Norepinephrine reuptake inhibitor



A norepinephrine reuptake inhibitor (NRI, NERI) or adrenergic reuptake inhibitor (ARI), is a type of drug that acts as a reuptake inhibitor for the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET). This in turn leads to increased extracellular concentrations of norepinephrine and epinephrine and therefore an increase in adrenergic neurotransmission.

NRIs are commonly used in the treatment of conditions like ADHD and narcolepsy due to their psychostimulant effects and in obesity due to their appetite suppressant effects. They are also frequently used as antidepressants for the treatment of major depressive disorder. Additionally, many drugs of abuse such as cocaine and methylphenidate possess NRI activity, though it is important to mention that NRIs without combined dopamine reuptake inhibitor (DRI) properties are not significantly rewarding and hence are considered to have a negligible abuse potential. However, it is also mentionable that norepinephrine has been implicated as acting synergistically with dopamine when actions on the two neurotransmitters are combined (e.g., in the case of NDRIs) to produce rewarding effects in psychostimulant drugs of abuse.

List of NRIs
Many NRIs exist, including the following:


 * Selective norepinephrine reuptake inhibitors
 * Amedalin (UK-3540-1)
 * Atomoxetine (Strattera)
 * CP-39,332
 * Daledalin (UK-3557-15)
 * Edivoxetine (LY-2216684)
 * Esreboxetine
 * Lortalamine (LM-1404)
 * Mazindol (Mazanor, Sanorex)
 * Nisoxetine (LY-94,939)
 * Reboxetine (Edronax, Vestra)
 * Talopram (Lu 3-010)
 * Talsupram (Lu 5-005)
 * Tandamine (AY-23,946)
 * Viloxazine (Vivalan)


 * NRIs with activity at other sites
 * Bupropion (Wellbutrin, Zyban)
 * Ciclazindol (Wy-23,409)
 * Manifaxine (GW-320,659)
 * Radafaxine (GW-353,162)
 * Tapentadol (Nucynta)
 * Teniloxazine (Lucelan, Metatone)


 * Other NRIs
 * Ginkgo biloba extract in 100 mg/kg quantity taken over a 14 day period

Note: Only NRIs selective for the NET over the other monoamine transporters (MATs) are listed here. For a list of NRIs that act at multiple MATs, see the other monoamine reuptake inhibitor pages such as NDRI, SNRI, and SNDRI.