GPX3

Glutathione peroxidase 3 (GPx-3), also known as plasma glutathione peroxidase (GPx-P) or extracellular glutathione peroxidase is an is_associated_with::enzyme that in humans is encoded by the GPX3 is_associated_with::gene.

GPx-3belongs to the is_associated_with::glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a is_associated_with::selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.