PDGFRA

Alpha-type platelet-derived growth factor receptor is a is_associated_with::protein that in humans is encoded by the PDGFRA is_associated_with::gene.

Function
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of is_associated_with::mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.

Interactions
PDGFRA has been shown to interact with:


 * CRK,
 * is_associated_with::Caveolin 1,
 * is_associated_with::Cbl gene,
 * is_associated_with::PDGFC,
 * is_associated_with::PDGFRB,
 * is_associated_with::PLCG1, and
 * is_associated_with::Sodium-hydrogen antiporter 3 regulator 1.