GRIA1

Glutamate receptor 1 is a is_associated_with::protein that in humans is encoded by the GRIA1 is_associated_with::gene.

Function
is_associated_with::Glutamate receptors are the predominant excitatory is_associated_with::neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a is_associated_with::ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (is_associated_with::AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and is_associated_with::pyramidal cells in the is_associated_with::hippocampal formation.

Interactions
GRIA1 has been shown to interact with:
 * is_associated_with::DLG1
 * is_associated_with::EPB41L2, and
 * is_associated_with::GRID2.