UBE2I

SUMO-conjugating enzyme UBC9 is a is_associated_with::protein that in humans is encoded by the UBE2I is_associated_with::gene.

Function
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene.

Interactions
UBE2I has been shown to interact with:


 * ATF2,
 * is_associated_with::Androgen receptor,
 * is_associated_with::BLMH,
 * is_associated_with::DACH1,
 * is_associated_with::DNMT3A,
 * is_associated_with::DNMT3B,
 * DAXX,
 * is_associated_with::ETS1,
 * is_associated_with::FHIT,
 * is_associated_with::IPO13,
 * is_associated_with::MAP3K1 and
 * MITF,
 * is_associated_with::P53,
 * is_associated_with::PIAS1,
 * PIAS2,
 * is_associated_with::RAD51,
 * is_associated_with::RANBP2,
 * is_associated_with::RANGAP1,
 * is_associated_with::SAE2,
 * is_associated_with::SALL1,
 * SUMO1,
 * is_associated_with::TCF3,
 * is_associated_with::TNFRSF1A,
 * is_associated_with::TOP1, and
 * is_associated_with::WT1.