Nucleolin

Nucleolin is a is_associated_with::protein that in humans is encoded by the NCL is_associated_with::gene.

Gene
The human NCL gene is located on is_associated_with::chromosome 2 and consists of 14 is_associated_with::exons with 13 is_associated_with::introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a is_associated_with::small nucleolar RNA, termed U20.

Function
Nucleolin (NCL), a eukaryotic nucleolar is_associated_with::phosphoprotein, is involved in the synthesis and maturation of is_associated_with::ribosomes. The protein is located mainly in dense fibrillar regions of the is_associated_with::nucleolus.

Nucleolin is also able to act as a transcriptional coactivator with Chicken Ovalbumin Upstream Promoter Transcription Factor II (is_associated_with::COUP-TFII).

Clinical significance
is_associated_with::Midkine and is_associated_with::pleiotrophin bind to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.

Nucleolin at the cell surface is the receptor for the is_associated_with::Respiratory Syncytial Virus (RSV) fusion protein. Interference with the nucleolin - RSV fusion protein interaction has been shown to be therapeutic against RSV infection in cell cultures and animal models.

Interactions
Nucleolin has been shown to interact with:


 * is_associated_with::CSNK2A2,
 * is_associated_with::Centaurin, alpha 1,
 * is_associated_with::HuR,
 * is_associated_with::NPM1,
 * is_associated_with::P53,
 * is_associated_with::PPP1CB,
 * is_associated_with::S100A11,
 * is_associated_with::Sjogren syndrome antigen B,
 * is_associated_with::TOP1,  and
 * is_associated_with::Telomerase reverse transcriptase.