WWP1

NEDD4-like E3 ubiquitin-protein ligase WWP1 is an is_associated_with::enzyme that in humans is encoded by the WWP1 is_associated_with::gene.

Function
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined.

Interactions
WWP1 has been shown to interact with:
 * is_associated_with::CPSF6,
 * is_associated_with::KLF2, and
 * is_associated_with::Reticulon 4