Semenogelin

Semenogelin is a protein that is involved in the formation of a gel matrix that encases ejaculated spermatozoa, preventing capacitation. It blocks capacitation mainly via inhibition of reactive oxygen species (ROS) generation.

Proteolysis by prostate-specific antigen (PSA) breaks down the gel matrix and allows the spermatozoa to move more freely.

There are two variants of the semenogelin protein: Semenogelin 1 and Semenogelin 2.