ATF1

Cyclic AMP-dependent transcription factor ATF-1 is a is_associated_with::protein that in humans is encoded by the ATF1 is_associated_with::gene.

This gene encodes an activating is_associated_with::transcription factor, which belongs to the ATF subfamily and is_associated_with::bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and is_associated_with::cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation.

Clinical significance
Fusion of this gene and FUS on chromosome 16 or is_associated_with::EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in is_associated_with::angiomatoid fibrous histiocytoma and is_associated_with::clear cell sarcoma. This gene has a pseudogene on chromosome 6.

Interactions
ATF1 has been shown to interact with:
 * is_associated_with::BRCA1,
 * is_associated_with::CSNK2A2,
 * CSNK2A1, and
 * is_associated_with::EWS.