Feline sarcoma oncogene

Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an is_associated_with::enzyme that in humans is encoded by the FES is_associated_with::gene. FES was originally cloned as a retroviral oncogene from feline (v-FES) and avian (v-FPS) sarcomas. This triggered the subsequent identification and cloning of the cellular FES (c-FES) genes (also referred to as FPS) in birds and mammals.

Function
This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of is_associated_with::cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with is_associated_with::acute promyelocytic leukemia but it is also involved in normal is_associated_with::hematopoiesis. A truncated transcript has been identified that is generated utilizing a start site in one of the far downstream exons but a protein product associated with this transcript has not been identified.

Interactions
Feline sarcoma oncogene has been shown to interact with is_associated_with::BCAR1 and is_associated_with::BCR gene.