KLK4

Kallikrein-related peptidase 4 is a is_associated_with::protein which in humans is encoded by the KLK4 is_associated_with::gene.

is_associated_with::Kallikreins are a subgroup of is_associated_with::serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in is_associated_with::carcinogenesis and some have potential as novel cancer and other disease is_associated_with::biomarkers. In particular, they may serve as biomarkers for both prostate cancer and breast cancer.

This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Alternate splice variants for this gene have been described, but their biological validity has not been determined.