NDEL1

Nuclear distribution protein nudE-like 1 is a is_associated_with::protein that in humans is encoded by the NDEL1 is_associated_with::gene.

This gene encodes a is_associated_with::thiol-activated is_associated_with::oligopeptidase that is phosphorylated in is_associated_with::M phase of the is_associated_with::cell cycle. is_associated_with::Phosphorylation regulates the cell cycle-dependent distribution of this is_associated_with::protein, with a fraction of the protein bound strongly to is_associated_with::centrosomes in is_associated_with::interphase and localized to is_associated_with::mitotic spindles in early M phase. Overall, this protein plays a role in is_associated_with::nervous system development. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions
NDEL1 has been shown to interact with is_associated_with::Cyclin-dependent kinase 5, is_associated_with::YWHAE, is_associated_with::PAFAH1B1 and is_associated_with::DISC1.