STAT6

STAT6 is a human is_associated_with::gene. The is_associated_with::protein encoded by this gene is a member of the STAT family of is_associated_with::transcription factors.

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2), expression of cell surface markers, and class switch of immunoglobulins.

Interactions
STAT6 has been shown to interact with is_associated_with::EP300, is_associated_with::CREB-binding protein, is_associated_with::NFKB1, is_associated_with::Nuclear receptor coactivator 1, is_associated_with::IRF4 and is_associated_with::SND1.

Pathology

 * Gene fusion
 * Recurrent somatic fusions of the two genes, is_associated_with::NGFI-A–binding protein 2 (is_associated_with::NAB2) and STAT6, located at chromosomal region 12q13, have been identified in is_associated_with::solitary fibrous tumors.


 * Amplification
 * STAT6 is amplified in a subset of dedifferentiated liposarcoma.