Histone deacetylase 2

Histone deacetylase 2 is an is_associated_with::enzyme that in humans is encoded by the HDAC2 is_associated_with::gene.

Function
This gene product belongs to the is_associated_with::histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3 and H4). This protein also forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus it plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Interactions
Histone deacetylase 2 has been shown to interact with:


 * is_associated_with::Ataxia telangiectasia and Rad3 related,
 * is_associated_with::BUB3,
 * is_associated_with::CDC20,
 * CDH1,
 * is_associated_with::CHD3,
 * is_associated_with::CHD4,
 * is_associated_with::DNMT1,
 * is_associated_with::EED,
 * is_associated_with::EZH2 and
 * is_associated_with::FKBP3,
 * is_associated_with::GATA4,
 * is_associated_with::GTF2I,
 * is_associated_with::HDAC10,
 * is_associated_with::HDAC1,
 * is_associated_with::HMG20B,
 * is_associated_with::HSPA4,
 * is_associated_with::Host cell factor C1,
 * is_associated_with::MTA1,
 * is_associated_with::MTA2,
 * is_associated_with::MXD1,
 * is_associated_with::Mad1,
 * is_associated_with::Methyl-CpG-binding domain protein 2,
 * is_associated_with::PHF21A,
 * is_associated_with::PPP1R8,
 * is_associated_with::RBBP4,
 * is_associated_with::RCOR1,
 * is_associated_with::RELA,
 * is_associated_with::Retinoblastoma protein,
 * is_associated_with::SAP30,
 * is_associated_with::SIN3A,
 * is_associated_with::SMARCA5,
 * is_associated_with::SNW1,
 * is_associated_with::SUV39H1,
 * is_associated_with::Sp1 transcription factor,
 * is_associated_with::Sp3 transcription factor,
 * is_associated_with::TOP2B, and
 * is_associated_with::YY1.