Hypocretin (orexin) receptor 2

Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2, is a is_associated_with::protein that in humans is encoded by the HCRTR2 is_associated_with::gene.

Function
OX2 is a is_associated_with::G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with OX1. OX2 binds both is_associated_with::orexin A and orexin B neuropeptides. OX2 is involved in the central feedback mechanism that regulates feeding behaviour.

Agonists

 * is_associated_with::Orexin-A
 * is_associated_with::Orexin-B
 * is_associated_with::SB-668,875

Antagonists

 * is_associated_with::Almorexant - Dual OX1 and OX2 antagonist
 * EMPA - Selective OX2 antagonist
 * is_associated_with::Filorexant - Dual OX1 and OX2 antagonist
 * is_associated_with::JNJ-10397049 (600x selective for OX2 over OX1)
 * is_associated_with::JNJ-42847922 - Selective OX2 antagonist
 * is_associated_with::Lemborexant - Dual OX1 and OX2 antagonist
 * is_associated_with::MIN-202 - Selective OX2 antagonist
 * is_associated_with::MK-1064 - Selective OX2 antagonist
 * is_associated_with::MK-8133 - Selective OX2 antagonist
 * is_associated_with::SB-649,868 - Dual OX1 and OX2 antagonist
 * is_associated_with::Suvorexant - Dual OX1 and OX2 antagonist
 * is_associated_with::TCS-OX2-29 - Selective OX2 antagonist
 * (3,4-dimethoxyphenoxy)alkylamino acetamides
 * is_associated_with::Compound 1m - Selective OX2 antagonist