FCAR

Fc fragment of IgA receptor (FCAR) also known as CD89 (Cluster of Differentiation 89), is a human is_associated_with::gene.

Function
This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. is_associated_with::Alternative splicing of the transcript from this gene produces ten mRNA variants encoding different isoforms.

Interactions
FCAR has been shown to interact with is_associated_with::FCGR1A.