Rs1049331


 * rs11200638 1.7x10-14 (-625G>A)is the most significant associated SNP with a high OR of 7.6 (95%CI: 3.94-14.51)
 * rs2672598 3.0x10-10 (-487T>C)
 * rs1049331 3.7x10-12 (102C>T, Ala34Ala)
 * rs2293870 3.7x10-12 (108G>T, Gly36Gly)
 * haplotype ACCTT, significantly predisposes to AMD (p= 6.68x10-14)
 * smoking and rs800292 (184G>A, Val62Ile) of CFH.
 * The combined OR for disease of smoking and rs11200638 (HTRA1) caused a 15.7 fold increased risk
 * The combined OR for rs800292 and rs11200638 showed a 23.3 fold increased risk
 * An extremely high population attributable risk (PAR) of 78% was also found.