HOXA13

Homeobox protein Hox-A13 is a is_associated_with::protein that in humans is encoded by the HOXA13 is_associated_with::gene.

Function
In vertebrates, the genes encoding the class of is_associated_with::transcription factors called is_associated_with::homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during is_associated_with::embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate is_associated_with::gene expression, is_associated_with::morphogenesis, and differentiation.

Clinical significance
Expansion of a polyalanine tract in the encoded protein can cause hand-foot-genital syndrome, also known as hand-foot-uterus syndrome.