MED28

Mediator of RNA polymerase II transcription subunit 28 is an is_associated_with::enzyme that in humans is encoded by the MED28 is_associated_with::gene. It forms part of the Mediator complex.

Interactions
MED28 has been shown to interact with Merlin, is_associated_with::Grb2 and is_associated_with::MED26.

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress is_associated_with::smooth muscle is_associated_with::cell differentiation. Thus, is_associated_with::mammalian Mediator subunit Med28 functions as a is_associated_with::repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth is_associated_with::muscle is_associated_with::cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle is_associated_with::tumours.