Acatalasia

Acatalasia (also called acatalasemia, or Takahara's disease ) is an autosomal recessive peroxisomal disorder caused by a complete lack of catalase.

Presentation
The disorder is relatively benign, although it causes an increased incidence of periodontal infections, and can under rare circumstances lead to gangrene.

History
In 1948, Dr.Shigeo Takahara (1908–1994), a Japanese otolaryngologist first reported this new disease. He had examined a patient with an oral ulcer. He had spread hydrogen peroxide on the diseased part, but oxygen was not generated due to the lack of catalase.