Emerin

Emerin, together with MAN1, is a LEM domain-containing integral is_associated_with::protein of the inner nuclear membrane in vertebrates. The function of MAN1 is not extensively known, but emerin is known to interact with is_associated_with::nuclear lamins, is_associated_with::barrier-to-autointegration factor (BAF), nesprin-1α, and a transcription repressor.

Function
Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.

Clinical significance
Mutations in emerin cause X-linked recessive is_associated_with::Emery-Dreifuss muscular dystrophy.

Moreover, recent research have found that the absence of functional emerin may decrease the infectivity of is_associated_with::HIV-1. Thus, it is speculated that patients suffering from Emery-Dreifuss muscular dystrophy may have immunity to or show an irregular infection pattern to HIV-1.

Interactions
Emerin has been shown to interact with:
 * is_associated_with::ACTG2,
 * is_associated_with::LMNA,
 * is_associated_with::PSME1, and
 * is_associated_with::YTHDC1.