ARID1A

AT-rich interactive domain-containing protein 1A is a is_associated_with::protein that in humans is encoded by the ARID1A is_associated_with::gene.

Function
ARID1A is a member of the is_associated_with::SWI/SNF family, whose members have helicase and is_associated_with::ATPase activities and are thought to regulate transcription of certain genes by altering the is_associated_with::chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. It possesses at least two conserved domains that could be important for its function. First, it has an is_associated_with::ARID domain, which is a is_associated_with::DNA-binding domain that can specifically bind an AT-rich DNA sequence known to be recognized by a SNF/SWI complex at the beta-globin locus. Second, the is_associated_with::C-terminus of the protein can stimulate is_associated_with::glucocorticoid receptor-dependent transcriptional activation. It is thought that the protein encoded by this gene confers specificity to the SNF/SWI complex and may recruit the complex to its targets through either protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been found for this gene. This gene has been commonly found mutated in gastric cancers, ovarian clear cell carcinoma, and pancreatic cancer.

Interactions
ARID1A has been shown to interact with is_associated_with::SMARCB1 and is_associated_with::SMARCA4.