Rs1799724

rs1799724, a SNP near the tumor necrosis factor TNF gene, was found in a study of ~500 Caucasians to be both an independent risk factor for the development of Alzheimer's disease and also a modifier of the risk for individuals carrying ApoE4 alleles.

On its own, the rs1799724(T) allele led to an odds ratio of 1.63 (CI: 1.13-2.34, p=0.009). In carriers of ApoE4 alleles, the odds ratio changed from 2.92 (CI: 2.00-4.27) in the absence of rs1799724(T) to an OR of 6.65 (CI: 3.26-13.55, p=0.03) in its presence.

In a Chinese study, post-menopausal women were significantly more likely to have low bone mineral density if they had
 * CC-AA genotypes in rs1799724-rs1800629
 * a haplotype of rs1799724-rs1800629-rs6254-rs6256-IL-1ra-rs2227956-rs1801197

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