MAD1L1

Mitotic spindle assembly checkpoint protein MAD1 is a is_associated_with::protein that in humans is encoded by the MAD1L1 is_associated_with::gene.

MAD1L1 is also known as Human Accelerated Region 3. It may therefore have played a key role in differentiating Humans from Apes.

Function
MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of is_associated_with::anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with is_associated_with::MAD2L1. MAD1L1 may play a role in is_associated_with::cell cycle control and tumor suppression. Three transcript variants encoding the same protein have been found for this gene.

Interactions
MAD1L1 has been shown to interact with:
 * is_associated_with::HDAC1,
 * is_associated_with::Histone deacetylase 2, and
 * is_associated_with::MAD2L1,