Endothelial NOS

Endothelial NOS (eNOS), also known as nitric oxide synthase 3 (NOS3) or constitutive NOS (cNOS), is an is_associated_with::enzyme that in humans is encoded by the NOS3 is_associated_with::gene.

Endothelial NOS is a is_associated_with::nitric oxide synthase that generates NO in is_associated_with::blood vessels and is involved with regulating vascular tone by inhibiting is_associated_with::smooth muscle contraction and is_associated_with::platelet aggregation. A constitutive Ca2+ dependent NOS provides a basal release of NO. eNOS is associated with plasma membranes surrounding cells and the membranes of Golgi bodies within cells.

Clinical significance
Variations in this gene are associated with susceptibility to coronary spasm.

An association between a polymorphism in the gene and late-onset is_associated_with::Alzheimer's disease in Chinese have been reported.

Interactions
Endothelial NOS has been shown to interact with CAV1, HSP90AA1  and is_associated_with::GUCY1B3.