RIC3

RIC-3 also known as resistance to inhibitors of cholinesterase 3 is a is_associated_with::chaperone protein that in humans is encoded by the RIC3 is_associated_with::gene. The RIC3 gene was first discovered in C. elegans. RIC-3 protein is conserved in most animals and influences the maturation of various is_associated_with::ligand gated ion channels including the is_associated_with::serotonin 5-HT3 receptor and is_associated_with::nicotinic acetylcholine receptors, particularly the is_associated_with::homomeric α7 nicotinic receptor. RIC-3 enhances currents generated by these receptors by expediting receptor transport to the cell surface and by increasing receptor number.