R-type calcium channel

The R-type calcium channel is a type of is_associated_with::voltage-dependent calcium channel. Like the others of this class, the α1 subunit forms the pore through which calcium enters the cell and determines most of the channel's properties. This α1 subunit is also known as the calcium channel, voltage-dependent, R type, alpha 1E subunit (is_associated_with::CACNA1E) or Cav2.3 which in humans is encoded by the CACNA1E is_associated_with::gene. They are strongly expressed in cortex, hippocampus, striatum, amygdala and interpeduncular nucleus.

They are poorly understood, but like is_associated_with::Q-type calcium channels, they appear to be present in cerebellar granule cells. They have a high threshold of activation and relatively slow kinetics.