Rs198977

In 2014 study "Human kallikrein-2 gene and protein expression predicts prostate cancer at repeat biopsy" rs198977 T allele was found associated with prostate cancer at repeat biopsy with 1.8 odds ratio (95% CI: 1.04-3.13, p = 0.049). High serum hK2 level (> 0.163 ng/mL average in the study) correlated with rs198977, and combined they predicted prostate cancer with OR 3.77 (95% CI: 1.94-7.32, p <0.0001). However, addition of these factors did not significantly improve existing baseline model with age, ethnic background, PSA, DRE, past histology, prostate volume, and family history as risk indicators. This study was conducted with quite selective sample group of 941 patients and is likely not applicable to general population, however it does convincingly back up the association found in earlier studies.