Rs20417

rs20417, also known as -765G>C, is a SNP in the Prostaglandin endoperoxidase synthase 2 PTGS2 gene.

In a group of Pima Indians, individuals with the variant PTGS2 rs20417 CC genotype had a 30% higher Type 2 diabetes prevalence compared with subjects with the GG genotype

rs20417 was not found to be associated with prostate cancer in a large case-control study (n(cases)=1608, n(controls)=3058), nor in a meta-analysis of 3 other studies.

Data-mining analysis suggests an epigenetic pathogenesis for type 2 diabetes.

Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma.

Polymorphisms of prostaglandin-endoperoxide synthase 2 gene, and prostaglandin-E receptor 2 gene, C-reactive protein concentrations and risk of atherothrombosis: a nested case-control approach.

Cyclooxygenase-2 polymorphisms in Parkinson's disease.

Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk.

A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.

Association of prostaglandin-endoperoxide synthase 2 (PTGS2) polymorphisms and Alzheimer's disease in Chinese.

Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

Segment-specific genetic effects on carotid intima-media thickness: the Northern Manhattan study.

COX-2 promoter polymorphisms and the association with prostate cancer risk in South African men.

Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions.

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.

Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

The influence of COX-2 single nucleotide polymorphisms on abdominal aortic aneurysm development and the associated inflammation.

Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study.

Genetic variants in inflammation pathway genes and asthma in glioma susceptibility.

Association of -765G>C polymorphism of the COX-2 gene with recurrent embryo implantation failure in Southern Chilean women.

Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.

Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma.

A polymorphism in the cyclooxygenase 2 gene in type 1 diabetic patients with nephropathy.

Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis.

Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer.

Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population.

Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort.

Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.

Cyclooxygenase-2 -765G>C polymorphism is associated with C-reactive protein levels in resistant smokers but not in chronic obstructive pulmonary disease patients.

Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.