QRICH2

Glutamine-rich protein 2 is a is_associated_with::protein that in humans is edcoded by the QRICH2 is_associated_with::gene on human chromosome 17. The function of QRICH2 protein is mostly unknown, but it has been shown that QRICH2 gene contains a high molecular weight is_associated_with::Glutenin domain and an is_associated_with::ATPase involved domain. QRICH2 gene is highly expressed in is_associated_with::testis, and the is_associated_with::subcellular location of QRICH2 protein is in the nucleus.

Gene
QRICH2 mRNA is 5411 bp long, and its chromosomal location in human is 17q25.1. QRICH2 mRNA has 19 is_associated_with::exons and it contains two main function domains: a high molecular weight is_associated_with::Glutenin domain (amino acid 446-979) and an is_associated_with::ATPase involved domain (amino acid 1036-1413). QRICH2 locates between UBAL D2 gene and is_associated_with::PRPSAP1 gene on chromosome 17. There is no predicted is_associated_with::stem loop structure on QRICH2 mRNA because there isn't any complementary RNA sequences.

Protein
QRICH2 protein is 1663 amino acids long, and 10.9% of the amino acids are is_associated_with::Glutamine (Q). 38% of the QRICH2 protein secondary structure is is_associated_with::alpha-helix, 39% is is_associated_with::beta-sheet and 13% is turning. The human tissue type with the highest level of QRICH2 expression is is_associated_with::testis, and this result is confirmed by the Gene Expression Profile for mouse and dog too. The subcellular location of QRICH2 protein is in the nucleus. QRICH2 is a soluble protein, its average is_associated_with::hydrophobicity is -0.5995. QRICH2 protein interact with a number of other proteins including SSSCA1, is_associated_with::TSSC1, is_associated_with::GAPDH, is_associated_with::NUP98 and is_associated_with::SNAI1.

== Homology ==

paralogs
FLJ25737 mRNA sequences perfectly match with two regions on the QRICH2 mRNA (bp 3157-4302 on QRICH2 match with bp 1-1146 on FLJ25737, bp 4998-5307 on QRICH2 match with bp 1140-1499 on FLJ25737). However, FLJ25737 locates on chromosome 7 and QRICH2 locates on chromosome 17.

Orthologs
QRICH2 protein has well conserved orthologs in many species. The orthologous protein sequences match very well at the region where the high molecular weight Glutenin domain and ATPase involved domain is.

Function
The function of QRICH2 protein is mostly unknown. QRICH2 has been shown to belong to the common expression groups on human chromosome 17. The following genes belonged to the common expression groups on chromosome 17: is_associated_with::NCOR1, GFAP, QRICH2, is_associated_with::ANAPC11 and is_associated_with::PER1. QRICH2 may also be an up-regulated gene involved in cell is_associated_with::adhesion and cellular is_associated_with::morphogenesis. The high expression of QRICH2 gene in testis may suggest that QRICH2 protein has some functions related to hormone production in males. QRICH2 protein has some sequence similarities with the spermidine/spermine N(1)-acetyl-like protein 1 in several species.