with::TCF19, SNX29, is_associated_with::EEF1D, and is_associated_with::EEF1B2.

Clinical significance
In genetically engineered mice, certain CCHCR1 polymorphisms cause upregulation of the expression of is_associated_with::cytokeratins 6 (KRT6A), 16 (KRT16) and 17 (KRT17) and change in expression in other genes associated with terminal differentiation and formation of the cornified cell envelope. These CCHCR1 polymorphisms may therefore be associated with a susceptibility to is_associated_with::psoriasis. Defective functioning of CCHCR1 may lead to abnormal is_associated_with::keratinocyte proliferation which is a key feature of psoriasis.