UBIAD1

UbiA prenyltransferase domain-containing protein 1 (UBIAD1) also known as transitional epithelial response protein 1 (TERE1) is a is_associated_with::protein that in humans is encoded by the UBIAD1 is_associated_with::gene.

Recent evidence suggests that ubiad1 has enzymatic activity in the vitamin K pathway, a role in blood vessel development, and may be involved in oxidative stress pathways. Nakagawa K, Hirota Y, Sawada N, Yuge N, Watanabe M, Uchino Y, Okuda N, Shimomura Y, Suhara Y, Okano T.,Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme., Nature. 2010 Nov 4;468(7320):117-21. Epub 2010 Oct 17. Fredericks WJ, McGarvey T, Wang H, Lal P, Puthiyaveettil R, Tomaszewski J, Sepulveda J, Labelle E, Weiss JS, Nickerson ML, Kruth HS, Brandt W, Wessjohann LA, Malkowicz SB., The Bladder Tumor Suppressor Protein TERE1 (UBIAD1)Modulates Cell Cholesterol: Implications for Tumor Progression., DNA Cell Biol. 2011 Nov;30(11):851-64. Epub 2011 Jul 8. R Postel, Identification and Characterization of Novel Genes by Reverse and Forward Genetics in Zebrafish, igitur-archive.library.uu.nl/dissertations/2008-0522.../UUindex.html, 2008.

Clinical significance
Mutations of the UBIAD1 gene cause is_associated_with::Schnyder crystalline corneal dystrophy.