Alpha-1B adrenergic receptor

The alpha-1B adrenergic receptor (α1B adrenoreceptor), also known as ADRA1B, is an is_associated_with::alpha-1 adrenergic receptor, and also denotes the human is_associated_with::gene encoding it.

Receptor
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.

Gene
This gene encodes alpha-1B-adrenergic receptor, which induces neoplastic transformation when transfected into NIH 3T3 fibroblasts and other cell lines. Thus, this normal cellular gene is identified as a is_associated_with::protooncogene. This gene comprises 2 exons and a single large intron of at least 20 kb that interrupts the coding region.

Ligands

 * Antagonists
 * is_associated_with::L-765,314
 * is_associated_with::Risperidone

Interactions
Alpha-1B adrenergic receptor has been shown to interact with is_associated_with::AP2M1. A role in regulation of dopaminergic neurotransmission has also been suggested.