COX4I1

Cytochrome c oxidase subunit 4 isoform 1, mitochondrial is an is_associated_with::enzyme that in humans is encoded by the COX4I1 is_associated_with::gene.

is_associated_with::Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of is_associated_with::electrons from is_associated_with::cytochrome c to molecular is_associated_with::oxygen and contributes to a proton is_associated_with::electrochemical gradient across the inner is_associated_with::mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the is_associated_with::electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it. Antibodies against Cox4 can be used to identify the inner membrane of mitochondria in immunfluorescence studies.