SEMA4D

Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a is_associated_with::protein of the is_associated_with::semaphorin family that in humans is encoded by the SEMA4D is_associated_with::gene.

Function
Semaphorin 4D (Sema 4D) is an is_associated_with::axon guidance molecule which is secreted by is_associated_with::oligodendrocytes and induces is_associated_with::growth cone collapse in the is_associated_with::central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the mature central nervous system.

In the immune system, CD100 binds is_associated_with::CD72 to activate is_associated_with::B cells and is_associated_with::dendritic cells, though much about this interaction is still under investigation.

During is_associated_with::skin damage repairs, SEMA4D interacts with is_associated_with::Plexin B2 on is_associated_with::gamma delta t cells to play a role in the healing process.