LDL-receptor-related protein-associated protein

Low density lipoprotein receptor-related protein-associated protein 1 also known as LRPAP1 or RAP is a chaperone is_associated_with::protein which in humans is encoded by the LRPAP1 is_associated_with::gene.

Function
LRPAP1 is involved with trafficking of certain members of the is_associated_with::LDL receptor family including is_associated_with::LRP1 and is_associated_with::LRP2. It is a is_associated_with::glycoprotein that binds to the alpha-2-macroglobulin receptor, as well as to other members of the is_associated_with::low density lipoprotein receptor family. It acts to inhibit the binding of all known is_associated_with::ligands for these receptors, and may prevent receptor aggregation and degradation in the endoplasmic reticulum, thereby acting as a molecular chaperone. It may be under the regulatory control of calmodulin, since it is able to bind is_associated_with::calmodulin and be phosphorylated by calmodulin-dependent is_associated_with::kinase II.

Interactions
LDL-receptor-related protein-associated protein has been shown to interact with is_associated_with::LRP2.