TRIM24

Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1α (TIF1α) is a is_associated_with::protein that, in humans, is encoded by the TRIM24 is_associated_with::gene.

Function
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions
TRIM24 has been shown to interact with is_associated_with::Mineralocorticoid receptor, is_associated_with::TRIM33, is_associated_with::Estrogen receptor alpha and is_associated_with::Retinoid X receptor alpha.