Mir-145

In molecular biology, mir-145 microRNA is a short RNA molecule that in humans is encoded by the MIR145 is_associated_with::gene. is_associated_with::MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Targets
MicroRNAs are involved in down-regulation of a variety of target genes. Götte et al. have shown that experimental over-expression of mir-145 down-regulates the junctional cell adhesion molecule is_associated_with::JAM-A as well as the actin bundling protein fascin. Larsson et al. showed that miR-145 targets the 3' UTR of the is_associated_with::FLI1 gene, a finding that was later supported by Zhang et al.

Role in cancer
miR-145 is hypothesised to be a is_associated_with::tumor suppressor. miR-145 has been shown to be down-regulated in is_associated_with::breast cancer. miR-145 is also involved in colon cancer.