CCDC57

Coiled-coil domain-containing protein 57 is a is_associated_with::protein that in humans is encoded by the CCDC57 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of CCDC57 function. A conditional is_associated_with::knockout mouse line, called Ccdc57tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on is_associated_with::mutant mice and two significant abnormalities were observed. The animals displayed is_associated_with::hydrocephaly and had abnormal is_associated_with::hypodermis fat layer morphology.