APOBEC

APOBEC ("apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like") is a family of evolutionary conserved proteins:

A mechanism of generating protein diversity is mRNA editing. Members of this family are C-to-U editing enzymes. The N-terminal domain of APOBEC like proteins is the catalytic domain, while the C-terminal domain is a pseudocatalyitc domain. More specifically, the catalytic domain is a zinc dependent cytidine deaminase domain and is essential for cytidine deamination. RNA editing by APOBEC-1 requires homodimerisation and this complex interacts with RNA binding proteins to from the editosome.

Family members
Human genes encoding members of the APOBEC protein family include:
 * APOBEC1
 * APOBEC2
 * APOBEC3A
 * APOBEC3C
 * APOBEC3D ("APOBEC3E" now refers to this)
 * APOBEC3F
 * APOBEC3G
 * APOBEC3H
 * APOBEC4