FMO4

Dimethylaniline monooxygenase [N-oxide-forming] 4 is an is_associated_with::enzyme that in humans is encoded by the FMO4 is_associated_with::gene.

Function
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing is_associated_with::monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, is_associated_with::FMO1 found in fetal liver, is_associated_with::FMO2 found in adult liver, and is_associated_with::FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and is_associated_with::xenobiotics.