Rs3132293

A screen of SNPs in the RXRA gene in 405 Alzheimer's disease patients (mean age 74 +/- 9 years) suggests that the rs3132293(G) allele (in dbSNP orientation) is associated with lower risk for the disease.

However, it should be noted that (1) this allele is quite common, (2) there was a significant difference in the % of females (79%) in the patient population compared to the control population (57%), and (3) the magnitude of associated changes in cerebral cholesterol is not high.