RAMP2

Receptor activity modifying protein 2, also known as RAMP2, is a is_associated_with::protein which in humans is encoded by the RAMP2 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular is_associated_with::N-terminus and a cytoplasmic is_associated_with::C-terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a is_associated_with::calcitonin gene-related peptide (CGRP) receptor or an is_associated_with::adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an is_associated_with::adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.