RAMP1

Receptor activity modifying protein 1 is a is_associated_with::protein that in humans is encoded by the RAMP1 is_associated_with::gene.

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular is_associated_with::N terminus and a cytoplasmic is_associated_with::C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a is_associated_with::calcitonin gene-related peptide (CGRP) receptor or an is_associated_with::adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. The RAMP1 protein can also interact with the is_associated_with::calcitonin receptor (CT) protein, where is_associated_with::heteromerisation of RAMP1 with CT converts CT from a is_associated_with::calcitonin receptor to the is_associated_with::amylin receptor AMY1