Rs664143

600+ Korean lung cancer patients were part of a study that concluded that the rs664143(T) allele, as oriented vis-a-vis dbSNP, located in the ATM gene and also known as IVS62+60G>A, was associated with increased risk, with an odds ratio of 1.68 (CI: 1.1-2.1, p<0.05).

In a study of 119 American patients with potentially resectable pancreatic cancer, the rs664143(C) allele was associated with poorer overall survival (ie response) to combined gerncitabine radiation therapy. Also, as 1 of 3 SNPs its risk allele is associated with poorer overall survival for pancreatic cancer patients being treated with combined gerncitabine radiation therapy; median overall survival times of 31.0, 16.2, and 10.5 months were calculated for pancreatic cancer patients carrying < or = 1, 2, and 3 risk alleles from rs664143(C), rs2227928(C), and rs521102(T;T), respectively (P=0.004).