DNASE1L2

Deoxyribonuclease-1-like 2 is an is_associated_with::enzyme that in humans is encoded by the DNASE1L2 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of DNASE1L2 function. A conditional is_associated_with::knockout mouse line, called Dnase1l2tm1(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::mutant mice and eight significant abnormalities were observed. Homozygous mutant animals had a decreased body weight, grip strength and bone mineral content; a kinked tail, abnormal is_associated_with::indirect calorimetry and is_associated_with::femur/is_associated_with::tibia morphology. Females also had an increased blood is_associated_with::urea nitrogen level while males had a decreased is_associated_with::leukocyte cell number.