Rs324650

In 2009, a large, multi-sample replication study failed to find any significant association with Intelligence for this or other SNPs in CHRM2.

Earlier work had observed that this snp (and perhaps its neighbors) influenced intelligence and alcohol dependence

CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. And the earlier

and or this pdf poster show association between the CHRM2 gene and intelligence. In this study of ~300 Caucasians, the (T;T) genotype appeared to typically have a 4 point higher IQ than the (A;T) genotype, which had a 4 point higher IQ (on average) than the (A;A) genotype. A nearby SNP, rs324640, showed similar results to rs324650, and was in linkage disequilibrium (r2 = 0.90) with it. .


 * is_associated_with_disease::Drug dependence