INPP1

Inositol polyphosphate 1-phosphatase is an is_associated_with::enzyme that, in humans, is encoded by the INPP1 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of INPP1 function. A conditional is_associated_with::knockout mouse line, called Inpp1tm1a(KOMP)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on is_associated_with::mutant mice, and one significant abnormality was observed: a decreased susceptibility to is_associated_with::bacterial infection.