ADIPOR2

Adiponectin receptor 2 also known as ADIPOR2 is a is_associated_with::protein which in humans is encoded by the ADIPOR2 is_associated_with::gene.

Structure
Similar to is_associated_with::G protein-coupled receptors (GPCRs), ADIPOR2 also possesses 7 is_associated_with::transmembrane domains. However ADIPOR2 is orientated oppositely to GPCRs in the membrane (i.e., cytoplasmic is_associated_with::N-terminus, extracellular is_associated_with::C-terminus) and does not associate with is_associated_with::G proteins.

Function
The adiponectin receptors, is_associated_with::ADIPOR1 and ADIPOR2 (this protein), serve as receptors for globular and full-length is_associated_with::adiponectin and mediate increased AMPK and PPAR-α ligand activities, as well as is_associated_with::fatty acid oxidation and glucose uptake by adiponectin.