Fructosamine-3-kinase

Fructosamine-3-kinase is an is_associated_with::enzyme that in humans is encoded by the FN3K is_associated_with::gene.

Function
FN3K catalyzes is_associated_with::phosphorylation of is_associated_with::fructosamines formed by is_associated_with::glycation, the nonenzymatic reaction of glucose with primary amines followed by is_associated_with::Amadori rearrangement. Phosphorylation of fructosamines may initiate metabolism of the modified amine and result in deglycation of glycated proteins.

FN3K is responsible for the formation of fructose 3-phosphate (F3P), a compound identified in the lenses of diabetic rats. The spontaneous decomposition of F3P leads to the formation of is_associated_with::3-deoxyglucosone (3DG). 3DG contributes to diabetic complications. Treatment of normal and diabetic rats with an inhibitor of FN3K demonstrated a large reduction (~50%) in systemic 3DG in both groups. Removal of 3DG at its source by inhibition of FN3K is a viable option to treat diabetes related diseases since it would require a much smaller dose of drug.