XPB

XPB (is_associated_with::xeroderma pigmentosum type B) is an ATP-dependent is_associated_with::DNA is_associated_with::helicase in humans that is a part of the is_associated_with::TFIIH is_associated_with::transcription factor complex.

Structure
The 3D-structure of the archaeal homolog of XPB has been solved by X-ray crystallography by Dr. John Tainer and his group at is_associated_with::The Scripps Research Institute.

Function
XPB plays a significant role in normal basal transcription, is_associated_with::transcription coupled repair (TCR), and is_associated_with::nucleotide excision repair (NER). Purified XPB has been shown to unwind DNA with 3’-5’ polarity.

Disorders
Mutations in XPB and other related complementation groups, XPA-XPG, leads to a number of genetic disorders such as is_associated_with::Xeroderma pigmentosum, is_associated_with::Cockayne's syndrome, and is_associated_with::trichothiodystrophy.

Interactions
XPB has been shown to interact with:


 * is_associated_with::BCR gene,
 * CDK7,
 * is_associated_with::ERCC2,
 * is_associated_with::GTF2H1,
 * is_associated_with::GTF2H2,
 * is_associated_with::GTF2H4,
 * is_associated_with::GTF2H5,
 * is_associated_with::P53,
 * is_associated_with::PSMC5, and
 * XPC.