Lloyd Mayer

Lloyd Mayer, is an American gastroenterologist and immunologist. He is Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center Mayer's research on inflammatory bowel disease pathogenesis was among the first to demonstrate the role played by T-regulatory cells in setting the stage for chronic mucosal inflammation (IBD). He was the first to describe the role of T cells in immunoglobulin class switching and to identify a novel T-cell-derived cytokine (446-BCDF) that stimulates antibody secretion by human B cells.

Mayer is Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center and the Dorothy and David Merksamer Professor of Medicine, as well as Professor of Microbiology at the Mount Sinai School of Medicine.

Mayer is the author of multiple book chapters and close to 200 peer-reviewed papers. He has been included in New York Magazine’s list of Best Doctors since its inception in the 1990s.

Biography
Mayer was born in 1952. He graduated from Union College in with a degree in Biology and earned his medical degree from the Mount Sinai School of Medicine in 1976. He completed an internship and a residency in Internal Medicine at Bellevue Hospital Center/New York University and a fellowship in Gastroenterology at the Mount Sinai Medical Center in 1981.

Mayer held an appointment at the Rockefeller University from 1980–1984, first as a post-doctoral fellow then Assistant Professor. He was Associate Professor of Medicine and Microbiology at Mount Sinai Medical Center from 1985–1986 and was named Director of the Division of Clinical Immunology in 1986. He was named Professor of both Medicine and Microbiology in 1990, then Vice Chair of Medicine. In 1994, he became the David and Dorothy Merksamer Chair of Medicine, and in 1997, Professor of Immunobiology and Chair of Mount Sinai's Immunobiology Center.

From 1992–1997, Mayer served on the Immunological Sciences Study Section of the National Institutes of Health.

Mayer served as Director of the Mount Sinai's Division of Gastroenterology from 2003–2010. In 2007, he was named Co-Director of Mount Sinai's Immunology Institute. He has served as Chairman of the National Scientific Advisory Committee of the Crohn's & Colitis Foundation of America since 2008.

Mayer was elected to the American Society for Clinical Investigation in 1991 and the Association of American Physicians in 1997. He is currently a member of the American Board of Internal Medicine and Gastroenterology.

Honors and awards

 * Sigma Xi (Science Honor Society), 1972
 * Alpha Omega Alpha, 1975 and 1976
 * Mosby Award for Clinical Excellence, 1976
 * Irma T. Hirschl Trust Award, 1986
 * Saul Horowitz, Jr. Award, 1986
 * Jeffrey Modell Foundation Lifetime Achievement Award, 1990
 * American Society for Clinical Investigation, 1991
 * Immunological Sciences Study section, 1992–1997
 * Association of American Physicians, 1997
 * Jaffe Food Allergy Institute Scientific Achievement Award, 1998
 * Scientific Achievement Award, Crohn's and Colitis Foundation of America, 2000
 * Jacobi Medallion, 2002
 * Scientific Achievement in IBD: Basic Research Award, Crohn's & Colitis Foundation of America, 2010

Grants
A partial list of active grants on which Mayer is a principal or co-investigator:
 * Immunologic Basis of Cow Milk-Induced Hypersensitivities, NIH/NIAD, 5 U19 AI044236-11
 * Innate/Adaptive Immune Interaction in Gut Inflammation, NIH/NIDDK, 5 P01 DK072201-04
 * Cellular & Molecular Defects in Human B Cell Development, NIH/NIAID, 5 P01 AI061093-05
 * Immunobiology of Peanut Allergy and its Treatment: A Prototype, NIH/NIAID, 1 U19 AI066738-03
 * Epithelial TLR Signaling and IgA Production, NIH/NIAID, 1 R21 AI083381-01
 * Oral Vaccine Platform for Class A Bacterial Agents, NIH, 1 R01 AI084952
 * Generation and Characterization of Intestinal CD8+ Regulatory T cell lines, NIH 1 RC1 DK086605

Clinical trials
Active clinical trials include:
 * Infliximab for post-op recurrence of Crohn's disease

Publications
Partial list:
 * Blázquez AB, Knight AK, Getachew H, Bromberg JS, Lira SA, Mayer L, Berin MC. A Functional Role for CCR6 on Proallergic T Cells in the Gastrointestinal Tract.. Gastroenterology. 2010. 138:275-284 PMID 19782082
 * Sicherer SH, Wood RA, Stablein D, Burks AW, Liu AH, Jones SM, Fleischer DM, Leung DY, Grishin A, Mayer L, Shreffler W, Lindblad R, Sampson HA. Immunologic features of infants with milk or egg allergy enrolled in an observational study (Consortium of Food Allergy Research) of food allergy. J Allergy Clin Immunol. 2010 125:1077-1083 PMID 20451041
 * WJ Sandborn, J-F Colombel, M Frankel, D Hommes, J Lowder, L Mayer, S Plevy, P Stokkers, S Travis, G Van Assche, D Baumgart, and S Targan. 2010. Anti-CD3 Antibody Visilizumab is Not Effective in Patients with Intravenous Corticosteroid-Refractory Ulcerative Colitis. Gut 59:1485-92 PMID 20947884
 * Blázquez AB, Mayer L, Berin MC. 2010. Thymic Stromal Lymphopoietin is Required for Gastrointestinal Allergy but not Oral Tolerance. Gastroenterology 138:275-84 PMID 20600023
 * Murphy SJ, Mayer L, Abreu MT. 2010. Mesalamine (5-Aminosalicylic Acid) Therapy Well Tolerated in a Patient With Aspirin Hypersensitivity and Ulcerative Colitis. J Clin Gastroenterol. 45(1):83-4 PMID 20535023
 * Roda G, Caponi A, Benevento M, Nanni P, Mezzanotte L, Belluzzi A, Mayer L, Roda A. 2010. New proteomic approaches for biomarker discovery in inflammatory bowel disease. Inflamm Bowel Dis. 16:1239-46. PMID 20127998
 * Baumgart DC, Targan SR, Dignass AU, Mayer L, van Assche G, Hommes DW, Hanauer SB, Mahadevan U, Reinisch W, Plevy SE, Salzberg BA, Buchman AL, Mechkov GM, Krastev ZA, Lowder JN, Frankel MB, Sandborn WJ. 2010. Prospective randomized open-label multicenter phase I/II dose escalation trial of visilizumab (HuM291) in severe steroid-refractory ulcerative colitis. Inflamm Bowel Dis. 16:620-9. PMID 19714757
 * Viejo-Borbolla A, AP Martin, LR Muniz, L Shang, F Marchesi, N Thirunarayanan, N Harpaz, RA Garcia, M Apostolaki, GC Furtado, L Mayer, G Kollias, A Alcami, and SA Lira. 2010. Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD. Mucosal Immunology 3:633-44 PMID 20664576
 * Bongers G, D Maussang, LR Muniz, VM Noriega, A Fraile-Ramos, N Barker, F Marchesi, N Thirunarayanan, HF Vischer, L Qin, L Mayer, N Harpaz, R Leurs, GC Furtado,H Clevers, D Tortorella, MJ Smit,2 and SA Lira. 2010. The cytokine-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. JCI 120:3969-78 PMID 20978345
 * Yu JE, De Ravin SS, Uzel G, Landers C, Targan S, Malech HL, Holland SM, Cao W, Harpaz N, Mayer L, Cunningham-Rundles C. 2011. High Levels of Crohn's Disease-Associated Anti-Microbial Antibodies Are Present and Independent of Colitis in Chronic Granulomatous Disease Clin Immunol 138(1):14-22. PMID 20956091
 * Dahan S, K Rabinowitz, AP Martin, MC Berin, JC Unkeless and L Mayer. 2011. The Notch-1 signaling pathway regulates intestinal epithelial barrier function in mice and humans through interaction with CD4+ T cells. Gastroenterology 140:550-9 PMID 21056041
 * Fukata, M, L Shang, R Santaolalla, JSotolongo, C Pastorini, C España, R Ungaro, N Harpaz, HS Cooper, G Elson, M Kosco-Vilbois, J Zaias, MT. Perez,  L Mayer, AS Vamadevan, SA Lira and MT. Abreu. 2011. Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis IBD Journal in press PMID 21674704
 * Hovhannisyan Z, J Treatman, D Littman and L Mayer. 2011. Characterization of IL-17-producing regulatory T cells in inflamed gut mucosa. Gastroenterology 140(3):957-65 PMID 21147109
 * Dotan, I, L Werner, S Vigodman, S Agarwal, J Pfeffer, N Horowitz, L Malter, M Abreu, T Ullman, H Guzner-Gur, Z Halpern, L Mayer. 2011. Normal Response to Vaccines in Inflammatory Bowel Disease Patients Treated with Thiopurines. IBD Journal in press PMID 21438101
 * Dunkin D, M. C Berin, and L Mayer. 2011. Allergic Sensitization to Cow’s Milk Antigens Can Be Induced via Multiple Physiologic Routes in an Adjuvant-Dependent Manner. JACI in press PMID 21762973
 * Ouyang X, R Zhang, J Yang, Q Li, L Qin, C Zhu, J Liu, H Ning, MS Shin, M Gupta, C-F Qi, JC He, SA Lira, HC Morse III, K Ozato, L Mayer and H Xiong. 2011. Transcription factor IRF8 directs a silencing program for TH17 cell differentiation. Nature Communications 2:314 PMID 21587231