KDM4C

Lysine-specific demethylase 4C is an is_associated_with::enzyme that in humans is encoded by the KDM4C is_associated_with::gene.

Function
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two is_associated_with::Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.

Model organisms
is_associated_with::Model organisms have been used in the study of KDM4C function. A conditional is_associated_with::knockout mouse line, called Kdm4ctm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. is_associated_with::Homozygous mutant males had decreased is_associated_with::haematocrit and is_associated_with::haemoglobin levels, while animals of both sex displayed an increase in is_associated_with::sebaceous gland size.