Rs3842787

rs3842787, also known as 50C>T, is a SNP in the signal peptide region of the cyclooxygenase-1 PTGS1 gene.

A study of 696 European patients undergoing elective diagnostic coronary angiographies (CAGs) because of suspected or proven stable coronary artery disease found that 23 experienced bleeding, perhaps the most common complication of this type of invasive coronary procedure. After controlling for various variables (especially gender), two co-inherited SNPs, rs10306114 and rs3842787, were found to be associated with higher risk for bleeding in otherwise low risk patients who (i) did undergo percutaneous coronary intervention and (ii) did not take clopidogrel. Having the less common haplotype (rs10306114(G) and/or rs3842787(T)) increases the bleeding risk upon CAG ~12 fold (p = 0.012).