CXCL9

Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small is_associated_with::cytokine belonging to the CXC is_associated_with::chemokine family that is also known as Monokine induced by gamma interferon (MIG). CXCL9 is a T-cell is_associated_with::chemoattractant, which is induced by IFN-γ. It is closely related to two other CXC chemokines called is_associated_with::CXCL10 and is_associated_with::CXCL11, whose genes are located near the is_associated_with::gene for CXCL9 on human is_associated_with::chromosome 4. CXCL9, CXCL10 and CXCL11 all elicit their chemotactic functions by interacting with the is_associated_with::chemokine receptor CXCR3.

is_associated_with::Neutrophil is_associated_with::collagenase/is_associated_with::matrix metalloproteinase 8 (MMP-8) degrades CXCL9 and cleaves CXCL10 at two positions.

is_associated_with::Gelatinase B/matrix metalloproteinase 9 (MMP-9) degrades CXCL10 and cleaves CXCL9 at three different sites in its extended carboxy-terminal region.

Interactions
CXCL9 has been shown to interact with is_associated_with::CXCR3.