PDS5B

Sister chromatid cohesion protein PDS5 homolog B is a is_associated_with::protein that in humans is encoded by the PDS5B is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PDS5B function. A conditional is_associated_with::knockout mouse line, called Pds5btm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out and two is_associated_with::phenotypes were reported. Almost all is_associated_with::homozygous is_associated_with::mutant animals died prior to birth, and therefore they did not survive until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant mice, and no significant abnormalities were observed.