EN2 (gene)

is_associated_with::Homeobox protein engrailed-2 is a is_associated_with::protein that in humans is encoded by the EN2 is_associated_with::gene.

Function
is_associated_with::Homeobox-containing genes are thought to have a role in controlling development. In is_associated_with::Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of is_associated_with::pattern formation during development of the central nervous system.

In cancer diagnosis
A method for diagnosing is_associated_with::prostate cancer by detection of EN2 in urine has developed. The results of a clinical trial of 288 men suggest that EN2 could be a marker for prostate cancer which might prove more reliable than current methods that use is_associated_with::prostate-specific antigen (PSA). If effective, a urine test is considered easier and less embarrassing for the patient than blood tests or rectal examinations and, therefore, less likely to discourage early diagnosis. At the time of the report, it was not clear whether or not the EN2 test could distinguish between aggressive tumours that would require intervention and relatively benign ones that would not.

Licensing & Marketing
The EN2 test for prostate cancer has been licensed to Zeus Scientific, as they reported in March 2013. In that announcement they said they expected the test to be submitted to the US-FDA in a year, and available worldwide in 2 years.