F-15,599

F-15,599 is a very potent and highly selective 5-HT1A receptor full agonist. It displays functional selectivity by strongly activating 5-HT1A receptors in the prefrontal cortex while having little effect on autoreceptors in the raphe nucleus. As a result, it has been touted as a preferential postsynaptic 5-HT1A receptor agonist and is being investigated as a novel potential antidepressant.