HNRNPL

Heterogeneous nuclear ribonucleoprotein L is a is_associated_with::protein that in humans is encoded by the HNRNPL is_associated_with::gene.

Function
is_associated_with::Heterogeneous nuclear RNAs (hnRNAs) which include is_associated_with::mRNA precursors and mature mRNAs are associated with specific proteins to form heterogeneous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the is_associated_with::cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene.

Interactions
HNRNPL has been shown to interact with:
 * is_associated_with::HNRNPLL,
 * is_associated_with::HNRPK,
 * is_associated_with::PCBP2, and
 * is_associated_with::PTBP1.