Non-receptor tyrosine kinase

Non-receptor tyrosine kinases or non-specific protein-tyrosine kinases are enzymes that can transfer a phosphate group from ATP to a tyrosine residue in a protein. Non-receptor tyrosine kinases are a subgroup of the larger class of tyrosine kinases. Phosphorylation of proteins by kinases is an important mechanism in signal transduction for regulation of enzyme activity.

Structural studies
As of late 2007, 37 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , and.