Rs4402960

rs4402960 replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.23 (CI: 1.11-1.36, p = 8.1 x 10e-5)

associated with type-2 diabetes

significantly associated with type-2 diabetes p = 0.00009; in 1,630 Japanese subjects and in 1,064 controls

1,638 type-2 diabetes patients and 1,858 controls
 * rs4402960 borderline (OR 1.10, 95% CI: 0.99-1.22).

Neither rs4402960 or rs1470579 were found to be associated with type-2 diabetes in a study of 3,000 French Caucasians.

This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Note: rs4402960 is fairly tightly linked (r2=0.87) with another IGF2BP2 gene SNP also associated with type-2 diabetes, rs1470579

Called into question by table 1 of