PPP5C

Serine/threonine-protein phosphatase 5 is an is_associated_with::enzyme that in humans is encoded by the PPP5C is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PPP5C function. A conditional is_associated_with::knockout mouse line, called Ppp5ctm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and five significant abnormalities were observed. is_associated_with::Homozygous mutant males had decreased body weight, body length and is_associated_with::respiratory quotient. Both sexes had increased is_associated_with::T cell numbers and a range of skeletal abnormalities identified by is_associated_with::radiography.

Interactions
PPP5C has been shown to interact with is_associated_with::ASK1, is_associated_with::CRY2 is_associated_with::GNA12. and is_associated_with::Rac1,