Cofilin 1

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human is_associated_with::gene, part of the ADF/cofilin family.

Cofilin is a widely distributed intracellular is_associated_with::actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from is_associated_with::cytoplasm to nucleus.

One group reports that is_associated_with::reelin signaling leads to serine3-is_associated_with::phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.

Interactions
Cofilin 1 has been shown to interact with is_associated_with::HSPH1 and is_associated_with::LIMK1.