Vav (protein)

Vav is a family of proteins involved in cell signalling. They act as guanine nucleotide exchange factors (GEFs) for small G proteins of the Rho family. GEF activity is mediated via module of tandem DH-PH domains. Vav proteins also appear to exhibit GEF-independent functions.

There are three members of this family:


 * Vav1
 * Vav2
 * Vav3

Vav-Proteine