ANXA6

Annexin A6 is a is_associated_with::protein that in humans is encoded by the ANXA6 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of ANXA6 function. A conditional is_associated_with::knockout mouse line, called Anxa6tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and one significant abnormality was observed: female is_associated_with::homozygous mutant animals had an increased susceptibility to is_associated_with::Citrobacter infection.

Interactions
ANXA6 has been shown to interact with is_associated_with::RAS p21 protein activator 1.