Gamma-synuclein

Gamma-synuclein is a is_associated_with::protein that in humans is encoded by the SNCG is_associated_with::gene.

Gamma-synuclein is a is_associated_with::synuclein is_associated_with::protein found primarily in the is_associated_with::peripheral nervous system (in primary sensory is_associated_with::neurons, sympathetic neurons, and is_associated_with::motor neurons) and is_associated_with::retina. It is also detected in the is_associated_with::brain, ovarian tumors, and in the is_associated_with::olfactory epithelium. Gamma-synuclein is the least conserved of the synuclein proteins.

Gamma-Synucleins expression in breast tumors is a marker for is_associated_with::tumor progression as is_associated_with::mammalian gamma-synuclein was first identified as breast cancer-specific is_associated_with::gene 1 (BCSG1). A change in the expression of gamma-synuclein has been observed in the retina of patients with is_associated_with::Alzheimer's disease. The normal cellular function of gamma-synuclein remains unknown.

Interactions
Gamma-synuclein has been shown to interact with is_associated_with::BUB1B.