MAPK10

Mitogen-activated protein kinase 10 also known as c-Jun N-terminal kinase 3 (JNK3) is an is_associated_with::enzyme that in humans is encoded by the MAPK10 is_associated_with::gene.

Function
The protein encoded by this gene is a member of the is_associated_with::MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its is_associated_with::phosphorylation and is_associated_with::nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal is_associated_with::apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by is_associated_with::MAP kinase kinase 4 (MKK4). is_associated_with::Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.

Interactions
MAPK10 has been shown to interact with is_associated_with::MAPK8IP3.