Rs1080985

rs1080985 is a SNP near the CYP2D6 gene. Depending on the publication source, it may be called "-1584C/G" or "1496C>G" or the like.

The wild type (normal) allele at this SNP is (C). The (G) variant indicates the presence of a non-wild type CYP2D6 variant, but it appears in many different variants so it can not be used to determine the presence of any particular variant.

The rs1080985(G) allele defines the CYP2D6*2A variant, which has been reported to have relatively normal function yet in some cases may also lead to the intermediate metabolism phenotype.

Please be careful when interpreting results for this SNP as it is in dbSNP and SNPedia in minus orientation where the risk allele is G, but test results are usually in plus orientation where the risk allele is C. This SNP has an ambiguous flip which can make this very confusing.


 * is_associated_with_disease::Alzheimer's disease