Prostaglandin D2 receptor

Prostaglandin D2 receptor (DP1) is a is_associated_with::G-protein coupled receptor, encoded by the PTGDR is_associated_with::gene, for prostaglandin D2.

Mechanism
DP1 is a is_associated_with::G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate is_associated_with::adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+.

Function
Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a is_associated_with::mast cell-derived mediator to trigger asthmatic responses. It also causes is_associated_with::vasodilation