Acylphosphatase

In enzymology, an acylphosphatase is an enzyme that catalyzes the following chemical reaction:



Thus, the two substrates of this enzyme are acylphosphate and H2O, whereas its two products are carboxylate and phosphate.

Function
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is acylphosphate phosphohydrolase. Other names in common use include acetylphosphatase, 1,3-diphosphoglycerate phosphatase, acetic phosphatase, Ho 1-3, and GP 1-3.

This enzyme participates in 3 metabolic pathways:
 * glycolysis / gluconeogenesis
 * pyruvate metabolism, and
 * benzoate degradation via coa ligation.

Structural studies
As of late 2008, 14 structures have been solved for this class of enzymes, with PDB accession codes, , , , , , , , , , , , and.

Isozymes
Humans express the following two acylphosphatase isozymes: