MAP2K5

Dual specificity mitogen-activated protein kinase kinase 5 is an is_associated_with::enzyme that in humans is encoded by the MAP2K5 is_associated_with::gene.

Upstream
This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs).

Downstream
This kinase specifically interacts with and activates MAPK7/ERK5.

Interactions
MAP2K5 has been shown to interact with is_associated_with::MAPK7, is_associated_with::MAP3K2, is_associated_with::Protein kinase Mζ and is_associated_with::MAP3K3.