RNASE1

Ribonuclease pancreatic is an is_associated_with::enzyme that in humans is encoded by the RNASE1 is_associated_with::gene.

Function
This gene encodes a member of the pancreatic-type of secretory is_associated_with::ribonucleases, a subset of the is_associated_with::ribonuclease A superfamily. The encoded is_associated_with::endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of is_associated_with::pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. is_associated_with::Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.