Rs2014307

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rs572515 was the most significantly associated with AMD risk (P <10-6).

rs9288410 and rs2014307 (PLEKHA1/HTRA1) on 10q26 were significantly associated with AMD status (P= .03 and P <10-6 respectively). After controlling for smoking history, gender and age, the most significant gene-gene interaction appears to be between rs10801575 (CFH) and rs2014307 (PLEKHA1/HTRA1) (P <10-11).