FTH1

Ferritin heavy chain is a is_associated_with::ferroxidase is_associated_with::enzyme that in humans is encoded by the FTH1 is_associated_with::gene.

Function
This gene encodes the heavy subunit of is_associated_with::ferritin, the major intracellular is_associated_with::iron storage protein in is_associated_with::prokaryotes and is_associated_with::eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in ferritin proteins are associated with several neurodegenerative diseases. This gene has multiple pseudogenes. Several alternatively spliced transcript variants have been observed, but their biological validity has not been determined.

Interactions
FTH1 has been shown to interact with is_associated_with::Ferritin light chain.