Rs2075650

Located close to ApoE4, yet may independently (also) influence risk of Alzheimer's disease.

A case-control study of 381 patients found a 2x higher risk for Alzheimer's disease associated with the rarer rs2075650(G) allele.

This allele is associated with earlier onset of Alzheimer's disease, by ~7 years. (news) The data from this study are available online at. The association of this SNP with late-onset Alzheimer's disease was confirmed by a study reported in PLoS Genetics.

The A allele of this SNP is one of 150 identified as relevant to exceptional longevity in

Recent work suggests, however, that the linkage disequilibrium between rs2075650 and the ApoE &#949;4 defining SNP rs429358 means that there may be little, if any, independent effect of rs2075650 on Alzheimer's risk. 

rs2075650 was found to be associated with Alzheimer's disease based on a study by the eMERGE network in which electronic medical records were searched to find clinical associations associated with selected SNPs.