APLP1

Amyloid-like protein 1, also known as APLP1, is a is_associated_with::protein that in humans is encoded by the APLP1 is_associated_with::gene. APLP1 along with is_associated_with::APLP2 are important modulators of is_associated_with::glucose and is_associated_with::insulin is_associated_with::homeostasis.

Function
This gene encodes a member of the highly conserved is_associated_with::amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by is_associated_with::secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

APLP1 and is_associated_with::APLP2 double knockout mice display is_associated_with::hypoglycemia and is_associated_with::hyperinsulinemia indicating that these two proteins are important modulators of glucose and insulin homeostasis.