OTUD6B

OTU domain containing 6B is a is_associated_with::protein that in humans is encoded by the OTUD6B is_associated_with::gene.

OTUD6B is a functional is_associated_with::deubiquitinating enzyme, a class of is_associated_with::protease that specifically cleaves is_associated_with::ubiquitin linkages, negating the action of is_associated_with::ubiquitin ligases. OTUD6B, also known as DUBA5, belongs to a DUB subfamily characterized by an is_associated_with::ovarian tumor domain (OTU).

Model organisms
is_associated_with::Model organisms have been used in the study of OTUD6B function. A conditional is_associated_with::knockout mouse line, called Otud6btm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice, however no significant abnormalities were observed.