TRIM45

tripartite motif containing 45, also known as TRIM45, is a human is_associated_with::gene.

This gene encodes a member of the is_associated_with::tripartite motif family. The encoded protein may function as a [transcriptional repressor of the is_associated_with::mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.

Model organisms
is_associated_with::Model organisms have been used in the study of TRIM45 function. A conditional is_associated_with::knockout mouse line, called Trim45tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; males had increased circulating magnesium levels while animals of both sex displayed increased bone strength.