RTF1

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a is_associated_with::protein that in humans is encoded by the RTF1 is_associated_with::gene.

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.

Model organisms
is_associated_with::Model organisms have been used in the study of RTF1 function. A conditional is_associated_with::knockout mouse line, called Rtf1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; vertebral fusion was observed in male animals.