Rs397514693

rs397514693, also known as His46Arg or H46R, is a SNP in the casein kinase 1, delta CSNK1D gene.

Heterozygotes for rs397514693 have been reported to have a sleep disorder, Familial Advanced Sleep Phase syndrome 2 (FASPS2), and it is therefore considered to be inherited as an autosomal dominant trait. The condition is marked by a ~4 hour shift towards earlier bedtime and rising time compared to most people.

There is also a report that finds a complex connection to migraine in association with this SNP, requiring further study.