MUL1

Mitochondrial E3 ubiquitin protein ligase 1 is an is_associated_with::enzyme that in humans is encoded by the MUL1 is_associated_with::gene.

Gene
The gene MUL1 encodes one of the E3 ubiquitin ligases. The human gene MUL1 has 5 Exons and locates at chromosome band 1p36.12.

Protein
The human protein Mitochondrial E3 ubiquitin protein ligase 1 is 39.8 kDa in size and composed of 352 amino acids. The calculated theoretical pI of this protein is 8.46.

Function
Exhibits weak E3 ubiquitin-protein ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a is_associated_with::thioester and then directly transfer the is_associated_with::ubiquitin to targeted substrates. Can ubiquitinate AKT1 preferentially at 'Lys-284' involving 'Lys-48'-linked polyubiquitination and seems to be involved in regulation of Akt signaling by targeting is_associated_with::phosphorylated Akt to proteosomal degradation. Proposed to preferentially act as a SUMO E3 ligase at physiological concentrations. Plays a role in the control of is_associated_with::mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. The function may implicate its abiltiy to sumoylate is_associated_with::DNM1L. Inhibits cell growth. When overexpressed, activates is_associated_with::JNK through is_associated_with::MAP3K7/TAK1 and induces caspase-dependent is_associated_with::apoptosis. Involved in the modulation of innate immune defense against viruses by inhibiting is_associated_with::DDX58-dependent antiviral response. Can mediate DDX58 sumoylation and disrupt its polyubiquitination.