Alpha-enolase

Enolase 1, more commonly known as alpha-enolase, is a glycolytic is_associated_with::enzyme expressed in most tissues, one of the is_associated_with::isozymes of is_associated_with::enolase. It is a homodimer composed of 2 alpha subunits.

Relationship to Myc-binding protein-1
Its gene, the ENO1, also encodes the Myc-binding protein-1(MBP1), which downregulates the activity of is_associated_with::c-myc is_associated_with::protooncogene. Alpha-enolase is the longer form (48 kDa) localized in both cytoplasm and nuclei, while MBP1 is shorter (37 kDa) and is found mostly in the nuclei.

Clinical significance
Alpha-enolase has been identified as an is_associated_with::autoantigen in is_associated_with::Hashimoto's encephalopathy. Single studies have also identified it as an autoantigen associated with severe is_associated_with::asthma and a putative target antigen of anti-endothelial cell antibody in is_associated_with::Behçet's disease. Reduced expression of the enzyme has been found in the is_associated_with::corneal epithelium of people suffering from is_associated_with::keratoconus.

Interactions
Alpha-enolase has been shown to interact with is_associated_with::TRAPPC2.