TNFAIP3

Tumor necrosis factor, alpha-induced protein 3 is a is_associated_with::protein that in humans is encoded by the TNFAIP3 is_associated_with::gene.

Interactions
TNFAIP3 has been shown to interact with is_associated_with::TNIP1, is_associated_with::TRAF1, is_associated_with::TRAF2, is_associated_with::IKBKG, is_associated_with::TAX1BP1, is_associated_with::YWHAB, is_associated_with::YWHAZ, is_associated_with::TRAF6 and is_associated_with::YWHAH.

Association with rheumatoid arthritis
The TNFAIP3 locus is implicated as a positively associated factor in is_associated_with::rheumatoid arthritis (RA). The rs5029937 (T) and the rs6920220 (A) SNPs increase risk of RA by 20 to 40% respectively. A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.