RNF10

RING finger protein 10 is a is_associated_with::protein that in humans is encoded by the RNF10 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of RNF10 function. A conditional is_associated_with::knockout mouse line, called Rnf10tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::mutant mice and five significant abnormalities were observed. is_associated_with::Homozygous mutant animals displayed increased chromosomal stability in a is_associated_with::micronucleus test. Females also had increased body weight, an increased amount of total body fat and an abnormal is_associated_with::complete blood count. Males additionally displayed an increase in eating behavior.