ARG1 (gene)

The human ARG1 is_associated_with::gene encodes the is_associated_with::protein arginase.

Function
is_associated_with::Arginase catalyzes the is_associated_with::hydrolysis of is_associated_with::arginine to is_associated_with::ornithine and is_associated_with::urea. At least two is_associated_with::isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a is_associated_with::cytosolic enzyme and expressed predominantly in the is_associated_with::liver as a component of the is_associated_with::urea cycle. Inherited deficiency of this enzyme results in is_associated_with::argininemia, an is_associated_with::autosomal recessive disorder characterized by is_associated_with::hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene.