ARID4B

AT-rich interactive domain-containing protein 4B is a is_associated_with::protein that in humans is encoded by the ARID4B is_associated_with::gene.

Function
This gene encodes a protein with sequence similarity to is_associated_with::retinoblastoma-binding protein-1. The encoded protein is a subunit of the is_associated_with::histone deacetylase-dependent is_associated_with::SIN3A transcriptional is_associated_with::corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, is_associated_with::apoptosis, is_associated_with::oncogenesis, and is_associated_with::cell fate determination. The gene product is recognized by is_associated_with::IgG is_associated_with::antibody isolated from a is_associated_with::breast cancer patient and appears to be a is_associated_with::molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different is_associated_with::isoforms have been characterized.