Journal of Clinical Investigation

The Journal of Clinical Investigation (JCI or J. Clin. Invest.) is a biomedical journal, with a 2010 impact factor of 14.152. The journal makes its research articles — including access to articles back to 1924 — freely available online.

The website of the journal describes it as "a premier venue for critical advances in biomedical research, authoritative reviews, and commentaries that place research articles in context." The first issue of the journal appeared in 1924, and within a few decades it had established itself as a reputed journal for primary clinical research.

The JCI's Editorial Board is unique in that its members are located chiefly at a singular academic medical center and are predominantly members of the American Society for Clinical Investigation. The leadership of the Editorial Board changes every five years: As of March 2007, the Editorial Board is located at the University of Pennsylvania under the leadership of Laurence A. Turka, M.D. From March 2002 to March 2007, the Editorial Board was located at Columbia University under the leadership of Andrew Marks, M.D. Ushma S. Neill, formerly with Nature Medicine, is the journal's Executive Editor.

This monthly journal publishes original research and review articles, including periodic review series focusing on important topics in biomedicine.