NFYA

Nuclear transcription factor Y subunit alpha is a is_associated_with::protein that in humans is encoded by the NFYA is_associated_with::gene.

Function
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms.

Interactions
NFYA has been shown to interact with is_associated_with::Serum response factor and is_associated_with::ZHX1.