Notch 2

Neurogenic locus notch homolog protein 2 also known as notch 2 is a is_associated_with::protein that in humans is encoded by the NOTCH2 is_associated_with::gene.

NOTCH2 is associated with is_associated_with::Alagille syndrome and is_associated_with::Hajdu–Cheney syndrome.

Function
Notch 2 is a member of the notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells. In is_associated_with::Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development.

Mutations within the last coding exon of Notch2 that remove the PEST domain and escape the is_associated_with::nonsense-mediated mRNA decay have been shown to be the main cause of the is_associated_with::Hajdu-Cheney syndrome.

Interactions
NOTCH2 has been shown to interact with:
 * is_associated_with::Delta-like 1
 * is_associated_with::GSK3B,
 * is_associated_with::JAG1,   and
 * is_associated_with::JAG2.