Host cell factor C1

Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein, is a is_associated_with::protein that in humans is encoded by the HCFC1 is_associated_with::gene.

Structure
HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five is_associated_with::Kelch repeats, a fibronectin-like motif, and six is_associated_with::HCF repeats, each of which contains a highly specific cleavage signal. This nuclear is_associated_with::transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an is_associated_with::N-terminal chain and the corresponding is_associated_with::C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

Function
HCF1 is involved in control of the is_associated_with::cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative is_associated_with::longevity determinant. Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.

Mutations in this gene have been linked to disorders of the is_associated_with::cobalamine metabolism.

Interactions
Host cell factor C1 has been shown to interact with:


 * is_associated_with::BAP1,
 * is_associated_with::CREB3,
 * is_associated_with::GABPA,
 * is_associated_with::HDAC1,
 * HDAC2,
 * MLL,
 * OGT,
 * is_associated_with::PDCD2,
 * is_associated_with::POU2F1,
 * is_associated_with::PPP1CA,
 * is_associated_with::SIN3A,
 * SP1,
 * is_associated_with::SUDS3,
 * is_associated_with::WDR5, and
 * is_associated_with::ZBTB17.