STARD8

StAR-related lipid transfer domain protein 8 (STARD8) also known as deleted in liver cancer 3 protein (DLC-3) is a is_associated_with::protein that in humans is encoded by the STARD8 is_associated_with::gene and is a member of the DLC family.

Structure and function
The protein is 1103 amino acids long, which like other DLC proteins consists of a is_associated_with::sterile alpha motif (SAM), RhoGAP and a StAR-related lipid-transfer (START) domains.

The protein is a Rho GTPase-activating protein (GAP), a type of protein that regulates members of the is_associated_with::Rho family of GTPases. STARD8 is characterized as activating Rho GTPases. Its expression inhibits the growth of human breast and prostate cancer cells in culture.

Tissue distribution and pathology
The protein is expressed in tissues throughout the body, but is absent or reduced in many kinds of is_associated_with::tumor cells.

While there are no known disorders caused by STARD8, partial loss of the STARD8 gene occurs in cases of is_associated_with::craniofrontonasal syndrome where the is_associated_with::EFNB1 gene (which causes the syndrome) is completely deleted.

Model organisms
is_associated_with::Model organisms have been used in the study of STARD8 function. A conditional is_associated_with::knockout mouse line called Stard8tm1b(EUCOMM)Wtsi was generated at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping

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