Actinin, alpha 1

Alpha-actinin-1 is a is_associated_with::protein that in humans is encoded by the ACTN1 is_associated_with::gene.

Function
Alpha actinins belong to the is_associated_with::spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and is_associated_with::dystrophins. Alpha actinin is an is_associated_with::actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along is_associated_with::microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene.

Interactions
Actinin, alpha 1 has been shown to interact with:
 * is_associated_with::CDK5R1,
 * is_associated_with::CDK5R2,
 * is_associated_with::Collagen, type XVII, alpha 1,
 * is_associated_with::GIPC1,
 * is_associated_with::PDLIM1,
 * is_associated_with::Protein kinase N1,
 * is_associated_with::SSX2IP, and
 * is_associated_with::Zyxin.
 * is_associated_with::PTPRT(PTPrho)