HAT1

Histone acetyltransferase 1, also known as HAT1, is an is_associated_with::enzyme that, in humans, is encoded by the HAT1 is_associated_with::gene.

Function
The protein encoded by this gene is a type B is_associated_with::histone acetyltransferase (HAT) that is involved in the rapid is_associated_with::acetylation of newly synthesized cytoplasmic is_associated_with::histones, which are, in turn, imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, in particular, of is_associated_with::histone H4, plays an important role in replication-dependent chromatin assembly. To be specific, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and, to a lesser degree, histone H2A at lysine 5.