ARHGEF7

Rho guanine nucleotide exchange factor 7 is a is_associated_with::protein that in humans is encoded by the ARHGEF7 is_associated_with::gene.

Function
Rho GTPase play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through is_associated_with::G protein-coupled receptors. The encoded protein belongs to a family of is_associated_with::cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce is_associated_with::membrane ruffling. Multiple is_associated_with::alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.

Interactions
ARHGEF7 has been shown to interact with:


 * is_associated_with::Cbl gene,
 * is_associated_with::GIT1,
 * is_associated_with::SHANK1
 * is_associated_with::SHANK2, and
 * is_associated_with::SHANK3.