PANX1

Pannexin 1 is a is_associated_with::protein in humans that is encoded by the PANX1 is_associated_with::gene.

The protein encoded by this gene belongs to the is_associated_with::innexin family. Innexin family members are the structural components of is_associated_with::gap junctions. This protein and pannexin 2 are abundantly expressed in central nerve system (CNS) and are coexpressed in various neuronal populations. Studies in is_associated_with::Xenopus oocytes suggest that this protein alone and in combination with pannexin 2 may form cell type-specific gap junctions with distinct properties.

Clinical relevance
Disruptions of this gene have been associated to melanoma tumor progression.