Nephrin

Nephrin is a is_associated_with::protein necessary for the proper functioning of the renal filtration barrier. The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, and the is_associated_with::podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of the slit diaphragm.

A defect in the gene for nephrin, NPHS1, is associated with is_associated_with::congenital nephrotic syndrome of the Finnish type and causes massive amounts of protein to be leaked into the urine, or is_associated_with::proteinuria. Nephrin is also required for cardiovascular development.

Interactions
Nephrin has been shown to interact with:
 * is_associated_with::CASK,
 * is_associated_with::CD2AP,
 * CDH3 and
 * is_associated_with::CTNND1,
 * is_associated_with::FYN,
 * is_associated_with::KIRREL,  and
 * is_associated_with::NPHS2.