Rs578776

identifies a region associated with nicotine dependence in this particular study (1,050 dependents, 879 non-dependent controls, all of European descent), noted as distinct from the loci which rs16969968 defines

Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs.

Variants in nicotinic receptors and risk for nicotine dependence.

Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence.

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.

Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.

Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smoking.

Nicotinic receptor gene variants influence susceptibility to heavy smoking.

A testable prognostic model of nicotine dependence.

Genome-wide and candidate gene association study of cigarette smoking behaviors.

Human neuronal acetylcholine receptor A5-A3-B4 haplotypes are associated with multiple nicotine dependence phenotypes.

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.

Variation in nicotinic acetylcholine receptor genes is associated with multiple substance dependence phenotypes.

Associations of variants in CHRNA5/A3/B4 gene cluster with smoking behaviors in a Korean population.

Risk gene variants for nicotine dependence in the CHRNA5-CHRNA3-CHRNB4 cluster are associated with cognitive performance.

Association of the nicotine metabolite ratio and CHRNA5/CHRNA3 polymorphisms with smoking rate among treatment-seeking smokers.

Single nucleotide polymorphisms in CHRNA5 rs16969968, CHRNA3 rs578776, and LOC123688 rs8034191 are associated with heaviness of smoking in women in Northeastern Ontario, Canada.

Genetic polymorphisms in 15q25 and 19q13 loci, cotinine levels, and risk of lung cancer in EPIC.

Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.