MED12

Mediator of RNA polymerase II transcription, subunit 12 homolog (S. cerevisiae), also known as MED12, is a human is_associated_with::gene found on the is_associated_with::X chromosome.

Clinical significance
Mutations in MED12 are responsible for at least two different forms of is_associated_with::X-linked dominant is_associated_with::mental retardation, is_associated_with::Lujan-Fryns syndrome and is_associated_with::FG syndrome, as well as instances of prostate cancer.

Mutations in MED12 are associated to uterine leiomyomas.

Interactions
MED12 has been shown to interact with:


 * is_associated_with::Calcitriol receptor,
 * is_associated_with::Cyclin-dependent kinase 8
 * is_associated_with::Estrogen receptor alpha,
 * is_associated_with::Gli3, is_associated_with::G9a, is_associated_with::PPARGC1A,
 * is_associated_with::MED26,
 * is_associated_with::SOX9, and
 * is_associated_with::Thyroid hormone receptor alpha.