AP1S1

AP-1 complex subunit sigma-1A is a is_associated_with::protein that in humans is encoded by the AP1S1 is_associated_with::gene.

Function
The protein encoded by this gene is part of the clathrin coat assembly complex which links is_associated_with::clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium (mu) chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.

A mutation in the AP1S1 causes the rare familial is_associated_with::MEDNIK syndrome described in 2008.

Interactions
AP1S1 has been shown to interact with is_associated_with::AP1G1  and is_associated_with::RAB10.