PRPSAP2

Phosphoribosyl pyrophosphate synthetase-associated protein 2 is a protein that in humans is encoded by the PRPSAP2 is_associated_with::gene.

Function
The enzyme phosphoribosyl pyrophosphate synthetase (PRS) catalyzes the formation of is_associated_with::phosphoribosyl pyrophosphate which is a substrate for synthesis of is_associated_with::purine and is_associated_with::pyrimidine nucleotides, is_associated_with::histidine, is_associated_with::tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS.

Model organisms
is_associated_with::Model organisms have been used in the study of PRPSAP2 function. A conditional is_associated_with::knockout mouse line, called Prpsap2tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out and two is_associated_with::phenotypes were reported. is_associated_with::Homozygous is_associated_with::mutant males displayed more rearing in an open field test, and mutants of both sex had decreased is_associated_with::IgG1 levels.