SIGLEC10

Sialic acid-binding Ig-like lectin 10 is a is_associated_with::protein that in humans is encoded by the SIGLEC10 is_associated_with::gene. The mouse orthologue is Siglec G.

Structure and Function
Like most but not all other Siglecs, Siglec-10 bears an ITIM (is_associated_with::Immunoreceptor tyrosine-based inhibitory motif) within its cytoplasmic domain. Siglec-10 is a ligand for is_associated_with::CD52, the target of the therapeutic monoclonal antibody is_associated_with::Alemtuzumab. It is also reported to bind to is_associated_with::Vascular adhesion protein 1 (VAP-1) and to the co-stimulatory molecule is_associated_with::CD24 also known as HSA (Heat-stable antigen).