DCC1

Sister chromatid cohesion protein DCC1 is a is_associated_with::protein that in humans is encoded by the DSCC1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of DSCC1 function. A conditional is_associated_with::knockout mouse line, called Dscc1tm1a(KOMP)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. Few is_associated_with::homozygous mutant embryos were identified during gestation, and some displayed is_associated_with::oedema, therefore less than expected survived until is_associated_with::weaning. Those that did survive had increased chromosomal instability in a is_associated_with::micronucleus test and numerous skeletal abnormalities by is_associated_with::radiography.

Interactions
DCC1 has been shown to interact with is_associated_with::CHTF18.