3-dehydrosphinganine reductase

3-dehydrosphinganine reductase also known as 3-ketodihydrosphingosine reductase (KDSR) or follicular variant translocation protein 1 (FVT1) is an is_associated_with::enzyme that in humans is encoded by the KDSR is_associated_with::gene.

Function
3-dehydrosphinganine reductase catalyzes the is_associated_with::chemical reaction:


 * sphinganine + NADP+ $$\rightleftharpoons$$ 3-dehydrosphinganine + NADPH + H+

Thus, the two substrates of this enzyme are is_associated_with::sphinganine and NADP+, whereas its 3 products are is_associated_with::3-dehydrosphinganine, NADPH, and H+.

This enzyme belongs to the family of is_associated_with::oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. This enzyme participates in is_associated_with::sphingolipid metabolism.

Tissue distribution
Follicular lymphoma variant translocation 1 is a secreted protein which is weakly expressed in hematopoietic tissue.

Clinical significance
FVT1 shows a high rate of transcription in some is_associated_with::T cell malignancies and in phytohemagglutinin-stimulated is_associated_with::lymphocytes. The proximity of FVT1 to BCL2 suggests that it may participate in the tumoral process.