PLCG2

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an is_associated_with::enzyme that in humans is encoded by the PLCG2 is_associated_with::gene.

Function
Enzymes of the phospholipase C family catalyze the hydrolysis of phospholipids to yield diacylglycerols and water-soluble phosphorylated derivatives of the lipid head groups. A number of these enzymes have specificity for phosphoinositides. Of the phosphoinositide-specific phospholipase C enzymes, C-beta is regulated by heterotrimeric G protein-coupled receptors, while the closely related C-gamma-1 (PLCG1; MIM 172420) and C-gamma-2 enzymes are controlled by receptor tyrosine kinases. The C-gamma-1 and C-gamma-2 enzymes are composed of phospholipase domains that flank regions of homology to noncatalytic domains of the SRC oncogene product, SH2 and SH3.[supplied by OMIM]

Interactions
PLCG2 has been shown to interact with:
 * is_associated_with::Bruton's tyrosine kinase,
 * is_associated_with::GAB2,
 * is_associated_with::LYN,
 * is_associated_with::PTPN11, and
 * is_associated_with::SHC1