CIZ1

Cip1-interacting zinc finger protein is a is_associated_with::protein that in humans is encoded by the CIZ1 is_associated_with::gene.

Function
The protein encoded by this gene is a is_associated_with::zinc finger DNA binding is_associated_with::transcription factor that interacts with CIP1 (is_associated_with::p21 / CDKN1A), part of a complex with is_associated_with::cyclin E. The encoded protein may regulate the cellular localization of CIP1.

Clinical significance
An altered circulating form of the Ciz1 protein is synthesized by is_associated_with::lung cancer cells, even when they are at a very early stage. Hence detection of this protein variant in blood could be used as a is_associated_with::biomarker for early detection of lung cancer.

Interactions
CIZ1 has been shown to interact with is_associated_with::P21.