GPR77

C5a anaphylatoxin chemotactic receptor C5a2 also known as C5L2, G protein-coupled receptor 77, is a is_associated_with::protein that in humans is encoded by the C5AR2 is_associated_with::gene.

Function
The is_associated_with::anaphylatoxins C3a, C4a, and C5a are cationic fragments generated during the complement cascade that participate in host defense. In the case of inappropriate is_associated_with::complement activation, anaphylatoxins may be involved in is_associated_with::autoimmunity and is_associated_with::sepsis. C5a2 is coexpressed with the is_associated_with::C5a receptor, (C5a1, C5aR, C5R1, CD88), on polymorphonuclear is_associated_with::neutrophils and may modulate C5a1 activity.