TRPV2

Transient receptor potential cation channel subfamily V member 2 is a is_associated_with::protein that in humans is encoded by the TRPV2 is_associated_with::gene.

Function
This gene encodes an is_associated_with::ion channel that is activated by high temperatures above 52 °C. The protein may be involved in transduction of high-temperature heat responses in sensory is_associated_with::ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat.

History
TRPV2 was independently discovered by two research groups and described in 1999. It was identified in the lab of David Julius as a close homolog of is_associated_with::TRPV1, the first identified thermosensitive ion channel. The group of Itaru Kojima from is_associated_with::Gunma University was looking for a protein which is responsible for the entry of calcium into cells in response to is_associated_with::insulin-like growth factor-1 (IGF-1). Upon stimulation of cells with IGF-1 TRPV2 translocates towards and integrates into the cell membrane and increases intracellular calcium concentrations.

Activators and inhibitors
TRPV2 is activated by high temperatures above 52 °C. Alternatively it can be activated at lower temperatures by chemicals, such as the research tool is_associated_with::2-APB, the plant cannabinoid is_associated_with::cannabidiol, and is_associated_with::probenecid. It is blocked by is_associated_with::ruthenium red and is_associated_with::lanthanum.