NuRD

The NURD complex, in molecular biology, is a complex with both ATP-dependent chromatin-remodelling and histone-deacetylase activities.

The nucleosome remodelling and histone deacetylase NuRD complex contains seven subunits: the histone deacetylase core proteins HDAC1 and HDAC2, the histone-binding proteins RbAp46 and RbAp48, the metastasis-associated proteins MTA1 and MTA2, the methyl-CpG-binding domain protein MBD3 and the chromodomain-helicase-DNA-binding protein Mi2 or CHD2.

The histone deacetylases HDAC1 and HDAC2 and the histone binding proteins RbAp48 and RbAp46 form a core complex shared between NuRD and Sin3-histone deacetylase complexes.