Litoxetine

Litoxetine (SL 81-0385) is an antidepressant which was under clinical development for the treatment of depression in the early 1990s. It acts as a selective serotonin reuptake inhibitor (SSRI) and 5-HT 3 receptor antagonist. It has prominent antiemetic properties, and unlike other SSRIs, it was shown to have a negligible incidence of nausea and emesis. Development of litoxetine was apparently halted in the late 1990s.