PBRM1

Protein polybromo-1 (PB1) also known as BRG1-associated factor 180 (BAF180) is a is_associated_with::protein that in humans is encoded by the PBRM1 is_associated_with::gene.

Structure and function
Component of the is_associated_with::SWI/SNF-B (PBAF) chromatin-remodeling complex, which contains at least is_associated_with::SMARCA4/BRG1, is_associated_with::SMARCB1/SNF5/INI1/BAF47, is_associated_with::ACTL6A/BAF53A or is_associated_with::ACTL6B/BAF53B, is_associated_with::SMARCE1/BAF57, is_associated_with::SMARCD1/BAF60A, is_associated_with::SMARCD2/BAF60B, and is_associated_with::actin.

Chicken PB1 possesses 5 is_associated_with::bromodomains, 2 bromo-adjacent homology (BAH) domains, and 1 truncated is_associated_with::high-mobility group (HMG) motif. cPB1 is also homologous to yeast Rsc1, Rsc2, and Rsc4, essential proteins that are required for is_associated_with::cell cycle progression through is_associated_with::mitosis.

Clinical significance
PBRM1 is a tumor suppressor gene in many cancer subtypes. Mutations are especially prevalent in is_associated_with::clear cell renal cell carcinoma.