HSP90B1

Heat shock protein 90kDa beta member 1 (HSP90B1), known also as endoplasmin, gp96, grp94 and ERp99, is a is_associated_with::chaperone protein that in humans is encoded by the HSP90B1 is_associated_with::gene.

HSP90B1 is an HSP90 paralogue that is found in the is_associated_with::endoplasmic reticulum. It plays critical roles in folding proteins in the secretory pathway such as is_associated_with::Toll-like receptors and is_associated_with::integrins. It has been implicated as an essential immune chaperone to regulate both innate and adaptive immunity. Tumor-derived HSP90B1 (vitespen) has entered clinical trials for is_associated_with::cancer immunotherapy.