Ectodysplasin A

Ectodysplasin A (EDA) is a is_associated_with::protein that in humans is encoded by the EDA is_associated_with::gene.

Ectodysplasin A is a is_associated_with::transmembrane protein of the is_associated_with::TNF family which plays an important role in the development of ectodermal tissues such as the is_associated_with::skin in humans. It is recognized by the is_associated_with::ectodysplasin A receptor.

Function
The protein encoded by this gene is a type II membrane protein that can be cleaved by is_associated_with::furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a is_associated_with::homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of is_associated_with::ectodermal dysplasia, anhidrotic, which is also known as X-linked is_associated_with::hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different is_associated_with::isoforms have been found for this gene.