KIRREL

Kin of IRRE-like protein 1, also known as NEPH1, is a is_associated_with::protein that in humans is encoded by the KIRREL is_associated_with::gene.

Function
NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (is_associated_with::KIRREL2, MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of is_associated_with::podocin (NPHS2; MIM 604766). NEPH1 is expressed in is_associated_with::filtration slits of kidney is_associated_with::podocytes, cells involved in ensuring size- and charge-selective ultrafiltration of is_associated_with::blood (Sellin et al., 2003).[supplied by OMIM]

Interactions
KIRREL has been shown to interact with is_associated_with::Nephrin and is_associated_with::Tight junction protein 1.