Michael M. Gottesman

Michael M. Gottesman (born October 7, 1946 in Jersey City, New Jersey ) is an American biochemist, the Deputy Director (Intramural) of the National Institutes of Health (NIH) in the United States, and also Chief of the Laboratory of Cell Biology at the National Cancer Institute (NCI) within the NIH. He graduated summa cum laude in biochemical sciences in 1966 from Harvard College, and received his M.D. magna cum laude from Harvard Medical School in 1970. He then worked as an intern and resident at the Peter Dent Brigham Hospital in Boston, a research associate at the NIH, and an assistant professor at Harvard before taking a permanent position at the NIH in 1976.

His areas of expertise includes a major contribution to the discovery of P-glycoprotein (MDR1, ABCB1), the multidrug resistance efflux transporter associated with clinical resistance to anti-cancer agents. In 2007, he reported for the first time in Science magazine that silent polymorphisms can impact on the tertiary structure and function of a protein.

He has been a Fellow of the American Association for the Advancement of Science since 1988.