ITGB7

Integrin beta-7 is an is_associated_with::integrin is_associated_with::protein that in humans is encoded by the ITGB7 is_associated_with::gene. It can pair with is_associated_with::ITGA4 (CD49d) to form the heterodimeric integrin receptor α$4$β$7$, or with is_associated_with::ITGAE (CD103) to form α$E$β$7$.

Structure
Like all integrin subunits, β$7$ is a highly flexible, membrane-bound, extracellular protein that must pair with an α subunit for stability. The molecule's flexibility allows it to dynamically regulate its affinity for ligand through conformational changes. Beginning with the apical end of the protein, farthest from the cell membrane, the β$7$ is composed of a head and upper legs, collectively known as the headpiece, lower legs, a is_associated_with::transmembrane domain and a is_associated_with::cytoplasmic tail. The top of the head is the I-like domain, sometimes called the βI domain, which, in combination with the α subunit, binds ligand. Just below this is the hybrid domain, a portion of which is is_associated_with::N-terminal to the I-like domain. Below the hybrid domain is the PSI domain, which completes the headpiece. The lower legs consist of is_associated_with::EGF domains 1-4 and the β tail domain. Finally there is a transmembrane domain, and the is_associated_with::C-terminal cytoplasmic tail.

Interactions
ITGB7 has been shown to interact with is_associated_with::EED.