Angiomotin

Angiomotin is a is_associated_with::protein that in humans is encoded by the AMOT is_associated_with::gene.

Function
Angiomotin is a 675-residue protein that increases the random migration of endothelial cells as well as the migration of endothelial cells toward is_associated_with::growth factors.

In the presence of is_associated_with::angiostatin, endothelial cells that overexpress angiomotin exhibit a significant reduction in migration toward growth factors as well as an inability to form is_associated_with::tubules is_associated_with::in vitro. These observations are consistent with the localization of angiomotin in the leading edge of migrating cells. Angiostatin, therefore, disrupts the normal migratory function of Angiomotin.

This gene belongs to the motin family of is_associated_with::angiostatin binding proteins characterized by conserved is_associated_with::coiled coil domains and is_associated_with::C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in is_associated_with::endothelial cells of is_associated_with::capillaries as well as larger vessels of the is_associated_with::placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward is_associated_with::growth factors during the formation of new blood vessels. Alternatively spliced transcript variants encoding different is_associated_with::isoforms have been described, but their full-length nature has not been completely determined.