CD163

CD163 (Cluster of Differentiation 163) is a is_associated_with::protein that in humans is encoded by the CD163 is_associated_with::gene. CD163 is a is_associated_with::scavenger receptor for the is_associated_with::hemoglobin-is_associated_with::haptoglobin complex. It has also been shown to mark cells of is_associated_with::monocyte/is_associated_with::macrophage lineage.

The receptor was discovered in 1987.

Structure
The molecular size is 130 is_associated_with::kDa. The receptor belongs to the scavenger receptor cysteine rich family type B and consists of an 1048 amino acid residues extracellular domain, a single transmembrane segment and a cytoplasmic tail with several splice variants.

Clinical significance
A soluble form of the receptor exists in plasma, commonly denoted sCD163. It is generated by ectodomain shedding of the membrane bound receptor. sCD163 is upregulated in a large range of inflammatory diseases including liver cirrhosis, type 2 diabetes, is_associated_with::macrophage activation syndrome, is_associated_with::Gaucher's disease, is_associated_with::sepsis, HIV infection, rheumatoid arthritis and is_associated_with::Hodgkin Lymphoma.

Interactions
CD163 has been shown to interact with is_associated_with::CSNK2B.