Centaurin, alpha 1

Arf-GAP with dual PH domain-containing protein 1 is a is_associated_with::protein that in humans is encoded by the ADAP1 is_associated_with::gene.

Interactions
Centaurin, alpha 1 has been shown to interact with:


 * is_associated_with::Casein kinase 1, alpha 1
 * is_associated_with::Nucleolin,
 * is_associated_with::P110α,
 * is_associated_with::PRKCI,
 * is_associated_with::Protein kinase D1, and
 * is_associated_with::Protein kinase Mζ.

Model organisms
is_associated_with::Model organisms have been used in the study of ADAP1 function. A conditional is_associated_with::knockout mouse line called Adap1tm1a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping