GPR3

G-protein coupled receptor 3 is a is_associated_with::protein that in humans is encoded by the GPR3 is_associated_with::gene. The is_associated_with::protein encoded by this gene is a member of the is_associated_with::G protein-coupled receptor family of is_associated_with::transmembrane receptors and is involved in is_associated_with::signal transduction.

Function
GPR3 activates is_associated_with::adenylate cyclase in the absence of ligand. GPR3 is expressed in mammalian is_associated_with::oocytes where it maintains meiotic arrest and is thought to be a communication link between oocytes and the surrounding somatic tissue. It has been proposed that is_associated_with::sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine (SPC) are GPR3 ligands, however this result was not confirmed in a β-arrestin recruitment assay.