Rs1111875

rs1111875 is a SNP of the HHEX homeobox gene. In several studies, it has been associated with risk for type-2 diabetes (T2D).

In a study of 500 unrelated Caucasian T2D patients, the rs1111875(G) allele was overrepresented; the odds ratio was 1.68 (CI: 1.19-2.35, p=0.003). In this population, the population attributable risk for this allele was estimated to be 36%.

In a study of ~400 Japanese, rs1111875(G) was also associated with type-2 diabetes (odds ratio 1.42, CI: 1.13-1.78, p=0.0024). Heterozygous and homozygous carriers of the risk allele had odds ratios of 1.31 (CI: 0.97-1.77, p=0.0810) and 2.40 (CI: 1.34-4.32, p=0.0028) relative to non-carriers.

And in a third study, 1,630 Japanese patients were also found to have this SNP significantly overrepresented (p=0.0064).

rs1111875 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.27 (CI: 1.14-1.40, p = 1.4 x 10e-5)

1,638 type 2 diabetes patients and 1,858 controls
 * rs1111875 non-significant

rs7923837 and rs1111875 were significantly associated with decreased insulin secretion and lower insulinogenic index. Reduced insulin clearance was also observed in heterozygous carriers of rs1111875


 * is_associated_with_disease::Alzheimer's disease
 * is_associated_with_disease::Polycystic ovary syndrome
 * is_associated_with_disease::Gestational diabetes
 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Type 2 diabetes mellitus
 * is_associated_with_disease::Breast cancer