SEC63

Translocation protein SEC63 homolog is a is_associated_with::protein that in humans is encoded by the SEC63 is_associated_with::gene.

Function
The is_associated_with::Sec61 complex is the central component of the protein translocation apparatus of the is_associated_with::endoplasmic reticulum (ER) membrane. The protein encoded by this gene and is_associated_with::SEC62 protein are found to be associated with is_associated_with::ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the is_associated_with::ubiquitin-is_associated_with::proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.

Clinical significance
Mutations of this gene have been linked with autosomal dominant is_associated_with::polycystic liver disease.