Regulator of cell cycle RGCC

Regulator of cell cycle RGCC (RGCC) also known as response gene to complement 32 protein (RGC-32) is a is_associated_with::protein that in humans is encoded by the RGCC is_associated_with::gene.

Function
This gene is thought to regulate is_associated_with::cell cycle progression. It is induced by is_associated_with::p53 in response to DNA damage, or by sublytic levels of is_associated_with::complement system proteins that result in activation of the cell cycle. The encoded protein localizes to the is_associated_with::cytoplasm during interphase and to is_associated_with::centrosomes during is_associated_with::mitosis. The protein forms a complex with is_associated_with::polo-like kinase 1. The protein also translocates to the nucleus in response to treatment with complement system proteins, and can associate with and increase the kinase activity of is_associated_with::cell division cycle 2 protein. In different assays and cell types, overexpression of this protein has been shown to activate or suppress cell cycle progression.