PLCG1

Phospholipase C, gamma 1, also known as PLCG1, is a is_associated_with::protein that in humans is encoded by the PLCG1 is_associated_with::gene.

Function
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from is_associated_with::phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated is_associated_with::tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras is_associated_with::guanine nucleotide exchange factor is_associated_with::RASGRP1 to translocate to the is_associated_with::Golgi apparatus, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. The receptor protein tyrosine phosphatase PTPmu (is_associated_with::PTPRM) is capable of dephosphorylating PLCG1. Two transcript variants encoding different isoforms have been found for this gene.

Clinical significance
Researchers studying PLCg1 and its role in breast cancer metastasis discovered this gene can promote cancer metastasis and subsequently blocking it stopped cancer from spreading. Research is ongoing but this gene could lead to the development of new anti-cancer drugs.

Interactions
PLCG1 has been shown to interact with:


 * is_associated_with::BAG3,
 * is_associated_with::CD117,
 * is_associated_with::CD31,
 * is_associated_with::Cbl gene
 * is_associated_with::Epidermal growth factor receptor,
 * is_associated_with::Eukaryotic translation elongation factor 1 alpha 1,
 * is_associated_with::FLT1,
 * is_associated_with::GAB1,
 * is_associated_with::GIT1,
 * is_associated_with::Grb2,
 * is_associated_with::HER2/neu,
 * is_associated_with::IRS2,
 * ITK,
 * is_associated_with::KHDRBS1,
 * is_associated_with::Linker of activated T cells,
 * is_associated_with::Lymphocyte cytosolic protein 2,
 * is_associated_with::PDGFRA,
 * is_associated_with::PLD2,
 * is_associated_with::RHOA,
 * is_associated_with::SOS1,
 * TUB,
 * is_associated_with::TrkA,
 * is_associated_with::TrkB,
 * is_associated_with::VAV1, and
 * is_associated_with::Wiskott-Aldrich syndrome protein.