ACER1

Alkaline ceramidase 1 also known as ACER1 is a is_associated_with::ceramidase enzyme which in humans is encoded by the ACER1 is_associated_with::gene.

Function
ACER1 mediates is_associated_with::cellular differentiation by controlling the generation of is_associated_with::sphingosine (SPH) and is_associated_with::sphingosine-1-phosphate (S1P).

Model organisms
is_associated_with::Model organisms have been used in the study of ACER1 function. A conditional is_associated_with::knockout mouse line called Acer1tm1a(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping