WD repeat-containing protein 11

WD repeat-containing protein 11 (WDR11) also known as bromodomain and WD repeat-containing protein 2 (BRWD2) is a is_associated_with::protein that in humans is encoded by the WDR11 is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 is_associated_with::amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or is_associated_with::multiprotein complexes. Members of this family are involved in a variety of cellular processes, including is_associated_with::cell cycle progression, is_associated_with::signal transduction, is_associated_with::apoptosis, and gene regulation.

Clinical significance
This gene is located in the chromosome 10q25-26 region, which is frequently deleted in is_associated_with::gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in is_associated_with::glioblastoma cells. The gene location suggests that it is a candidate gene for the is_associated_with::tumor suppressor locus.