CD16

CD16 is a low affinity Fc receptor.

It is a cluster of differentiation found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. It can be used to isolate populations of these cells by antibodies directed towards CD16, utilising FACS (fluorescent-activated cell sorting) or MACS (magnetic-activated cell sorting).

Function
CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies.