Globotriaosylceramide

Globotriaosylceramide is a ganglioside.

It is also known as "CD77". It is one of the few clusters of differentiation that is not a protein.

It is also known as "ceramide trihexoside".

It is formed by A4GALT.

It is metabolized by Alpha-galactosidase.

Clinical significance
Defects in the enzyme alpha-galactosidase lead to the build up of globotriaosylceramide, and this is the cause of Fabry's disease.

Globotriaosylceramide is also the one of the targets of Shiga toxin, which is responsible for pathogenicity of Escherichia coli.