FGR (gene)

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog, also known as FGR, is a is_associated_with::protein which in humans is encoded by the FGR is_associated_with::gene.

Function
This gene is a member of the Src family of protein is_associated_with::tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for is_associated_with::myristoylation and is_associated_with::palmitoylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 is_associated_with::integrin signal transduction pathway. Infection with is_associated_with::Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Discovery
The feline version of this gene was discovered by Suraiya Rasheed, Murray Gardner, and co-workers.

Interactions
FGR (gene) has been shown to interact with is_associated_with::Wiskott-Aldrich syndrome protein.