PLD2

Phospholipase D2 is an is_associated_with::enzyme that in humans is encoded by the PLD2 is_associated_with::gene.

Function
is_associated_with::Phosphatidylcholine (PC)-specific phospholipases D (PLDs) catalyze the hydrolysis of PC to produce is_associated_with::phosphatidic acid and is_associated_with::choline. Activation of PC-specific PLDs occurs as a consequence of agonist stimulation of both is_associated_with::tyrosine kinase and is_associated_with::G protein-coupled receptors. PC-specific PLDs have been proposed to function in regulated secretion, cytoskeletal reorganization, transcriptional regulation, and cell cycle control.[supplied by OMIM]

Interactions
PLD2 has been shown to interact with:


 * is_associated_with::ARF1,
 * is_associated_with::Aldolase A,
 * is_associated_with::Amphiphysin,
 * is_associated_with::BIN1,
 * is_associated_with::Caveolin 1,
 * is_associated_with::Glyceraldehyde 3-phosphate dehydrogenase,
 * is_associated_with::PLCG1,
 * is_associated_with::PRKCD,
 * Src, and
 * is_associated_with::Wiskott-Aldrich syndrome protein.

Inhibitors

 * N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1, IC50 = 20 nM.