Optineurin

Optineurin is a is_associated_with::protein that in humans is encoded by the OPTN is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of OPTN function. A conditional is_associated_with::knockout mouse line, called Optntm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program – a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists – at the is_associated_with::Wellcome Trust Sanger Institute.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty one tests were carried out on is_associated_with::mutant mice, however no significant abnormalities were observed.

Interactions
Optineurin has been shown to interact with is_associated_with::Huntingtin and is_associated_with::RAB8A.