DDX27

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27, also known as DDX27, is a human is_associated_with::gene.

The is_associated_with::protein encoded by this gene belongs to the family of DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), and are putative is_associated_with::RNA is_associated_with::helicases. They are implicated in a number of cellular processes involving alteration of RNA is_associated_with::secondary structure such as translation initiation, nuclear and mitochondrial splicing, and is_associated_with::ribosome and is_associated_with::spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in is_associated_with::embryogenesis, is_associated_with::spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined.

Model organisms
is_associated_with::Model organisms have been used in the study of DDX27 function. A conditional is_associated_with::knockout mouse line, called Ddx27tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out and two is_associated_with::phenotypes were reported. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and in a separate study only 1% survived until is_associated_with::weaning (significantly less than the is_associated_with::Mendelian ratio). The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no significant abnormalities were observed in these animals.