HOOK1

Protein Hook homolog 1 is a is_associated_with::protein that in humans is encoded by the HOOK1 is_associated_with::gene.

Function
This gene encodes a member of the hook family of is_associated_with::coiled coil proteins, which bind to is_associated_with::microtubules and is_associated_with::organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in is_associated_with::endocytosis. It is thought to link endocytic membrane trafficking to the microtubule is_associated_with::cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.