Mothers against decapentaplegic homolog 5

Mothers against decapentaplegic homolog 5 also known as SMAD5 is a is_associated_with::protein that in humans is encoded by the SMAD5 is_associated_with::gene.

SMAD5, as its name describes, is a homolog of the is_associated_with::Drosophila gene: "is_associated_with::Mothers against decapentaplegic". It belongs to the SMAD family of proteins, which belong to the TGFβ superfamily of modulators. Like many other TGFβ family members SMAD5 is involved in is_associated_with::cell signalling and modulates signals of is_associated_with::bone morphogenetic proteins (BMP's). The binding of ligands causes the is_associated_with::oligomerization and is_associated_with::phosphorylation of the SMAD5 protein. SMAD5 is a receptor regulated SMAD (is_associated_with::R-SMAD) and is activated by bone morphogenetic protein type 1 receptor kinase. It may play a role in the pathway where TGFβ is an inhibitor of is_associated_with::hematopoietic progenitor cells.