Aquaporin 1

Aquaporin 1 is a is_associated_with::protein that in humans is encoded by the AQP1 is_associated_with::gene.

AQP1 is a widely expressed water channel, whose physiological function has been most thoroughly characterized in the is_associated_with::kidney. It is found in the basolateral and apical plasma membranes of the proximal tubules, the descending limb of the is_associated_with::loop of Henle, and in the descending portion of the is_associated_with::vasa recta. Additionally, it is found in is_associated_with::red blood cells, vascular is_associated_with::endothelium, the is_associated_with::gastrointestinal tract, is_associated_with::sweat glands, and is_associated_with::lungs.

It is not regulated by is_associated_with::vasopressin (ADH).

Function
is_associated_with::Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and is_associated_with::N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement.