PA2G4

Proliferation-associated protein 2G4 (PA2G4) also known as ErbB3-binding protein 1 (EBP1) is a is_associated_with::protein that in humans is encoded by the PA2G4 is_associated_with::gene.

Function
This gene encodes an is_associated_with::RNA-binding protein that is involved in growth regulation. This protein is present in pre-is_associated_with::ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional is_associated_with::corepressor of is_associated_with::androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with is_associated_with::histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified.

Interactions
PA2G4 has been shown to interact with is_associated_with::ERBB3, is_associated_with::retinoblastoma protein, and is_associated_with::androgen receptor.