RAS p21 protein activator 1

RAS p21 protein activator 1 or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-is_associated_with::kDa cytosolic human protein that provides two principal activities:
 * Inactivation of Ras from its active GTP-bound form to its inactive GDP-bound form by enhancing the endogenous is_associated_with::GTPase activity of Ras, via its C-terminal GAP domain
 * Mitogenic signal transmission towards downstream interacting partners through its N-terminal SH2-SH3-SH2 domains

Domains
RasGAP contains one is_associated_with::SH3 domain and two is_associated_with::SH2 domains, a is_associated_with::PH domain, and a is_associated_with::GAP domain.

Interactions
RAS p21 protein activator 1 has been shown to interact with:


 * is_associated_with::ANXA6,
 * CAV2,
 * is_associated_with::DNAJA3,
 * is_associated_with::DOK1,
 * EPHB2,
 * is_associated_with::EPHB3,
 * is_associated_with::GNB2L1
 * is_associated_with::HCK,
 * is_associated_with::HRAS,
 * HTT,
 * IGF1R,
 * is_associated_with::KHDRBS1,
 * is_associated_with::NCK1,
 * is_associated_with::PDGFRB,
 * is_associated_with::PTK2B,
 * is_associated_with::SOCS3, and
 * Src.

The mRNA can interact with is_associated_with::Mir-132 microRNA; this process is linked to angiogenesis.

Disease Database
RASA1 gene variant database