Transferrin receptor 2

Transferrin receptor 2 (TfR2) is a is_associated_with::protein that in humans is encoded by the TFR2 is_associated_with::gene. This protein is involved in the uptake of is_associated_with::transferrin-bound iron into cells by is_associated_with::endocytosis, although its role is minor compared to is_associated_with::transferrin receptor 1.

Function
This gene is a member of the is_associated_with::transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary is_associated_with::hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.