Mitochondrial antiviral-signaling protein

Mitochondrial antiviral-signaling protein (MAVS) is a is_associated_with::protein that in humans is encoded by the MAVS is_associated_with::gene. The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate is_associated_with::IRF3 dimerization.

Function
is_associated_with::Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor is_associated_with::TLR3 or by the cytoplasmic RNA helicases is_associated_with::MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases is_associated_with::IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate is_associated_with::NFKB, or TBK1 and is_associated_with::IKBKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein is_associated_with::TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound MAVS.