SGCZ

Sarcoglycan zeta also known as SGCZ is a is_associated_with::protein which in humans is encoded by the SGCZ is_associated_with::gene.

Function
The zeta-sarcoglycan gene measures over 465 kb and localizes to 8p22. This protein is part of the is_associated_with::sarcoglycan complex, a group of 6 proteins. The sarcoglycans are all N-glycosylated transmembrane proteins with a short intra-cellular domain, a single transmembrane region and a large extra-cellular domain containing a carboxyl-terminal cluster with several conserved cysteine residues. The sarcoglycan complex is part of the is_associated_with::dystrophin-associated is_associated_with::glycoprotein complex (DGC), which bridges the inner is_associated_with::cytoskeleton and the is_associated_with::extracellular matrix.

Clinical significance
Zeta-sarcoglycan is reduced in mouse models of is_associated_with::muscular dystrophy and SGCZ is found as a component of the vascular smooth muscle sarcoglycan complex. Hence SGCZ may be important in the pathogenesis of muscular dystrophy.