Cholecystokinin A receptor

The Cholecystokinin A receptor is a human is_associated_with::protein, also known as CCKAR or CCK1, with CCK1 now being the is_associated_with::IUPHAR-recommended name.

The extracellular, is_associated_with::N-terminal, domain of this protein adopts a tertiary structure consisting of a few is_associated_with::helical turns and a disulfide-cross linked loop. It is required for interaction of the cholecystokinin A receptor with its corresponding hormonal ligand.

Agonists

 * is_associated_with::Cholecystokinin
 * is_associated_with::Gastrin
 * is_associated_with::CCK-4
 * SR-146,131
 * A-71623 - modified tetrapeptide, potent and selective CCKA agonist, IC50 3.7nM, 1200x selectivity over CCKB, CAS# 130408-77-4

Antagonists

 * is_associated_with::Proglumide
 * is_associated_with::Lorglumide
 * is_associated_with::Devazepide
 * is_associated_with::Dexloxiglumide
 * is_associated_with::Asperlicin
 * SR-27897
 * IQM-95333
 * JNJ-17156516