UGT1A6

UDP-glucuronosyltransferase 1-6 is an is_associated_with::enzyme that in humans is encoded by the UGT1A6 is_associated_with::gene.

Function
UDP-glucuronosyltransferase 1-6 is a is_associated_with::UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, is_associated_with::bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants.

UDP-glucuronosyltransferase is also responsible for the inactivation of popular is_associated_with::analgesic drugs, such as is_associated_with::aspirin and acetaminophen, by glucuronidation. The loss of a functional UGT1A6 gene in certain is_associated_with::hypercarnivores, and particularly cats, renders the animals extremely sensitive to the adverse effects of these analgesics.