Bcl-xL

B-cell lymphoma-extra large (Bcl-xl) is a transmembrane molecule in the mitochondria. It is involved in the signal transduction pathway of the FAS-L. It is one of several anti-apoptotic proteins which are members of the Bcl-2 family of proteins. It has been implicated in the survival of cancer cells. Other Bcl-2 proteins include Bcl-2, Bcl-w, Bcl-xs, and Mcl-1.