HLTF

Helicase-like transcription factor is an is_associated_with::enzyme that in humans is encoded by the HLTF is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::SWI/SNF family. Members of this family have is_associated_with::helicase and is_associated_with::ATPase activities and are thought to regulate transcription of certain genes by altering the is_associated_with::chromatin structure around those genes. The encoded protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform that is truncated at the N-terminus compared to the full-length protein.

HLTF is a double-stranded DNA translocase, one of two human homologs of Saccharomyces cerevisiae RAD5 besides is_associated_with::SHPRH (SNF2 histone linker PHD RING helicase), that is able to carry out fork regression, similarly to Rad5.

Interactions
HLTF has been shown to interact with is_associated_with::UBE2N, is_associated_with::RAD18 and is_associated_with::UBE2V2 (see also STRING functional and physical associations network : under the option  'search by name'  enter  'protein name'  of interest, HLTF, klick on  'GO! ', choose  'organism ', klick on  'continue ->' ).