Rs45539432

rs45539432, also known as Gln456Ter or Q456X, is a SNP in the PINK1 gene. In one German family studied, rs45539432(T;T) homozygotes exhibited early onset Parkinson's disease. Of the rs45539432(C;T) heterozygotes, half showed no signs of Parkinson's, but the other half had subtle signs of disease, consisting of unilaterally reduced or absent arm swing and rigidity.