CDC42

Cell division control protein 42 homolog also known as CDC42 is a is_associated_with::protein involved in regulation of the is_associated_with::cell cycle. In humans, CDC42 is encoded by the CDC42 is_associated_with::gene.

Function
Human CDC42 is a small is_associated_with::GTPase of the is_associated_with::Rho family, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate is_associated_with::actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

Interactions
CDC42 has been shown to interact with:


 * is_associated_with::ARHGAP1,
 * is_associated_with::ARHGDIA,
 * is_associated_with::BAIAP2,
 * is_associated_with::BNIP2,
 * is_associated_with::BNIPL,
 * is_associated_with::CDC42EP2,
 * is_associated_with::CDC42EP3,
 * is_associated_with::ERRFI1,
 * is_associated_with::GDI1,
 * is_associated_with::IQGAP1,
 * is_associated_with::IQGAP2,
 * is_associated_with::ITSN1,
 * is_associated_with::MAP3K10,
 * is_associated_with::MAP3K11,
 * is_associated_with::PAK1,
 * is_associated_with::PAK2,
 * is_associated_with::PAK4.
 * is_associated_with::PAK7,
 * is_associated_with::PARD6A,
 * is_associated_with::PARD6B,
 * is_associated_with::Phospholipase D1,
 * RICS
 * is_associated_with::TRIP10,
 * WASL,
 * is_associated_with::Wiskott-Aldrich syndrome protein,