Rs8175347

The rs8175347 SNP consists of variation of a short (TA)(n) repeat sequence covering the TATA box of the UGT1A1 UDP-glucuronosyltransferase1A1 gene. This SNP is associated with hyperbilirubinaemia (Gilbert's syndrome) and adverse drug reactions, and is used for dosage advice for irinotecan. The low-activity (risk) alleles are rs8175347(TA)7 and (TA)8.

UGT1A1 genetic polymorphisms, endogenous estrogen exposure, soy food intake, and endometrial cancer risk.

Genome-wide association meta-analysis for total serum bilirubin levels.

Serum bilirubin levels on ICU admission are associated with ARDS development and mortality in sepsis.

Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

UGT1A1, SLCO1B1, and SLCO1B3 polymorphisms versus neonatal hyperbilirubinemia: is there an association?