Rs117039649

rs117039649, also known as SNP285 or SNP285C, is a SNP in an intron of the MDM2 p53 binding protein homolog gene. This SNP appears to only be found (so far) in Caucasians, and, in a subset of the alleles carrying the SNP309G>C (rs2279744) variant.

A 2011 study comparing MDM2 promoter status among different cohorts of ovarian cancer (n = 1993) and breast cancer (n = 1973) patients concluded that rs117039649(C) carriers were at reduced risk for both ovarian (odds ratio 0.74, CI: 0.58-0.94) and breast (odds ratio 0.79, CI: 0.62-1.00) cancer compared to SNP309G carriers (lacking SNP285).