WBP2

WW domain-binding protein 2 is a is_associated_with::protein that in humans is encoded by the WBP2 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of WBP2 function. A conditional is_associated_with::knockout mouse line, called Wbp2tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. is_associated_with::Homozygous mutant animals displayed an abnormal brainstem is_associated_with::auditory evoked potential, while females also had decreased circulating is_associated_with::amylase levels.