RSPO2

R-spondin 2 also known as roof plate-specific spondin-2 is a is_associated_with::protein that in humans that is encoded by the RSPO2 is_associated_with::gene.

R-spondin 2 synergizes with is_associated_with::Wnt to activate is_associated_with::beta-catenin. RSPO2 has been proposed to regulate is_associated_with::craniofacial patterning and is_associated_with::morphogenesis within is_associated_with::pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.

In dogs, the Rspo2 gene determines hair growth.