CBLB (gene)

CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB is_associated_with::gene. CBLB is a member of the CBL gene family.

Function
CBL-B functions as a negative regulator of is_associated_with::T-cell activation.

Clinical significance
Mutation of the CBLB gene has been associated with autoimmune conditions such as type 1 diabetes.

Interactions
CBLB has been shown to interact with:
 * is_associated_with::CRKL,
 * is_associated_with::Epidermal growth factor receptor,
 * is_associated_with::Grb2,
 * is_associated_with::NEDD4,
 * is_associated_with::PIK3R1, and
 * is_associated_with::SH3KBP1.