HCN4

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 is a is_associated_with::protein that in humans is encoded by the HCN4 is_associated_with::gene.

There are four is_associated_with::HCN channels. HCN4 is prominently expressed in the is_associated_with::pace maker region of the mammalian is_associated_with::heart. Some humans with is_associated_with::bradycardia and is_associated_with::Sick sinus syndrome have been shown to have mutations in their HCN4 gene. The role of HCN channels in autonomic control of heart rate is currently a matter of ongoing investigation.

Interactions
HCN4 has been shown to interact with is_associated_with::HCN2.