ARHGEF4

Rho guanine nucleotide exchange factor 4 is a is_associated_with::protein that in humans is encoded by the ARHGEF4 is_associated_with::gene.

Function
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through is_associated_with::G protein-coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat is_associated_with::collybistin protein. Alternative splicing of this gene generates two transcript variants that encode different isoforms. Also, there is possibility for the usage of multiple polyadenylation sites for this gene.

Model organisms
is_associated_with::Model organisms have been used in the study of ARHGEF4 function. A conditional is_associated_with::knockout mouse line, called Arhgef4tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::homozygous is_associated_with::mutant mice and one significant abnormality was observed: males has atypical is_associated_with::peripheral blood lymphocyte parameters, including a decreased is_associated_with::B cell number and an increased is_associated_with::granulocyte number.

Interactions
ARHGEF4 has been shown to interact with APC.