ORC6

Origin recognition complex subunit 6 is a is_associated_with::protein that in humans is encoded by the ORC6 (ORC6L) is_associated_with::gene.

Background
The is_associated_with::origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the is_associated_with::DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to is_associated_with::origins of replication and serves as a platform for the assembly of additional is_associated_with::initiation factors such as is_associated_with::Cdc6 and Mcm proteins.

Function
The protein encoded by this gene is a subunit of the ORC complex. It has been shown that this protein and is_associated_with::ORC1 are loosely associated with the core complex consisting of is_associated_with::ORC2, -3, -4 and -5. Gene silencing studies with is_associated_with::small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with is_associated_with::cytokinesis.

Interactions
ORC6 has been shown to interact with is_associated_with::MCM5, is_associated_with::ORC2, is_associated_with::Replication protein A1, is_associated_with::ORC4, is_associated_with::DBF4, is_associated_with::ORC3, is_associated_with::CDC45-related protein, is_associated_with::MCM4 and is_associated_with::Cell division cycle 7-related protein kinase.