Lymphoid enhancer-binding factor 1

Lymphoid enhancer-binding factor 1 (LEF1) is a is_associated_with::protein that in humans is encoded by the LEF1 is_associated_with::gene.

Function
Lymphoid enhancer-binding factor-1 (LEF1) is a 48-kD nuclear protein that is expressed in pre-B and is_associated_with::T cells. It binds to a functionally important site in the T-cell receptor-alpha (TCRA) enhancer and confers maximal enhancer activity. LEF1 belongs to a family of regulatory proteins that share homology with high mobility group protein-1 (HMG1).

Clinical significance
LEF1 is highly overexpressed and associated with disease progression and poor prognosis in is_associated_with::B-cell chronic lymphocytic leukemia. It is also a promising potential drug target.

Interactions
Lymphoid enhancer-binding factor 1 has been shown to interact with:
 * is_associated_with::ALX4,
 * AML-1,
 * CTNNB1,
 * is_associated_with::EP300,
 * MITF
 * is_associated_with::PIAS4,
 * SMAD2, and
 * SMAD3.