AKAP12

A-kinase anchor protein 12 is an is_associated_with::enzyme that in humans is encoded by the AKAP12 is_associated_with::gene.

Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of is_associated_with::protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in is_associated_with::endothelial cells, cultured is_associated_with::fibroblasts, and is_associated_with::osteosarcoma cells. It associates with is_associated_with::protein kinase A and C and is_associated_with::phosphatase, and serves as a scaffold protein in is_associated_with::signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

Interactions
AKAP12 has been shown to interact with is_associated_with::Beta-2 adrenergic receptor.