NISCH

Nischarin is a is_associated_with::protein that in humans is encoded by the NISCH is_associated_with::gene.

Function
This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the is_associated_with::cytosol and anchors to the inner layer of the plasma membrane. The is_associated_with::orthologous mouse protein has been shown to influence is_associated_with::cytoskeletal organization and is_associated_with::cell migration by binding to alpha-5-beta-1 integrin. In humans, this protein has been shown to bind to the adapter insulin receptor substrate 4 (is_associated_with::IRS4) to mediate translocation of alpha-5 integrin from the cell membrane to is_associated_with::endosomes. In human cardiac tissue, this gene was found to affect cell growth and death while in neural tissue it affected neuronal growth and differentiation.

Clinical significance
Expression of this protein was reduced in human breast cancers while its overexpression reduced tumor growth and metastasis; possibly by limiting the expression of alpha-5 integrin.

Interactions
NISCH has been shown to interact with is_associated_with::IRS4.