MTA1

Metastasis-associated protein MTA1 is a is_associated_with::protein that in humans is encoded by the MTA1 is_associated_with::gene.

Function
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary is_associated_with::adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in is_associated_with::metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, is_associated_with::NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two is_associated_with::DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by is_associated_with::chromatin remodeling.

Interactions
MTA1 has been shown to interact with:
 * ESR1,
 * is_associated_with::HDAC1,
 * HDAC2,
 * is_associated_with::MNAT1, and
 * is_associated_with::MTA2.

MTA1 has also been shown to inhibit is_associated_with::SMAD7 at the transcriptional level.