Rs356219

rs356219, a tagging SNP in the SNCA gene for a Parkinson's disease associated haplotype, predicts the amount of SNCA (alpha-synuclein) mRNA found in post mortem substantia nigra and cerebellum brain tissue.

replicates the association of rs356219 with late-onset Parkinson's disease, calculating an odds ratio of 1.3 (CI: 1.13 - 1.5, p=2x10e-4) per rs356219(G) allele among the 1145 patients from northern Spain studied.

Linkage disequilibrium patterns and tagSNP transferability among European populations.

Tau and alpha-synuclein in susceptibility to, and dementia in, Parkinson's disease.

Genetic variability in the SNCA gene influences alpha-synuclein levels in the blood and brain.

Cerebellar alpha-synuclein levels are decreased in Parkinson's disease and do not correlate with SNCA polymorphisms associated with disease in a Swedish material.

Genomewide association study for susceptibility genes contributing to familial Parkinson disease.

Genetic susceptibility in Parkinson's disease.

Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy.

Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.

Independent and joint effects of the MAPT and SNCA genes in Parkinson disease.

SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.


 * is_associated_with_disease::Parkinson's disease
 * is_associated_with_disease::Dementia
 * is_associated_with_disease::Multiple system atrophy