MAP2K1

Dual specificity mitogen-activated protein kinase kinase 1 is an is_associated_with::enzyme that in humans is encoded by the MAP2K1 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the dual-specificity protein kinase family that acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as is_associated_with::extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein is_associated_with::kinase lies upstream of is_associated_with::MAP kinases and stimulates the enzymatic activity of MAP kinases upon activation by a wide variety of extra- and intracellular signals. As an essential component of the MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, is_associated_with::transcription regulation and development.

Interactions
MAP2K1 has been shown to interact with is_associated_with::C-Raf, is_associated_with::Phosphatidylethanolamine binding protein 1, is_associated_with::MAP2K1IP1, is_associated_with::GRB10, is_associated_with::MAPK3,    is_associated_with::MAPK8IP3,  is_associated_with::MAPK1     MP1, and is_associated_with::MAP3K1.