Rs8192284

A study of 219 female melanoma patients and an equal number of controls concluded that 4 linked SNPs within the IL6R gene were associated with increased melanoma risk, but only when heterozygous. The odds ratio associated with the minor allele of this SNP, rs8192284 (also known as Asp358Ala), was 1.68 (CI: 1.04-2.73). The 4 linked SNPs from identified in this study are: rs6684439, rs4845618, rs4845622, and rs8192284.

linked to diabetes by

multiple myeloma
 * rs1801278 [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1]
 * rs6684439 (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0)
 * rs7529229 (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0)
 * rs8192284 (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)