EIF2C1

Protein argonaute-1 is a is_associated_with::protein that in humans is encoded by the EIF2C1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of EIF2C1 function. A conditional is_associated_with::knockout mouse line, called Eif2c1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed: homozygous mutants were subviable and females also had decreased circulating is_associated_with::aspartate transaminase levels.