Granulocyte macrophage colony-stimulating factor receptor

The granulocyte macrophage colony-stimulating factor receptor also known as CD116 (Cluster of Differentiation 116), is a receptor for is_associated_with::granulocyte macrophage colony-stimulating factor, which stimulates the production of white blood cells. The receptor is normally located on is_associated_with::myeloblast, mature is_associated_with::neutrophil, but not on any erythroid or megakaryocytic lineage cells.

It is associated with is_associated_with::Surfactant metabolism dysfunction type 4.

Structure
The granulocyte macrophage colony-stimulating factor receptor is a heterodimer composed of at least two different subunits; an α chain, and a β chain which is also present in the receptors for IL-3 and IL-5. The α subunit contains a binding site for granulocyte macrophage colony-stimulating factor. The β chain is involved in signal transduction. Association of the α and β subunits results in receptor activation.

Signal transduction
Upon dimerisation of the α and β subunits the β subunit becomes phosphorylated on tyrosine residues by members of the Janus kinase (JAK) family. This leads to association with a Shc adaptor protein. Then Shc interacts with is_associated_with::GRB2/SoS complex which results in activation of more downstream molecules in the pathway.