KCNN2

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, also known as KCNN2, is a is_associated_with::protein which in humans is encoded by the KCNN2 is_associated_with::gene. KCNN2 is an is_associated_with::ion channel protein also known as KCa2.2.

Function
is_associated_with::Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The KCa2.2 protein is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. KCa2.2 is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This protein is a member of the is_associated_with::calcium-activated potassium channel family. Two transcript variants encoding different isoforms have been found for the KCNN2 gene.

In a study SK2 (KCNN2) potassium channel was overexpressed in the basolateral is_associated_with::amygdala using a herpes simplex viral system. This reduced anxiety and stress-induced is_associated_with::corticosterone secretion at a systemic level. SK2 overexpression also reduced dendritic arborization of the amygdala neurons.