IκBα

IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha) is one member of a family of cellular proteins that function to inhibit the is_associated_with::NF-κB is_associated_with::transcription factor. IκBα inhibits NF-κB by masking the is_associated_with::nuclear localization signals (NLS) of NF-κB proteins and keeping them sequestered in an inactive state in the cytoplasm. In addition, IκBα blocks the ability of NF-κB transcription factors to bind to DNA, which is required for NF-κB's proper functioning.

Disease linkage
The gene encoding the IκBα protein is mutated in some is_associated_with::Hodgkin's lymphoma cells; such mutations inactivate the IκBα protein, thus causing NF-κB to be chronically active in the lymphoma tumor cells and this activity contributes to the malignant state of these tumor cells.

Interactions
IκBα has been shown to interact with:


 * BTRC,
 * is_associated_with::C22orf25,
 * is_associated_with::CHUK,
 * is_associated_with::DYNLL1,
 * is_associated_with::G3BP2,
 * is_associated_with::Heterogeneous nuclear ribonucleoprotein A1,
 * is_associated_with::IKK2,
 * is_associated_with::NFKB1,
 * is_associated_with::P53,
 * is_associated_with::RELA,
 * is_associated_with::RPS6KA1,
 * is_associated_with::SUMO4, and
 * is_associated_with::Valosin-containing protein.