MYLIP

Myosin regulatory light chain interacting protein, also known as MYLIP, is a is_associated_with::protein that in humans is encoded by the MYLIP is_associated_with::gene.

MYLIP is also known as IDOL "Inducible Degrader of the LDL receptor" based on its involvement in cholesterol regulation. The expression of IDOL is induced by the sterol-ativated is_associated_with::liver X receptor.

Increased Degradation of LDL Receptor Protein (IDOL) is a ubiquitin ligase that ubiquinates LDL receptors in endosomes and directs the receptors to the lysosomal compartment for degradation. IDOL is transcriptionally up-regulated by LXR/RXR in response to an increase in intracellular cholesterol. Pharmacologic inhibition of IDOL could reduce plasma LDL cholesterol by increasing plasma LDL receptor density.

Function
The is_associated_with::ERM protein family members is_associated_with::ezrin, is_associated_with::radixin, and is_associated_with::moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits is_associated_with::neurite outgrowth.