Beta-synuclein

Beta-synuclein is a is_associated_with::protein that in humans is encoded by the SNCB is_associated_with::gene.

Beta-synuclein is a is_associated_with::synuclein is_associated_with::protein found primarily in brain tissue and is seen mainly in is_associated_with::presynaptic terminals. Beta-synuclein is predominantly expressed in the is_associated_with::neocortex, is_associated_with::hippocampus, is_associated_with::striatum, is_associated_with::thalamus, and is_associated_with::cerebellum. It is not found in Lewy bodies, but it is associated with hippocampal pathology in PD and DLB.

Beta-synuclein is suggested to be an inhibitor of is_associated_with::alpha-synuclein aggregation, which occurs in is_associated_with::neurodegenerative diseases such as is_associated_with::Parkinson's disease. Thus, beta-synuclein may protect the is_associated_with::central nervous system from the neurotoxic effects of alpha-synuclein and provide a novel treatment of neurodegenerative disorders.