CEBPA

CCAAT/enhancer-binding protein alpha is a is_associated_with::protein that in humans is encoded by the CEBPA is_associated_with::gene.

Function
The protein encoded by this intronless gene is a is_associated_with::bZIP is_associated_with::transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.

Interactions
CEBPA has been shown to interact with is_associated_with::Cyclin-dependent kinase 2 and is_associated_with::Cyclin-dependent kinase 4.

Clinical significance
It has been shown that mutation of CEBPA has been linked to good outcome in both adult and pediatric is_associated_with::acute myeloid leukemia patients.