Yangonin

Yangonin is one of the six major kavalactones found in the kava plant. It has been shown to possess significant binding affinity for the cannabinoid receptor CB1.

Yangonin displays marked in vitro toxicity on human hepatocytes with approximately 40% reduction in viability based on an ethidium bromide assay. The predominant mode of cell death turned out to be apoptosis rather than necrosis. No significant changes were observed in glutathione levels.