ZC3HC1

Nuclear-interacting partner of ALK is a is_associated_with::protein that in humans is encoded by the ZC3HC1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of ZC3HC1 function. A conditional is_associated_with::knockout mouse line, called Zc3hc1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::mutant mice and eleven significant abnormalities were observed. Fewer than expected is_associated_with::homozygous is_associated_with::mutant mice were identified at is_associated_with::weaning. Mutants appear to be subfertile, had decreased vertical activity in an open field, decreased lean body mass, decreased rib number and decreased mature is_associated_with::B cell number. Males also had a decreased body weight, an abnormal posture and atypical is_associated_with::indirect calorimetry data. Females also had an abnormally short snout and atypical haematology parameters.