TREX1

Three prime repair exonuclease 1 is an is_associated_with::enzyme that in humans is encoded by the TREX1 is_associated_with::gene.

Function
This gene encodes the major 3'-&gt;5' DNA is_associated_with::exonuclease in human cells. The protein is a non-processive exonuclease that may serve a proofreading function for a human DNA polymerase. It is also a component of the SET complex, and acts to rapidly degrade 3' ends of nicked DNA during granzyme A-mediated cell death. Mutations in this gene result in is_associated_with::Aicardi-Goutieres syndrome, chilblain lupus, RVCL (Retinal Vasculopathy with Cerebral Leukodystrophy), and Cree encephalitis. Multiple transcript variants encoding different isoforms have been found for this gene.