HEY2

Hairy/enhancer-of-split related with YRPW motif protein 2 (HEY2) also known as cardiovascular helix-loop-helix factor 1 (CHF1) is a is_associated_with::protein that in humans is encoded by the HEY2 is_associated_with::gene.

Function
CHF1 is a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type is_associated_with::transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a is_associated_with::histone deacetylase complex to repress transcription. Expression of this gene is induced by the is_associated_with::Notch signaling pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in is_associated_with::neurogenesis and is_associated_with::somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.

Clinical significance
Common variants of is_associated_with::SCN5A, is_associated_with::SCN10A, and HEY2 (this gene) are associated with is_associated_with::Brugada syndrome.

Interactions
HEY2 has been shown to interact with is_associated_with::Sirtuin 1 and is_associated_with::Nuclear receptor co-repressor 1.