Rs2241766

A study of 733 breast cancer cases for 10 SNPs concluded that the rs2241766(G;T) genotype, in combination with certain genotypes at rs1501299, was at reduced risk (odds ratio 0.61, CI: 0.46-0.80). After categorizing individuals by adiponectin signaling status, this study found that compared with high signalers, intermediate signalers had a 4.16-fold increase in breast cancer risk (CI: 0.49-35.19), and low signalers had a 6.56x higher breast cancer risk (CI: 0.78-54.89, p(trend) = 0.001).

Adiponectin signaling status was assigned as follows:

rs1501299(G,G) + rs2241766(T,T) = low signaler rs1501299(G,T) + rs2241766(T,T) = low signaler rs1501299(G,G) + rs2241766(G,T) = low signaler rs1501299(T,T) + rs2241766(T,T) = intermediate signaler rs1501299(G,T) + rs2241766(G,T) = intermediate signaler rs1501299(G,G) + rs2241766(G,G) = intermediate signaler rs1501299(G,T) + rs2241766(G,G) = high signaler rs1501299(T,T) + rs2241766(G,G) = high signaler rs1501299(T,T) + rs2241766(G,T) = high signaler

Based on these criteria, adiponectin signaling status is now determined by genosets Gs119 and Gs120 for Promethease users.

Note that adiponectin, a hormone produced by adipose tissue (body fat), is involved in lipid metabolism.

In other words, you are a low adiponectin signaler, and thus possibly at 6-fold higher risk of breast cancer, if you have one of these combinations of alleles:
 * rs1501299 GG and also rs2241766 either GT or TT
 * rs1501299 GT and also rs2241766 TT

You are an intermediate adiponectin signaler, and thus possibly at 4-fold higher risk of breast cancer, if you have one of these combinations of alleles:
 * rs1501299 GG and also rs2241766 GG
 * rs1501299 GT and also rs2241766 GT
 * rs1501299 TT and also rs2241766 TT

You are a high adiponectin signaler if you have one of these combinations of alleles:
 * rs1501299 GT and also rs2241766 GG
 * rs1501299 TT and also rs2241766 either GG or GT