Provirus

A provirus is a virus genome that is integrated into the DNA of a host cell.

This state can be a stage of virus replication, or a state that persists over longer periods of time as either inactive viral infections or an endogenous retrovirus. In inactive viral infections the virus will not replicate itself but through replication of its host cell. This state can last over many host cell generations.

Special viruses - endogenous retroviruses are always in the state of a provirus.

When a (nonendogenous) retrovirus invades a cell, the RNA of the retrovirus is reverse-transcribed into DNA by reverse transcriptase, then inserted into the host genome by an integrase.

A provirus does not directly make new DNA copies of itself while integrated into a host genome in this way. Instead, it is passively replicated along with the host genome and passed on to the original cell's offspring; all descendants of the infected cell will also bear proviruses in their genomes. Integration can result in a latent infection or a productive infection. In a productive infection, the provirus is transcribed into messenger RNA which directly produces new virus, which in turn will infect other cells. A latent infection results when the provirus is transcriptionally silent rather than active.

A latent infection may become productive in response to changes in the host's environmental conditions or health, the provirus may be activated and begin transcription of its viral genome. This can result in the destruction of its host cell because the cell's protein synthesis machinery is hijacked to produce more viruses.

It is thought that provirus may account for approximately 8% of the human genome in the form of inherited endogenous retroviruses.

Examples in humans include HIV and HTLV.

A provirus not only refers to a retrovirus but is also used to describe other viruses that can integrate into the host chromosomes, another example being adeno-associated virus.