CD43

Leukosialin also known as sialophorin or CD43 (is_associated_with::cluster of differentiation 43) is a is_associated_with::transmembrane cell surface is_associated_with::protein that in humans is encoded by the SPN ( s ialo p hori n ) is_associated_with::gene.

Function
Sialophorin (leukosialin) is a major sialoglycoprotein on the surface of human is_associated_with::T lymphocytes, is_associated_with::monocytes, is_associated_with::granulocytes, and some is_associated_with::B lymphocytes, which appears to be important for immune function and may be part of a physiologic ligand-receptor complex involved in T-cell activation.

Clinical significance
Defects in the CD43 molecule are associated with the development of is_associated_with::Wiskott-Aldrich syndrome. It also appears in about 25% of intestinal MALTomas. Using is_associated_with::immunohistochemistry, CD43 can be demonstrated in the paracortical T-cells of healthy lymph nodes and tonsils; it is also positive in a range of lymphoid and myeloid tumours. Although it is present in over 90% of T-cell is_associated_with::lymphomas, it is generally less effective at demonstrating this condition than is CD3 antigen. However, it may be useful as part of a panel to demonstrate B-cell is_associated_with::lymphoblastic lymphoma, since the malignant cells in this condition are often CD43 positive, and may be difficult to stain with other antibodies. Because it stains granulocytes and their precursors, it is also an effective marker for myeloid tumours.

Interactions
CD43 has been shown to interact with EZR and is_associated_with::Moesin.