2'-5'-oligoadenylate synthase

In molecular biology, 2'-5'-oligoadenylate synthase is an enzyme. It is an antiviral enzyme that counteracts viral attack by degrading viral RNA. The enzyme uses ATP in 2'-specific nucleotidyl transfer reactions to synthesise 2'-5'-oligoadenylates, which activate latent ribonuclease, resulting in degradation of viral RNA and inhibition of virus replication.

The C-terminal half of 2'-5'-oligoadenylate synthetase, also referred to as domain 2 of the enzyme, is largely alpha-helical and homologous to a tandem ubiquitin repeat. It carries the region of enzymic activity between at the extreme C-terminal end.