MAPK11

Mitogen-activated protein kinase 11 is an is_associated_with::enzyme that in humans is encoded by the MAPK11 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, is_associated_with::transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory is_associated_with::cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (is_associated_with::MKKs), preferably by is_associated_with::MKK6. is_associated_with::Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.

Interactions
MAPK11 has been shown to interact with is_associated_with::HDAC3 and is_associated_with::Promyelocytic leukemia protein.