HULC (gene)

In molecular biology, Highly Up-regulated in Liver Cancer (non-protein coding), also known as HULC, is a is_associated_with::long non-coding RNA. It was first identified in is_associated_with::hepatocellular carcinoma, and is also expressed in is_associated_with::colorectal carcinomas that is_associated_with::metastasise to the is_associated_with::liver. It may have a role in the is_associated_with::post-transcriptional regulation of is_associated_with::gene expression. It downregulates the expression of several is_associated_with::microRNAs, including is_associated_with::miR-372. Expression of HULC is upregulated by is_associated_with::CREB, there is a CREB-binding site in the promoter of HULC. miR-372 represses translation of the is_associated_with::kinase is_associated_with::PRKACB, so downregulation of miR-372 leads to increased levels of PRKACB. PRKACB activates CREB by is_associated_with::phosphorylation, therefore leading to increased expression of HULC.