Rs1800584

rs1800584 is a rare SNP in the TPMT gene, potentially encoding a variant incapable of detoxifying byproducts of certain antineoplastic and immunosuppressant drugs. In general, individuals must have two nonfunctioning TPMT alleles for the toxicity to be pronounced.

The rs1800584(A) SNP defines the TPMT*4A allele (OMIM).

[| wikipedia] thiopurine drugs metabolized by TPMT include azathioprine, mercaptopurine, and thioguanine