Desmoglein-2

Desmoglein-2 is a is_associated_with::protein that in humans is encoded by the DSG2 is_associated_with::gene.

Function
is_associated_with::Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein-2 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, four desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This second family member is expressed in colon, colon carcinoma, and other simple and stratified epithelial-derived cell lines.

Interactions
Desmoglein-2 has been shown to interact with:


 * is_associated_with::DSC1,
 * is_associated_with::PKP3, and
 * is_associated_with::Plakoglobin