Rs6277

rs6277 (957C>T, Pro319Pro) is one of several SNPs in the dopamine receptor DRD2 gene.

In a study of 300+ Russian patients with schizophrenia, the rs6277(C) allele was associated with higher risk. From a pooled meta-study (total of 4 other reports plus this one) the allelic odds ratio is 1.42 (CI: 1.26-1.61, p<0.00005), and the genotypic odds ratio for the (C;C) genotype was 1.6 (CI: 1.32-1.95, p<0.00005).

Note that rs6275 and rs6277 are only 18bp apart, hence their very tight linkage (r2=1).

gs278 reflects a gene-gene interaction between this SNP and a NR3A SNP, rs10989591, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory.

C allele associated significantly (p = 0.021) with post-traumatic stress disorder in a sample of (assumedly Australian) 127 war veterans w/ 228 controls

23andMe blog people with two As at rs6277(T;T) were better at NoGo learning.

[pharmgkb] T allele associated with decrease in mRNA levels