CD61

Integrin beta-3 (β3) or CD61 is a is_associated_with::protein that in humans is encoded by the ITGB3 is_associated_with::gene. CD61 is a is_associated_with::cluster of differentiation found on is_associated_with::thrombocytes.

Structure and function
The ITGB3 protein product is the integrin beta chain beta 3. is_associated_with::Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.

Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of is_associated_with::endometriosis, and has been suggested as a putative marker of this condition.

Interactions
CD61 has been shown to interact with is_associated_with::PTK2, is_associated_with::ITGB3BP,  is_associated_with::TLN1  and is_associated_with::CIB1.