U2AF2

Splicing factor U2AF 65 kDa subunit is a is_associated_with::protein that in humans is encoded by the U2AF2 is_associated_with::gene.

Function
U2 auxiliary factor (is_associated_with::U2AF), composed of a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the U2AF large subunit, which contains a sequence-specific RNA-binding region with 3 RNA recognition motifs and an Arg/Ser-rich domain necessary for splicing. The large subunit binds to the polypyrimidine tract of is_associated_with::introns early during is_associated_with::spliceosome assembly. Multiple alternatively spliced transcript variants have been detected for this gene, but the full-length natures of only two have been determined to date.

Interactions
U2AF2 has been shown to interact with:


 * is_associated_with::PUF60,
 * SF1,
 * is_associated_with::SFRS11,
 * is_associated_with::SFRS2IP,
 * is_associated_with::SRPK2,
 * is_associated_with::U2 small nuclear RNA auxiliary factor 1 and
 * is_associated_with::WT1.