N-myc-interactor

N-myc-interactor also known as N-myc and STAT interactor is a is_associated_with::protein that in humans is encoded by the NMI is_associated_with::gene.

Function
NMYC interactor (NMI) interacts with NMYC and CMYC (two members of the oncogene is_associated_with::Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except is_associated_with::STAT2 and augments STAT-mediated transcription in response to cytokines IL-2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-is_associated_with::myeloid leukemias.

Interactions
NMI (gene) has been shown to interact with is_associated_with::BRCA1, is_associated_with::IFI35, is_associated_with::Myc, and is_associated_with::STAT5A, and TUBA3C.