SHANK2

SH3 and multiple ankyrin repeat domains protein 2 is a is_associated_with::protein that in humans is encoded by the SHANK2 is_associated_with::gene. Two alternative splice variants, encoding distinct isoforms, are reported. Additional splice variants exist but their full-length nature has not been determined.

Function
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the is_associated_with::postsynaptic density (PSD). Shank proteins contain multiple domains for protein-protein interaction, including is_associated_with::ankyrin repeats, an is_associated_with::SH3 domain, a PSD-95/Dlg/ZO-1 domain, a sterile alpha motif domain, and a proline-rich region. This particular family member contains a is_associated_with::PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The is_associated_with::alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the PSDs of adult and developing brain.

It is thought that SHANK2 might play a role in is_associated_with::synaptogenesis by attaching is_associated_with::metabotropic glutamate receptors (mGluRs) to an existing pool of is_associated_with::NMDA receptors (NMDA-R), bylinking to the NMDA-R through PSD-95, and the mGluRs through is_associated_with::HOMER1. An alternative hypothesis is that the Homer/Shank/GKAP/PSD-95 assembly mediates physical association of the NMDAR with IP3R/RYR and intracellular Ca2+ stores.

Interactions
SHANK2 has been shown to interact with:
 * is_associated_with::ARHGEF7,
 * is_associated_with::Cortactin,
 * is_associated_with::DLG4,
 * is_associated_with::DLGAP1, and
 * is_associated_with::DNM2.