CBX1

Chromobox protein homolog 1 is a is_associated_with::protein that in humans is encoded by the CBX1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of CBX1 function. A conditional is_associated_with::knockout mouse line, called Cbx1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out and two is_associated_with::phenotypes were reported. No is_associated_with::homozygous is_associated_with::mutant animals survived until two weeks of age, therefore the remaining tests were carried out on is_associated_with::heterozygous mutant mice. Male heterozygotes showed increased is_associated_with::VO2, rate of elimination of is_associated_with::carbon dioxide, and energy expenditure as determined by is_associated_with::indirect calorimetry.

Interactions
CBX1 has been shown to interact with is_associated_with::C11orf30, CBX5, is_associated_with::CBX3 and is_associated_with::SUV39H1.