PDE10A

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A is an is_associated_with::enzyme that in humans is encoded by the PDE10A is_associated_with::gene.

Various cellular responses are regulated by the second messengers cAMP and cGMP. is_associated_with::Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.

Inhibitors

 * Compound 96: IC50 = 700 pM, high selectivity against all other members of the PDE family
 * is_associated_with::Papaverine
 * is_associated_with::PF-2545920
 * TAK-063: IC50 = 300 pM
 * AMG 579