Rs121912762

rs121912762, also known as Leu110Pro, represents an important SNP in the rhesus factor RHD gene.

As reported in several publications, such as, the rs121912762(C) allele leads to a lack of epD8 and the expression of the low frequency antigen Rh40. The result of this a rare Rh-positive variant known as D(VII). RHD D(VII) individuals will be typed as Rh+, yet they can develop anti-D antibodies following immunization by pregnancy or transfusion.

See also: OMIM 111680.0002