Amphiphysin

Amphiphysin is a is_associated_with::protein that in humans is encoded by the AMPH is_associated_with::gene.

Amphiphysin is a brain-enriched is_associated_with::protein with an N-terminal is_associated_with::lipid interaction, dimerisation and membrane bending is_associated_with::BAR domain, a middle is_associated_with::clathrin and adaptor binding domain and a C-terminal SH3 domain. In the brain, its primary function is thought to be the recruitment of is_associated_with::dynamin to sites of clathrin-mediated is_associated_with::endocytosis. There are 2 mammalian amphiphysins with similar overall structure. A ubiquitous splice form of amphiphysin 2 that does not contain clathrin or adaptor interactions is highly expressed in is_associated_with::muscle tissue and is involved in the formation and stabilization of the T-tubule network. In other tissues amphiphysin is likely involved in other membrane bending and curvature stabilization events.

Interactions
Amphiphysin has been shown to interact with is_associated_with::DNM1,    is_associated_with::Phospholipase D1, is_associated_with::CDK5R1, is_associated_with::PLD2, is_associated_with::CABIN1 and is_associated_with::SH3GL2.