GPR35

G protein-coupled receptor 35 also known as GPR35 is a is_associated_with::G protein-coupled receptor which in humans is encoded by the GPR35 is_associated_with::gene. Heightened expression of GPR35 is found in immune and gastrointestinal tissues, including the is_associated_with::crypts of Lieberkühn.

Agonists
Selective is_associated_with::agonists of GPR35 include:
 * 5-nitro-2-(3-phenylpropylamino) benzoic acid
 * is_associated_with::Kynurenic acid
 * is_associated_with::Lysophosphatidic acid
 * is_associated_with::Pamoic acid
 * is_associated_with::Zaprinast

Antagonists
is_associated_with::Antagonists of GPR35 include:
 * ML145 (CID-2286812)
 * ML144 (CID-1542103)

Clinical significance
Deletion of GPR35 gene may be responsible for is_associated_with::brachydactyly mental retardation syndrome and is mutated in is_associated_with::2q37 monosomy and is_associated_with::2q37 deletion syndrome. In one study GPR35 has been recognised as a potential is_associated_with::oncogene in is_associated_with::stomach cancer.