C14orf159

UPF0317 protein C14orf159, mitochondrial is a is_associated_with::protein that in humans is encoded by the C14orf159 is_associated_with::gene (chromosome 14 open reading frame 159).

Orthologs
The human gene, c14orf159 mRNA, is highly conserved in mammals and birds. is_associated_with::Orthologs gathered from BLAST and BLAT searches reveal that the human c14orf159 mRNA sequence is conserved with a sequence identity of 98% in is_associated_with::chimpanzees, 88% in mice, and 81% in is_associated_with::platypus and is_associated_with::chicken. The following table contains a list orthologs that were gathered from BLAST searches. Sequence alignments were performed using blastn to derive sequence identity, score, and E-values between the human c14orf159 variant 1 mRNA and its orthologs.

The protein that the human gene c14orf159 encodes has been found to be highly conserved among mammals, birds, amphibians, fish, is_associated_with::tunicates, is_associated_with::cnidarians, and is_associated_with::echinoderms. However, no protein orthologs have been found in is_associated_with::nematodes, is_associated_with::arthropods, fungi, protists, plants, bacteria, or is_associated_with::archea. Fungi and bacteria contain the DUF1445 conserved domain which is found in human c14orf159 and its orthologs. BLAST and BLAT searches have been utilized to find orthologs to the c14orf159 protein. The following table lists protein orthologs for the human protein with sequence identity, sequence similarity, scores, and E-values derived from blastp sequence comparisons.

Post-translational modification
The protein product of the C14orf159 gene is predicted and was found to be translocated to is_associated_with::mitochondrion.

Post-translational modifications are predicted for the protein c14orf159. All predicted sites in human c14orf159 were compared to orthologs using multiple sequence alignments to determine likelihood of modification.

Regulation
is_associated_with::Estrogen receptor alpha, in the presence of is_associated_with::estradiol, binds to the C14orf159 gene and likely regulates its expression.