Tricho-rhino-phalangeal syndrome Type 1

Zinc finger transcription factor Trps1 is a is_associated_with::protein that in humans is encoded by the TRPS1 is_associated_with::gene.

This gene encodes a GATA-like is_associated_with::transcription factor that represses GATA-regulated genes and binds to a is_associated_with::dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of is_associated_with::tricho-rhino-phalangeal syndrome (TRPS) types I-III (also known as the is_associated_with::Langer-Giedion syndrome).