Gamma-glutamyl hydrolase

Gamma-glutamyl hydrolase is an is_associated_with::enzyme   that catalyses the following is_associated_with::chemical reaction:


 * is_associated_with::Hydrolysis of a gamma-glutamyl bond

This is_associated_with::lysosomal or secreted, is_associated_with::thiol-dependent is_associated_with::peptidase, most active at is_associated_with::acidic is_associated_with::pH.

In humans, gamma-glutamyl hydrolase is encoded by the GGH is_associated_with::gene. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate.

Nomenclature
Gamma-glutamyl hydrolase is also known as conjugase, folate conjugase, lysosomal gamma-glutamyl carboxypeptidase, gamma-Glu-X carboxypeptidase, pteroyl-poly-gamma-glutamate hydrolase, carboxypeptidase G, folic acid conjugase, poly(gamma-glutamic acid) endohydrolase, polyglutamate hydrolase, poly(glutamic acid) hydrolase II, pteroylpoly-gamma-glutamyl hydrolase.