HCK

Tyrosine-protein kinase HCK is an is_associated_with::enzyme that in humans is encoded by the HCK is_associated_with::gene.

Function
The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types, and belongs to the Src family of tyrosine kinases. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization.

Interactions
HCK has been shown to interact with is_associated_with::BCR gene, is_associated_with::ELMO1, is_associated_with::Cbl gene,  is_associated_with::RAS p21 protein activator 1, is_associated_with::RASA3, is_associated_with::Granulocyte colony-stimulating factor receptor, is_associated_with::ADAM15 and is_associated_with::RAPGEF1.