Adenosine A2B receptor

The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled is_associated_with::adenosine receptor, and also denotes the human adenosine A2b receptor is_associated_with::gene which encodes it.

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Mechanism
This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

Gene
The gene is located near the Smith-Magenis syndrome region on chromosome 17. }}

Ligands
Research into selective A2B ligands has lagged somewhat behind the development of ligands for the other three adenosine receptor subtypes, but a number of A2B-selective compounds have now been developed,         and research into their potential therapeutic applications is ongoing.

Agonists

 * is_associated_with::BAY 60-6583
 * NECA (N-ethylcarboxamidoadenosine)
 * (S)-PHPNECA - high affinity and efficacy at A2B, but poor selectivity over other adenosine receptor subtypes
 * LUF-5835
 * LUF-5845 - partial agonist

Antagonists and inverse agonists

 * Compound 38: antagonist, high affinity and good subtype selectivity
 * ATL-801
 * CVT-6883
 * is_associated_with::MRS-1706
 * MRS-1754
 * OSIP-339,391
 * PSB-603
 * PSB-0788
 * PSB-1115