TTC8

Tetratricopeptide repeat domain 8 (TTC8) also known as Bardet-Biedl syndrome 8 is a is_associated_with::protein that in humans is encoded by the TTC8 is_associated_with::gene.

Function
TTC8 is associated with gamma-tubulin, is_associated_with::BBS4, and is_associated_with::PCM1 in the is_associated_with::centrosome. PCM1 in turn is involved in centriolar replication during ciliogenesis.

TTC8 is located in the cilia of is_associated_with::spermatids, is_associated_with::retina, and bronchial is_associated_with::epithelium cells.

Clinical significance
Mutations in the TTC8 gene is one of 14 genes identified as causal for is_associated_with::Bardet-Biedl syndrome.