YWHAE

14-3-3 protein epsilon is a is_associated_with::protein that in humans is encoded by the YWHAE is_associated_with::gene.

Function
This gene product belongs to the is_associated_with::14-3-3 family of proteins which mediate is_associated_with::signal transduction by binding to is_associated_with::phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, is_associated_with::RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of is_associated_with::insulin sensitivity. It has also been implicated in the pathogenesis of is_associated_with::small cell lung cancer.

Interactions
YWHAE has been shown to interact with:


 * is_associated_with::C-Raf,
 * is_associated_with::CDC25B,
 * is_associated_with::HDAC4,
 * is_associated_with::HERG,
 * is_associated_with::IRS1 and
 * IGF1R,
 * is_associated_with::MAP3K3,
 * is_associated_with::NDEL1,
 * is_associated_with::NGFRAP1, and
 * is_associated_with::TGF beta 1.