LRP2

Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a is_associated_with::protein which in humans is encoded by the LRP2 is_associated_with::gene.

Function
LRP2 is a multiligand binding receptor found in the is_associated_with::plasma membrane of many absorptive epithelial cells. LRP2 is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (is_associated_with::LDLR). LRP2 functions to mediate is_associated_with::endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2 (previously called glycoprotein 330) together with RAP (is_associated_with::LRPAP1) forms the Heymann nephritis antigenic complex. LRP2 is expressed in epithelial cells of the is_associated_with::thyroid (thyrocytes), where it can serve as a receptor for the protein is_associated_with::thyroglobulin (Tg).

Clinical significance
Mutations in the LRP2 gene are associated with is_associated_with::Donnai-Barrow syndrome.

Interactions
LRP2 has been shown to interact with:
 * is_associated_with::DAB2,
 * is_associated_with::DLG4,
 * is_associated_with::GIPC1,
 * is_associated_with::ITGB1BP1,
 * is_associated_with::LDL-receptor-related protein associated protein,
 * is_associated_with::LDLRAP1,
 * is_associated_with::MAGI1,
 * is_associated_with::MAPK8IP1,
 * is_associated_with::MAPK8IP2,
 * is_associated_with::NOS1AP, and
 * is_associated_with::SYNJ2BP.