GRIN2A

Glutamate [NMDA] receptor subunit epsilon-1 is a is_associated_with::protein that in humans is encoded by the GRIN2A is_associated_with::gene.

Function
N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

Associations
Variants of the gene are associated with the protective effect of is_associated_with::coffee on is_associated_with::Parkinson's disease.

Mutations in GRIN2A are associated to refractory epilepsy.

Interactions
GRIN2A has been shown to interact with:
 * is_associated_with::DLG1,
 * is_associated_with::DLG3,
 * is_associated_with::DLG4,
 * is_associated_with::FYN,
 * is_associated_with::Interleukin 16,
 * is_associated_with::PTK2B  and
 * Src.