BCAR3

Breast cancer anti-estrogen resistance protein 3 is a is_associated_with::protein that in humans is encoded by the BCAR3 is_associated_with::gene.

Function
Breast tumors are initially dependent on is_associated_with::estrogens for growth and progression and can be inhibited by anti-estrogens such as is_associated_with::tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hallmark of cellular is_associated_with::tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein is_associated_with::CDC48.