ARFGAP1

ADP-ribosylation factor GTPase-activating protein 1 is an is_associated_with::enzyme that in humans is encoded by the ARFGAP1 is_associated_with::gene. Two transcript variants encoding different isoforms have been found for this gene.

Function
The protein encoded by this gene is a is_associated_with::GTPase-activating protein (GAP) which associates with the is_associated_with::Golgi apparatus and which interacts with ADP-ribosylation factor 1 (is_associated_with::ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by is_associated_with::phosphoinositides and inhibited by is_associated_with::phosphatidylcholine.

The protein has two ALPS (amphipatic lipid packing sensor) motifs, that let the protein sense the curvature of the membrane (<30 nm) or lipid packing defects, and in this way evaluate if the vesicule is mature and ready for coat disassembly.

Interactions
ARFGAP1 has been shown to interact with is_associated_with::KDELR1 and is_associated_with::LRRK2.