TECR

Trans-2,3-enoyl-CoA reductase is an is_associated_with::enzyme that in humans is encoded by the TECR is_associated_with::gene.

This gene encodes a multi-pass membrane protein that resides in the is_associated_with::endoplasmic reticulum, and belongs to the steroid is_associated_with::5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.

Clinical relevance
Mutations in this gene have been shown to cause non-syndromic mental retardation.