SYTL1

Synaptotagmin-like protein 1 is a is_associated_with::protein that in humans is encoded by the SYTL1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SYTL1 function. A conditional is_associated_with::knockout mouse line, called Sytl1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on homozygous is_associated_with::mutant mice and six significant abnormalities were observed. Females had abnormal locomotor coordination, caudal vertebral transformation, decreased circulating is_associated_with::amylase levels and increased mean is_associated_with::platelet volume. Both sexes displayed decreased is_associated_with::IgG2b levels and abnormal peripheral blood is_associated_with::lymphocyte parameters.

Interactions
SYTL1 has been shown to interact with is_associated_with::RAB27A.