SREBF2

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a is_associated_with::protein that in humans is encoded by the SREBF2 is_associated_with::gene.

Function
This gene encodes a ubiquitously expressed is_associated_with::transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix leucine zipper (bHLH-Zip) domain. Various single nucleotide polymorphisms (SNPs) of the SREBF2 have been identified and some of them are found to be associated with higher risk of knee is_associated_with::osteoarthritis.

Interactions
SREBF2 has been shown to interact with is_associated_with::INSIG1 and is_associated_with::CREB-binding protein.