ADI1

The human ADI1 is_associated_with::gene encodes the is_associated_with::enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.

Function
The enzyme belongs to the aci-reductone is_associated_with::dioxygenase family of metal-binding enzymes, which are involved in is_associated_with::methionine salvage. This enzyme may regulate is_associated_with::mRNA processing in the nucleus, and may carry out different functions depending on its localization.

Clinical significance
Diseases associated with ADI1 include is_associated_with::Klebsiella, and is_associated_with::refsum disease.

ADI1 is capable for supporting is_associated_with::hepatitis C virus replication in an otherwise non-permissive cell line. Mouse hepatoma cells coexpressing human is_associated_with::CD81 and ADI1/Sip-L supported HCV infection and replication. Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.