Rs1044498

blog ENPP1 harbors a mutation with a derived state known to protect against obesity and type II diabetes27 that is present in 90% of non-Africans but virtually absent in Africans

K121Q (rs1044498) The Q allele of ENPP1 K121Q is associated with hyperglycemia and insulin resistance in whites. increased fasting plasma glucose (FPG), A1C, fasting insulin, and insulin resistance by homeostasis model assessment (HOMA-IR; all P = 0.01-0.006).

Association of ENPP1 gene polymorphisms with hand osteoarthritis in a Chuvasha population.

Studies of the relationship between the ENPP1 K121Q polymorphism and type 2 diabetes, insulin resistance and obesity in 7,333 Danish white subjects.

Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity.

ENPP1 K121Q polymorphism and obesity, hyperglycaemia and type 2 diabetes in the prospective DESIR Study.

Association of the distal region of the ectonucleotide pyrophosphatase/phosphodiesterase 1 gene with type 2 diabetes in an African-American population enriched for nephropathy.

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.

Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

Comprehensive association study of type 2 diabetes and related quantitative traits with 222 candidate genes.

Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.

Association of the Q121 variant of ENPP1 gene with decreased kidney function among patients with type 2 diabetes.

The association of ENPP1 K121Q with diabetes incidence is abolished by lifestyle modification in the diabetes prevention program.

Contribution of type 2 diabetes associated loci in the Arabic population from Tunisia: a case-control study.

Association of maternally inherited GNAS alleles with African-American male birth weight.

Genetic risk factors for type 2 diabetes with pharmacologic intervention in African-American patients with schizophrenia or schizoaffective disorder.

The ENPP1 K121Q polymorphism is not associated with type 2 diabetes or obesity in the Chinese Han population.

Studies of the association of Arg72Pro of tumor suppressor protein p53 with type 2 diabetes in a combined analysis of 55,521 Europeans.

Meta-analysis of association studies between five candidate genes and type 2 diabetes in Chinese Han population.