MDH1

Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an is_associated_with::enzyme that in humans is encoded by the MDH1 is_associated_with::gene.

Function
is_associated_with::Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.