BRCT domain

BRCA1 C Terminus (BRCT) domain  is a family of evolutionarily related proteins. The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.

Examples
Human proteins containing this domain include:


 * BARD1; BRCA1
 * CTDP1; DNTT
 * ECT2
 * LIG4
 * MCPH1; MDC1
 * NBN
 * PARP1; PARP4; PAXIP1; PES1
 * REV1; RFC1; TOPBP1; TP53BP1; XRCC1