Folate receptor 1

Folate receptor alpha is a is_associated_with::protein that in humans is encoded by the FOLR1 is_associated_with::gene.

Clinical significance
FRA can be overexpressed by a number of epithelial-derived tumors including ovarian, breast, renal, lung, colorectal, and brain. Hence antibodies to it are used in targeted therapies and diagnostic tests, e.g. is_associated_with::farletuzumab in phase III trial for is_associated_with::ovarian cancer.