Rs4986893

rs4986893 is a SNP in the CYP2C19 gene, potentially encoding the CYP2C19*3 variant. This variant has been linked to poor metabolism of compounds like mephenytoin as well as proguanil, and it therefore has implications for malaria prophylaxis. [PMID 7969038, PMID 9093256]

The risk allele is rs4986893(A).

As a nonfunctioning CYP2C19, this variant would be expected to be a poor metabolizer of several commonly prescribed drugs, including anti-ulcer drugs like omeprazole (trade names Losec and Prilosec), esomeprazole (trade name Nexium), and lansoprazole (Prevacid).

Clopidogrel Efficacy


 * is_associated_with_disease::Myocardial infarction
 * is_associated_with_disease::Malaria
 * is_associated_with_disease::Gastroesophageal reflux disease
 * is_associated_with_disease::Cancer