LINGO1

Leucine rich repeat and Ig domain containing 1 also known as LINGO-1 is a is_associated_with::protein which in humans is encoded by the LINGO1 is_associated_with::gene.

Structure
LINGO-1 contains an N-terminal is_associated_with::leucine-rich repeat (LRR) domain, followed by 9 typical LRR domains, C-terminal  LRR domain, an is_associated_with::IgC2 domain, a transmembrane domain, and a cytoplasmic tail.

LINGO-1 interacts with the Nogo receptor.

Function
LINGO-1 is primarily expressed in neuronal tissue, and most abundantly in cortex. It has been implicated in the inhibition of axon regeneration through a ternary complex formed with NgR1 (ligand-binding subunit) and is_associated_with::p75 (signal transducing subunit). The inhibitory action is achieved through is_associated_with::RhoA-GTP upregulation in response to the presence of MOG, MAG or Nogo-66 in the central nervous system. LINGO-1 also inhibits is_associated_with::oligodendrocyte precursor differentiation and is_associated_with::myelination, by a mechanism that also involves activation of RhoA, but which apparently does not require p75 or NgR1.

Recent post mortem studies have evidenced an increase in LINGO1 in the is_associated_with::cerebellum of people with essential tremor.