Rs4444903

rs4444903 is a SNP, also known as +61, located in the promoter region of the epidermal growth factor EGF gene that influences the amount of EGF produced. The rs4444903(G) allele appears to produce higher amounts of EGF than the (A) allele.

A study of 2 Caucasian populations of patients with alcoholic cirrhosis indicates that, for these patients, the presence of the risk allele rs4444903(G) increases the chances of developing hepatocellular carcinoma (liver cancer). After adjusting for age, sex, race, etiology, and severity of cirrhosis the number of (G) copies led to an odds ratio for either (G;G) or (A;G) genotypes versus the (A;A) genotype of 3.49 (CI: 1.29-9.44, p=.01).

In another study, analysis of 197 glioma patients showed that the rs4444903(G) allele conferred higher risks for gliomas (odds ratio 1.32, CI: 1.04-1.67), glioblastomas (OR, 1.47, CI: 1.02-2.10), and oligodendrogliomas (OR, 1.55, CI: 1.07-2.23). In general, the risk was about the same for a carrier or one or two (G) alleles, however, no significant association was observed with patients' overall survival.

A study of 126 Indian gallbladder cancer patients concluded that the rs4444903(G;G) genotype was at increased risk, but only in females (odds ratio 3.45, CI: 1.52-7.82, p = 0.003).

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rs4444903, rs2298991, rs7692976 and rs4533485 significantly interacted with gender for acute respiratory distress syndrome risk.

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Epidermal growth factor gene polymorphism is different between schizophrenia and lung cancer patients in Korean population.

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Development of a fingerprinting panel using medically relevant polymorphisms.

Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study.

A functional epidermal growth factor (EGF) polymorphism, EGF serum levels and renal cell carcinoma risk in a Chinese population.

A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma.

Carriage of the EGF rs4444903 A>G functional polymorphism associates with disease progression in chronic HBV infection.