Histone deacetylase 5

Histone deacetylase 5 is an is_associated_with::enzyme that in humans is encoded by the HDAC5 is_associated_with::gene.

Function
is_associated_with::Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters is_associated_with::chromosome structure and affects is_associated_with::transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses is_associated_with::histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

is_associated_with::AMP-activated protein kinase regulation of the glucose transporter is_associated_with::GLUT4 occurs by is_associated_with::phosphorylation of HDAC5.

HDAC5 is involved in is_associated_with::memory consolidation and suggests that development of more selective is_associated_with::HDAC inhibitors for the treatment of is_associated_with::Alzheimer's disease should avoid targeting HDAC5.

Interactions
Histone deacetylase 5 has been shown to interact with:


 * is_associated_with::BCL6,
 * CBX5,
 * is_associated_with::GATA1,
 * is_associated_with::HDAC3,
 * is_associated_with::IKZF1,
 * MEF2A,
 * is_associated_with::NRIP1,
 * NCOR1,
 * NCOR2,
 * is_associated_with::YWHAQ, and
 * ZBTB16.