Rs35705950

rs35705950 is a SNP located 3 kb upstream of the start of transcription from the mucin 5B MUC5B gene.

Two independent research groups both published articles in April 2011 associating the minor (T) allele of rs35705950 with highly increased risk for interstitial pneumonia and/or pulmonary fibrosis.

For interstitial pneumonia, the odds ratio for heterozygotes was 6.8 (CI: 3.9 - 12.0) and for homozygotes, 20.8 (CI: 3.8 - 113.7).

For pulmonary fibrosis, the reported odds ratios for heterozygotes and homozygotes in one study were 9.0 (CI: 6.2 to 13.1) and 21.8 (CI: 5.1 to 93.5), respectively, and were 5.9 (CI: 4.4 - 7.8) and 9.7 (CI: 4.7 - 19.9) in the other.