PLXNA2

Plexin-A2 is a is_associated_with::protein that in humans is coded by the PLXNA2 is_associated_with::gene.

This gene encodes a member of the is_associated_with::plexin-A family of is_associated_with::semaphorin is_associated_with::co-receptors. Semaphorins are a large family of secreted or membrane-bound proteins that mediate repulsive effects on is_associated_with::axon pathfinding during is_associated_with::nervous system development. A subset of semaphorins are recognized by plexin-A/neuropilin transmembrane receptor complexes, triggering a cellular signal transduction cascade that leads to is_associated_with::axon repulsion. This plexin-A family member is thought to transduce signals from is_associated_with::semaphorin-3A and -3C.

In some studies, the PLXNA2 gene is associated with is_associated_with::schizophrenia. and is_associated_with::anxiety.