Rs9652490

rs9652490 is a SNP in the LINGO1 gene. Note: it is unclear why one set of authors report the risk allele for essential tremors to be (G), while the others just as clearly report the risk allele to be (A).

A follow-up case-control study replicated the original association of rs9652490(A;A) to an ~2x increased risk for Parkinson's disease, but also found the same risk for essential tremor (ET), thus linking the two diseases. The ET study was based on ~300 patients.

23andMe blog "In a combined analysis of 752 subjects with essential tremor from Iceland, Austria, Germany and the United States and 15,797 controls, Stefansson et al found that the G version of rs9652490 in the LINGO1 gene is associated with increased odds of the condition. Carrying one G increases the odds of essential tremor by 1.55 times compared to two As. The approximately 5% of the population with European ancestry with two Gs has 2.40 times increased odds."

Finds no evidence that rs9652490 is associated with Parkinson's disease in a Chinese population, or, based on a meta-analysis.


 * is_associated_with_disease::Parkinson's disease
 * is_associated_with_disease::Multiple sclerosis
 * is_associated_with_disease::Essential tremor