Rs7977109

After scanning a region of chromosome 12 previously linked to restless legs syndrome in ~900 patients, German investigators found SNPs within the NOS1 gene to be most associated with the syndrome. SNP rs7977109 yielded an odds ratio of 0.76 (CI: 0.64 -0.90, p=-.002). The risk allele is said to be defined in Supplementary materials available online, but they aren't. Furthermore, the significant association seen for this SNP and one other (rs693534) are in opposite directions in the explorative versus the replication populations.


 * is_associated_with_disease::Restless legs syndrome