TRPC1

Transient receptor potential channel 1 (TRPC1) is a is_associated_with::protein that in humans is encoded by the TRPC1 is_associated_with::gene.

Function
TRPC1 is an is_associated_with::ion channel located on the plasma membrane of numerous human and animal cell types. It is a nonspecific cation channel, which means that both sodium and calcium ions can pass through it. TRPC1 is thought to mediate calcium entry in response to depletion of endoplasmic calcium stores or activation of receptors coupled to the is_associated_with::phospholipase C system. In HEK293 cells the unitary current-voltage relationship of is_associated_with::endogenous TRPC1 channels is almost linear, with a slope conductance of about 17 pS. The extrapolated reversal potential of TRPC1 channels is +30 mV. The TRPC1 protein is widely expressed throughout the mammalian brain and has a similar corticolimbic expression pattern as TRPC4 and TRPC5. The highest density of TRPC1 protein is found in the lateral septum, an area with dense TRPC4 expression, and hippocampus and prefrontal cortex, areas with dense TRPC5 expression.

History
TRPC1 was the first mammalian Transient Receptor Potential channel to be identified. In 1995 it was cloned when the research groups headed by Craig Montell and Lutz Birnbaumer were searching for proteins similar to the is_associated_with::TRP channel in is_associated_with::Drosophila. Together with TRPC3 they became the founding members of the is_associated_with::TRPC is_associated_with::ion channel family.

Interactions
TRPC1 has been shown to interact with is_associated_with::HOMER3, is_associated_with::Polycystic kidney disease 2, is_associated_with::TRPC5, is_associated_with::TRPC3, is_associated_with::RHOA and is_associated_with::TRPC4.