Rs242557

An initial case-control study of 300 patients with Alzheimer's disease found that subjects carrying both the rs2071746(T;T) and rs242557(A;A) genotypes had increased risk, however the confidence interval was huge (CI: 1.12-39.29; p = 0.037) and later studies have either failed to replicate the results or shown them to only partially hold in APOE4 carriers.

Reports that they found only "nominally significant" association between Alzheimer's and rs242557 in ApoE4 positive individuals.