Rs8050894

rs8050894, is located on chromosome 16 in the gene VKORC1. VKORC1 is the primary target of the drug warfarin (Coumadin), a commonly used oral anticoagulant. rs8050894 is one of several polymorphisms found in VKORC1 that is associated with specific warfarin doses. Other polymorphisms in VKORC1 (rs7196161, rs9923231, rs9934438, rs2359612) are equally predictive of warfarin dose requirement in both European and Asian-descent individuals.

Other polymorphisms found in the gene cytochrome P450 2C9 (CYP2C9) influence the metabolism of warfarin and have a smaller effect on warfarin dose. These polymorphisms are rs1799853 (CYP2C9*2) and rs1057910 (CYP2C9*3).

In several hundred Europeans, no association was found between rs8050894 and risk for ischemic stroke.

Genetic-based dosing in orthopedic patients beginning warfarin therapy.

Evaluation of genetic factors for warfarin dose prediction.

Warfarin pharmacogenetics: CYP2C9 and VKORC1 genotypes predict different sensitivity and resistance frequencies in the Ashkenazi and Sephardi Jewish populations.

Use of pharmacogenetic and clinical factors to predict the therapeutic dose of warfarin.

Influence of CYP2C9 and VKORC1 on warfarin dose, anticoagulation attainment and maintenance among European-Americans and African-Americans.

Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

Warfarin dose and INR related to genotypes of CYP2C9 and VKORC1 in patients with myocardial infarction.

Warfarin pharmacogenetics.

Ethnic differences in cardiovascular drug response: potential contribution of pharmacogenetics.

VKORC1 polymorphisms, haplotypes and haplotype groups on warfarin dose among African-Americans and European-Americans.

Relative contribution of CYP2C9 and VKORC1 genotypes and early INR response to the prediction of warfarin sensitivity during initiation of therapy.

Estimation of the warfarin dose with clinical and pharmacogenetic data.

Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.

The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected.