ADARB2

Double-stranded RNA-specific editase B2 is an is_associated_with::enzyme that in humans is encoded by the ADARB2 is_associated_with::gene.

Function
RNA-editing deaminase-2 (RED2, or ADARB2) is a member of the double-stranded RNA (dsRNA) is_associated_with::adenosine deaminase family of RNA-editing enzymes. Adenosine deamination of pre-mRNA results in a change in the amino acid sequence of the gene product, which differs from that predicted by the genomic DNA sequence. Other members of this family include DRADA (is_associated_with::ADAR) and RED1 (is_associated_with::ADARB1).

Unlike ADAR1 and ADAR2, ADAR3 has demonstrated no editing ability in vitro. It has been shown to suppress is_associated_with::5-HT2C RNA editing in vitro through a yet unknown mechanism, and may thus work as a negative regulator.