Rs3091244

This is a triallelic SNP - note that the sidebar (currently) only shows 3 of the 6 possible genotypes.

CRP
claims that this SNP does not affect the serum concentration of CRP, while older resources seem to disagree. However, they do report an association between CRP levels and risk of abdominal aortic aneurysm (AAA).

rs3091244 serum CRP level and cardiovascular risk in the NHLBI Family Heart Study.

the AA genotype of the triallelic SNP rs3091244 in the gene C-reactive protein was associated with prevalent coronary heart disease in the non-Hispanic white population

Association study of CRP gene polymorphisms with serum CRP level and cardiovascular risk in the NHLBI Family Heart Study. rs3093059 rs3091244

Weaker linkage disequilibrium in this region in African Americans allows the conclusion that basal CRP levels are influenced in an additive manner by the T allele.

Non CRP
increased risk for the presence of severe hand osteoarthritis with an OR of 2.3 (95% confidence interval (C.I.) 1.2-4.3, P = 0.009)

rs3093061 associated with SLE and functional haplotypes containing rs3091244/rs3093062

According to a 23andMe discussion This is one of the SNPs which were re-analyzed April 2009. Customers with older data may wish to redownload. SNPs effected rs4420638, rs34276300, rs3091244, rs34601266, rs2033003, rs7900194, rs9332239, rs28371685, rs1229984, and rs28399504.

Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels.

Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level.

Allelic spectrum of the natural variation in CRP.

A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

Genotyping of triallelic SNPs using TaqMan PCR.

C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

Genome-wide association with select biomarker traits in the Framingham Heart Study.

Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.

C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

Genetic determinants of basal C-reactive protein expression in Filipino systemic lupus erythematosus families.

Association of common C-reactive protein (CRP) gene polymorphisms with baseline plasma CRP levels and fenofibrate response: the GOLDN study.

Bayesian meta-analysis of genetic association studies with different sets of markers.

Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants.

Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

C-reactive protein polymorphisms and genetic susceptibility to ischemic stroke and hemorrhagic stroke in the Chinese Han population.

IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk.

Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery.

C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk.

Marked differences in CRP genotype frequencies between the Fulani and sympatric ethnic groups in Africa.

Genetic Loci associated with C-reactive protein levels and risk of coronary heart disease.

Association of a single nucleotide polymorphism in the C-reactive protein gene (-286) with susceptibility to Plasmodium falciparum malaria.

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

Association between functional variants of the ICAM1 and CRP genes and metabolic syndrome in Taiwanese subjects.

Usefulness of Mendelian randomization in observational epidemiology.

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization.

C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

Fatigued breast cancer survivors and gene polymorphisms in the inflammatory pathway.

Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.

C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.