Rs699

rs699 is a SNP in the angiotensin AGT gene that encodes a functional change. In most published literature, the name for this SNP is M235T, or perhaps Met235Thr, however its amino acid 268 (not 235) that varies based on the numbering in todays databases. rs699 is also occasionally known as C4072T.

In any case, the rs699(C) allele encodes the threonine variant, which is associated with higher plasma angiotensin levels, and ultimately higher blood pressure leading to increased risk for hypertension associated disorders.

This association was first reported in 1992, and many studies, though not all, have replicated these findings.

rs699 is also (generally) reported to be in tight linkage with rs5051, a neighboring SNP in the promoter of the AGT gene.

rs699(C) has also been implicated as a risk allele in at least two Caucasian populations for pre-eclampsia (pregnancy-induced hypertension)[PMID 8513325, PMID 8348146] but did not present a risk in one African population.

A haplotype of rs4311, rs4343, rs699 increases risk of diabetic nephropathy 4x.