DLG3

Disks large homolog 3 (DLG3) also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a is_associated_with::protein that in humans is encoded by the DLG3 is_associated_with::gene. DLG3 is a member of the is_associated_with::membrane-associated guanylate kinase (MAGUK) superfamily of proteins.

Interactions
DLG3 has been shown to interact with:


 * APC,
 * is_associated_with::CRIPT,
 * is_associated_with::DLG4,
 * is_associated_with::EXOC3,
 * is_associated_with::EXOC4,
 * is_associated_with::GRIN2A,
 * is_associated_with::GRIN2B,
 * is_associated_with::GRIN2C,
 * is_associated_with::KCNJ12
 * is_associated_with::PTK2B, and
 * is_associated_with::SYNGAP1.

Model organisms
is_associated_with::Model organisms have been used in the study of DLG3 function. A conditional is_associated_with::knockout mouse line called Dlg3tm1a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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