Type I cytokine receptor

Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction.

Signal transduction chains
The signal transducing chains are often shared between different receptors within this receptor family.


 * The IL-2 receptor common gamma chain (also known as CD132) is shared between:
 * IL-2 receptor
 * IL-4 receptor
 * IL-7 receptor
 * IL-9 receptor
 * IL-13 receptor
 * IL-15 receptor


 * The common beta chain (CD131 or CDw131) is shared between the following type I cytokine receptors:
 * GM-CSF receptor
 * IL-3 receptor
 * IL-5 receptor.


 * The gp230 receptor common gamma chain (also known as gp130, IL6ST, IL6-beta or CD130) is shared between:
 * IL-6 receptor
 * IL-11 receptor
 * Leukamia inhibitory factor receptor
 * Oncostatin M receptor

Examples
Type I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors

Colony stimulating factor receptors

 * Erythropoietin receptor
 * GM-CSF receptor
 * G-CSF receptor

Hormone receptor/neuropeptide receptor

 * growth hormone receptor
 * prolactin receptor

Other

 * Oncostatin M receptor
 * Leukemia inhibitory factor receptor