JTB (gene)

Protein JTB, also known as the jumping translocation breakpoint protein or prostate androgen-regulated protein (PAR), is a is_associated_with::protein that in humans is encoded by the JTB is_associated_with::gene.

The JTB family of proteins contains several jumping translocation breakpoint is_associated_with::proteins or JTBs. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various is_associated_with::telomeres. JTB has been found to fuse with the telomeric repeats of acceptor is_associated_with::telomeres in a case of JT. Homo sapiens JTB (hJTB) encodes a is_associated_with::transmembrane protein that is highly conserved among divergent is_associated_with::eukaryotic is_associated_with::species. JT results in a hJTB truncation, which potentially produces an hJTB product devoid of the is_associated_with::transmembrane domain. hJTB is located in a gene-rich region at 1q21, called EDC (Epidermal Differentiation Complex). JTB has also been implicated in is_associated_with::prostatic carcinomas.