RPS6KA3

Ribosomal protein S6 kinase, 90kDa, polypeptide 3, also known as RPS6KA3, is an is_associated_with::enzyme that in humans is encoded by the RPS6KA3 is_associated_with::gene.

Function
This gene encodes a member of the RSK (is_associated_with::ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation.

Clinical significance
Mutations in this gene have been associated with is_associated_with::Coffin-Lowry syndrome (CLS).

Interactions
RPS6KA3 has been shown to interact with is_associated_with::CREB-binding protein, is_associated_with::MAPK1 and is_associated_with::PEA15.