IGFBP1

Insulin-like growth factor-binding protein 1 (IBP-1) also known as placental protein 12 (PP12) is a is_associated_with::protein that in humans is encoded by the IGFBP1 is_associated_with::gene.

Function
This gene is a member of the is_associated_with::Insulin-like growth factor-binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a type-I is_associated_with::thyroglobulin domain. The protein binds both is_associated_with::insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.