TSPAN12

Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a is_associated_with::tetraspanin is_associated_with::protein that in humans is encoded by the TSPAN12 is_associated_with::gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.

Function
Its main binding partner is the is_associated_with::ADAM10 protein, a is_associated_with::sheddase that interacts with a variety of adhesion molecules that are found on the cell membrane including L1-CAM, E-Cadherin, N-Cadherin and is_associated_with::CD44. It also binds to the MT1-MMP is_associated_with::metalloprotease protein that is closely related to ADAM10 but has a minimal effect on promotion of expression and function. TSPAN12 also seems to regulate vascular development, as shown by a study involving TSPAN12 knockout mice. TSPAN12 is a significant contributor to primary and metastatic cancer and is responsible for protecting is_associated_with::β-catenin from degradation.