Rs13266634

rs13266634 is a SNP in the zinc transporter protein member 8 SLC30A8 gene that has primarily been associated with type-2 diabetes in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W).

significantly associated p = 0.0073; in 1,630 Japanese subjects with type-2 diabetes and in 1,064 controls

The major alleles of the SLC30A8 SNP rs13266634 and the HHEX SNP rs7923837 associate with reduced insulin secretion, but not with insulin resistance.

46% of European non-diabetic offspring of type-2 diabetes patients are rs13266634(C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load.


 * Note: this SNP, rs13266634, is not represented on the Affymetrix 5.0 chip. Since it is also in an area of high recombination, it also lacks a proxy on the Affy chip and thus could not have been detected in the large genome-wide type-2 diabetes study performed by the Wellcome Trust Consortium.

1,638 type-2 diabetes patients and 1,858 controls
 * rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p = 3.9 x 10(-4)).

rs13266634(C) allele is associated with younger age of onset of type-1 diabetes

This SNP was confirmed to be associated with type-2 diabetes in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

spitotoon associated with blood sugar levels (glycated hemoglobin levels) rs13266634(C)