UPF1

Regulator of nonsense transcripts 1 is a is_associated_with::protein that in humans is encoded by the UPF1 is_associated_with::gene.

Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the is_associated_with::exon junction complex, involved in both is_associated_with::mRNA nuclear export and is_associated_with::mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates is_associated_with::nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the is_associated_with::cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.

Interactions
UPF1 has been shown to interact with:


 * is_associated_with::DCP1A,
 * is_associated_with::DCP2,
 * SMG1,
 * is_associated_with::UPF2,
 * is_associated_with::UPF3A,  and
 * is_associated_with::UPF3B.