PON3

Paraoxonase 3, also known as PON3, is a is_associated_with::protein which in humans is encoded by the PON3 is_associated_with::gene.

Function
This gene is a member of the is_associated_with::paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes is_associated_with::lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of is_associated_with::atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.