ARHGAP26

Rho GTPase activating protein 26 (ARHGAP26) also known as  G TPase R egulator A ssociated with F ocal Adhesion Kinase (GRAF) is a is_associated_with::protein that in humans is encoded by the ARHGAP26 is_associated_with::gene.

Function
GRAF is a multidomain protein that is necessary for the CLIC/is_associated_with::GEEC endocytic pathway, the most prevalent is_associated_with::clathrin-independent endocytic pathway discovered to date. By virtue of an N-terminal is_associated_with::BAR domain, GRAF1 sculpts the endocytic membranes of this pathway into 40 nm diameter tubules and vesicles that allow uptake of extracellular fluid, GPI-linked proteins and certain bacterial exotoxins into cells. The role of is_associated_with::dynamin in the CLIC/GEEC pathway is controversial, but GRAF1 interacts strongly with this protein and acute inhibition of is_associated_with::dynamin action abrogates CLIC/GEEC is_associated_with::endocytosis. There are several members of the GRAF family of proteins, including GRAF2, GRAF3, and is_associated_with::oligophrenin, all of which likely playing similar roles during clathrin-independent endocytic events. Mutations of both GRAF1 and oligophrenin are strongly implicated in causing human disease (is_associated_with::leukaemia and is_associated_with::mental retardation, respectively). Recently, autoantibodies to ARHGAP26 have been implicated in autoimmune is_associated_with::cerebellar ataxia.

Interactions
ARHGAP26 has been shown to interact with PKN3.