CDKN2BAS

CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 is_associated_with::exons, spanning 126.3kb in the is_associated_with::genome, and its spliced product is a 3834bp is_associated_with::RNA. It is located within the p15/is_associated_with::CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the is_associated_with::antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with many diseases, including is_associated_with::coronary artery disease, is_associated_with::diabetes and many is_associated_with::cancers. It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to is_associated_with::SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.