PTPRZ1

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an is_associated_with::enzyme that in humans is encoded by the PTPRZ1 is_associated_with::gene.

Function
This gene is a member of the is_associated_with::receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a is_associated_with::fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.

Clinical significance
Expression of this gene is induced in gastric cancer cells, in the remyelinating is_associated_with::oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in is_associated_with::glioblastoma cells, promoting their haptotactic migration.