GSK3A

Glycogen synthase kinase-3 alpha is an is_associated_with::enzyme that in humans is encoded by the GSK3A is_associated_with::gene.

Glycogen synthase kinase 3-alpha is a multifunctional protein serine is_associated_with::kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including is_associated_with::glycogen synthase and various is_associated_with::transcription factors (e.g., JUN). It also plays a role in the WNT and is_associated_with::phosphoinositide 3-kinase (especially is_associated_with::PIK3CG) signaling pathways.

Model organisms
is_associated_with::Model organisms have been used in the study of GSK3A function. A conditional is_associated_with::knockout mouse line, called Gsk3atm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on is_associated_with::mutant mice but no significant abnormalities were observed.