SH2B1

SH2B adapter protein 1 is a is_associated_with::protein that in humans is encoded by the SH2B1 is_associated_with::gene.

Interactions
SH2B1 has been shown to interact with:
 * is_associated_with::Grb2,
 * is_associated_with::Insulin receptor,
 * is_associated_with::Janus kinase 2, and
 * is_associated_with::TrkA.

Clinical significance
Variations close to or in the SH2B1 gene have been found to associatate with is_associated_with::obesity in two very large genome wide association studies of is_associated_with::body mass index (BMI). Furthermore SH2B1 deletions are associated with severe early-onset obesity.