AKAP9

A-kinase anchor protein 9 is a is_associated_with::protein that in humans is encoded by the AKAP9 is_associated_with::gene.

Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins which have the common function of binding to the regulatory subunit of is_associated_with::protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternate splicing of this gene results in many isoforms that localize to the centrosome and the is_associated_with::Golgi apparatus, and interact with numerous signaling proteins from multiple is_associated_with::signal transduction pathways. These signaling proteins include type II protein kinase A, serine/threonine kinase protein kinase N, is_associated_with::protein phosphatase 1, protein phosphatase 2a, protein kinase C-epsilon and phosphodiesterase 4D3.

Model organisms
is_associated_with::Model organisms have been used in the study of AKAP9 function. A conditional is_associated_with::knockout mouse line, called Akap9tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and eight significant abnormalities were observed. Fewer than expected is_associated_with::homozygous is_associated_with::mutant mice survived until is_associated_with::weaning. The remaining tests were carried out on both homozygous and is_associated_with::heterozygous mutant adult mice. Animals of both sex displayed decreased body fat and body weight, is_associated_with::hematopoietic abnormalities and an atypical plasma chemistry panel. Female homozygotes also displayed abnormal tooth morphology while males heterozygous animals displayed an abnormal is_associated_with::pelvic girdle bone morphology.

Interactions
AKAP9 has been shown to interact with:


 * is_associated_with::CALM2,
 * CALM1,
 * is_associated_with::FNBP1,
 * is_associated_with::KvLQT1
 * is_associated_with::PRKAR2A,
 * PKN1, and
 * is_associated_with::TRIP10.