MCM3

DNA replication licensing factor MCM3 is a is_associated_with::protein that in humans is encoded by the MCM3 is_associated_with::gene.

Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the is_associated_with::pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.

Interactions
MCM3 has been shown to interact with:
 * is_associated_with::CDC45-related protein,
 * is_associated_with::CDC6,
 * is_associated_with::DBF4,
 * is_associated_with::MCM2
 * is_associated_with::MCM3AP,
 * is_associated_with::MCM5,
 * is_associated_with::MCM7,
 * is_associated_with::ORC4L, and
 * is_associated_with::ORC5L.