CRADD

Death domain-containing protein CRADD is a is_associated_with::protein that in humans is encoded by the CRADD is_associated_with::gene.

Function
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins.

Interactions
CRADD has been shown to interact with is_associated_with::RIPK1 and is_associated_with::Caspase 2.