CDS1 (gene)

Phosphatidate cytidylyltransferase 1 is an is_associated_with::enzyme that in humans is encoded by the CDS1 is_associated_with::gene.

Function
Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many is_associated_with::G protein-coupled receptors and is_associated_with::tyrosine kinases regulating cell growth, calcium metabolism, and is_associated_with::protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of is_associated_with::phosphatidic acid to CDP-is_associated_with::diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and is_associated_with::cardiolipin. and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (is_associated_with::CDS2) to 20p13.