Peripheral myelin protein 22

Peripheral myelin protein 22, also known as PMP22, is a is_associated_with::protein which in humans is encoded by the PMP22 is_associated_with::gene. is_associated_with::Alternative splicing of this gene results in three transcript variants that encode the same protein.

Function
The is_associated_with::integral membrane protein encoded by this gene is a hydrophobic, tetraspan is_associated_with::glycoprotein expressed mainly in is_associated_with::Schwann cells and is a major component of compact is_associated_with::myelin in the is_associated_with::peripheral nervous system.

Clinical significance
Various mutations of the gene are causes of is_associated_with::Charcot–Marie–Tooth disease type IA, is_associated_with::Dejerine–Sottas disease, and is_associated_with::hereditary neuropathy with liability to pressure palsy.

Interactions
Peripheral myelin protein 22 has been shown to interact with is_associated_with::myelin protein zero.