Nepicastat

Nepicastat (INN, codenamed SYN117, RS-25560-197) is an inhibitor of dopamine beta-hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine.

It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such. As of 2008, clinical trials to assess nepicastat as a treatment for post-traumatic stress disorder (PTSD) and cocaine dependence are recruiting participants.