TP53RK

TP53-regulating kinase, also known as PRPK is an is_associated_with::enzyme that in humans is encoded by the TP53RK is_associated_with::gene. This protein is a serine/threonine protein kinase that phosphorylates is_associated_with::p53 at Ser15.

PRPK is part of the is_associated_with::KEOPS/EKC complex, which participates in transcription control, telomere regulation and tRNA modification.

Model organisms
is_associated_with::Model organisms have been used in the study of TP53RK function. A conditional is_associated_with::knockout mouse line called Trp53rktm1a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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