Rs894160

"We studied a population-based sample of Caribbean-origin Hispanics (n = 920, aged 45-74 y) living in the Boston area. Obesity measures (waist and hip circumference, BMI) did not differ between GG subjects and carriers of the A allele (GA and AA). In multivariate linear regression models, we found a significant interaction between complex carbohydrate intake as a continuous variable and PLIN 11482 G > A genotype for waist circumference (P = 0.002). By dichotomizing complex carbohydrate intake, we found significantly different effects across PLIN 11482G > A genotypes. When complex carbohydrate intake was <144 g/d, waist circumference was larger in PLIN 11482G > A carriers (P = 0.024). Conversely, when complex carbohydrate intake was >/=144 g/d, waist and hip circumferences were less in PLIN 11482G > A carriers (P < 0.05). These interactions were not found for simple sugars or total carbohydrates. In subjects with higher complex carbohydrate intake, the minor allele was protective against obesity, whereas in subjects with lower carbohydrate intake, the minor allele was associated with increased obesity."

Study of the impact of perilipin polymorphisms in a French population.

Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women.

Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.

PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores.

Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance.

Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.

Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women.


 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Syndrome