KIRREL3

Kin of IRRE-like protein 3 (KIRREL3) also known as kin of irregular chiasm-like protein 3 or nephrin-like protein 2 (NEPH2) is a is_associated_with::protein that in humans is encoded by the KIRREL3 is_associated_with::gene.

NEPH2 is a member of the nephrin-like protein family of is_associated_with::transmembrane proteins, which includes NEPH1 (is_associated_with::KIRREL) and NEPH3 (is_associated_with::KIRREL2). The nephrin-like proteins can interact with is_associated_with::nephrin and is_associated_with::CASK.

Function
NEPH2 has been implicated in is_associated_with::synapse formation. Disruption of KIRREL3 gene function had been associated with abnormal is_associated_with::brain function.

NEPH1 and NEPH2 are involved in the blood filtration function of the is_associated_with::kidney and are located in the is_associated_with::slit diaphragm.