Tachykinin receptor 3

Tachykinin receptor 3, also known as TACR3, is a is_associated_with::protein which in humans is encoded by the TACR3 is_associated_with::gene.

Function
This gene belongs to a family of genes that function as receptors for is_associated_with::tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as is_associated_with::neurokinin B.

Selective ligands
Several selective ligands are available for NK3. Two compounds is_associated_with::osanetant and is_associated_with::talnetant are being developed for treatment of various indications.

Agonists

 * Senktide - 7-amino acid polypeptide, NK3 selective, CAS# 106128-89-6

Antagonists

 * is_associated_with::Osanetant
 * is_associated_with::Talnetant
 * SB-222,200 - potent and selective antagonist, Ki = 4.4 nM, 3-Methyl-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide, CAS# 174635-69-9
 * SB-218,795 - more selective than SB-222,200, Ki = 13 nM, (R)-[(2-Phenyl-4-quinolinylcarbonyl)amino]-methyl ester benzeneacetic acid, CAS# 174635-53-1