Rs5277

rs5277 is a SNP in the prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) PTGS2 gene, also known as COX-2.

A meta-analysis involving nine studies with 6,968 breast cancer cases and 9,126 controls found just a borderline significant increased risk (of breast cancer) in a recessive model (odds ratio 1.217, CI: 0.958-1.547, p = 0.107).

Cyclooxygenase-2 polymorphisms in Parkinson's disease.

A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study.

Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population.

Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies.

Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.

Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study.

Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study.

Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.

Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk.

No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk.

Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China.