PITX3

Pituitary homeobox 3 is a is_associated_with::protein that in humans is encoded by the PITX3 is_associated_with::gene.

Function
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of is_associated_with::homeodomain proteins. Members of this family act as is_associated_with::transcription factors. This protein is involved in lens formation during eye development.

Clinical significance
Mutations of this gene have been associated with is_associated_with::anterior segment mesenchymal dysgenesis (ASMD) and is_associated_with::congenital cataracts.