MEGF10

Multiple EGF-like-domains 10 is a is_associated_with::protein that in humans is encoded by the MEGF10 is_associated_with::gene.

MEGF10 is a regulator of is_associated_with::satellite cell is_associated_with::myogenesis. It has been shown to be the cause of early-onset is_associated_with::myopathy, is_associated_with::areflexia, is_associated_with::respiratory distress and is_associated_with::dysphagia.

MEGF10 and is_associated_with::MEGF11, have critical roles in the formation of mosaics by two retinal interneuron subtypes, starburst amacrine cells and horizontal cells in mice. These cells are less likely to be near neighbours of the same subtype than would occur by chance, resulting in ‘exclusion zones’ that separate them. Mosaic arrangements provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements.