BBX (gene)

HMG box transcription factor BBX also known as bobby sox homolog or HMG box-containing protein 2 is a is_associated_with::protein that in humans is encoded by the BBX is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of BBX function. A conditional is_associated_with::knockout mouse line, called Bbxtm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program, a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice and four significant abnormalities were observed. A study of body composition found decreases in is_associated_with::bone mineral density and content, and a reduction in body length in female mice, while mutants of both sexes showed a reduction in is_associated_with::lean body mass. Radiography found that males had abnormal teeth morphology. Females had a decreased heart weight, and both sexes had reduced is_associated_with::IgA levels in their plasma.