CUL1

Cullin 1, also known as CUL1, is a human protein and is_associated_with::gene from is_associated_with::cullin family.

This protein plays an important role in is_associated_with::protein degradation and protein is_associated_with::ubiquitination.

This is an essential component of the SCF (is_associated_with::SKP1-CUL1-is_associated_with::F-box protein) E3 is_associated_with::ubiquitin ligase complex, which mediates the is_associated_with::ubiquitination of proteins involved in is_associated_with::cell cycle progression, is_associated_with::signal transduction and transcription. In the is_associated_with::SCF complex, it serves as a rigid scaffold that organizes the SKP1-F-box protein and is_associated_with::RBX1 subunits. May contribute to catalysis through positioning of the substrate and the is_associated_with::ubiquitin-conjugating enzyme.

This protein is a part of a SCF complex consisting of CUL1, is_associated_with::RBX1, is_associated_with::SKP1 and is_associated_with::SKP2. It also interacts with is_associated_with::RNF7. Part of a complex with is_associated_with::TIP120A/is_associated_with::CAND1 and is_associated_with::RBX1. The unneddylated form interacts with TIP120A/CAND1 and the interaction negatively regulates the association with SKP1 in the SCF complex. Interacts with is_associated_with::COPS2. It is expressed in lung is_associated_with::fibroblasts.

The protein is neddylated, which enhances the ubiquitination activity of SCF. Deneddylated via its interaction with the is_associated_with::COP9 signalosome (CSN) complex.