TSC2

Tuberous Sclerosis Complex 2 (TSC2), also known as Tuberin, is a is_associated_with::protein that in humans is encoded by the TSC2 is_associated_with::gene.

Function
Mutations in this gene lead to is_associated_with::tuberous sclerosis. Its gene product is believed to be a is_associated_with::tumor suppressor and is able to stimulate specific is_associated_with::GTPases. The protein associates with is_associated_with::hamartin in a cytosolic complex, possibly acting as a chaperone for is_associated_with::hamartin. is_associated_with::Alternative splicing results in multiple transcript variants encoding different is_associated_with::isoforms of the protein.

Interactions
TSC2 functions within a multi-protein complex knowns as the TSC complex which consists of the core proteins TSC2, TSC1, and TBC1D7.

TSC2 has been reported to interact with several other proteins that are not a part of the TSC complex including:


 * is_associated_with::AKT1,
 * is_associated_with::AXIN1,
 * is_associated_with::FOXO1,
 * is_associated_with::GSK3B,
 * is_associated_with::MAPK1,
 * is_associated_with::PTK2,
 * PAM,
 * PRKAA1,
 * is_associated_with::RAP1A,
 * is_associated_with::RHEB,
 * is_associated_with::RPS6KA1,
 * is_associated_with::UBE3A  and
 * is_associated_with::YWHAZ.