HARS

Histidyl-tRNA synthetase (HARS) also known as is_associated_with::histidine-tRNA ligase, is an is_associated_with::enzyme which in humans is encoded by the HARS is_associated_with::gene.

Function
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate is_associated_with::amino acids. The protein encoded by this gene is a is_associated_with::cytoplasmic enzyme which belongs to the class II family of is_associated_with::aminoacyl tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of is_associated_with::histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter.

Clinical significance
The gene product is a frequent target of autoantibodies in the human autoimmune disease is_associated_with::polymyositis/is_associated_with::dermatomyositis.

Interactions
HARS has been shown to interact with is_associated_with::EEF1B2 and is_associated_with::EEF1G.