HDAC7

Histone deacetylase 7 is an is_associated_with::enzyme that in humans is encoded by the HDAC7 is_associated_with::gene.

Function
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via transcriptional corepressor SMRT. Multiple alternatively spliced transcript variants encoding several isoforms have been found for this gene.

Interactions
HDAC7A has been shown to interact with:


 * is_associated_with::BCL6,
 * is_associated_with::Endothelin receptor type A,
 * is_associated_with::HDAC3,
 * is_associated_with::HTATIP,
 * is_associated_with::IKZF1, and
 * is_associated_with::Nuclear receptor co-repressor 1l.