LRDD

Leucine-rich repeats and death domain containing, also known as LRDD or p53-induced protein with a death domain (PIDD), is a is_associated_with::protein which in humans is encoded by the LRDD is_associated_with::gene.

Function
The protein encoded by this gene contains a is_associated_with::leucine-rich repeat and a is_associated_with::death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (is_associated_with::FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor is_associated_with::p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent is_associated_with::apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. Besides its pro-apoptotic function it may also be involved in is_associated_with::DNA repair as part of a protein complex formed together with the catalytic subunit of DNA-PK (is_associated_with::DNA-PKcs)and is_associated_with::caspase 2.