PLEKHM2

Pleckstrin homology domain-containing family M member 2 is a is_associated_with::protein that in humans is encoded by the PLEKHM2 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of PLEKHM2 function. A conditional is_associated_with::knockout mouse line, called Plekhm2tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. Male homozygous mutants had increased circulating is_associated_with::alkaline phosphatase levels and an increased susceptibility to is_associated_with::bacterial infection, while females had an increased is_associated_with::leukocyte cell number.