PCGEM1

Prostate-specific transcript 1 (non-protein coding), also known as PCGEM1, is a is_associated_with::long non-coding RNA is_associated_with::gene. In humans, it is located on is_associated_with::chromosome 2q32. It is over-expressed in is_associated_with::prostate cancer. In a study of prostate tumours from 88 men, levels of PCGEM1 were found to be higher in prostate cancer cells in is_associated_with::African-American men than in is_associated_with::Caucasian-American men. The mortality rate of prostate cancer is highest in African-American men.

PCGEM1 inhibits is_associated_with::doxorubicin-induced is_associated_with::apoptosis of cells, via delayed induction of is_associated_with::p53 and is_associated_with::p21.