Nucleoporin 214

Nucleoporin 214 (Nup2014) is a is_associated_with::protein that in humans is encoded by the NUP214 is_associated_with::gene.

The is_associated_with::nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of is_associated_with::macromolecules between the nucleus and the is_associated_with::cytoplasm. is_associated_with::Nucleoporins are the main components of the nuclear pore complex in is_associated_with::eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper is_associated_with::cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with is_associated_with::acute myeloid leukemia and is_associated_with::myelodysplastic syndrome.

Interactions
NUP214 has been shown to interact with is_associated_with::NXF2, is_associated_with::ZFP36 and is_associated_with::NXF1.