Rs1799782

rs1799782, a SNP also known as Arg194Trp located in the DNA-repair gene XRCC1, is associated with a reduced risk for certain types of cancer. The (T) allele encodes the Trp amino acid.

A study of ~200 Korean cases of skin cancer indicated that the rs1799782(T;T) genotype was inversely associated with squamous cell cancer risk (adjusted odds ratio 0.06, CI: 0.006-0.63).

A meta-analysis of 8 case-control studies concluded that significant association was found between the rs1799782 polymorphism and oral cancer risk among Asians, showing an odds ratio of 1.347 (CI: 1.0 - 1.81) for allele comparison, 1.378 (CI: 1.070 - 1.775) for (T;T) homozygotes vs (C;C) homozygotes, and 1.420 (CI: 1.041 - 1.936) for comparison under a dominant model.

18067C>T possibly related to non-Hodgkin lymphoma

rs2040639-AG, contribute to oral cancer risk.

pseudo-haplotype with AG-CC genotypes in
 * 2.45x risk rs2040639-rs861539
 * 5.03x risk rs2040639-rs861539-rs2075685
 * 10.10x risk rs2040639-rs861539-rs2075685-rs1799782

A meta-analysis concludes that this SNP is not associated with risk of gastric cancer.