Rs401681

rs401681 is a SNP in the CLPTM1-like CLPTM1 gene.

The following studies span several types of cancer, and over 30,000 cases and 45,000 controls.

deCODE press release reports rs401681 linked to basal cell carcinoma and many cancers for individuals with shorter telomeres, whereas those with long telomeres are at greater risk of melanoma. Neighboring rs2736098 also increases risk of cancer by affecting telomerase reverse transcriptase. The risk of these different cancers conferred by these two SNPs appears to be independent.

23andMe blog rs2736098 and rs401681 linked to many cancers, including susceptibility to pancreatic cancer

However, a very large study (encompassing thousands of cases and controls) found no association between rs401681 and either (1) mean telomere length, or, (2) breast cancer, colorectal cancer, or melanoma.

lung cancer rs401681 P = 7.90 x 10(-9)

Prostate-Specific Antigen