HDAC8

Histone deacetylase 8 is an is_associated_with::enzyme that in humans is encoded by the HDAC8 is_associated_with::gene.

Function
is_associated_with::Histones play a critical role in is_associated_with::transcriptional regulation, is_associated_with::cell cycle progression, and developmental events. Histone is_associated_with::acetylation / deacetylation alters is_associated_with::chromosome structure and affects is_associated_with::transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter.

Histone deacetylase 8 is involved in skull is_associated_with::morphogenesis and metabolic control of the ERR-alpha / PGC1-alpha transcriptional complex.

Clinical significance
HDAC8 has been linked to number of disease states notably to is_associated_with::acute myeloid leukemia and is related to actin cytoskeleton in smooth muscle cells. is_associated_with::siRNA targeting HDAC8 showed anticancer effects. Inhibition of HDAC8 induced apoptosis has been observed in T cell lymphomas. In addition the HDAC8 enzyme has been implicated in the pathogenesis of is_associated_with::neuroblastoma. Therefore, there has been interest in developing HDAC8 selective inhibitors.

Interactions

 * is_associated_with::ERR-alpha.