Metabotropic glutamate receptor 7

Metabotropic glutamate receptor 7 is a is_associated_with::protein that in humans is encoded by the GRM7 is_associated_with::gene.

Function
is_associated_with::L-glutamate is the major excitatory is_associated_with::neurotransmitter in the central nervous system and activates both ionotropic and is_associated_with::metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.

Agonists

 * is_associated_with::AMN082: is_associated_with::allosteric agonist; induces rapid is_associated_with::internalization; non-glutamatergic binding component

Antagonists

 * is_associated_with::MMPIP: allosteric antagonist/inverse agonist

Negative allosteric modulator

 * ADX-71743

Interactions
Metabotropic glutamate receptor 7 has been shown to interact with is_associated_with::PICK1.