Dopamine receptor D3

D3 dopamine receptor is a is_associated_with::protein that in humans is encoded by the DRD3 is_associated_with::gene.

This gene encodes the D3 subtype of the is_associated_with::dopamine receptor. The D3 subtype inhibits is_associated_with::adenylyl cyclase through inhibitory G-proteins. This receptor is expressed in phylogenetically older regions of the brain, suggesting that this receptor plays a role in cognitive and emotional functions. It is a target for drugs which treat is_associated_with::schizophrenia, is_associated_with::drug addiction, and is_associated_with::Parkinson's disease. Alternative splicing of this gene results in multiple transcript variants that would encode different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

D3 agonists like is_associated_with::7-OH-DPAT, is_associated_with::pramipexole, and is_associated_with::rotigotine, among others, display is_associated_with::antidepressant effects in rodent models of depression.

Agonists

 * trans-N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]cyclohexyl}-3-methoxybenzamide, full agonist, > 200-fold binding selectivity over D4, D2, 5-HT1A, and α1-receptors
 * (-)-7-{[2-(4-Phenylpiperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol
 * is_associated_with::5-OH-DPAT
 * is_associated_with::7-OH-DPAT
 * is_associated_with::8-OH-PBZI (cis-8-Hydroxy-3-(n-propyl)-1,2,3a,4,5,9b-hexahydro-1H-benz[e]indole)
 * is_associated_with::Apomorphine (non-selective dopamine agonist)
 * is_associated_with::Bromocriptine (non-selective dopamine agonist)
 * is_associated_with::Captodiame
 * is_associated_with::CJ-1639
 * compound R,R-16: 250x binding selectivity over D2
 * is_associated_with::Dopamine (endogenous agonist)
 * is_associated_with::ES609
 * FAUC 54
 * FAUC 73
 * is_associated_with::PD-128,907
 * is_associated_with::PF-219,061 (extremely selective)
 * is_associated_with::PF-592,379
 * is_associated_with::Piribedil (non-selective dopamine agonist)
 * is_associated_with::Pramipexole (non-selective dopamine agonist)
 * is_associated_with::Quinelorane (also D2 agonist)
 * is_associated_with::Quinpirole (also D2 agonist)
 * is_associated_with::Ropinirole (non-selective dopamine agonist)
 * is_associated_with::Rotigotine (non-selective dopamine agonist)

Partial agonists

 * is_associated_with::Aripiprazole (non-selective)
 * is_associated_with::BP-897
 * is_associated_with::Buspirone (non-selective)
 * is_associated_with::CJB 090
 * CJ-1037 (extremely selective)
 * FAUC 460 (highly selective)
 * FAUC 346 (highly selective)
 * is_associated_with::Pardoprunox (non-selective)
 * is_associated_with::Roxindole (possibly a partial agonist at the D3 autoreceptors, non-selective)
 * is_associated_with::OS-3-106
 * is_associated_with::UH-232
 * is_associated_with::WW-III-55

Antagonists

 * Most is_associated_with::Antipsychotics
 * is_associated_with::Amisulpride (non-selective)
 * is_associated_with::Cyproheptadine (non-selective)
 * PG 01037
 * is_associated_with::Domperidone (peripheral D2 and D3 antagonist)
 * FAUC 365, silent antagonist, subtype selective
 * is_associated_with::GR-103,691
 * is_associated_with::GSK598809 (highly selective)
 * is_associated_with::Haloperidol (non-selective)
 * N-(4-(4-(2,3-Dichloro- or 2-methoxyphenyl)piperazin-1-yl)butyl)heterobiarylcarboxamides
 * is_associated_with::Nafadotride
 * is_associated_with::NGB-2904
 * is_associated_with::PNU-99,194 (moderately selective over D2)
 * is_associated_with::Raclopride (also D2 antagonist)
 * is_associated_with::S-14,297 (selective)
 * is_associated_with::S33084
 * is_associated_with::SB-277011-A, selective D3 antagonist, 80x selectivity over D2 with no partial agonist effects, used in drug addiction research as a potential therapy for addiction to several different drugs
 * is_associated_with::SR 21502 (highly selective)
 * is_associated_with::Sulpiride (also D2 antagonist)
 * is_associated_with::U99194
 * is_associated_with::YQA14 (high affinity and selectivity)
 * is_associated_with::Risperidone

Interactions
Dopamine receptor D3 has been shown to interact with is_associated_with::CLIC6 and is_associated_with::EPB41L1.