ARHGAP8

Rho GTPase-activating protein 8 is an is_associated_with::protein that in humans is encoded by the ARHGAP8 is_associated_with::gene.

Function
This gene encodes a member of the RHOGAP family. GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in is_associated_with::cytoskeletal changes. GAP proteins alternate between an active (GTP-bound) and inactive (GDP-bound) state based on the GTP:GDP ratio in the cell. Rare read-through transcripts, containing is_associated_with::exons from the PRR5 gene which is located immediately upstream, led to the original description of this gene as encoding a RHOGAP protein containing the is_associated_with::proline-rich domains characteristic of PRR5 proteins. is_associated_with::Alternatively spliced variants encoding different isoforms have been described.