HNRPD

Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD) also known as AU-rich element RNA-binding protein 1 (AUF1) is a is_associated_with::protein that in humans is encoded by the HNRNPD is_associated_with::gene. Alternative splicing of this gene results in four transcript variants.

Function


This gene belongs to the subfamily of ubiquitously expressed is_associated_with::heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are nucleic acid binding proteins and they complex with is_associated_with::heterogeneous nuclear RNA (hnRNA). The interaction sites on the RNA are frequently biased towards particular sequence motifs. These proteins are associated with is_associated_with::pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the is_associated_with::cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It localizes to both the nucleus and the cytoplasm. This protein is implicated in the regulation of mRNA stability.

Interactions
HNRPD has been shown to interact with is_associated_with::SAFB and is_associated_with::Hsp27.