GTF2I

General transcription factor II-I is a is_associated_with::protein that in humans is encoded by the GTF2I is_associated_with::gene.

Function
This gene encodes a multifunctional phosphoprotein with roles in transcription and signal transduction. It is deleted in is_associated_with::Williams-Beuren syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at chromosome 7q11.23. The exon(s) encoding 5' UTR has not been fully defined, but this gene is known to contain at least 34 exons, and its alternative splicing generates 4 transcript variants.

Interactions
GTF2I has been shown to interact with:


 * is_associated_with::Bruton's tyrosine kinase,
 * is_associated_with::HDAC3,
 * is_associated_with::Histone deacetylase 2,
 * is_associated_with::MAPK3,
 * is_associated_with::Myc,
 * is_associated_with::PRKG1,
 * is_associated_with::Serum response factor  and
 * is_associated_with::USF1 (human gene).