Estrogen receptor alpha

Estrogen receptor alpha (ER-α), also known as NR3A1 (nuclear receptor subfamily 3, group A, member 1), is one of two main types of is_associated_with::estrogen receptor, a is_associated_with::nuclear receptor that is activated by the sex hormone is_associated_with::estrogen. In humans, ER-α is encoded by the is_associated_with::gene ESR1 (EStrogen Receptor 1).

Structure
The estrogen receptor (ESR) is a ligand-activated is_associated_with::transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. is_associated_with::Alternative splicing results in several ESR1 mRNA transcripts, which differ primarily in their 5-prime untranslated regions. The translated receptors show less variability.

Coactivators
Coactivators of ER-α include:
 * SRC-1
 * AIB1 – amplified in breast 1
 * is_associated_with::BCAS3 – Breast carcinoma amplified sequence 3
 * is_associated_with::PELP-1 – Proline-, glutamic acid-, leucine-rich protein 1

Interactions
Estrogen receptor alpha has been shown to interact with:


 * is_associated_with::AKAP13
 * AHR
 * is_associated_with::BRCA1
 * CAV1
 * CCNC
 * is_associated_with::CDC25B
 * is_associated_with::CEBPB
 * COBRA1
 * is_associated_with::COUP-TFI
 * CREBBP
 * is_associated_with::CRSP3
 * is_associated_with::Cyclin D1
 * is_associated_with::DDX17
 * is_associated_with::DDX5
 * is_associated_with::DNTTIP2
 * is_associated_with::EP300
 * ESR2
 * is_associated_with::FOXO1
 * is_associated_with::GREB1
 * is_associated_with::GTF2H1
 * HSP90AA1
 * is_associated_with::ISL1
 * is_associated_with::JARID1A
 * MVP
 * is_associated_with::MED1
 * is_associated_with::MED12
 * is_associated_with::MED14
 * is_associated_with::MED16
 * is_associated_with::MED24
 * is_associated_with::MED6
 * MGMT
 * is_associated_with::MNAT1
 * is_associated_with::MTA1
 * is_associated_with::NCOA6
 * NCOA1
 * NCOA2
 * NCOA3
 * is_associated_with::NRIP1
 * is_associated_with::PDLIM1
 * is_associated_with::POU4F1
 * is_associated_with::POU4F2
 * is_associated_with::PRDM2
 * is_associated_with::PRMT2
 * is_associated_with::RBM39
 * is_associated_with::RNF12
 * is_associated_with::SAFB
 * is_associated_with::SAFB2
 * is_associated_with::SHC1
 * SHP
 * is_associated_with::SMARCA4
 * is_associated_with::SMARCE1
 * is_associated_with::SRA1
 * Src
 * TR2
 * TR4
 * TDG
 * is_associated_with::TRIM24 and
 * is_associated_with::XBP1.