Vasodilator-stimulated phosphoprotein

Vasodilator-stimulated phosphoprotein is a is_associated_with::protein that in humans is encoded by the VASP is_associated_with::gene.

Function
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an N-terminal is_associated_with::EVH1 domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions cell membranes. In the mid-region of the protein, family members have a is_associated_with::proline-rich region that binds SH3 and is_associated_with::WW domain-containing proteins. Their C-terminal is_associated_with::EVH2 domain mediates tetramerization and binds both G and F is_associated_with::actin. VASP is associated with filamentous actin formation and likely plays a widespread role in is_associated_with::cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate is_associated_with::integrin-is_associated_with::extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.

Interactions
Vasodilator-stimulated phosphoprotein has been shown to interact with is_associated_with::Zyxin, is_associated_with::Profilin 1 and is_associated_with::PFN2.