DDX20

Probable ATP-dependent RNA helicase DDX20, also known as Gemin3 is an is_associated_with::enzyme that in humans is encoded by the DDX20 is_associated_with::gene.

Function
is_associated_with::DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative is_associated_with::RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and is_associated_with::ribosome and is_associated_with::spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in is_associated_with::embryogenesis, is_associated_with::spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an is_associated_with::ATPase activity and is a component of the is_associated_with::survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.

Interactions
DDX20 has been shown to interact with:


 * is_associated_with::EIF2C2,
 * is_associated_with::GEMIN4,
 * is_associated_with::GEMIN5,
 * is_associated_with::LSM2,
 * is_associated_with::SMN1,
 * is_associated_with::SNRPB,
 * is_associated_with::SNRPD3 and
 * is_associated_with::SNRPG,
 * SNRPD1,
 * SNRPD2,
 * SNRPE,
 * SNRPF, and
 * SIP1.