C19orf2

Unconventional prefoldin RPB5 interactor, also called URI1, is a is_associated_with::protein that in humans is encoded by the C19orf2 is_associated_with::gene.

Function
The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the is_associated_with::chromatin structure. Two is_associated_with::alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions
C19orf2 has been shown to interact with is_associated_with::DMAP1 and is_associated_with::STAP1.

Model organisms
is_associated_with::Model organisms have been used in the study of URI1 function. A conditional is_associated_with::knockout mouse line called Uri1tm1a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping