Von Willebrand factor type C domain

Von Willebrand factor, type C is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII, XII and XIV; and other extracellular proteins.

Function
Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome.

A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands.

Mutation effects
A number of human diseases arise from mutations in VWA domains.

The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. For the von Willebrand factor the duplicated VWFC domain is thought to participate in oligomerization, but not in the initial dimerization step. The presence of this region in a number of other complex-forming proteins points to the possible involvement of the VWFC domain in complex formation.

Human proteins containing this domain
BMPER;    CHRD;      CHRDL1;    CHRDL2;    COL1A1;    COL2A1;    COL3A1;    COL5A2; CRIM1;    CTGF;      CYR61;     ECM2;      FKSG37;    FRAS1;     MUC2;      MUC5B; NELL1;    NELL2;     NOV;       PXDNL;     SSPO;      THBS1;     THBS2;     VWC2; VWCE;     VWF;       WISP1;     WISP2;