Poliovirus receptor-related 3

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the is_associated_with::immunoglobulin superfamily which forms part of is_associated_with::adherens junctions.

Function
is_associated_with::Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM]

Interactions
PVRL3 has been shown to interact with:
 * is_associated_with::MLLT4,
 * is_associated_with::PARD3,
 * is_associated_with::PTPRM.