Growth differentiation factor-9

Growth/differentiation factor 9 is a is_associated_with::protein that in humans is encoded by the GDF9 is_associated_with::gene.

GDF9 plays an important role in the development of primary follicles in the is_associated_with::ovary. It has a critical role in is_associated_with::granulosa cell and is_associated_with::theca cell growth, as well as in differentiation and maturation of the oocyte.

GDF9 has been connected to differences in is_associated_with::ovulation rate and in premature cessation of ovary function, therefore has a significant role in is_associated_with::fertility.

The cell surface receptor through which GDF9 generates a signal is the is_associated_with::bone morphogenetic protein type II receptor (is_associated_with::BMPR2).