Hypocretin (orexin) receptor 1

Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1, is a is_associated_with::protein that in humans is encoded by the HCRTR1 is_associated_with::gene.

Function
The orexin 1 receptor (OX1), is a is_associated_with::G-protein coupled receptor expressed in the is_associated_with::hypothalamus and involved in the regulation of feeding behaviour. OX1 selectively binds the is_associated_with::orexin-A neuropeptide. It shares 64% identity with OX2.

Agonists

 * is_associated_with::Orexin-A

Antagonists

 * is_associated_with::RTIOX-276 - Selective OX1 antagonist
 * is_associated_with::ACT-335827 - Selective OX1 antagonist
 * is_associated_with::Almorexant - Dual OX1 and OX2 antagonist
 * is_associated_with::Lemborexant - Dual OX1 and OX2 antagonist
 * is_associated_with::SB-334,867 - Selective OX1 antagonist
 * is_associated_with::SB-408,124 - Selective OX1 antagonist
 * is_associated_with::SB-649,868 - Dual OX1 and OX2 antagonist
 * is_associated_with::Suvorexant - Dual OX1 and OX2 antagonist