Lamin B receptor

Lamin-B receptor is a is_associated_with::protein that in humans is encoded by the LBR is_associated_with::gene.

Function
The protein encoded by this gene belongs to the ERG4/ERG24 family. It localizes to the inner membrane of the is_associated_with::nuclear envelope and anchors the lamina and the is_associated_with::heterochromatin to the membrane. It may mediate interaction between chromatin and is_associated_with::lamin B. Mutations of this gene has been associated with autosomal recessive HEM/Greenberg skeletal dysplasia. Alternative splicing occurs at this locus and two transcript variants encoding the same protein have been identified.

Clinical significance
There is evidence tying it to is_associated_with::Greenberg dysplasia and is_associated_with::Pelger-Huet anomaly.

Interactions
Lamin B receptor has been shown to interact with is_associated_with::CBX3 and CBX5.