Rs28937316

rs28937316, also known as Arg1644His or R1664H, is a SNP in the cardiac sodium channel SCN5A gene on chromosome 3.

Acting in a dominant manner, one copy of a rs28937316(A) allele is considered causative for long QT syndrome 3.

This variant meets the criteria published in 2013 by the ACMG regarding incidental findings in exome or genome sequencing, as a variant that they do recommend informing a patient about.