CCL9

Chemokine (C-C motif) ligand 9 (CCL9) is a small is_associated_with::cytokine belonging to the CC is_associated_with::chemokine family. It is also called macrophage inflammatory protein-1 gamma (MIP-1γ), macrophage inflammatory protein-related protein-2 (MRP-2) and CCF18, that has been described in rodents. CCL9 has also been previously designated CCL10, although this name is no longer in use. It is secreted by follicle-associated is_associated_with::epithelium (FAE) such as that found around is_associated_with::Peyer's patches, and attracts is_associated_with::dendritic cells that possess the cell surface molecule CD11b and the is_associated_with::chemokine receptor CCR1. CCL9 can activate is_associated_with::osteoclasts through its receptor CCR1 (the most abundant chemokine receptor found on osteoclasts) suggesting an important role for CCL9 in is_associated_with::bone resorption. CCL9 is constitutively expressed in is_associated_with::macrophages and is_associated_with::myeloid cells. The is_associated_with::gene for CCL9 is located on is_associated_with::chromosome 11 in mice.