Lymphotoxin beta receptor

Lymphotoxin beta receptor (LTBR), also known as tumor necrosis factor receptor superfamily member 3 (TNFRSF3), is a is_associated_with::cell surface receptor for is_associated_with::lymphotoxin involved in is_associated_with::apoptosis and is_associated_with::cytokine release. It is a member of the is_associated_with::tumor necrosis factor receptor superfamily.

Function
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and is_associated_with::myeloid lineages, but not on T and B is_associated_with::lymphocytes. The protein specifically binds the is_associated_with::lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and transformed cells. Activation of the encoded protein can trigger apoptosis.

Not only does the LTBR help trigger apoptosis, it can lead to the release of the is_associated_with::cytokine is_associated_with::interleukin 8. Overexpression of LTBR in HEK293 cells increases IL-8 promoter activity and leads to IL-8 release. LTBR is also essential for development and organization of the secondary lymphoid organs and chemokine release.

Structure
The Ramachandran plots show that 64.6% of all residues were in a favored region. This structure was found using X-ray diffraction. The resolution is 3.50 angstroms. The alpha and beta angles are 90 degrees while the gamma angle is 120 degrees.

Interactions
Lymphotoxin beta receptor has been shown to interact with is_associated_with::Diablo homolog and is_associated_with::TRAF3.