SKP1A

S-phase kinase-associated protein 1  is an is_associated_with::enzyme that in humans is encoded by the SKP1 is_associated_with::gene.

This gene encodes a is_associated_with::protein that is a member of the SCF is_associated_with::ubiquitin ligase is_associated_with::protein complex. It binds to is_associated_with::F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in is_associated_with::ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. is_associated_with::Alternative splicing of this gene results in two transcript variants. A related is_associated_with::pseudogene has been identified on chromosome 7.

Interactions
SKP1A has been shown to interact with:


 * BTRC,
 * is_associated_with::CACYBP,
 * is_associated_with::CDCA3,
 * is_associated_with::CDK9,
 * is_associated_with::CUL1,
 * is_associated_with::FBXL3,
 * is_associated_with::FBXO4,
 * is_associated_with::FBXO5,
 * is_associated_with::FBXO7,
 * is_associated_with::FBXW2,
 * is_associated_with::FBXW7, and
 * is_associated_with::SKP2.