Rs6835457

rs6835457 is a SNP in the 3'-UTR flanking region of the IL21 gene.

A study including both European (4,248 patients) and African-Americans (1,569 patients) with lupus focusing on the IL2/IL21 gene region on chromosome 4q27 concluded that 2 tightly linked SNPs were associated with increased risk for the disease, rs907715 and rs6835457, with odds ratios of 1.16 (CI: 1.1-1.22, p=2x10e-8) and 1.11 (CI:1.05-1.17, p=9x10e-5), respectively.