TRPM1

Transient receptor potential cation channel subfamily M member 1 is a is_associated_with::protein that in humans is encoded by the TRPM1 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::transient receptor potential (TRP) family of non-selective cation channels. The expression of this protein is inversely correlated with is_associated_with::melanoma aggressiveness, suggesting that it suppresses is_associated_with::melanoma is_associated_with::metastasis. The expression of the TRPM1 gene is regulated by the is_associated_with::Microphthalmia-associated transcription factor.

Clinical significance
Mutations in TRPM1 are associated with is_associated_with::congenital stationary night blindness in humans   and  coat spotting patterns in is_associated_with::Appaloosa horses.