MAP2K6

Dual specificity mitogen-activated protein kinase kinase 6 also known as MAP kinase kinase 6 (MAPKK 6) or MAPK/ERK kinase 6 is an is_associated_with::enzyme that in humans is encoded by the MAP2K6 is_associated_with::gene, on is_associated_with::chromosome 17.

Function
MAPKK 6 is a member of the dual specificity protein kinase family, which functions as a is_associated_with::mitogen-activated protein (MAP) kinase kinase. is_associated_with::MAP kinases, also known as is_associated_with::extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein is_associated_with::phosphorylates and activates p38 MAP kinase in response to inflammatory is_associated_with::cytokines or environmental stress. As an essential component of p38 MAP kinase mediated is_associated_with::signal transduction pathway, this gene is involved in many cellular processes such as is_associated_with::stress-induced cell cycle arrest, transcription activation and is_associated_with::apoptosis.

Interactions
MAP2K6 has been shown to interact with is_associated_with::TAOK2, is_associated_with::ASK1, is_associated_with::MAPK14   and is_associated_with::MAP3K7.