ABCC3

Canalicular multispecific organic anion transporter 2 is a is_associated_with::protein that in humans is encoded by the ABCC3 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The is_associated_with::constitutive androstane receptor, is_associated_with::pregnane X receptor and is_associated_with::nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional is_associated_with::antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to is_associated_with::oxidative stress.