Rs182549

Also known as "G/A(-22018)" and located in the MCM6 but with influence on the lactase LCT gene, rs182549 is one of two SNPs that is associated with the primary haplotype associated with hypolactasia, more commonly known as lactose intolerance in European Caucasian populations. [PMID 11788828, PMID 15114531]

In these populations, the rs182549(C) allele (as named in accordance with dbSNP) is both the more common allele and the one associated with lactose intolerance.

In populations of sub-Saharan Africans, though, the rs182549(C) allele is unlikely to be predictive of lactose intolerance, and other SNPs are predictive instead. [PMID 15106124, PMID 17159977]


 * See also OMIM 601806.0002

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Variation in the 4q25 chromosomal locus predicts atrial fibrillation after coronary artery bypass graft surgery.


 * is_associated_with_disease::Lactose intolerance