IRF4

Interferon regulatory factor 4 also known as MUM1 is a is_associated_with::protein that in humans is encoded by the IRF4 is_associated_with::gene,  located at 6p25-p23.

The MUM1 symbol is polysemous; although it is an older synonym for IRF4 (HGNC:6119), it is also the current HGNC official symbol for melanoma associated antigen (mutated) 1 (HGNC:29641; located at 19p13.3).

Clinical significance
In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color.

Interactions
IRF4 has been shown to interact with:
 * is_associated_with::BCL6,
 * is_associated_with::NFATC2,
 * is_associated_with::SPI1, and
 * is_associated_with::STAT6.