Cleft lip and palate transmembrane protein 1

Cleft lip and palate transmembrane protein 1 is a is_associated_with::protein that in humans is encoded by the CLPTM1 is_associated_with::gene. It belongs to a family of several eukaryotic cleft lip and palate transmembrane protein 1 sequences.

Cleft lip with or without cleft palate is a common is_associated_with::birth defect that is genetically complex. The nonsyndromic forms have been studied genetically using linkage and candidate-gene association studies with only partial success in defining the loci responsible for orofacial clefting. CLPTM1 encodes a transmembrane protein and has strong homology to two is_associated_with::Caenorhabditis elegans genes, suggesting that CLPTM1 may belong to a new gene family. This family also contains the is_associated_with::Homo sapiens cisplatin resistance related protein CRR9p which is associated with CDDP-induced apoptosis.