ICAM2

Intercellular adhesion molecule 2 (ICAM2), also known as CD102 (Cluster of Differentiation 102), is a human is_associated_with::gene, and the protein resulting from it.

Protein structure
The protein encoded by this gene is a member of the is_associated_with::intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2–9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.

Protein functions
ICAM-2 molecules regulate is_associated_with::spermatid adhesion on is_associated_with::Sertori cell on the apical side of the is_associated_with::blood-testis barrier (towards the lumen), thus playing a major role in is_associated_with::spermatogenesis.

This protein may also play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.

Interactions
ICAM2 has been shown to interact with EZR.