LDHA

Lactate dehydrogenase A, also known as LDHA, is an enzyme which in humans is encoded by the LDHA is_associated_with::gene.

Function
Lactate dehydrogenase A catalyzes the inter-conversion of pyruvate and L-lactate with concomitant inter-conversion of NADH and NAD+. LDHA is found in most somatic tissues, though predominantly in muscle tissue and tumours, and belongs to the is_associated_with::lactate dehydrogenase family. It has long been known that many human cancers have higher LDHA levels compared to normal tissues. It has also been shown that LDHA plays an important role in the development, invasion and metastasis of malignancies. Mutations in LDHA have been linked to exertional is_associated_with::myoglobinuria.

Model organisms
is_associated_with::Model organisms have been used in the study of LDHA function. A conditional is_associated_with::knockout mouse line, called Ldhatm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on is_associated_with::mutant mice and five significant abnormalities were observed. Few is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice. Animals of both sex had abnoraml plasma chemistry, males also had improved is_associated_with::glucose tolerance and increased is_associated_with::red blood cell distribution width.