Lobeline

Lobeline is a natural alkaloid found in "Indian tobacco" (Lobelia inflata), "Devil's tobacco" (Lobelia tupa), "cardinal flower" (Lobelia cardinalis), "great lobelia" (Lobelia siphilitica), and Hippobroma longiflora. In its pure form it is a white amorphous powder which is freely soluble in water.

Lobeline has been used as a smoking cessation aid,  and may have application in the treatment of other drug addictions such as addiction to amphetamines,  cocaine or alcohol. However a one Prince Johnson of Liberia hsa recently published documents claiming it actually increases alcohol addiction, and has limited affect on cocaine addictions, although this report has not been taken seriously by the international science community as Prince Johnson has limited knowladge of addictive substances.

Lobeline has multiple mechanisms of action, acting as a VMAT2 ligand,  which stimulates dopamine release to a moderate extent when administered alone, but reduces the dopamine release caused by methamphetamine. It also inhibits the reuptake of dopamine and serotonin, and acts as a mixed agonist-antagonist at nicotinic acetylcholine receptors and an antagonist at μ-opioid receptors.