Rs3813929

rs3813929, also known as -759C/T, is a SNP in the 5-hydroxytryptamine (serotonin) receptor 2C HTR2C gene.

A study of 107 patients with schizophrenia being treated with olanzapine reported a protective effect against weight-gain from the (T) allele of this SNP; zero patients (of 28) with a rs3813929(T) allele had a body mass index increase of >=10% (p=0.002), whereas (C;C) homozygotes did. This effect may also involve nearby SNP rs518147.

T allele showed borderline significant association with higher BMI and incidence of lifetime major depressive disorder among 4978 persons from the European Prospective Investigation into Cancer (EPIC)-Norfolk study, however, only the association with BMI remained borderline significant within the full EPIC-Norfolk cohort (20,981 persons)

The association between HTR2C polymorphisms and obesity in psychiatric patients using antipsychotics: a cross-sectional study.

Association of the HTR2C gene and antipsychotic induced weight gain: a meta-analysis.

The association between HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia.

Multivariate permutation analysis associates multiple polymorphisms with subphenotypes of major depression.

Focus on HTR2C: A possible suggestion for genetic studies of complex disorders.

HTR2C gene polymorphisms and the metabolic syndrome in patients with schizophrenia: a replication study.

Cohort profile: risk patterns and processes for psychopathology emerging during adolescence: the ROOTS project.

Association of polymorphisms of the serotonergic system with smoking initiation in Caucasians.

Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.

Functional consequences of two HTR2C polymorphisms associated with antipsychotic-induced weight gain.


 * is_associated_with_disease::Schizophrenia
 * is_associated_with_disease::Diabetes mellitus
 * is_associated_with_disease::Major depressive disorder
 * is_associated_with_disease::Cancer
 * is_associated_with_disease::Syndrome
 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Attention deficit hyperactivity disorder