TAS2R31

Taste receptor, type 2, member 31, also known as TAS2R31, is a is_associated_with::protein which in humans is encoded by the TAS2R31 is_associated_with::gene. This bitter taste receptor has been shown to respond to saccharin in vitro.

TAS2R31 is also expressed in the is_associated_with::smooth muscle of human airways, along with several other bitter taste receptors. Their activation in these cells causes an increase in intracellular is_associated_with::calcium ion, which in turn triggers the opening of is_associated_with::potassium channels which hyperpolarize the membrane and cause the smooth muscle to relax. Hence, activation of these receptors leads to is_associated_with::bronchodilation.

Polymorphisms in this gene have been associated with the perceived bitterness of sweetener is_associated_with::acesulfame potassium.