MALT1

Mucosa-associated lymphoid tissue lymphoma translocation protein 1 is a is_associated_with::protein that in humans is encoded by the MALT1 is_associated_with::gene.

Function
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in is_associated_with::mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Interactions
MALT1 has been shown to interact with is_associated_with::BCL10 and is_associated_with::TRAF6.

Protease substrates
MALT1 is part of the is_associated_with::paracaspase family and shows proteolytic activity. Since many of the substrates are involved in regulation of inflammatory responses, the protease activity of MALT1 has emerged as an interesting therapeutic target. Currently known protease substrates are:
 * is_associated_with::TNFAIP3 (A20)
 * is_associated_with::BCL10
 * CYLD
 * NIK (specifically the oncogenic IAP2-MALT1 fusion)
 * is_associated_with::RELB
 * regnase-1