Rs4712653

SNPs clustered in one region of chromosome 6p22 have been linked to increased risk for the exceedingly rare childhood cancer known as neuroblastoma. A study involving 720 patients determined that rs4712653(C;C) genotypes had increased likelihood of neuroblastoma development (odds ratio 1.96, CI: 1.57 to 2.43, p=7 x 10-8). At-risk homozygotes diagnosed with neuroblastoma had, on average, more malignant clinical presentation, more aggressive disease, and poorer long-term survival.

For more information on this cluster of SNPs, see rs6939340.

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.


 * is_associated_with_disease::Neuroblastoma