Sudden cardiac death

Sudden cardiac death is natural death from cardiac causes, heralded by abrupt loss of consciousness within one hour of the onset of acute symptoms. Other forms of sudden death may be noncardiac in origin. Examples of this include respiratory arrest (such as due to airway obstruction, which may be seen in cases of choking or asphyxiation), toxicity or poisoning, anaphylaxis, or trauma.

It is important to make a distinction between this term and the related term cardiac arrest, which refers to cessation of cardiac pump function which may be reversible. The phrase sudden cardiac death is a public health concept incorporating the features of natural, rapid, and unexpected. It does not specifically refer to the mechanism or cause of death.

Causes
The most common cause of sudden cardiac death in adults over the age of 30 is coronary artery atheroma. The most common finding at postmortem examination is chronic high-grade stenosis of at least one segment of a major coronary artery, the arteries which supply the heart muscle with its blood supply. A significant number of cases also have an identifiable thrombus (clot) in a major coronary artery which causes transmural occlusion of that vessel. Death in these cases is thought to result from a period of transient or prolonged ischaemia (lack of blood supply) in the myocardium (muscle of the heart wall) which induces an arrhythmia (a conduction disturbance), usually a ventricular arrhythmia, which terminates into ventricular fibrillation. As a consequence there may be no changes in the myocardium. The absence of the histological signs of acute necrosis and a healed infarct are a common finding. Chronic high-grade stenosis may have caused previous episodes of ischaemia and areas of focal fibrosis may be seen histologically in the myocardium. Ventricular arrhythmias may arise from a myocardium which has been previously scarred by episodes of ischaemia.

Left ventricular hypertrophy is the second leading cause of sudden cardiac death in the adult population. This is most commonly the result of longstanding raised high blood pressure which has caused secondary damage to the wall of the main pumping chamber of the heart, the left ventricle. Once again, hypertrophy is associated with cardiac arrhythmias.

The mechanism of death in a the majority of patients dying of sudden cardiac death is ventricular fibrillation and as a consequence there may be no prodromal symptoms associated with the death. These patients may be going about their daily business and suddenly collapse without the typical features of myocardial infarction such as chest pain and shortness of breath. There are a number of cases in which patients feel the effect of myocardial ischaemia. Myocardial ischaemia is associated with referred pain, classically to the front of the chest, the left arm and the jaw. Patients may feel generally unwell, with nausea, dizziness and vomiting. These symptoms may precede the death for any length of time between a few minutes and several hours.

Cardiac rapid response units and the use of portable defibrillators have contributed to the survival of many people who have collapsed with ventricular fibrillation. However, in cases of sudden cardiac death, the heart appears to be resistant to attempts of resuscitation. Early defibrillation in these cases rarely results in survival. The mechanism underlying this resistance is currently being investigated.

Much attention in the press has been focused on young athletes who die suddenly whilst training as a consequence of sudden cardiac death. Though these cases are rare compared to the hundreds who die each year of coronary artery atheroma and left ventricular hypertrophy, they attract much more attention due to the sensational nature of young, otherwise healthy persons suddenly and unexpectedly dying. A great deal of time and money is being spent on researching these cases and implementing schemes to screen young athletes to prevent their occurrence.

Although the most frequent cause of sudden cardiac death is coronary artery disease, other causes include:


 * Non-atherosclerotic coronary artery abnormalities
 * Hypertrophy of ventricular myocardium
 * Myocardial diseases and heart failure, including
 * Arrhythmogenic right ventricular cardiomyopathy
 * Hypertrophic cardiomyopathy
 * Dilated cardiomyopathy
 * Myocardial infarction
 * Noncompaction cardiomyopathy
 * Inflammatory, infiltrative, neoplastic, and degenerative processes
 * Diseases of the cardiac valves
 * Congenital heart disease
 * Primary electrophysiological abnormalities, such as
 * Long QT syndrome, both congenital and acquired
 * Sick sinus syndrome
 * Brugada syndrome
 * Catecholaminergic polymorphic ventricular tachycardia
 * Magnesium deficiency
 * Rhythm instability related to neurohumoral and central nervous system influences
 * Cystic tumour of the atrioventricular nodal region
 * Commotio cordis
 * Mechanical interference with venous return
 * Aortic dissection
 * Toxic/metabolic disturbances