Promyelocytic leukemia protein

Probable transcription factor PML is a tumor suppressor is_associated_with::protein that in humans is encoded by the PML is_associated_with::gene.

Function
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies (is_associated_with::Nuclear dots) where it functions as a is_associated_with::transcription factor and is_associated_with::tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with is_associated_with::acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different is_associated_with::isoforms have been identified.

Interactions
Promyelocytic leukemia protein has been shown to interact with:


 * is_associated_with::ANKRD2,
 * is_associated_with::CREB-binding protein,
 * is_associated_with::Cyclin T1,
 * is_associated_with::Death associated protein 6,
 * is_associated_with::GATA2,
 * is_associated_with::HDAC1,
 * is_associated_with::HDAC3,
 * is_associated_with::HHEX,
 * is_associated_with::MAPK11,
 * is_associated_with::MYB,
 * is_associated_with::Mdm2,
 * is_associated_with::Nerve Growth factor IB,
 * is_associated_with::Nuclear receptor co-repressor 1,
 * is_associated_with::Nuclear receptor co-repressor 2,
 * is_associated_with::P53,
 * is_associated_with::RPL11,
 * is_associated_with::Retinoblastoma protein,
 * is_associated_with::Retinoic acid receptor alpha,
 * is_associated_with::SIN3A,
 * is_associated_with::SKI protein,
 * is_associated_with::STAT3,
 * is_associated_with::Serum response factor and
 * is_associated_with::Small ubiquitin-related modifier 1,
 * is_associated_with::Sp1 transcription factor,
 * is_associated_with::TOPBP1,
 * is_associated_with::Thymine-DNA glycosylase, and
 * is_associated_with::Zinc finger and BTB domain-containing protein 16.