FMNL2

Formin-like protein 2 is a is_associated_with::protein that in humans is encoded by the FMNL2 is_associated_with::gene.

Expression
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described. The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2 ) is regulated through autoinhibition, and may become activated through Rho proteins. The FMNL2 gene is expressed in multiple human tissues.

Function
Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.

Clinical significance
FMNL2 expression is considerably higher in is_associated_with::colorectal cancer tumors compared to normal tissue.