IRS2

Insulin receptor substrate 2 is a is_associated_with::protein that in humans is encoded by the IRS2 is_associated_with::gene.

Function
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of is_associated_with::insulin, is_associated_with::insulin-like growth factor 1, and other is_associated_with::cytokines by acting as a molecular adaptor between diverse is_associated_with::receptor tyrosine kinases and downstream effectors. The product of this gene is is_associated_with::phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment.

Mice lacking IRS2 have a diabetic phenotype as well as a 40% reduction in brain mass.

Interactions
IRS2 has been shown to interact with:
 * is_associated_with::PLCG1,
 * SOCS1, and
 * is_associated_with::PIK3R1,