Notch 1

Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human is_associated_with::gene encoding a single-pass transmembrane receptor.

Function
This gene encodes a member of the Notch family. Members of this Type 1 is_associated_with::transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple is_associated_with::epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an is_associated_with::evolutionarily conserved intercellular is_associated_with::signaling pathway that regulates interactions between physically adjacent cells. In is_associated_with::Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the is_associated_with::trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play multiple roles during development.

A deficiency can be associated with is_associated_with::bicuspid aortic valve.

There is evidence that activated Notch 1 and is_associated_with::Notch 3 promote differentiation of progenitor cells into is_associated_with::astroglia. Notch 1, then activated before birth, induces is_associated_with::radial glia differentiation, but postnatally induces the differentiation into is_associated_with::astrocytes. One study shows that Notch-1 cascade is activated by is_associated_with::Reelin in an unidentified way. Reelin and Notch1 cooperate in the development of the is_associated_with::dentate gyrus, according to another.

Interactions
NOTCH1 has been shown to interact with:


 * is_associated_with::GSK3B,
 * is_associated_with::Lck,
 * is_associated_with::MAML1,
 * is_associated_with::Mothers against decapentaplegic homolog 3
 * is_associated_with::NFKB1,
 * NOV,
 * is_associated_with::RBPJ,
 * is_associated_with::SNW1,
 * is_associated_with::Ubiquitin C, and
 * is_associated_with::YY1.