AEBP2

Adipocyte Enhancer-Binding Protein is a is_associated_with::zinc finger protein that in humans is encoded by the evolutionarily well-conserved is_associated_with::gene AEBP2. It was initially identified due to its binding capability to the promoter of the adipocyte P2 gene, and was therefore named Adipocyte Enhancer Binding Protein 2. AEBP2 is a potential targeting protein for the mammalian Polycomb Repression Complex 2 (PRC2).

Function
AEBP2 is a DNA-binding transcriptional is_associated_with::repressor. It may interact with and stimulate the activity of the PRC2 complex.

AEBP2 may regulate the migration and development of the is_associated_with::neural crest cells through the PRC2-mediated epigenetic mechanism and is most likely a targeting protein for the mammalian PRC2 complex.

Clinical significance
Diseases associated with AEBP2 include is_associated_with::Waardenburg's syndrome, and is_associated_with::Hirschsprung's disease.