Rs80359675

rs80359675, also known as 999del5, c.771_775delTCAAA and p.Asn257_Arg259?fs, is a variant in the BRCA2 gene considered pathogenic for breast cancer in ClinVar.rs80359675, aka 999del5, represents a 5bp deletion in the BRCA2 gene on chromosome 13. An alternative rs# for this same deletion is rs80359671. The BRCA2 999del5 deletion has been associated with significantly increased risk for breast cancer as well as some other cancers, at least in certain populations. For more information, see OMIM 600185.0010.