Rs1801278

The INSR A-603G promoter rs1864010 SNP, which is located within a known Sp1-binding site, was associated with the risk of colorectal cancer, with carriers of the G allele having a decreased risk (odds ratios (OR) 0.71, 95% confidence interval (CI) 0.54-0.93). Carrying the variant allele of the IRS1 Gly972Arg rs1801278 SNP further decreased the risk among the INSR-603G allele carriers (OR 0.28, 95% CI 0.11-0.70)

multiple myeloma
 * rs1801278 [C/T versus C/C genotypes; OR, 4.3; 95% confidence interval (CI), 1.5-12.1]
 * rs6684439 (T/T versus C/C; OR, 2.9; 95% CI, 1.2-7.0)
 * rs7529229 (C/C versus T/T; OR, 2.5; 95% CI, 1.1-6.0)
 * rs8192284 (C/C versus A/A; OR, 2.5, 95% CI, 1.1-6.0)


 * is_associated_with_disease::Alzheimer's disease
 * is_associated_with_disease::Hereditary breast ovarian cancer
 * is_associated_with_disease::Gestational diabetes
 * is_associated_with_disease::Type 2 diabetes mellitus
 * is_associated_with_disease::Breast cancer
 * is_associated_with_disease::Ovarian cancer
 * is_associated_with_disease::Polycystic ovary syndrome
 * is_associated_with_disease::Colorectal cancer
 * is_associated_with_disease::Multiple myeloma