Serine racemase

Serine racemase is an is_associated_with::enzyme which generates D-is_associated_with::serine from L-serine. D-serine acts as a neuronal signaling molecule by activating is_associated_with::NMDA receptors in the brain. In humans, the serine racemase is_associated_with::protein is encoded by the SRR is_associated_with::gene.

Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D-serine and also the elimination of water from L-serine, generating pyruvate and ammonia. The enzyme is physiologically stimulated by divalent cations (e.g., magnesium) and is allosterically activated by the magnesium/ATP complex.