Rs12097901

rs12097901, also known as c.380G>C or Cys127Ser, is a SNP in the EGLN1 egl-9 family hypoxia-inducible factor 1 gene. The EGLN1 gene encodes prolyl hydroxylase 2 (PHD2) protein.

Along with another SNP seen frequently primarily in Tibetans, rs186996510, this SNP is reported to have arisen ~8,000 years ago as an adaptation protecting Tibetans from hypoxia at the high altitudes they inhabit.