LPHN3

Latrophilin-3 is a is_associated_with::protein that in humans is encoded by the LPHN3 is_associated_with::gene.

Function
This gene encodes a member of the is_associated_with::latrophilin subfamily of is_associated_with::G protein-coupled receptors (GPCR). Latrophilins may function in both is_associated_with::cell adhesion and is_associated_with::signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane.

Clinical significance
A version of this gene has been linked to is_associated_with::Attention Deficit/Hyperactivity Disorder (ADHD).