Aprataxin

Aprataxin is a is_associated_with::protein that in humans is encoded by the APTX is_associated_with::gene.

This gene encodes a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. The encoded protein may play a role in single-stranded DNA repair. Mutations in this gene have been associated with ataxia-ocular apraxia. Multiple transcript variants encoding distinct isoforms have been identified for this gene, however, the full length nature of some variants has not been determined.

Function
Aprataxin removes AMP from DNA ends following abortive ligation attempts by DNA Ligase IV during is_associated_with::non-homologous end joining, thereby permitting subsequent attempts at ligation.

Interactions
Aprataxin has been shown to interact with:
 * is_associated_with::PARP1,
 * is_associated_with::P53,
 * is_associated_with::XRCC1, and
 * is_associated_with::XRCC4.