GEMIN8

Gem-associated protein 8 (Gemin-8) is a is_associated_with::protein that in humans is encoded by the GEMIN8 is_associated_with::gene.

Function
Gemin-8 is part of the SMN complex, which is necessary for spliceosomal is_associated_with::snRNP assembly in the cytoplasm and pre-mRNA splicing in the nucleus. Gemin-8 binds to both is_associated_with::SMN1 and the GEMIN6 / GEMIN7 heterodimer, mediating their interaction. This protein is found in nuclear Gemini of Cajal bodies (gems) and in the is_associated_with::cytoplasm. Three transcript variants encoding the same protein have been found for this gene.