TBX6

T-box 6 is a is_associated_with::protein that in humans is encoded by the TBX6 is_associated_with::gene.

Function
This gene is a member of a phylogenetically conserved family of genes that share a common is_associated_with::DNA-binding domain, the is_associated_with::T-box. T-box genes encode is_associated_with::transcription factors involved in the regulation of developmental processes. Knockout studies in mice indicate that this gene is important for specification of paraxial is_associated_with::mesoderm structures.

Tbx6 is also required for the is_associated_with::segmentation of the is_associated_with::paraxial mesoderm into is_associated_with::somites, and for the normal development of the dermomyotome in zebrafish. In the absence of Tbx6, the central dermomyotome of zebrafish fails to develop.

Tbx6 functions in a gene regulatory network with mesp-b and ripply1.