Rs858518

is a SNP in the sex-hormone binding globulin (SHBG) gene. SHBG binds steroid hormones, mostly testosterone and estradiol, rendering them biologically unavailable.

Ten SNPs within or close to the SHBG gene were significantly associated with SHBG levels as was the (TAAAA)(n) polymorphism. The best-fitting combination of rs6259, rs858521, and rs727428 and body mass index, waist, hip, age, and smoking status accounted for 24% of the variance in SHBG levels (natural logarithm transformed).