Rs4779584

A study of 7000+ UK patients with colorectal cancer identified two SNPs that increase disease risk, one of which is rs4779584. Inheriting the rs4779584(T) risk allele is estimated to increase overall risk odds by 1.26x (CI: 1.19-1.34, p=4x10e-14). When analyzing data between genotypes, the odds ratios reported for heterozygotes was 1.23x (CI:1.13-1.33), and for rs4779584(T;T) homozygotes, 1.70 (CI: 1.41-2.04).

Inheriting the risk variant at both SNP loci (i.e. rs4779584 and rs6983267) is estimated to increase the overall risk of developing colorectal cancer about 3 fold. The authors of this study are quoted as saying that "the lifetime risk [of bowel cancer] is about 5% in the UK so it's going up to 7% or so if you've got both bad copies of a variant." nature

This SNP has also been associated with increased colorectal cancer risk in a French study of 1,000+ patients.

Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.

The utility and predictive value of combinations of low penetrance genes for screening and risk prediction of colorectal cancer.

Low-penetrance susceptibility variants in familial colorectal cancer.

Association studies on 11 published colorectal cancer risk loci.

Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations.

Systematic search for enhancer elements and somatic allelic imbalance at seven low-penetrance colorectal cancer predisposition loci.

GWAS-identified colorectal cancer susceptibility locus associates with disease prognosis.

Relationship between 16 susceptibility loci and colorectal cancer phenotype in 3146 patients.

Susceptibility genetic variants associated with early-onset colorectal cancer.