ALOX15B

Arachidonate 15-lipoxygenase type II is an is_associated_with::enzyme that in humans is encoded by the ALOX15B is_associated_with::gene. ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or 15-LOX-2), is distinguished from its related oxygenase, is_associated_with::ALOX15 or 15-lipoxygenase-1.

Function
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. 15-LOX-2 has 38-39% amino acid sequence identity to human 15-LOX-1 and is_associated_with::12-lipoxygenase and 44% amino acid sequence identity to human is_associated_with::5-lipoxygenase. 15-LOX-2 converts is_associated_with::arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described.