RRM2B

Ribonucleoside-diphosphate reductase subunit M2 B is an is_associated_with::enzyme that in humans is encoded by the RRM2B is_associated_with::gene. The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by designations MTDPS8A, MTDPS8B, and p53R2.

Interactions
RRM2B has been shown to interact with is_associated_with::Mdm2 and is_associated_with::Ataxia telangiectasia mutated.

Clinical relevance
Mutations in this gene have been shown to cause progressive external is_associated_with::ophthalmoplegia. Increased expression of RRM2B has been correlated with is_associated_with::gemcitabine resistance in human cholangiocarcinoma cells and may be predictive of lack of clinical benefit from gemcitabine for human cancers.