HERC2

Probable E3 ubiquitin-protein ligase HERC2 is an is_associated_with::enzyme that in humans is encoded by the HERC2 is_associated_with::gene.

A mutation in the HERC2 gene adjacent to is_associated_with::OCA2, affecting OCA2's expression in the human iris, is found common to nearly all people with blue eyes. It has been hypothesized that all blue eyed humans share a single common ancestor with whom the mutation originated.