Tachykinin receptor 2

Substance-K receptor is a is_associated_with::protein that in humans is encoded by the TACR2 is_associated_with::gene.

Selective Ligands
Several selective ligands for NK2 are now available, and although most of the compounds developed so far are peptides, one small-molecule antagonist Saredutant is currently in clinical trials as an is_associated_with::anxiolytic and is_associated_with::antidepressant.

Agonists

 * is_associated_with::GR-64349 - potent and selective agonist, EC50 3.7nM, 7-amino acid polypeptide chain. CAS# 137593-52-3

Antagonists

 * is_associated_with::Ibodutant
 * is_associated_with::Saredutant
 * is_associated_with::GR-159,897
 * is_associated_with::MEN-10376 - potent and selective antagonist, 7-amino acid polypeptide chain. CAS# 135306-85-3