DNMT3B

DNA (cytosine-5-)-methyltransferase 3 beta, also known as DNMT3B, is a protein associated with is_associated_with::immunodeficiency, centromere instability and facial anomalies syndrome.

Function
CpG methylation is an epigenetic modification that is important for is_associated_with::embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a is_associated_with::DNA methyltransferase which is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. Eight alternatively spliced transcript variants have been described. The full length sequences of variants 4 and 5 have not been determined.

Interactions
DNMT3B has been shown to interact with:


 * CBX5,
 * is_associated_with::DNMT1,
 * is_associated_with::DNMT3A,
 * is_associated_with::KIF4A,
 * is_associated_with::NCAPG,
 * is_associated_with::SMC2,
 * SUMO1 and
 * is_associated_with::UBE2I.