BPIFB1

BPI fold containing family B, member 1 is a is_associated_with::protein that in humans is encoded by the BPIFB1 is_associated_with::gene.

Function
The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008].

Model organisms
is_associated_with::Model organisms have been used in the study of BPIFB1 function. A conditional is_associated_with::knockout mouse line called Bpifb1tm1e(KOMP)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping