CARD14

Caspase recruitment domain-containing protein 14, also known as CARD-containing MAGUK protein 2 (Carma 2), is a is_associated_with::protein that in humans is encoded by the CARD14 is_associated_with::gene.

Function
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure with CARD11 protein. The CARD domains of both proteins have been shown to specifically interact with is_associated_with::BCL10, a protein known to function as a positive regulator of cell apoptosis and is_associated_with::NF-κB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Link to Psoriasis
The CARD14 gene was recently identified as the first gene directly linked to the most common form of is_associated_with::Psoriasis. It has been suggested that a mutation in the gene plus an environmental trigger were enough to elicit is_associated_with::plaque psoriasis.