Related to receptor tyrosine kinase

The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

History
The is_associated_with::gene encoding mouse RYK was first identified in 1992. Subsequently is_associated_with::cDNA encoding the RYK protein have been isolated from the following species.
 * is_associated_with::rat
 * is_associated_with::chicken
 * is_associated_with::Human
 * is_associated_with::Zebrafish
 * Drosophila and
 * C. elegans

Structure
In common with other is_associated_with::receptor tyrosine kinase family members, RYK is composed of three domains, an is_associated_with::N-terminal domain, an is_associated_with::extracellular ligand-binding domain, a is_associated_with::transmembrane spanning domain and a is_associated_with::C-terminal is_associated_with::intracellular domain. However, in contrast to other is_associated_with::receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable is_associated_with::kinase activity.