EPS8

Epidermal growth factor receptor kinase substrate 8 is an is_associated_with::enzyme that in humans is encoded by the EPS8 is_associated_with::gene.

Function
This gene encodes a member of the EPS8 family. This protein contains one is_associated_with::PH domain and one is_associated_with::SH3 domain. It functions as part of the EGFR pathway, though its exact role has not been determined. Highly similar proteins in other organisms are involved in the transduction of signals from Ras to Rac and growth factor-mediated is_associated_with::actin remodeling. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Clinical significance
Mutations in EPS8 cause congenital deafness.

Interactions
EPS8 has been shown to interact with:


 * is_associated_with::ABI1,
 * is_associated_with::BAIAP2,
 * is_associated_with::DVL1,
 * SHB,
 * is_associated_with::SHC1
 * is_associated_with::SOS1,  and
 * Src.