AH receptor-interacting protein

AH receptor-interacting protein (AIP) also known as aryl-hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, or HBV X-associated protein 2 (XAP-2) is a is_associated_with::protein that in humans is encoded by the AIP is_associated_with::gene.

Function
AIP may play a positive role in is_associated_with::aryl hydrocarbon receptor-mediated signalling possibly by influencing its receptivity for ligand and/or its nuclear targeting. AIP is the cellular negative regulator of the is_associated_with::hepatitis B virus (HBV) X protein.

Role in Disease
AIP mutations may be the cause of a familial form of is_associated_with::acromegaly, familial isolated pituitary adenoma (FIPA). Somatotropinomas (i.e. GH-producing pituitary adenomas), sometimes associated with prolactinomas, are present in most AIP mutated patients.

Interactions
AIP has been shown to interact with the is_associated_with::aryl hydrocarbon receptor, is_associated_with::peroxisome proliferator-activated receptor alpha and the is_associated_with::aryl hydrocarbon receptor nuclear translocator.