Rs10811661

rs10811661 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.15-1.40, p = 1.9 x 10e-6)

rs10811661 is mentioned in part 2 of a series

significantly associated with type-2 diabetes p = 0.0024; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls

1,638 type 2 diabetes patients and 1,858 controls
 * rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p = 0.004)

T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 rs7903146 SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)
 * CDKAL1 (OR(rs7756992) = 1.30[1.19-1.42], P = 2.3x10(-9))
 * CDKN2A/2B (OR(rs10811661) = 0.74[0.66-0.82], P = 3.5x10(-8))
 * IGFBP2 (OR(rs1470579) = 1.17[1.07-1.27], P = 0.0003) SNPs.

Association between [r[s10811661]] and type-2 diabetes was replicated in a French Europid population, with an odds ratio of 1.43 (CI: 1.24-1.64, p = 3.8 x 10e-7).

This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).


 * is_associated_with_disease::Pre-eclampsia
 * is_associated_with_disease::Abdominal aortic aneurysm
 * is_associated_with_disease::Intracranial aneurysm
 * is_associated_with_disease::Gestational diabetes
 * is_associated_with_disease::Atherosclerosis
 * is_associated_with_disease::Type 2 diabetes mellitus
 * is_associated_with_disease::Periodontitis
 * is_associated_with_disease::Hypersensitivity reaction type II disease
 * is_associated_with_disease::Myocardial infarction
 * is_associated_with_disease::Coronary heart disease
 * is_associated_with_disease::Obesity