CKAP5

Cytoskeleton-associated protein 5 is a is_associated_with::microtubule-associated protein that in humans is encoded by the CKAP5 is_associated_with::gene. It is the homolog of the is_associated_with::Xenopus protein XMAP215 and is also known as ch-Tog.

It has at least two distinct roles in spindle formation: it protects is_associated_with::kinetochore is_associated_with::microtubules from depolymerization by MCAK (is_associated_with::KIF2C), and ch-Tog plays an essential role in centrosomal microtubule assembly, a function independent of MCAK activity.

Interactions
CKAP5 has been shown to interact with is_associated_with::TACC1.