ARHGEF12

Rho guanine nucleotide exchange factor 12 is a is_associated_with::protein that in humans is encoded by the ARHGEF12 is_associated_with::gene.

Function
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through is_associated_with::G protein coupled receptor. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals.

Clinical significance
This protein is observed to form myeloid/lymphoid fusion partner in is_associated_with::acute myeloid leukemia.

Interactions
ARHGEF12 has been shown to interact with:


 * is_associated_with::GNA12,
 * is_associated_with::GNA13,
 * IGF1R,
 * is_associated_with::PLXNB1,
 * is_associated_with::RHOA, and
 * TEC.