Neuromedin U receptor

The neuromedin U receptors are two G-protein coupled receptors which bind the neuropeptide hormones neuromedin U and neuromedin S. There are two subtypes of the neuromedin U receptor, each encoded by a separate gene.

Selective Ligands
Neuromedin U is an agonist at both the NMU1 and NMU2 subtypes, while neuromedin S is selective for NMU2, and is a more potent agonist at this subtype than neuromedin U. Several other peptide and non-peptide ligands are also available for the NMU receptors.

Agonists

 * Non-selective
 * Neuromedin U
 * non-peptide NMU modulators


 * NMU2 selective
 * Neuromedin S

Antagonists

 * NMU2 selective
 * R-PSOP