Rs353016

SNPs in the SNAP25 gene were initially linked to intelligence but have failed to replicate.

While now suspect, the original work can be found in.

The (T;T) genotype averages almost 3 PIQ points higher than the (C;T) genotype, which averages almost 3 PIQ points higher than the (C;C) genotype.

rs353016 is in close linkage with rs363050, with r2 = 0.98, such that the rs363050(A) allele typically is linked to the rs353016(T) allele. For SNPs rs363039 - rs363043 - rs353016, respectively, the haplotype C-T-T is most associated with higher intelligence in children, whereas the haplotype C-C-T is most associated in adults (SNPs oriented as in dbSNP).