Kaptin (actin binding protein)

Kaptin is a is_associated_with::protein that in humans is encoded by the KPTN is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of KPTN function. A conditional is_associated_with::knockout mouse line, called Kptntm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty two tests were carried out on is_associated_with::mutant mice and six significant abnormalities were observed. is_associated_with::Homozygous mutant mice had is_associated_with::hyperalbuminemia, decreased mature is_associated_with::B cell numbers and increased susceptibility to is_associated_with::bacterial infection. Female mice also had increased body weight, body fat and impaired is_associated_with::glucose tolerance.