LMO2

LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2. LMO2 is a is_associated_with::protein which in humans is encoded by the LMO2 is_associated_with::gene.

Function
LMO2 encodes a cysteine-rich, two is_associated_with::LIM domain protein that is required for yolk sac is_associated_with::erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved.

Clinical significance
The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number of is_associated_with::T-cell acute lymphoblastic leukemia-specific translocations occur.

Interactions
LMO2 has been shown to interact with:


 * is_associated_with::GATA1,
 * is_associated_with::GATA2,
 * is_associated_with::JARID1A,
 * is_associated_with::MLLT4, and
 * is_associated_with::TAL1