HP1BP3

Heterochromatin protein 1, binding protein 3 is a is_associated_with::protein that in humans is encoded by the HP1BP3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of HP1BP3 function. A conditional is_associated_with::knockout mouse line, called Hp1bp3tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty three tests were carried out and six significant is_associated_with::phenotypes were reported. Fewer is_associated_with::homozygous is_associated_with::mutant embryos were identified during gestation than predicted by is_associated_with::Mendelian ratio. Homozygous mutant female adults had decreased body weight, heart weight and is_associated_with::bone mineral density, and increased blood is_associated_with::urea levels and is_associated_with::T cell number.