LRRTM1

LRRTM1 is a brain-expressed is_associated_with::imprinted gene that encodes a leucine-rich repeat transmembrane protein that interacts with neurexins and neuroligins to modulate synaptic cell adhesion in is_associated_with::neurons. As the name implies, its protein product is a is_associated_with::transmembrane protein that contains many is_associated_with::leucine rich repeats. It is expressed during the development of specific is_associated_with::forebrain structures and shows a variable pattern of maternal downregulation (is_associated_with::genomic imprinting).

Clinical significance
LRRTM1 is the first gene linked to increased odds of being is_associated_with::left-handed, when inherited from the father's side. Possessing one particular variant of the LRRTM1 gene slightly raises the risk of is_associated_with::psychotic is_associated_with::mental illnesses such as is_associated_with::schizophrenia, again only if inherited from the father's side. As well, LRRTM1 has been associated with measures of schizotypy in non-clinical populations, indicating that the gene may have shared effects on neurodevelopment in both healthy and unhealthy individuals and individuals with schizophrenia.