PI4KA

Phosphatidylinositol 4-kinase alpha is an is_associated_with::enzyme that in humans is encoded by the PI4KA is_associated_with::gene.

Function
This gene encodes a is_associated_with::1-phosphatidylinositol 4-kinase which catalyzes the first committed step in the biosynthesis of is_associated_with::phosphatidylinositol 4,5-bisphosphate. The mammalian PI 4-kinases have been classified into two types, II and III, based on their molecular mass, and modulation by detergent and is_associated_with::adenosine. Two transcript variants encoding different isoforms have been described for this gene.

Clinical significance
The alpha isoform of PI4KIII plays a role in replication of is_associated_with::hepatitis C virus (HCV). Furthermore the PI4KA lipid kinase affects HCV replication by altering phosphorylation of the HCV is_associated_with::NS5A protein.