NOS1

Nitric oxide synthase 1 (neuronal), also known as NOS1, is an is_associated_with::enzyme that in humans is encoded by the NOS1 is_associated_with::gene.

Function
is_associated_with::Nitric oxide (NO) is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a is_associated_with::neurotransmitter and may be involved in is_associated_with::long term potentiation. It is implicated in is_associated_with::neurotoxicity associated with is_associated_with::stroke and neurodegenerative diseases, neural regulation of smooth muscle, including is_associated_with::peristalsis, and penile erection. NO is also responsible for is_associated_with::endothelium-derived relaxing factor activity regulating blood pressure. In is_associated_with::macrophages, NO mediates tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. Neuronal NOS and macrophage NOS are distinct isoforms. Both the neuronal and the macrophage forms are unusual among oxidative enzymes in requiring several electron donors: is_associated_with::FAD, is_associated_with::flavin mononucleotide (FMN), is_associated_with::NADPH, and is_associated_with::tetrahydrobiopterin.

Clinical significance
It has been implicated in is_associated_with::asthma, is_associated_with::schizophrenia  and is_associated_with::restless leg syndrome. It has also been investigated with respect to is_associated_with::bipolar disorder and is_associated_with::air pollution exposure.

Interactions
NOS1 has been shown to interact with is_associated_with::DLG4 and is_associated_with::NOS1AP.