NCOA6

Nuclear receptor coactivator 6 is a is_associated_with::protein that in humans is encoded by the NCOA6 is_associated_with::gene.

Function
The is_associated_with::protein encoded by this gene is a is_associated_with::transcriptional is_associated_with::coactivator that can interact with nuclear is_associated_with::hormone receptors to enhance their transcriptional activator functions. The encoded protein has been shown to be involved in the hormone-dependent coactivation of several receptors, including prostanoid, retinoid, vitamin D3, thyroid hormone, and is_associated_with::steroid receptors. The encoded protein may also act as a general coactivator since it has been shown to interact with some basal transcription factors, is_associated_with::histone acetyltransferases, and is_associated_with::methyltransferases.

Interactions
NCOA6 has been shown to interact with:


 * is_associated_with::ASCL2 and
 * is_associated_with::Activating transcription factor 2,
 * is_associated_with::Androgen receptor,
 * is_associated_with::CREB-binding protein,
 * is_associated_with::DNA-PKcs,
 * is_associated_with::E2F1,
 * is_associated_with::EP300,
 * is_associated_with::Estrogen receptor alpha,
 * is_associated_with::Estrogen receptor beta,
 * is_associated_with::HBXIP,
 * is_associated_with::HIST2H3C,
 * is_associated_with::HSF1,
 * is_associated_with::Ku70,
 * is_associated_with::Ku80,
 * is_associated_with::Liver X receptor beta,
 * is_associated_with::MLL3,
 * is_associated_with::RBBP5,
 * is_associated_with::Retinoblastoma protein,
 * is_associated_with::Retinoic acid receptor alpha,
 * is_associated_with::Retinoid X receptor alpha,
 * Src,
 * is_associated_with::TGS1,
 * is_associated_with::TUBA4A,
 * is_associated_with::TUBB,
 * is_associated_with::Thyroid hormone receptor alpha,  and
 * is_associated_with::Thyroid hormone receptor beta.