Rs6733839

rs6733839 is a SNP in the bridging integrator 1 BIN1 gene.

BIN1 is a well established risk gene for Alzheimer's disease which was recently confirmed in the International Genomics of Alzheimer's Project (IGAP) study.

This SNP has a population attributable fraction for AD of 8.1 which is second only to APOE4's of 27.3. The minor allele T is the risk allele with an associated odds ratio of 1.22 (1.18–1.25) and P-value = 7 x 10^^-44. http://www.genome.gov/GWASStudySNPS.cfm?id=7523

rs6733839 and rs744373 are less than 2,000 base pairs apart,and they have similar ORs and MAFs. Therefore, it seems reasonable to suspect that these 2 SNPs are actually reporting the same signal.

rs744373	rs6733839	1805	0.580	0.909	None	chr2	127609280

This line is taken from the SNAP file for rs744373 http://www.broadinstitute.org/mpg/snap/ldsearch.php. The first two entries identify the SNPs, then the base pair distance between them, their r^^2, DPrime, arrays present on, chromosome number, and the location.

Review: The genetics of Alzheimer's disease; putting flesh on the bones