DFNB31

Whirlin is a is_associated_with::protein that in humans is encoded by the DFNB31 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of WHRN function. A conditional is_associated_with::knockout mouse line, called Whrntm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. Whrntm1a(EUCOMM)Wtsi is_associated_with::homozygote mice show a moderate to severe is_associated_with::hearing loss at 14 weeks. Female homozygous mutant animals also displayed an increased thermal nociceptive threshold in a is_associated_with::hot plate test.