SLC38A10

Sodium-coupled neutral amino acid transporter 10 also known as solute carrier family 38, member 10 is a is_associated_with::protein that in humans is encoded by the SLC38A10 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SLC38A10 function. A conditional is_associated_with::knockout mouse line, called Slc38a10tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and four significant abnormalities were observed. is_associated_with::Homozygous animals of both sex had decreased body weights, and is_associated_with::DEXA analysis showed that this correlated with decreased is_associated_with::bone mineral content and decreased body length. is_associated_with::Indirect calorimetry analysis showed that males displayed increased oxygen consumption and energy expenditure, while is_associated_with::clinical chemistry tests found that females had decreased circulating is_associated_with::amylase levels and males had is_associated_with::hypoalbuminemia and increased circulating is_associated_with::creatinine levels.