HDAC11

Histone deacetylase 11 is a 39kDa is_associated_with::histone deacetylase is_associated_with::enzyme that in humans is encoded by the HDAC11 is_associated_with::gene on chromosome 3 in humans and chromosome 6 in mice.

It is the only Class IV HDAC. (Class IV have characteristics of both class I and class II HDAC.) It was first described in 2002.

Interactions
HDAC11 has been shown to interact with is_associated_with::HDAC6.

Functions
HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.

HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.