MAPK8IP2

C-jun-amino-terminal kinase-interacting protein 2 is a is_associated_with::protein or the name of the is_associated_with::gene that encodes it. The gene is also known as Islet-Brain-2 (IB2).

This protein is highly expressed in the brain and is almost always deleted in is_associated_with::Phelan-McDermid syndrome (PMS). MAPK8IP2 appears to regulate the ratio of is_associated_with::AMPA receptors to is_associated_with::NMDA receptors at glutamate synapses, and thus may be an important contributor to the intellectual dysfunction and related neurological manifestations characteristic of PMS.

Interactions
MAPK8IP2 has been shown to interact with is_associated_with::MAP3K10, is_associated_with::Mitogen-activated protein kinase 9, is_associated_with::LRP2, is_associated_with::LRP1, is_associated_with::MAPK8IP3, is_associated_with::MAP3K12, is_associated_with::MAPK8IP1, is_associated_with::MAP2K7 and is_associated_with::MAP3K11.