Substituted phenethylamine



The substituted phenethylamines are chemical compounds with the 2-phenethylamine chemical structure modified at the phenyl ring, sidechain, and/or amino group. Some of them are psychoactive drugs, including stimulants, psychedelics, opioids, and entactogens, which exert their effects primarily through modulation of the monoamine neurotransmitter systems. Other substituted phenethylamines, such as dopamine and epinephrine are neurotransmitters. The substituted phenethylamines encompass the substituted amphetamines, the substituted methylenedioxyphenethylamines as well as a very large group of alkaloids derived from phenethylamines, including but by no means limited to tetrahydroisoquinolines, benzylisoquinolines, protoberberines, aporphines, morphinans, protopines and narcotine. p. 74

Substituted phenethylamines fall into a wide variety of therapeutic classes, including but not limited to psychotropic drugs (including hallucinogens such as dl-2,5-dimethoxy-4-methylamphetamine a.k.a. DOM), central nervous system stimulants (e.g. amphetamine), appetite depressants (e.g. phentermine), antilipemic agents, vasoconstrictors (including nasal decongestants such as levomethamphetamine and pseudoephedrine), bronchodilators, cardiotonic agents, vasodilators, calcium channel blockers, antidepressants (e.g. bupropion, phenelzine, and tranylcypromine), neuroprotective agents and Antiparkinson agents.

Substituted phenethylamines are known to act as adrenergic agents (including adrenergic uptake inhibitors such as methamphetamine, adrenergic beta-agonists like methoxyphenamine and the adrenergic alpha-agonist mephentermine), antilipemic agents (e.g. benfluorex), dopamine agents (including dopamine uptake inhibitors such as bupropion), serotonin agents (including serotonin agonists such as 2,5-dimethoxy-4-bromoamphetamine and the serotonin uptake inhibitor fenfluramine), calcium channel blockers (e.g. prenylamine and verapamil) and monoamine oxidase inhibitors (e.g. selegiline).