Proteasome inhibitor

Proteasome inhibitors are drugs that block the action of proteasomes, cellular complexes that break down proteins, like the p53 protein. Proteasome inhibitors are being studied in the treatment of cancer.

See also Proteasome.

Examples

 * In 2003, bortezomib was the first proteasome inhibitor to be approved for use in the U.S.


 * Disulfiram has been proposed as another proteasome inhibitor.


 * Epigallocatechin-3-gallate has also been proposed.


 * Salinosporamide A has started clinical trials for multiple myeloma.