WNT10A

Wnt-10a is a is_associated_with::protein that in humans is encoded by the WNT10A is_associated_with::gene.

Function
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family.

Clinical significance
WNT10A is strongly expressed in the cell lines of is_associated_with::promyelocytic leukemia and is_associated_with::Burkitt's lymphoma. In addition, it and another family member, the is_associated_with::WNT6 gene, are strongly coexpressed in colorectal cancer cell lines. The gene overexpression may play key roles in carcinogenesis through activation of the WNT-beta-catenin-TCF signaling pathway. This gene and the WNT6 gene are clustered in the chromosome 2q35 region.

Mutations in the WNT10A gene are associated with is_associated_with::Schöpf–Schulz–Passarge syndrome and is_associated_with::hypodontia.