SLITRK6

SLIT and NTRK-like protein 6 is a is_associated_with::protein that in humans is encoded by the SLITRK6 is_associated_with::gene.

Function
Members of the SLITRK family, such as SLITRK6, are integral membrane proteins with 2 N-terminal leucine-rich repeat (LRR) domains similar to those of SLIT proteins (see SLIT1; MIM 603742). Most SLITRKs, including SLITRK6, also have C-terminal regions that share homology with neurotrophin receptors (see NTRK1; MIM 191315). SLITRKs are expressed predominantly in neural tissues and have neurite-modulating activity (Aruga et al., 2003).[supplied by OMIM]

Clinical significance
Mutations in SLITRK6 cause high myopia and deafness in humans and mice.