COTL1

Coactosin-like protein is a is_associated_with::protein that in humans is encoded by the COTL1 is_associated_with::gene.

Function
This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes.

Interactions
COTL1 has been shown to interact with is_associated_with::Arachidonate 5-lipoxygenase.