Linker of activated T cells

The Linker for Activation of T cells, also known as LAT, is a is_associated_with::protein which in humans is encoded by the LAT is_associated_with::gene. is_associated_with::Alternative splicing results in multiple transcript variants encoding different isoforms.

Function
The protein encoded by this gene is phosphorylated by is_associated_with::ZAP70/is_associated_with::Syk protein is_associated_with::tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to is_associated_with::lipid rafts (also known as is_associated_with::glycosphingolipid-enriched microdomains or GEMs) and acts as a docking site for is_associated_with::SH2 domain-containing proteins. Upon is_associated_with::phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement.

Discovery
LAT was described in the early 1990s as a is_associated_with::phosphoprotein of 36–38 is_associated_with::kDa (pp. 36–38) rapidly phosphorylated on is_associated_with::tyrosine residues following TCR ligation. Cloning of the is_associated_with::gene revealed that the is_associated_with::protein product is a type III (leaderless) transmembrane protein of 262 aminoacids (long form) or 233 aminoacids (short form) in humans, 242 aminoacids in mouse, and 241 aminoacids in rat.

Interactions
The Linker for Activation of T cells has been shown to interact with:


 * is_associated_with::GRAP2,
 * is_associated_with::GRAP,
 * is_associated_with::Grb2,
 * ITK,
 * is_associated_with::MAP4K1
 * is_associated_with::PIK3R1,
 * is_associated_with::PLCG1,
 * SHB,
 * is_associated_with::VAV1, and
 * is_associated_with::ZAP-70.