HOXD10

Homeobox D10, also known as HOXD10, is a is_associated_with::protein which in humans is encoded by the HOXD10 is_associated_with::gene.

Function
This gene is a member of the Abd-B is_associated_with::homeobox family and encodes a protein with a homeobox is_associated_with::DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific is_associated_with::transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development.

Clinical significance
Mutations in this gene have been associated with is_associated_with::Wilms' tumor and congenital vertical talus (also known as "is_associated_with::rocker-bottom foot" deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in is_associated_with::Charcot-Marie-Tooth disease.

Regulation
The HOXD10 gene is repressed by the is_associated_with::microRNAs miR-10a and miR-10b.