NCAPH

Condensin complex subunit 2 also known as chromosome-associated protein H (CAP-H) or non-SMC condensin I complex subunit H (NCAPH) is a is_associated_with::protein that in humans is encoded by the NCAPH is_associated_with::gene. CAP-H is a subunit of is_associated_with::condensin I, a large protein complex involved in chromosome condensation

Function
CAP-H is a member of the barr protein family and a regulatory subunit of the condensin complex. This complex is required for the conversion of is_associated_with::interphase is_associated_with::chromatin into condensed is_associated_with::chromosomes. CAP-H is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate is_associated_with::nucleolar localization.

Model organisms
is_associated_with::Model organisms have been used in the study of NCAPH function. A conditional is_associated_with::knockout mouse line, called Ncaphtm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice and three significant abnormalities were observed. No is_associated_with::homozygous mutant embryos were identified during gestation, and therefore none survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice and an increased susceptibility to is_associated_with::bacterial infection was observed in male animals.