AKR1B1

Aldo-keto reductase family 1, member B1 (aldose reductase), also known as AR, is an is_associated_with::enzyme that in humans is encoded by the AKR1B1 is_associated_with::gene.

Function
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of is_associated_with::aldehydes, including the aldehyde form of is_associated_with::glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to is_associated_with::sorbitol.

Gene
There are a few putative pseudogenes for this gene, and one of them has been confirmed and mapped to chromosome 3.