Neutrophil cytosolic factor 1

Neutrophil cytosol factor 1 is a is_associated_with::protein that in humans is encoded by the NCF1 is_associated_with::gene.

Function
The protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil is_associated_with::NADPH oxidase. This oxidase is a multicomponent enzyme that is activated to produce is_associated_with::superoxide anion. Mutations in this gene have been associated with is_associated_with::chronic granulomatous disease. p47 is vital to the activation of NADPH oxidase. P47 becomes heavily phosphorylated

Interactions
Neutrophil cytosolic factor 1 has been shown to interact with:
 * is_associated_with::Moesin,
 * is_associated_with::Neutrophil cytosolic factor 4,  and
 * is_associated_with::RELA.