Ribosomal protein SA

40S ribosomal protein SA is a is_associated_with::Ribosomal protein that in humans is encoded by the RPSA is_associated_with::gene.

Function
is_associated_with::Laminins, a family of is_associated_with::extracellular matrix is_associated_with::glycoproteins, are the major noncollagenous constituent of is_associated_with::basement membranes. They have been implicated in a wide variety of biological processes including is_associated_with::cell adhesion, differentiation, migration, signaling, is_associated_with::neurite outgrowth and is_associated_with::metastasis. Many of the effects of laminin are mediated through interactions with is_associated_with::cell surface receptors. These receptors include members of the is_associated_with::integrin family, as well as non-integrin laminin-binding proteins. The RPSA gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The is_associated_with::amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key is_associated_with::biological function. It has been observed that the level of the laminin receptor transcript is higher in colon is_associated_with::carcinoma tissue and lung cancer cell lines than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic is_associated_with::phenotype. Multiple copies of this gene exist; however, most of them are is_associated_with::pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions
Ribosomal protein SA has been shown to interact with is_associated_with::RPS21.