DEPTOR

DEP domain-containing mTOR-interacting protein (DEPTOR) also known as DEP domain-containing protein 6 (DEPDC6) is a is_associated_with::protein that in humans is encoded by the DEPTOR is_associated_with::gene.

Structure
The gene DEPTOR can be found only in vertebrates. In human, DEPTOR gene locates at chromosome 8, 8q24.12 with protein size 409 a.a. Human DEPTOR contains two is_associated_with::N-terminal is_associated_with::DEP domains and a is_associated_with::C-terminal is_associated_with::PDZ domain.

Function
DEPTOR is involved in mTOR signaling pathway as an inhibitor. A direct interaction between DEPTOR and mTOR has been shown. Overexpression of DEPTOR downregulates the activity of is_associated_with::mTORC1 while activates is_associated_with::mTORC2. mTORC1 and mTORC2 can both inhibit DEPTOR through is_associated_with::phosphorylation.

Clinical cancer
Although in most cancer, mTOR pathway is constitutively activated and the expression of DEPTOR is low, one study has found that DEPTOR is overexpressed in is_associated_with::multiple myeloma cells and is necessary for their survival.