Retinoic acid receptor alpha

Retinoic acid receptor alpha (RAR-α), also known as NR1B1 (nuclear receptor subfamily 1, group B, member 1) is a is_associated_with::nuclear receptor that in humans is encoded by the RARA is_associated_with::gene.

Function
is_associated_with::Retinoid signaling is transduced by 2 families of nuclear receptors, retinoic acid receptor (RAR) and retinoid X receptor (RXR), which form RXR/RAR heterodimers. In the absence of ligand, DNA-bound RXR/RARA represses transcription by recruiting the corepressors NCOR1, SMRT (NCOR2), and is_associated_with::histone deacetylase. When ligand binds to the complex, it induces a conformational change allowing the recruitment of coactivators, histone acetyltransferases, and the basic transcription machinery.

Clinical significance
Translocations that always involve rearrangement of the RARA gene are a cardinal feature of acute promyelocytic leukemia (APL; MIM 612376). The most frequent translocation is t(15,17)(q21;q22), which fuses the RARA gene with the PML gene.

Interactions
Retinoic acid receptor alpha has been shown to interact with:


 * is_associated_with::BAG1,
 * is_associated_with::CLOCK,
 * CCND3,
 * is_associated_with::NCOA6,
 * NCOR1,
 * NCOR2,
 * is_associated_with::NPAS2,
 * is_associated_with::NRIP1,
 * NR0B2,
 * NR4A2,
 * PML
 * RXRA.
 * Src,
 * is_associated_with::TADA3L, and
 * ZBTB16.