PTPRN

Receptor-type tyrosine-protein phosphatase-like N is an is_associated_with::enzyme that in humans is encoded by the PTPRN is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::protein tyrosine phosphatase (PTP) family. PTPs are known to be is_associated_with::signaling molecules that regulate a variety of cellular processes including is_associated_with::cell growth, differentiation, mitotic cycle, and is_associated_with::oncogenic transformation. This PTP possesses an is_associated_with::extracellular region, a single is_associated_with::transmembrane region, and a single is_associated_with::catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an is_associated_with::autoantigen that is reactive with is_associated_with::insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of is_associated_with::autoimmunity in diabetes mellitus.

Interactions
PTPRN has been shown to interact with is_associated_with::SPTBN4.