PLS3

Plastin-3 is a highly conserved is_associated_with::protein that in humans is encoded by the PLS3 is_associated_with::gene on the X chromosome.

Function
Plastins are a family of is_associated_with::actin-binding proteins that are conserved throughout is_associated_with::eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as is_associated_with::Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in is_associated_with::hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the is_associated_with::N-terminus.

Clinical significance
Defects in PLS3 are associated with is_associated_with::osteoporosis and bone fracture in humans and in knockout zebrafish.