ANXA9

Annexin A9 is a is_associated_with::protein that in humans is encoded by the ANXA9 is_associated_with::gene.

Function
The is_associated_with::annexins are a family of calcium-dependent is_associated_with::phospholipid-binding proteins. Members of the annexin family contain 4 internal repeat domains, each of which includes a type II calcium-binding site. The calcium-binding sites are required for annexins to aggregate and cooperatively bind anionic phospholipids and is_associated_with::extracellular matrix proteins. This gene encodes a divergent member of the annexin protein family in which all four homologous type II calcium-binding sites in the conserved tetrad core contain amino acid substitutions that ablate their function. However, structural analysis suggests that the conserved putative ion channel formed by the tetrad core is intact.

Model organisms
is_associated_with::Model organisms have been used in the study of ANXA9 function. A conditional is_associated_with::knockout mouse line called Anxa9tm1b(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping

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