VIS1

VIS1 (viral integration site 1), also known as HIS-1, is a is_associated_with::long non-coding RNA. It was originally identified in mice in a screen for genes involved in the development of is_associated_with::myeloid leukemia. In is_associated_with::murine myeloid leukemias, this gene is a common site of viral insertion by the murine is_associated_with::ecotropic is_associated_with::retrovirus CasBrM It is conserved amongst is_associated_with::vertebrates, including human, mice, cats, pigs, cattle and dogs. Expression of VIS1 is restricted to is_associated_with::epithelial cells, is_associated_with::leukemias and is_associated_with::carcinomas.