Rs4633

rs4633 is a variant at codon 62 of the COMT gene, however, it does not change the amino acid sequence of the COMT protein.

In a study of 150 (Caucasian) cases of endometrial cancer, a significant increase in rs4633(T;T) genotype was observed in patients compared to controls (OR = 2.39, CI: 1.31-4.37, p = 0.004). Furthemore, the frequency of the C-G haplotype of rs4633-rs4680 was significantly higher in controls (p < 0.0001) than in patients. This correlated with lower expression levels of the COMT protein in carriers of these alleles.

pubmed 1180576 Schizophrenia Susceptibility

Genetic basis for individual variations in pain perception and the development of a chronic pain condition