IRAK1

Interleukin-1 receptor-associated kinase 1 is an is_associated_with::enzyme that in humans is encoded by the IRAK1 is_associated_with::gene.

Function
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.



Interactions
IRAK1 has been shown to interact with:


 * is_associated_with::CHUK,
 * is_associated_with::IKBKG,
 * is_associated_with::IKK2,
 * is_associated_with::Myd88,
 * is_associated_with::TRAF6,      and
 * UBC.