Cubilin

Cubilin is a is_associated_with::protein that in humans is encoded by the CUBN is_associated_with::gene.

Function
Cubilin (CUBN) acts as a receptor for intrinsic factor-vitamin B12 complexes. The role of receptor is supported by the presence of 27 CUB domains. Cubulin is located within the epithelium of intestine and kidney. Mutations in CUBN may play a role in autosomal recessive megaloblastic anemia. A complex of is_associated_with::amnionless and cubilin forms the is_associated_with::cubam receptor.