RSPH4A

Radial spoke head protein 4 homolog A, also known as radial spoke head-like protein 3, is a is_associated_with::protein that in humans is encoded by the RSPH4A is_associated_with::gene.

Function
TRadial spoke head protein 4 homolog A appears to be a component the is_associated_with::radial spoke head, as determined by homology to similar proteins in the biflagellate alga is_associated_with::Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along is_associated_with::cilia, sperm, and flagella is_associated_with::axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of is_associated_with::microtubules and is_associated_with::dynein.

Clinical significance
Mutations in the RSPH4A gene are associated with is_associated_with::primary ciliary dyskinesia.