INTS12

Integrator complex subunit 12 (Int12) also known as PHD finger protein 22 (PHF22) is a is_associated_with::protein that in humans is encoded by the INTS12 is_associated_with::gene.

INTS12 is a subunit of the is_associated_with::Integrator complex, which associates with the C-terminal domain of is_associated_with::RNA polymerase II large subunit (is_associated_with::POLR2A) and mediates 3-prime end processing of small nuclear RNAs U1 (is_associated_with::RNU1) and U2 (is_associated_with::RNU2)

Model organisms
is_associated_with::Model organisms have been used in the study of INTS12 function. A conditional is_associated_with::knockout mouse line, called Ints12tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty seven tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. No is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no additional significant abnormalities were observed in these animals.