Rs3783641

GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. A allele associated with higher tolerance to pain.

Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain. A allele associated with higher tolerance to pain.

Do genetic predictors of pain sensitivity associate with persistent widespread pain? A allele associated with higher pain tolerance.

GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. Part of a haplotype, rs10483639(C)-rs3783641(A)-rs8007267(T), associated with lower levels of tetrahydrobiopterin.


 * is_associated_with_disease::Major depressive disorder
 * is_associated_with_disease::Pancreatitis
 * is_associated_with_disease::Pain agnosia