STX8

Syntaxin-8 is a is_associated_with::protein that in humans is encoded by the STX8 is_associated_with::gene. Syntaxin 8 directly interacts with is_associated_with::HECTd3 and has similar subcellular localization. The is_associated_with::protein has been shown to form the is_associated_with::SNARE complex with is_associated_with::syntaxin 7, is_associated_with::vti1b and is_associated_with::endobrevin. These function as the machinery for the is_associated_with::homotypic fusion of late is_associated_with::endosomes.

Model organisms
is_associated_with::Model organisms have been used in the study of STX8 function. A conditional is_associated_with::knockout mouse line, called Stx8tm2a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the is_associated_with::Wellcome Trust Sanger Institute. Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::homozygous is_associated_with::mutant adult mice, however no significant abnormalities were observed.

Interactions
STX8 has been shown to interact with is_associated_with::Vesicle-associated membrane protein 8, is_associated_with::VTI1B and is_associated_with::STX7.