Tet methylcytosine dioxygenase 1

Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of is_associated_with::enzymes that in humans is encoded by the TET1 is_associated_with::gene.

TET1 catalyzes the conversion of the modified is_associated_with::DNA base is_associated_with::5-methylcytosine (5-mC) to is_associated_with::5-hydroxymethylcytosine (5-hmC). TET1 produces 5-hmC by is_associated_with::oxidation of 5-mC in an is_associated_with::iron and is_associated_with::alpha-ketoglutarate dependent manner. The conversion of 5-mC to 5-hmC has been proposed as the initial step of active is_associated_with::DNA demethylation in mammals.

TET1 appears to facilitate nuclear is_associated_with::reprogramming of somatic cells to is_associated_with::iPS cells.