Rs74315403

This SNP codes for residue 178 of the Prion protein gene. Normally Aspartate, a polymorphism can create the D178N mutation which is linked to inherited Creutzfeldt-Jakob disease or Fatal Familial Insomnia. A number of factors influence this, including PrP codon 129, Rs1799990, with 129MM homozygotes being more likely to develop Fatal Familial Insomnia.