STAT1

STAT1 is a member of the Signal Transducers and Activators of Transcription family of is_associated_with::transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III is_associated_with::interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with is_associated_with::STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with is_associated_with::STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon-Stimulated Genes).

Expression of STAT1 can be induced with is_associated_with::diallyl disulfide, a compound in garlic.

Interactions
STAT1 has been shown to interact with:


 * is_associated_with::BRCA1,
 * is_associated_with::C-jun,
 * is_associated_with::CD117,
 * is_associated_with::CREB-binding protein,
 * is_associated_with::Calcitriol receptor,
 * is_associated_with::Epidermal growth factor receptor,
 * is_associated_with::Fanconi anemia, complementation group C,
 * is_associated_with::GNB2L1,
 * is_associated_with::IFNAR2,
 * is_associated_with::IRF1,
 * is_associated_with::ISGF3G
 * is_associated_with::Interleukin 27 receptor, alpha subunit,
 * is_associated_with::MCM5,
 * is_associated_with::Mammalian target of rapamycin,
 * is_associated_with::PIAS1,
 * is_associated_with::PRKCD,
 * is_associated_with::PTK2,
 * is_associated_with::Protein kinase R,
 * is_associated_with::STAT2,
 * is_associated_with::STAT3,
 * Src,  and
 * is_associated_with::TRADD.