PDCD10

Programmed cell death protein 10 is a is_associated_with::protein that in humans is encoded by the PDCD10 is_associated_with::gene.

Gene
Loss of function mutations in PDCD10 result in the onset of Cerebral Cavernous Malformations (CCM) illness. Therefore, this gene is also called CCM3. Cerebral cavernous malformations (CCMs) are vascular malformations in the brain and spinal cord made of dilated capillary vessels.

Interactions
CCM3 encodes a protein called Programmed Cell Death 10 (PDCD10). The function of this protein has only recently begun to be understood. PDCD10 has roles in vascular development and VEGF signaling1, apoptosis and functions as part of a larger signaling complex that includes germinal center kinase III,. Specifically, PDCD10 has been shown to interact with is_associated_with::RP6-213H19.1, is_associated_with::STK25, is_associated_with::STRN, is_associated_with::STRN3, is_associated_with::MOBKL3, is_associated_with::CTTNBP2NL, is_associated_with::STK24 and is_associated_with::FAM40A.

Model organisms
is_associated_with::Model organisms have been used in the study of PDCD10 function. A conditional is_associated_with::knockout mouse line, called Pdcd10tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.