DLX3

is_associated_with::Homeobox protein DLX-3 is a is_associated_with::protein that in humans is encoded by the DLX3 is_associated_with::gene.

Function
Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Specifically, colocalization of is_associated_with::phosphorylated Smad1 / 5 / 8 complex and Dlx3 regulate role for BMP signaling to Dlx3 during hair is_associated_with::morphogenesis in animal models.

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a is_associated_with::homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, is_associated_with::DLX1-is_associated_with::DLX6. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of is_associated_with::chromosome 17.

Clinical significance
Mutations in this gene have been associated with the autosomal dominant conditions is_associated_with::trichodentoosseous syndrome (TDO) and is_associated_with::amelogenesis imperfecta with is_associated_with::taurodontism.