PADI1

Peptidyl arginine deiminase, type I, also known as PADI1, is a is_associated_with::protein which in humans is encoded by the PADI1 is_associated_with::gene.

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational is_associated_with::deimination of proteins by converting is_associated_with::arginine residues into is_associated_with::citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type I enzyme is involved in the late stages of epidermal differentiation, where it deiminates is_associated_with::filaggrin and keratin K1, which maintains hydration of the is_associated_with::stratum corneum, and hence the cutaneous barrier function. This enzyme may also play a role in is_associated_with::hair follicle formation. This gene exists in a cluster with four other paralogous genes.