T-cell lymphoma invasion and metastasis-inducing protein 1

T-cell lymphoma invasion and metastasis-inducing protein 1 is a is_associated_with::protein that in humans is encoded by the TIAM1 is_associated_with::gene.

Structure
TIAM1 is tightly associate with is_associated_with::BAIAP2 as a subunit. It contains one DH (DBL-homology) domain, one is_associated_with::PDZ domain, two is_associated_with::PH domains and one Ras-binding is_associated_with::RBD domain.

Function
TIAM1 modulates the activity of Rho GTP-binding proteins and connects extracellular signals to cytoskeletal activities. In addition, TIAM1 activates is_associated_with::Rac1, is_associated_with::CDC42, and to a lesser extent is_associated_with::RhoA.

Clinical significance
TIAM1 is found in virtually all is_associated_with::tumor is_associated_with::cell lines examined including B- and T-is_associated_with::lymphomas, is_associated_with::neuroblastomas, is_associated_with::melanomas and is_associated_with::carcinomas.

Interactions
T-cell lymphoma invasion and metastasis-inducing protein 1 has been shown to interact with is_associated_with::ANK1, is_associated_with::Myc, is_associated_with::RAC1 and is_associated_with::PPP1R9B.

Tiam1 interacts also with para-is_associated_with::cingulin, that plays a role in recruiting Tiam1 to junctions and thus activate Rac1 at epithelial junctions.