IMPDH1

Inosine-5'-monophosphate dehydrogenase 1, also known as IMP dehydrogenase 1, is an is_associated_with::enzyme that in humans is encoded by the IMPDH1 is_associated_with::gene.

Function
IMP dehydrogenase 1 acts as a homotetramer to regulate cell growth. IMPDH1 is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides.

Clinical significance
Defects in the IMPDH1 gene are a cause of is_associated_with::retinitis pigmentosa type 10 (RP10).