SPHK2

Sphingosine kinase 2 is a is_associated_with::protein that in humans is encoded by the SPHK2 is_associated_with::gene.

This gene encodes one of two is_associated_with::sphingosine kinase isozymes that catalyze the is_associated_with::phosphorylation of is_associated_with::sphingosine into is_associated_with::sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and is_associated_with::apoptosis, and also plays a role in several types of cancer by promoting is_associated_with::angiogenesis and is_associated_with::tumorigenesis. The encoded protein may play a role in breast cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].