GRIN2B

Glutamate [NMDA] receptor subunit epsilon-2 also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B) is a is_associated_with::protein that in humans is encoded by the GRIN2B is_associated_with::gene.

Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in is_associated_with::long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (is_associated_with::GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (is_associated_with::GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (is_associated_with::GRIN2C), and NMDAR2D (is_associated_with::GRIN2D). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.

NR2B has been associated with age and visual experience dependent plasticity in the neocortex of is_associated_with::rats, where an increased NR2B/NR2A ratio correlates directly with the stronger excitatory LTP in young animals. This is thought to contribute to experience-dependent refinement of developing cortical circuits.

Ligands

 * is_associated_with::Besonprodil
 * is_associated_with::CERC-301 selective NR2B receptor antagonist
 * is_associated_with::Eliprodil
 * Evt 101, a selective NR2B receptor antagonist, is being tested as a potentially fast acting antidepressant.
 * is_associated_with::Ro-25-6981 (also known as MI-4) - selective NR2B receptor antagonist
 * is_associated_with::Traxoprodil selective NR2B receptor antagonist

Interactions
GRIN2B has been shown to interact with:


 * is_associated_with::Actinin, alpha 2,
 * is_associated_with::DLG2,
 * is_associated_with::DLG3,
 * is_associated_with::DLG4,
 * is_associated_with::EXOC4,
 * is_associated_with::LIN7B, and
 * RICS.