Rs1801282

rs1801282, also known as Pro12Ala, is a common SNP in the peroxisome proliferator-activated receptor PPARG gene. The more common (C) allele (in dbSNP orientation) encodes the 'Pro' amino acid at this SNP position.

rs1801282 has been reported to be associated with metabolic syndrome, but other studies have not been able to replicate any strong or significant effect.

The association between type-2 diabetes and SNP rs1801282 is mentioned as being replicated in

rs1801282 and risk of cognitive decline in elders? Maybe with diabetes.

A ten-year study of 679 male patients with symptomatic coronary artery disease found that rs1801282(G) carriers had a much lower (10 year) cardiovascular risk, with the hazard ratio estimated to be 0.10 (CI: 0.01-0.70, p = 0.02) for ischemic heart disease and 0.24 for vascular death (CI: 0.08-0.74, p = 0.013) per copy of the allele.

23andMe blog carriers could be informed that they really need to watch out for high fat in their diets

Response to Diet and Exercise