CKMT1B

Creatine kinase, mitochondrial 1B also known as CKMT1B is one of two is_associated_with::genes which encode the ubiquitous mitochondrial is_associated_with::creatine kinase (ubiquitous mtCK or CKMT1).

Function
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from is_associated_with::mitochondria to the cytosolic carrier, is_associated_with::creatine. It belongs to the is_associated_with::creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK (is_associated_with::CKMT2) and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 (is_associated_with::CKMT1A and CKMT1B (this gene)) have been identified which encode identical mitochondrial creatine kinase proteins.

Clinical significance
Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis.