ABHD6

Monoacylglycerol lipase ABHD6 also known as abhydrolase domain-containing protein 6 or 2-arachidonoylglycerol hydrolase is an enzyme that in humans is encoded by the ABHD6 is_associated_with::gene.

Function
ABHD6 is a serine hydrolyzing enzyme that possesses typical α/β-hydrolase family domains. ABHD6 was first studied because of its over-expression in certain forms of tumours.

ABHD6 has been linked to the endocannabinoid system as it controls the accumulation of 2-AG at the cannabinoid receptors.

Alongside is_associated_with::MAGL and is_associated_with::ABHD12, ABHD6 controls 99% of 2-AG signalling in the brain.