Rs9574

rs9574 is a SNP that can indicate haplotype H1 of the PROCR gene. The protein product of the PROCR gene activates a part of the anticoagulation pathway. While the rs9574(G) allele could indicate haplotypes H2, H3 or H4, the rs9574(C) allele distinctly tags (identifies) the H1 haplotype.

The H1 haplotype (and thus rs9574(C)) has been reported to be associated with a reduced risk of venous thromboembolism (VTE), with an odds ratio of 0.59, CI: 0.41&#226;&#8364;&#8220;0.84. Two other groups have not found this association to be statistically valid in the populations they studied.[PMID 14576048, PMID 15304035]