DPH1

Diphthamide biosynthesis protein 1 is a is_associated_with::protein that in humans is encoded by the DPH1 is_associated_with::gene. It encodes a protein that performs is_associated_with::posttranslational modification of is_associated_with::histidine-715 on eukaryotic translation elongation factor 2 to is_associated_with::diphthamide. This modification appears to be important in the translation of is_associated_with::Cyclin D in ovarian cells. DPH1 is mutated in 90% of is_associated_with::ovarian cancers end stage, usually by is_associated_with::loss of heterozygosity.