TRPC5

Short transient receptor potential channel 5 (TrpC5) also known as transient receptor protein 5 (TRP-5) is a is_associated_with::protein that in humans is encoded by the TRPC5 is_associated_with::gene. TrpC5 is subtype of the is_associated_with::TRPC family of is_associated_with::mammalian transient receptor potential is_associated_with::ion channels.

Function
TrpC5 is one of the seven mammalian is_associated_with::TRPC (transient receptor potential channel) proteins. TrpC5 is a multi-pass membrane protein and is thought to form a receptor-activated non-selective calcium permeant cation channel. The protein is active alone or as a heteromultimeric assembly with is_associated_with::TRPC1, is_associated_with::TRPC3, and is_associated_with::TRPC4. It also interacts with multiple proteins including is_associated_with::calmodulin, CABP1, is_associated_with::enkurin, Na+–H+ exchange regulatory factor (NHERF), interferon-induced GTP-binding protein (is_associated_with::MX1), ring finger protein 24 (is_associated_with::RNF24), and SEC14 domain and spectrin repeat-containing protein 1 (is_associated_with::SESTD1).

TRPC4 and TRPC5 have been implicated in the mechanism of mercury toxicity and neurological behavior.

Activation
Homomultimeric TRPC5 and heteromultimeric TRPC5-is_associated_with::TRPC1 channels are activated by extracellular reduced is_associated_with::thioredoxin. This channel has also been found to be involved in the action of anaesthetics such as is_associated_with::chloroform, is_associated_with::halothane and is_associated_with::propofol.

Interactions
TRPC5 has been shown to interact with is_associated_with::STMN3, is_associated_with::TRPC1, and is_associated_with::TRPC4.