Rs891512

rs891512 (also known as G24943A, IVS25+15 [G→A]) is an intronic variant in the NOS3 gene significantly associated with blood pressure.

The intronic variant, IVS25+15 [G-->A], was significantly associated with blood pressure; GG homozygotes had significantly lower levels of diastolic blood pressure (DBP) (-2.8 mm Hg; P = 0.016) and systolic blood pressure (SBP) (-1.9 mm Hg; P = 0.018) than A-allele carriers.

eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).

Two specific SNPs in significant LD with each other (rs891512 and rs1808593) were significantly associated with ABI (ankle-brachial index) in both subsets.

protective haplotype C-T-A (rs2070744-rs1799983-rs891512) was observed (P = 0.01) with a pronounced effect against suicide completion (P = 0.005).