RHEB

GTP-binding protein Rheb also known as Ras homolog enriched in brain (RHEB) is a is_associated_with::protein that in humans is encoded by the RHEB is_associated_with::gene.

Function
Rheb is a recently discovered member of the is_associated_with::Ras superfamily that may be involved in neural plasticity. This function is novel and not typically associated with the Ras proteins.

This gene is a member of the small is_associated_with::GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. This protein is vital in regulation of growth and is_associated_with::cell cycle progression due to its role in the is_associated_with::insulin / TOR / S6K signaling pathway. The protein has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, and is_associated_with::farnesylation of the protein is required for this activity. Three pseudogenes have been mapped, two on chromosome 10 and one on chromosome 22.

Interactions
RHEB has been shown to interact with is_associated_with::C-Raf,  is_associated_with::Mammalian target of rapamycin,   is_associated_with::TSC2,     is_associated_with::Ataxia telangiectasia mutated, is_associated_with::KIAA1303 and is_associated_with::Ataxia telangiectasia and Rad3 related.