Integrin-linked kinase

Integrin-linked kinase (ILK) is a 59kDa protein originally identified while conducting a yeast-two hybrid screen with integrin β1 as the bait protein (Hannigan et al., 1996). Since its discovery, ILK has been associated with multiple cellular functions including cell migration, cell proliferation, cell-adhesions, and signal transduction.

In 2008, ILK was found to localize to the is_associated_with::centrosome and regulate is_associated_with::mitotic spindle organization.

Interactions
Integrin-linked kinase has been shown to interact with is_associated_with::LIMS1, is_associated_with::AKT1,   is_associated_with::ILKAP, is_associated_with::ACP6 and parvin.