TNFSF14

Tumor necrosis factor ligand superfamily member 14 is a is_associated_with::protein that in humans is encoded by the TNFSF14 is_associated_with::gene. TNFSF14 has also been designated as CD258, as well as LIGHT.

Interactions
TNFSF14 has been shown to interact with is_associated_with::TNFRSF14, is_associated_with::TNFRSF6B,  is_associated_with::BIRC2, is_associated_with::TRAF2 and is_associated_with::TRAF3.

Role in herpes simplex virus
Similar to how is_associated_with::CD4 is the primary mediating receptor in HIV infection, the HSV glycoprotein (gD) binds to the is_associated_with::HVEM receptor which is demanded by TNFSF14/LIGHT lowering the ability for LIGHT to activate the is_associated_with::NFκB pathway. NFκB is a survival factor helping to inhibit apoptosis which triggers a pathway inhibiting is_associated_with::caspase 8. When gD from HSV binds to HVEM, LIGHT is non-competitively inhibited from binding, encouraging apoptosis in the infected cell.