GATA2

GATA2 is a human is_associated_with::gene which makes a is_associated_with::protein called GATA binding protein 2 - a is_associated_with::transcription factor.

Function
The GATA family of transcription factors, which contain is_associated_with::zinc fingers in their is_associated_with::DNA binding domain, have emerged as candidate regulators of is_associated_with::gene expression in hematopoietic cells. is_associated_with::GATA1 is essential for normal primitive and definitive is_associated_with::erythropoiesis and is expressed at high levels in erythroid cells, is_associated_with::mast cells, and is_associated_with::megakaryocytes. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic is_associated_with::stem cells. In chicken erythroid progenitors, forced expression of GATA2 promotes proliferation at the expense of differentiation. is_associated_with::GATA3 expression is restricted to T-lymphocyte cells and some nonhematopoietic cell types, including embryonic stem cells.

Interactions
GATA2 has been shown to interact with:


 * is_associated_with::HDAC3,
 * is_associated_with::LMO2,
 * POU1F1,
 * PML
 * is_associated_with::SPI1, and
 * ZBTB16.

Genetic disorders
Multiple mutations on GATA2 gene have been recently implicated as the cause of primary immunodeficiency in patients with is_associated_with::MonoMAC Syndrome, and cases of dendritic cell, monocyte, B NK lymphoid deficiency and leukemia.

Lung cancer
GATA2 has recently been implicated in is_associated_with::non-small-cell lung cancer - specifically those tumours that are driven by a faulty Ras protein. Targeting processes that occur downstream of GATA2 signalling with clinically approved drugs had a significant effect in mouse models of the disease.