AUP1

Ancient ubiquitous protein 1 is a is_associated_with::protein that in humans is encoded by the AUP1 is_associated_with::gene.

Function
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the is_associated_with::archain 1 gene and a domain that may be involved in binding is_associated_with::ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in is_associated_with::platelets and is_associated_with::megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial is_associated_with::serine protease 25.

Interactions
AUP1 has been shown to interact with is_associated_with::ITGA2B.