TRAF3IP3

TRAF3-interacting JNK-activating modulator is a is_associated_with::protein that in humans is encoded by the TRAF3IP3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of TRAF3IP3 function. A conditional is_associated_with::knockout mouse line, called Traf3ip3tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on homozygous is_associated_with::mutant mice and two significant abnormalities were observed. Males had a decrease in is_associated_with::white blood cell count and females had an increased susceptibility to is_associated_with::bacterial infection.

Interactions
TRAF3IP3 has been shown to interact with is_associated_with::STRN, is_associated_with::MOBKL3, is_associated_with::STK24 and is_associated_with::FAM40A.