SOD3

Extracellular superoxide dismutase [Cu-Zn] is an is_associated_with::enzyme that in humans is encoded by the SOD3 is_associated_with::gene.

This gene encodes a member of the is_associated_with::superoxide dismutase (SOD) protein family. SODs are antioxidant is_associated_with::enzymes that catalyze the dismutation of two is_associated_with::superoxide radicals into is_associated_with::hydrogen peroxide and is_associated_with::oxygen. The product of this gene is thought to protect the is_associated_with::brain, is_associated_with::lungs, and other tissues from is_associated_with::oxidative stress. The protein is secreted into the is_associated_with::extracellular space and forms a glycosylated homotetramer that is anchored to the is_associated_with::extracellular matrix (ECM) and cell surfaces through an interaction with is_associated_with::heparan sulfate is_associated_with::proteoglycan and is_associated_with::collagen. A fraction of the protein is cleaved near the is_associated_with::C-terminus before secretion to generate circulating tetramers that do not interact with the ECM.