Agmatinase

In is_associated_with::enzymology, an agmatinase is an is_associated_with::enzyme that catalyzes the is_associated_with::chemical reaction


 * agmatine + H2O $$\rightleftharpoons$$ putrescine + urea

Thus, the two substrates of this enzyme are is_associated_with::agmatine and H2O, whereas its two products are is_associated_with::putrescine and is_associated_with::urea.

This enzyme belongs to the family of is_associated_with::hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in is_associated_with::urea cycle and metabolism of amino groups.

Genetics
In humans, the enzyme is encoded by the AGMAT is_associated_with::gene.

Structural studies
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes, , , , and.

Inhibitors

 * is_associated_with::Piperazine-1-carboxamidine