ARMCX5

ARMCX5

ARMCX5 is an armadillo repeat-containing protein that is encoded by the X-linked ARMCX5 gene. It is conserved only in Eutheriaundefined, a specific group of placental mammals, but no further back in evolutionary time. ARMCX5 contains 3 ARM-like repeats, DUF364, and ARM-type_fold.undefined

Splice Variants
ARMCX5 has 6 splice variants.

ORTHOLOGS
ARMCX5 has ten orthologs.

Paralogs
ARMCX5 has 8 paralogs listed by genecards: GRASP2, ARMCX1, BHLHB9, ARMCX2, GPRASP1, ARMCX6, ARMCX10, and ARMCX36 As well as two paralogs listed by [NCBI]: Homosapiens chromosome X, GRCh37.p5 Primary Assembly1 and Homosapiens chromosome X, alternate assembly HuRef, whole genome shotgun sequence.undefined

Function
Proteins containing this ARMCX5 domain interact with numerous other proteins. Through these interactions, they are involved in a wide variety of processes including carcinogenesis, control of cellular ageing and survival, regulation f circadian rhythm and lysosomal sorting of G-protein coupled receptors.undefined

Because DUF364 contains a PLP-dependent transferase-like fold, the genomic context suggests that it may have a role in anaerobic vitamin B12 biosynthesis. undefined

Expression
ARMCX5 is a highly ubiquitously expressed gene that has shown expression in many tissues.