Rs17300539

rs17300539, also known as -11391 G/A, is a SNP in the promoter of the adiponectin ADIPOQ gene.

A small study of 180 Spanish patients with obesity concluded that rs17300539(G;G) individuals are at increased risk of insulin resistance and MetS complications compared to carriers of an (A) allele. The rs17300539(A) allele confered protection from weight regain, particularly at 32-60 weeks after the low-calorie dietary intervention, when improvement in GG subjects had disappeared

adiponectin levels and risk of diabetes rs17300539 P(n) = 2.6 x 10(-8) and rs822387 (P(n) = 3.8 x 10(-5)