CSRP2BP

CSRP2 binding protein is a is_associated_with::protein that in humans is encoded by the CSRP2BP is_associated_with::gene.

CSRP2 is a protein containing two LIM domains, which are double is_associated_with::zinc finger motifs found in proteins of diverse function. CSRP2 and some related proteins are thought to act as protein adapters, bridging two or more proteins to form a larger is_associated_with::protein complex. The protein encoded by this gene binds to one of the LIM domains of CSRP2 and contains an is_associated_with::acetyltransferase domain. Although the encoded protein has been detected in the is_associated_with::cytoplasm, it is predominantly a nuclear protein. Alternatively spliced transcript variants have been described.

Model organisms
is_associated_with::Model organisms have been used in the study of CSRP2BP function. A conditional is_associated_with::knockout mouse line, called Csrp2bptm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion.

Twenty seven tests were carried out on is_associated_with::mutant mice and eight significant abnormalities were observed. Fewer than expected is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation. Fewer also survived until is_associated_with::weaning. Male homozygous mutant's eyelids fail to open, they had abnormal eye size, a decreased susceptibility to is_associated_with::bacterial infection and a decreased body length. Female homozygous mutants had a decreased lean body mass. Animals of both sex also had corneal opacity and spinal abnormalities (including is_associated_with::scoliosis and fusion of vertebral arches).