TMEM126B

Transmembrane protein 126B is a is_associated_with::protein that in humans is encoded by the TMEM126B is_associated_with::gene. TMEM126B is a is_associated_with::transmembrane protein with unknown function. The Tmem126b gene is conserved in mammals.

Discovery
TMEM126B was first discovered in a study of protein expression in tissues of the is_associated_with::hypothalamus-is_associated_with::pituitary-is_associated_with::adrenal axis using full is_associated_with::cDNA cloning. It has since been detected in other tissues.

Gene
TMEM126B is located on is_associated_with::chromosome 11 in humans, flanked by the following genes:
 * is_associated_with::DLG2: A member of the membrane-associated is_associated_with::guanylate kinase family.
 * is_associated_with::TMEM126A: A paralog of TMEM126B expressed in the is_associated_with::mitochondria.
 * is_associated_with::CREBZF: Also known as the is_associated_with::Zhangfei protein, a is_associated_with::protein that interacts with is_associated_with::herpes simplex virus.

Translation
A conceptual translation of the TMEM126B protein, including a projection of the is_associated_with::secondary structure, predictions of transmembrane regions, and putative phosphorylation and glycation sites is included below:



Tissue distribution
TMEM126B is expressed in most tissue types, with the notable exceptions of is_associated_with::adipose tissue, is_associated_with::ear tissue, the is_associated_with::larynx, is_associated_with::lymph tissue, is_associated_with::nerve tissue, pituitary gland, is_associated_with::spleen, is_associated_with::thymus, is_associated_with::thyroid, trachea, and is_associated_with::umbilical cord. It also appears to be highly expressed in is_associated_with::parathyroid, is_associated_with::bone marrow, and is_associated_with::urinary bladder tissue. There is also evidence that one of the is_associated_with::isoforms of TMEM126B is expressed in the is_associated_with::cell membrane of is_associated_with::memory B cells of the is_associated_with::adaptive immune system.



Predicted properties
The following properties of TMEM126B were predicted using bioinformatic analysis:


 * is_associated_with::Molecular Weight: 22.7 KDal
 * is_associated_with::Isoelectric point: 9.02
 * TMEM126B is_associated_with::orthologs have highly variable isoelectric points.
 * is_associated_with::Post-translational modification: several possible phosphorylation sites were detected, and a pair of possible  glycation sites were predicted
 * No is_associated_with::signal peptide has been predicted.

Structure
A cartoon representation, tentatively based on the phosphorylation and hydrophobicity data is shown below.