AKAP5

A-kinase anchor protein 5 is an is_associated_with::enzyme that in humans is encoded by the AKAP5 is_associated_with::gene.

Function
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of is_associated_with::protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene is intronless and encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to is_associated_with::protein kinase C and the phosphatase is_associated_with::calcineurin. It is predominantly expressed in is_associated_with::cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in is_associated_with::T lymphocytes and may function to inhibit is_associated_with::interleukin 2 transcription by disrupting calcineurin-dependent dephosphorylation of is_associated_with::NFAT.

Interactions
AKAP5 has been shown to interact with:
 * is_associated_with::Calcineurin and
 * is_associated_with::GABRB3.