TRPC4AP

Trpc4-associated protein is a is_associated_with::protein that in humans is encoded by the TRPC4AP is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of TRPC4AP function. A conditional is_associated_with::knockout mouse line, called Trpc4aptm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. Few is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation, and thus fewer than expected survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; females had an abnormal is_associated_with::anagen phase of the hair cycle.

Interactions
TRPC4AP has been shown to interact with is_associated_with::TNFRSF1A.