Rs10830963

rs10830963 was associated with an increased risk of type-2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele

rs10830962, rs4753426, and rs10830963 were significantly associated with higher fasting plasma glucose concentrations and reduced OGTT- and IVGTT-induced insulin release. rs3781638 displayed significant association with lower fasting plasma glucose levels and increased OGTT-induced insulin release

A study totaling 19,000+ Europeans concluded that rs10830963 had the most influence of any MTNR1B gene SNP on the risk for type-2 diabetes. Specifically, the (G) allele increased the risk of isolated impaired fasting glycemia (OR=1.64, P=5.5x10(-11)) but not isolated impaired glucose tolerance.

900+ patients with gestational diabetes were studied, and the rs10830963(G) SNP was postulated to perhaps be a causal SNP for the condition, with an odds ratio of ~1.3 - 1.4.