TGFBI

Transforming growth factor, beta-induced, 68kDa, also known as TGFBI (initially called BIGH3, BIG-H3), is a is_associated_with::protein which in humans is encoded by the TGFBI is_associated_with::gene.

Function
This gene encodes an RGD-containing protein that binds to type I, II and IV is_associated_with::collagens. The RGD motif is found in many is_associated_with::extracellular matrix proteins modulating is_associated_with::cell adhesion and serves as a ligand recognition sequence for several is_associated_with::integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by is_associated_with::transforming growth factor-beta and acts to inhibit cell adhesion.

Clinical significance
Mutations of the gene cause several forms of corneal dystrophies.