Barrier to autointegration factor 1

Barrier-to-autointegration factor is a is_associated_with::protein that in humans is encoded by the BANF1 is_associated_with::gene. It is a member of the is_associated_with::barrier-to-autointegration factor family of proteins.

Function
The protein encoded by this gene was identified by its ability to protect is_associated_with::retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The endogenous function of the protein is unknown. The protein forms a homodimer which localizes to the nucleus and is specifically associated with chromosomes during is_associated_with::mitosis. This protein binds to DNA in a non-specific manner and studies in rodents suggest that it also binds to lamina-associated polypeptide 2, a component of the is_associated_with::nuclear lamina. It also associates with the LEM Domain containing proteins LAP2, is_associated_with::Emerin, and is_associated_with::MAN1.

Interactions
Barrier to autointegration factor 1 has been shown to interact with is_associated_with::Thymopoietin.

Clinical relevance
Mutations in this gene have been shown to cause hereditary is_associated_with::progeroid syndrome.