TRIB3

Tribbles homolog 3 is a is_associated_with::protein that in humans is encoded by the TRIB3 is_associated_with::gene.

Function
The protein encoded by this gene is a putative is_associated_with::protein kinase that is induced by the transcription factor is_associated_with::NF-kappaB. The encoded protein is a negative regulator of NF-kappaB, and can also sensitize cells to is_associated_with::TNF- and is_associated_with::TRAIL-induced is_associated_with::apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase is_associated_with::AKT1.

Interactions
TRIB3 has been shown to interact with:
 * is_associated_with::AKT1,
 * is_associated_with::CSNK2B,
 * is_associated_with::Fibronectin
 * is_associated_with::MCM3AP,
 * is_associated_with::RELA,
 * is_associated_with::SIAH1, and
 * is_associated_with::TIAF1.