Erbin (protein)

Erbb2 interacting protein (ERBB2IP) also known as Erbin is a is_associated_with::protein which in humans is encoded by the ERBB2IP is_associated_with::gene. Discovered in 1997, Erbin is a 200kDa protein containing a is_associated_with::PDZ domain.

Function
This gene is a member of the leucine-rich repeat and is_associated_with::PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the is_associated_with::ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternate transcriptional splice variants encoding different isoforms have been found for this gene, but only two of them have been characterized to date.

Clinical significance
Erbin's C-terminal is_associated_with::PDZ domain is able to bind to is_associated_with::ErbB2, a protein tyrosine kinase which is often associated with poor prognosis in epidermal oncogenesis. Erbin's N-terminal region has been shown to disrupt Ras to Raf binding and may be, through this action, a tumor suppressing protein.

Interactions
Erbin (protein) has been shown to interact with:
 * is_associated_with::Dystonin,
 * is_associated_with::HER2/neu,
 * is_associated_with::ITGB4,
 * is_associated_with::Mothers against decapentaplegic homolog 3 and
 * is_associated_with::PKP4.