Rs10989591

rs10989591, aka Val362Met or V362M, is a SNP in the N-methyl-D-aspartate 3A GRIN3A gene, which codes for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor. The (C) allele encodes the Val and the (T) allele encodes the Met.

gs278 reflects a gene-gene interaction between this SNP and a DRD2 SNP, rs6277, in which older adults with a particular combination of genotypes at these two (independent) loci are reported to exhibit better episodic memory.

Based on electromagnetic activity during selective attention (auditory oddball task with target processing) measured in 281 healthy subjects, rs10989591(T;T) individuals appeared to show better prefrontal information processing (based on higher frontal P300 amplitudes), presumably reflecting higher NMDA receptor efficacy.