SLC25A21

Mitochondrial 2-oxodicarboxylate carrier also known as solute carrier family 25 member 21 (SLC25A21) is a is_associated_with::protein that in humans is encoded by the SLC25A21 is_associated_with::gene.

It is a homolog of the is_associated_with::S. cerevisiae ODC proteins, mitochondrial carriers that transport C5-C7 oxodicarboxylates across inner is_associated_with::mitochondrial membranes. One of the species transported by ODC is 2-oxoadipate, a common intermediate in the catabolism of lysine, tryptophan, and hydroxylysine in mammals. Within mitochondria, is_associated_with::2-oxoadipate is converted into is_associated_with::acetyl-CoA.

Model organisms
is_associated_with::Model organisms have been used in the study of SLC25A21 function. A conditional is_associated_with::knockout mouse line, called Slc25a21tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on homozygous is_associated_with::mutant mice and ten significant abnormalities were observed, including sub-viability at is_associated_with::weaning, decreased body weight, absent is_associated_with::pinna reflex, abnormal snout, skull, spine and tooth morphology, atypical is_associated_with::indirect calorimetry, body composition and plasma chemistry data, increased mean is_associated_with::platelet volume and moderate elevations in auditory thresholds.