Tumor necrosis factor receptor 1

Tumor necrosis factor receptor 1 (TNFR1), also known as tumor necrosis factor receptor superfamily member 1A (TNFRSF1A) and CD120a, is a ubiquitous membrane receptor that binds is_associated_with::tumor necrosis factor-alpha (TNFα).

Function
The protein encoded by this gene is a member of the is_associated_with::tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the is_associated_with::tumor necrosis factor-alpha. This receptor can activate the is_associated_with::transcription factor is_associated_with::NF-κB, mediate is_associated_with::apoptosis, and function as a regulator of is_associated_with::inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the is_associated_with::signal transduction mediated by the receptor.

Clinical significance
Germline mutations of the extracellular domains of this receptor were found to be associated with the human is_associated_with::genetic disorder called tumor necrosis factor associated periodic syndrome (TRAPS) or is_associated_with::periodic fever syndrome. Impaired receptor clearance is thought to be a mechanism of the disease.

Mutations in the TNFRSF1A gene is associated with elevated risk of multiple sclerosis.

Serum levels of TNFRSF1A are elevated in schizophrenia and bipolar disorder, and high levels are associated with more severe psychotic symptoms.

High serum levels is also associated with cognitive impairment and dementia.

Interactions
TNFRSF1A has been shown to interact with:


 * is_associated_with::BAG4,
 * CASP10,
 * is_associated_with::FADD,
 * is_associated_with::IKK2,
 * JAK1,
 * JAK2,
 * is_associated_with::PIP4K2B,
 * is_associated_with::PSMD2,
 * is_associated_with::RIPK1,
 * SUMO1,
 * is_associated_with::TRADD
 * is_associated_with::TRAF2,
 * is_associated_with::TRPC4AP,
 * TNF,  and
 * is_associated_with::UBE2I.