RAPGEF2

Rap guanine nucleotide exchange factor 2 is a is_associated_with::protein that in humans is encoded by the RAPGEF2 is_associated_with::gene.

RAPGEF2 is a is_associated_with::cyclic AMP binding protein.

Function
Members of the RAS subfamily of is_associated_with::GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. is_associated_with::Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation.

Interactions
RAPGEF2 has been shown to interact with is_associated_with::RAP1A and is_associated_with::RALGDS.