GAD2

Glutamate decarboxylase 2 is an is_associated_with::enzyme that in humans is encoded by the GAD2 is_associated_with::gene.

This gene encodes one of several forms of is_associated_with::glutamic acid decarboxylase, identified as a major is_associated_with::autoantigen in insulin-dependent is_associated_with::diabetes. The enzyme encoded is responsible for catalyzing the production of is_associated_with::gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this is_associated_with::enzyme has been identified in the human pancreas since it has been identified as an autoantibody and an autoreactive is_associated_with::T cell target in insulin-dependent diabetes. This gene may also play a role in the is_associated_with::stiff man syndrome.

Interactions
GAD2 has been shown to interact with is_associated_with::GAD1.