Kir2.1

The Kir2.1 is_associated_with::inward-rectifier potassium ion channel is encoded by the gene.

Clinical significance
A defect in this gene is associated with is_associated_with::Andersen-Tawil syndrome.

A mutation in the KCNJ2 gene has also been shown to cause is_associated_with::short QT syndrome.

In research
A trafficking sequence from Kir2.1 has been added to is_associated_with::halorhodopsin to improve its membrane localization. The resulting protein eNpHR3.0 is used in optogenetic research to inhibit neurons with light.

Interactions
Kir2.1 has been shown to interact with:
 * is_associated_with::DLG4,
 * is_associated_with::Interleukin 16, and
 * is_associated_with::TRAK2