TMEM106A

TMEM106A is a is_associated_with::gene that encodes the is_associated_with::transmembrane protein 106A (TMEM106A) in is_associated_with::Homo sapiens. It is located at 17q21.31 on the plus strand next to cancer-related genes is_associated_with::NBR1 and is_associated_with::BRCA1. The TMEM106A gene contains a is_associated_with::domain of unknown function, DUF1356.

Protein structure
The TMEM106A protein has a molecular weight of 28.9 kdal. It has 262 amino acids, 240 of which are in the domain of function. The protein has a is_associated_with::transmembrane region. There is evidence for a secondary transmembrane region in humans but this region is not conserved in related orthologs. The protein does not contain a is_associated_with::peptide signal protein. The protein structure contains a similar proportion of is_associated_with::alpha-helix and beta-strand secondary structures (this does not include transmembrane structures).

There are several areas for post-translational modification for TMEM106A including:
 * is_associated_with::Phosphorylation,
 * is_associated_with::N-glycosylation
 * Lysine glycosylation

Paralogs
The TMEM106A gene has two paralogs: is_associated_with::TMEM106B and is_associated_with::TMEM106C. These paralogs belong to the gene family pfam07092, which belongs to the DUF1356 superfamily. This family consists of several mammalian proteins that are around 250 amino acids in length. TMEM106B and TMEM106C are conserved in is_associated_with::invertebrates to mammals.

Orthologs
The TMEM106A gene has been found in only the is_associated_with::Chordate phylum. Of the three subphyla, TMEM106A is most commonly found in is_associated_with::Vertebrata and has also been found in select members of is_associated_with::Tunicata, which are invertebrate marine filter feeders. This phylum split occurred 722.5 million years ago. TMEM106A has not been seen in bacteria, plants, or fungi.

Expression
TMEM106A is expressed in several human tissues. The tissues with highest expression are is_associated_with::uterus, is_associated_with::kidneys, is_associated_with::small intestine, and is_associated_with::stomach. EST profiles for orthologs show expression is conserved with greatest expression in kidneys and lesser expression in several other areas. Some tissues never show expression including: is_associated_with::muscle, is_associated_with::adipose tissue, and is_associated_with::bone.

Gene neighborhood
In Homo sapiens, TMEM106A is located next to is_associated_with::NBR1, a gene identified as an ovarian is_associated_with::tumor antigen monitored in is_associated_with::ovarian cancer. It is also located near is_associated_with::BRCA1, a is_associated_with::breast cancer is_associated_with::tumor suppressor gene. The first 140 amino acids of the TMEM106A protein, including portions of DUF1356 and a transmembrane region, are deleted along with BRCA1 during early-onset breast cancer.