HRB (gene)

Arf-GAP domain and FG repeats-containing protein 1 is a is_associated_with::protein that in humans is encoded by the AGFG1 is_associated_with::gene.

Function
The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Interactions
HRB (gene) has been shown to interact with is_associated_with::EPS15L1 and is_associated_with::EPS15.