Ewing sarcoma breakpoint region 1

RNA-binding protein EWS is a is_associated_with::protein that in humans is encoded by the EWSR1 is_associated_with::gene on human chromosome 22.

This gene encodes a putative RNA binding protein. Alternative splicing of this gene results in two products.

Clinical relevance
Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause is_associated_with::Ewing sarcoma and other members of the is_associated_with::Ewing family of tumors. Other mutations have also been associated to is_associated_with::amyotrophic lateral sclerosis.

Interactions
Ewing sarcoma breakpoint region 1 has been shown to interact with:
 * is_associated_with::ATF1,
 * is_associated_with::BARD1,
 * ERG,
 * is_associated_with::POU4F1,
 * is_associated_with::PTK2B
 * SF1,
 * SNRPC, and
 * ZNF165.