IFI16

Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a is_associated_with::protein that in humans is encoded by the IFI16 is_associated_with::gene.

Function
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of is_associated_with::cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the is_associated_with::nucleoplasm and nucleoli, and interacts with is_associated_with::p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. IFI16 has been shown to play a role in the sensing of intracellular is_associated_with::DNA - a hallmark of virally infected cells - and has also been linked to is_associated_with::HIV-infected is_associated_with::helper T-cell is_associated_with::pyroptosis.