SND1

Staphylococcal nuclease domain-containing protein 1 also known as 100 kDa coactivator or Tudor domain-containing protein 11 (TDRD11) is a is_associated_with::protein that in humans is encoded by the SND1 is_associated_with::gene. SND1 is a main component of RISC complex and plays an important role in miRNA function. SND1 is Tudor Domain containing protein and Tudor Proteins are highly conserved proteins and even present in Drosophila melanogaster. SND1 is also involved in Autism.

Clinical significance
SND1 acts as is_associated_with::oncogene in many cancers  and in is_associated_with::hepatocellular carcinoma progression. SND1 promotes tumor angiogenesis in human hepatocellular carcinoma through a novel pathway which involves is_associated_with::NF-kappaB and miR-221. SND1 promotes migration and invasion via angiotensin II type 1 receptor and TGFβ signaling. SND1 expression is regulated by is_associated_with::Mir-184 in is_associated_with::gliomas.

Interactions
SND1 has been shown to interact with MYB,
 * is_associated_with::PIM1, is_associated_with::POLR2A, is_associated_with::RBPJ,  and is_associated_with::STAT6.

SND1 also interacts with G3BP (stress granule protein) and AEG-1.