Rs1541160

homozygosity for the favorable allele (CC) associated with a 14 month survival advantage in ALS patients. further analysis (sequence, genotypic, and functional) showed LD between rs1541160 and rs522444 and that favorable alleles correlate with reduced KIFAP3 expression.

However, a later study attempting to replicate these findings in a population-based cohort of 500 Italian ALS patients could not find any effect on either survival or gene expression based on any SNPs (including rs1541160) from the KIFAP3 locus.


 * is_associated_with_disease::Lateral sclerosis
 * is_associated_with_disease::Amyotrophic lateral sclerosis