Rs1734792

rs1734792 is one of several SNPs in the methyl CpG binding protein 2 (MECP2) that have been associated with risk for systemic lupus erythromatosis (SLE). The MECP2 gene is located on the X chromosome, which may be instructive since lupus is a predominantly female disease.

An initial survey of 600 Korean patients, followed by 1,000 Caucasian patients, ultimately led to a meta-analysis indicating an odds ratio for the rs1734792(A) risk allele of 1.42 (CI: 1.24-1.58, p = 3.3E-08).

Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus.


 * is_associated_with_disease::Rheumatoid arthritis
 * is_associated_with_disease::Systemic lupus erythematosus