Homeobox protein Nkx-2.5

Homeobox protein Nkx-2.5 is a is_associated_with::protein that in humans is encoded by the NKX2-5 is_associated_with::gene.

Interactions
NKX2-5 has been shown to interact with is_associated_with::GATA4  and TBX5. NKX 2.5 is a transcription factor that regulates heart development in humans. NKX2.5 works along with MEF2, HAND1, and HAND2 transcription factors to direct heart looping during early heart development. NKX2.5 in vertebrates is equivalent to the ‘tinman’ gene in Drosophila and directly activates the MEF2 gene to control cardiomyocyte differentiation. NKX2.5 operates in a positive feedback loop with GATA transcription factors to regulate cardiomyocyte formation. NKX2.5 influences HAND1 and HAND2 transcription factors that control the essential asymmetrical development of the heart’s ventricles. Gene mutations of NKX2.5 lead to heart looping defects, conduction defects, and atrial septal defects in the developing heart. Scientists developed a gene knockout model of NKX2.5 in mice and found that the number of myocytes that develop into conduction cells depends on the amount of NKX2.5 influence. Therefore, lack of NKX2.5 leads to reduced function of the atrioventricular (AV) node. Since the AV node electrically connects the atrial and ventricular chambers of the heart to control conductance, defects of the AV node would lead to congenital heart disease.