HDAC6

Histone deacetylase 6 is an is_associated_with::enzyme that in humans is encoded by the HDAC6 is_associated_with::gene.

Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromatin structure and affects transcription. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains that appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.

Clinical relevance
Mutations in this gene have been associated to is_associated_with::Alzheimer's disease.

Over expression of this protein correlates with is_associated_with::tumorigenesis and cell survival, HDAC6 also encourages is_associated_with::metastasis of cancer cells.

Functions
Retracts the is_associated_with::Cilium of the cell, which is necessary prior to is_associated_with::mitosis of the cell.

HDAC also encourages is_associated_with::cell motility and catalyzes is_associated_with::α-tubulin is_associated_with::deacetylation. as a result the enzyme also encourages cancer cell metastasis. HDAC6 also affects transcription and translation by regulating the heat-shock protein 90 (Hsp90) and stress granules (SGs), respectively.

HDAC6 is also known to bond with high affinity to is_associated_with::ubiquitinated proteins. HDAC6 is also required in the formation of SG (is_associated_with::Stress granule proteins and is instrumental in SG formation; pharmacological inhibition or genetic removal of HDAC6 abolished SG formation.

Interactions
HDAC6 has been shown to interact with is_associated_with::HDAC11 and is_associated_with::Zinc finger and BTB domain-containing protein 16.

HDAC6 interacts with SG (is_associated_with::Stress granule) protein is_associated_with::G3BP1.