TMC8

Transmembrane channel-like 8 is a is_associated_with::protein which in humans is encoded by the TMC8 is_associated_with::gene.

Function
The protein encoded by this gene is an integral membrane protein that localize to the is_associated_with::endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 is_associated_with::leucine zipper motifs.

Clinical significance
Mutations in the TMC8 gene are associated with is_associated_with::epidermodysplasia verruciformis (EV), an autosomal recessive is_associated_with::dermatosis characterized by abnormal susceptibility to human is_associated_with::papillomaviruses (HPVs) and a high rate of progression to is_associated_with::squamous cell carcinoma on sun-exposed skin.