Forkhead box L2

Forkhead box protein L2 is a is_associated_with::protein that in humans is encoded by the FOXL2 is_associated_with::gene.

Function
FOXL2 is a forkhead is_associated_with::transcription factor. The protein contains a fork-head is_associated_with::DNA-binding domain and may play a role in ovarian development and function.

Clinical significance
This protein is involved in sex determination. Female missing the FOXL2 gene appear male. FOXL2 knockout in mature mouse ovaries cause them to develop into is_associated_with::testes, however is_associated_with::oocytes are still formed.

Mutations in this gene are a cause of blepharophimosis syndrome and is_associated_with::premature ovarian failure 3.