Rs1805007

rs1805007, known as Arg151Cys or R151C, one of several SNPs in the MC1R gene associated with red hair color (redheads), and in redheaded females, linked to being more responsive to the anesthetics pentazocine, nalbuphine, and butorphanol, often used by dentists [PMID 9571181, PMID 12663858, PMID 18488028]

The risk allele is rs1805007(T), compared with the wild-type rs1805007(C) allele.

The risk allele has also been reported in several studies to be associated with increased risk for melanoma. For example, an odds ratio of 2.94 (CI: 1.04-8.31) has been reported for an Italian population, and similarly an odds ratio of 2.9 has been reported for a Polish population.

Blog entry about designing melanocortin analogs specific to these genotypes.

See also OMIM 155555.0004

Freckling