SMARCAL1

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 is a is_associated_with::protein that in humans is encoded by the SMARCAL1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of SMARCAL1 function. A conditional is_associated_with::knockout mouse line, called Smarcal1tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty tests were carried out and one significant phenotype was observed: homozygous mutant mice had abnormal brain is_associated_with::histopathology, including an enlarged is_associated_with::hippocampus and a thickened hippocampus is_associated_with::stratum oriens.