Dextrorphan

Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextro-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the abuse liability of dextromethorphan.

Pharmacology

 * Noncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonist.
 * σ1 and σ2 sigma receptor agonist.
 * α3β4, α4β2, and α7 nicotinic acetylcholine receptor antagonist.
 * L-type voltage-gated calcium channel (LVGCC) blocker.

The pharmacology of dextrorphan is similar to that of dextromethorphan (DXM). However, dextrorphan is much more potent as an NMDA receptor antagonist and much weaker as a serotonin reuptake inhibitor, producing a noticeably more body-affecting, "stoned" feeling.

Legality
Dextrorphan was formerly a Schedule I controlled substance in the United States, but was unscheduled on October 1, 1976.