SPPL2A

Signal peptide peptidase-like 2A, also known as SPPL2A, is a human is_associated_with::gene.

Function
This gene is a member of the is_associated_with::signal peptide peptidase-like protease (SPPL) family and encodes an endosomal membrane protein with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane domains (TMDs). This protein plays a role in innate and adaptive immunity by cleaving is_associated_with::TNFα in activated is_associated_with::dendritic cells. A pseudogene of this gene also lies on chromosome 15.