CCL12

Chemokine (C-C motif) ligand 12 (CCL12) is a small is_associated_with::cytokine belonging to the CC is_associated_with::chemokine family that has been described in mice. It is also known as monocyte chemotactic protein 5 (MCP-5) and, due to its similarity with the human chemokine MCP-1, sometimes it is called MCP-1-related chemokine. CCL12 specifically attracts is_associated_with::eosinophils, is_associated_with::monocytes and is_associated_with::lymphocytes. This chemokine is found predominantly in is_associated_with::lymph nodes and is_associated_with::thymus under normal conditions, and its expression can be hugely induced in macrophages. It is thought to coordinate cell movements during early is_associated_with::allergic reactions, and immune response to pathogens. The is_associated_with::gene for CCL12 is found in a cluster of CC chemokines on mouse is_associated_with::chromosome 11.