KCNA5

Potassium voltage-gated channel, shaker-related subfamily, member 5, also known as KCNA5 or Kv1.5, is a is_associated_with::protein that in humans is encoded by the KCNA5 is_associated_with::gene.

Function
is_associated_with::Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. KCNA5 encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, the function of which could restore the resting is_associated_with::membrane potential of is_associated_with::beta cells after depolarization, thereby contributing to the regulation of is_associated_with::insulin secretion. This gene is is_associated_with::intronless, and the gene is clustered with genes KCNA1 and is_associated_with::KCNA6 on chromosome 12. Mutations in this gene have been related to both is_associated_with::atrial fibrillation and sudden cardiac death. KCNA5 are also key players in pulmonary vascular function, where they play a role in setting the resting membrane potential and its involvement during hypoxic pulmonary vasoconstriction.

Interactions
KCNA5 has been shown to interact with is_associated_with::DLG4 and is_associated_with::Actinin, alpha 2.