Rs2631367

rs2631367, a SNP in the promoter region of the SLC22A5 gene, has been associated with an autoimmune disease, in this case, Crohn's disease, odds ratio = 2.1 (CI = 1.31â€“3.39, p = 0.002), based on a study of 203 cases and 200 controls. The risk allele is the more rare allele, which appears to be rs2631367(C).[Note: this orientation has not been confirmed relative to dbSNP.]

A nearby SNP (rs1050152) in the coding region of the SLC22A4 gene defines a haplotype along with rs2631367, with odds ratio reported as similar for either SNP or the haplotype. Referring to the TC risk haplotype, the population risk attributable to heterozygotes was 19%, and for homozygous haplotype carriers, 27%.


 * is_associated_with_disease::Ulcerative colitis
 * is_associated_with_disease::Sclerosing cholangitis
 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Crohn's disease
 * is_associated_with_disease::Celiac disease
 * is_associated_with_disease::Arthritis
 * is_associated_with_disease::Primary biliary cirrhosis
 * is_associated_with_disease::Psoriatic arthritis