Rs987525

A genome-wide association study involving 224 cases and 383 controls of Central European origin found that significant association between rs987525 and risk for nonsyndromic cleft lip with or without cleft palate (NSCL/P). The odds ratio for rs987525(A;G) individuals was 2.57 (CI: 2.02-3.26), and for rs987525(A;A), 6.05 (CI: 3.88-9.43). The calculated population attributable fraction for this marker is 0.41, suggesting that this study has identified a major genetic cause for NSCL/P.

23andMe blog article

Associated with European Facial Appearance
 * rs7590268
 * rs16903544
 * rs987525
 * rs9574565
 * rs227731
 * rs642961
 * rs1258763

Family-based study shows heterogeneity of a susceptibility locus on chromosome 8q24 for nonsyndromic cleft lip and palate.

Association between genetic variants of reported candidate genes or regions and risk of cleft lip with or without cleft palate in the polish population.

Genetic determination of human facial morphology: links between cleft-lips and normal variation.

Defining predictors of cleft lip and palate risk.

Cleft Lip and Cleft Palate