EIF2AK3

Eukaryotic translation initiation factor 2-alpha kinase 3, also known as PRKR-like endoplasmic reticulum kinase or protein kinase R (PKR)-like endoplasmic reticulum kinase, is an is_associated_with::enzyme that in humans is encoded by the EIF2AK3 is_associated_with::gene.

Function
The protein encoded by this gene is_associated_with::phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (is_associated_with::EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the is_associated_with::endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins.

Clinical significance
Patients with mutations in this gene develop is_associated_with::Wolcott-Rallison syndrome.

Interactions
EIF2AK3 has been shown to interact with is_associated_with::DNAJC3 and is_associated_with::NFE2L2.

Inhibitors

 * is_associated_with::GSK2606414
 * 3-Fluoro-GSK2606414