PTCH2

Patched 2 is a is_associated_with::protein that in humans is encoded by the PTCH2 is_associated_with::gene.

Function
This gene encodes a transmembrane receptor of the is_associated_with::patched gene family. The encoded protein may function as a is_associated_with::tumor suppressor in the is_associated_with::hedgehog signaling pathway.

Clinical significance
Alterations in this gene have been associated with is_associated_with::nevoid basal cell carcinoma syndrome, is_associated_with::basal cell carcinoma, is_associated_with::medulloblastoma, and susceptibility to congenital is_associated_with::macrostomia.