Interferon induced transmembrane protein 5

Interferon induced transmembrane protein 5 is a gene that encodes a membrane protein thought to play a role in bone mineralization.

Genomics
The gene is located on the short arm of the Crick strand of is_associated_with::chromosome 11 (11p15.5). It is located with a cluster of is_associated_with::interferon inducible genes but is itself not interferon inducible. The gene is 1,327 bases in length and encodes a protein of 132 amino acids with a predicted molecular weight of 14378 Daltons. Expression in adults is bone specific and highest in is_associated_with::osteoblasts.

The homolog in the is_associated_with::mouse is located on chromosome 7. A homolog is also known to be present in is_associated_with::lizards.

Evolution
The gene first appeared in bony fish and its bone specific expression appears to be limited to therian mammals.

Biochemistry
The protein has two transmembrane domains. It associates with is_associated_with::FK506 binding protein 11.

Clinical
Mutations in the gene are associated with is_associated_with::osteogenesis imperfecta type 5.