DARS (gene)

Aspartyl-tRNA synthetase, cytoplasmic is an is_associated_with::enzyme that in humans is encoded by the DARS is_associated_with::gene.

Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of is_associated_with::aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis.

Clinical signficance
Mutations in DARS have been identified as the cause of is_associated_with::leukoencephalopathy, hypomyelination with brain stem and spinal cord involvement and leg spasticity (HBSL).