Leukotriene C4 synthase

Leukotriene C4 synthase is an is_associated_with::enzyme that in humans is encoded by the LTC4S is_associated_with::gene.

The protein encoded by this gene, LTC4S (or glutathione S-transferase II) is an enzyme that converts is_associated_with::leukotriene A4 and is_associated_with::glutathione to create is_associated_with::leukotriene C4. This is a member of is_associated_with::MAPEG family of is_associated_with::transmembrane proteins. A trimer of Leukotriene C4 synthase is localized on the outer is_associated_with::nuclear membrane and is_associated_with::endoplasmic reticulum, where it forms a complex with is_associated_with::5-Lipoxygenase-activating protein. This protein is remotely related to microsomal is_associated_with::glutathione S-transferase.

Function
The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of is_associated_with::leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from is_associated_with::arachidonic acid. Leukotrienes have been implicated as mediators of is_associated_with::anaphylaxis and inflammatory conditions such as human is_associated_with::bronchial asthma. This protein localizes to the is_associated_with::nuclear envelope and adjacent is_associated_with::endoplasmic reticulum.