AMPD3

AMP deaminase 3 is an is_associated_with::enzyme that in humans is encoded by the AMPD3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of AMPD3 function. A conditional is_associated_with::knockout mouse line, called Ampd3tm2a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty eight tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. Mutant animals had increased IgG1 levels, increased is_associated_with::trabecular bone thickness, decreased B cell numbers / increased granulocyte number and unusual brain histopathology (the thickness of the is_associated_with::stratum radiatum was reduced and the dorsal is_associated_with::3rd ventricle area was increased).