Nuclear receptor coactivator 2

The nuclear receptor coactivator 2 also known as NCoA-2 is a is_associated_with::protein that in humans is encoded by the NCOA2 is_associated_with::gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function
NCoA-2 is a transcriptional coregulatory protein that contains several is_associated_with::nuclear receptor interacting domains and an intrinsic is_associated_with::histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.

GRIP1 is a transcriptional is_associated_with::co-activator of the is_associated_with::glucocorticoid receptor and interferon regulatory factor 1 (is_associated_with::IRF1).

Interactions
Nuclear receptor coactivator 2 has been shown to interact with:


 * AR,
 * ARNT,
 * is_associated_with::BRCA1,
 * is_associated_with::DDX17,
 * is_associated_with::DDX5,
 * ESR1,
 * NR3C1,
 * is_associated_with::PPFIA4,
 * PPARG,
 * RXRA,
 * is_associated_with::SRA1, and
 * VDR.