CADPS2

Calcium-dependent secretion activator 2 is a is_associated_with::protein that in humans is encoded by the CADPS2 is_associated_with::gene.

Function
This gene encodes a member of the calcium-dependent activator of secretion (CAPS) protein family, which are calcium-binding proteins that regulate the is_associated_with::exocytosis of synaptic and is_associated_with::dense-core vesicles in is_associated_with::neurons and is_associated_with::neuroendocrine cells.

Interactions
This gene interacts with is_associated_with::brain-derived neurotrophic factor.

Clinical significance
Cadps2 has been linked to is_associated_with::autism and is in the 7q autism susceptibility locus (AUTS1). However, the finding of aberrant CADPS2 splicing was not found to be significant in another study.

A is_associated_with::knockout mouse model was found to have autistic-like characteristics.

CADPS2 has been linked to human and mouse brain structure in two large genomic studies.