HMOX1

HMOX1 (heme oxygenase (decycling) 1) is a is_associated_with::human is_associated_with::gene that encodes for the enzyme heme oxygenase 1 (EC 1.14.99.3). Heme oxygenase is an essential enzyme in is_associated_with::heme catabolism, it cleaves is_associated_with::heme to form is_associated_with::biliverdin.

The HMOX gene is located on the long (q) arm of chromosome 22 at position 12.3, from base pair 34,101,636 to base pair 34,114,748.

Related conditions
is_associated_with::Heme oxygenase-1 deficiency

Anti-inflammatory effect
The ability of oxygenase 1 to catabolize free heme and produce carbon monoxide (CO) gives its antiinflammatory properties by up-regulation of IL-10 and IL-1R antagonist expression.