Lamin B2

Lamin B2 is a is_associated_with::protein that in humans is encoded by the LMNB2 is_associated_with::gene. It is the second of two type B is_associated_with::nuclear lamins, and it is associated with is_associated_with::laminopathies.

Model organisms
is_associated_with::Model organisms have been used in the study of Lamin B2 function. A conditional is_associated_with::knockout mouse line, called Lmnb2tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice. Male heterozygotes displayed increased circulating is_associated_with::creatinine levels and an increased susceptibility to is_associated_with::Salmonella infection.