DVL1

Segment polarity protein dishevelled homolog DVL-1 is a is_associated_with::protein that in humans is encoded by the DVL1 is_associated_with::gene.

Function
DVL1, the human homolog of the Drosophila is_associated_with::dishevelled gene (dsh) encodes a cytoplasmic is_associated_with::phosphoprotein that regulates is_associated_with::cell proliferation, acting as a transducer molecule for developmental processes, including segmentation and is_associated_with::neuroblast specification. DVL1 is a candidate gene for processes involved in cell transformations involved in is_associated_with::neuroblastoma. The is_associated_with::Schwartz-Jampel syndrome and is_associated_with::Charcot-Marie-Tooth disease type 2A have been mapped to the same region as DVL1. The phenotypes of these diseases may be consistent with defects which might be expected from aberrant expression of a DVL gene during development. Three transcript variants encoding three different isoforms have been found for this gene.

Interactions
DVL1 has been shown to interact with:
 * is_associated_with::AXIN1,
 * is_associated_with::DVL3,
 * is_associated_with::EPS8, and
 * is_associated_with::Mothers against decapentaplegic homolog 3.