TRPV5

Transient receptor potential cation channel subfamily V member 5 is a is_associated_with::protein that in humans is encoded by the TRPV5 is_associated_with::gene.

TRPV5 is mainly expressed in is_associated_with::kidney epithelial cells, where it plays an important role in the reabsorption of Ca2+. Genetic deletion of TRPV5 in mice leads to Ca2+ loss in the urine, and consequentual is_associated_with::hyperparathyroidism, and bone loss.

Function
This gene is a member of the transient receptor family and the is_associated_with::TRPV subfamily. The calcium-selective channel, TRPV5, encoded by this gene has 6 transmembrane-spanning domains, multiple potential is_associated_with::phosphorylation sites, an N-linked is_associated_with::glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.

Interactions
TRPV5 has been shown to interact with is_associated_with::S100A10.