NAB2

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a is_associated_with::protein that in humans is encoded by the NAB2 is_associated_with::gene.

Function
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate transcription induced by some members of the EGR (early growth response) family of is_associated_with::transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the is_associated_with::nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Pathology
Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and is_associated_with::STAT6, located at chromosomal region 12q13, have been identified in is_associated_with::solitary fibrous tumors.