PARP2

Poly [ADP-ribose] polymerase 2 is an is_associated_with::enzyme that in humans is encoded by the PARP2 is_associated_with::gene.

Function
This gene encodes poly(ADP-ribosyl)transferase-like 2 is_associated_with::protein, which contains a is_associated_with::catalytic domain and is capable of catalyzing a poly(ADP-ribosyl)ation reaction. This protein has a catalytic domain which is homologous to that of poly (ADP-ribosyl) is_associated_with::transferase, but lacks an N-terminal DNA binding domain which activates the C-terminal catalytic domain of poly (ADP-ribosyl) transferase. The basic residues within the N-terminal region of this protein may bear potential DNA-binding properties, and may be involved in the nuclear and/or is_associated_with::nucleolar targeting of the protein. Two alternatively spliced transcript variants encoding distinct isoforms have been found.

Interactions
PARP2 has been shown to interact with is_associated_with::XRCC1.