DDB1

DNA damage-binding protein 1 is a is_associated_with::protein that in humans is encoded by the DDB1 is_associated_with::gene.

Function
This gene encodes the large subunit of is_associated_with::DNA damage-binding protein that is a is_associated_with::heterodimer composed of a large and a small (is_associated_with::DDB2) subunit. As its name suggests, DDB1 was initially implicated in the process of a specific type of DNA repair known as is_associated_with::nucleotide excision repair. Since then, researchers have found that DDB1 primarily functions as a core component of the is_associated_with::CUL4A- and is_associated_with::CUL4B-based E3 is_associated_with::ubiquitin ligase complexes. DDB1 serves as a bridge or adaptor protein which interacts with dozens of proteins known as DDB1 and CUL4-associated factors (DCAFs). These DCAFs are often ubiquitin ligase substrates and regulate numerous essential processes in the cell including DNA repair (DDB2), DNA replication, chromatin remodeling (Cdt2) and more.

Interactions
DDB1 has been shown to interact with is_associated_with::Transcription initiation protein SPT3 homolog, is_associated_with::GCN5L2, is_associated_with::DDB2, is_associated_with::CUL4A, is_associated_with::CUL4B and is_associated_with::P21.