H2AFY

Core histone macro-H2A.1 is a is_associated_with::protein that in humans is encoded by the H2AFY is_associated_with::gene.

Function
is_associated_with::Histones are basic nuclear is_associated_with::proteins that are responsible for the is_associated_with::nucleosome structure of the chromosomal fiber in is_associated_with::eukaryotes. Nucleosomes consist of approximately 146 bp of is_associated_with::DNA wrapped around a is_associated_with::histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The is_associated_with::chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable is_associated_with::X chromosome inactivation. is_associated_with::Alternative splicing results in multiple is_associated_with::transcript variants encoding different isoforms. Expression of these isoforms is associated to several cancers, such as hepatocellular carcinoma.