FGF1

Heparin-binding growth factor 1 is a is_associated_with::protein that in humans is encoded by the FGF1 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::fibroblast growth factor (FGF) family. FGF family members possess broad is_associated_with::mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in is_associated_with::organogenesis. Three alternatively spliced variants encoding different isoforms have been described.

In mice with diet-induced diabetes, the equivalent of type 2 diabetes in humans, a single injection of the protein FGF1 is enough to restore blood sugar levels to a healthy range for > 2 days.

Interactions
FGF1 has been shown to interact with:


 * is_associated_with::CSNK2A2,
 * is_associated_with::CSNK2B,
 * CSNK2A1,
 * is_associated_with::FIBP,
 * FGFR1,
 * FGFR2
 * FGFR3,
 * FGFR4,
 * is_associated_with::HSPA9, and
 * is_associated_with::S100A13.