TCF7L1

transcription factor 7-like 1 (T-cell specific, HMG-box), also known as TCF7L1, is a human is_associated_with::gene.

This gene encodes a member of the is_associated_with::T cell factor/is_associated_with::lymphoid enhancer factor family of transcription factors. These is_associated_with::transcription factors are activated by beta catenin, mediate the is_associated_with::Wnt signaling pathway and are antagonized by the is_associated_with::transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and is_associated_with::cellular senescence.

Model organisms
is_associated_with::Model organisms have been used in the study of TCF7L1 function. A conditional is_associated_with::knockout mouse line, called Tcf7l1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. Few is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and those that did survive had a severe is_associated_with::craniofacial defect. None survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.