Rs4149601

rs4149601 has been associated with hypertension. This SNP by itself was associated with diastolic blood pressure (DBP) (p=0.03) and DBP progression over time (p=0.04); in genotypic combination with intronic NEDD4L SNP rs2288774 it was associated with systolic blood pressure (SBP) (p=0.01), DBP (p=0.04), and progression of both SBP (p=0.03) and DBP (p=0.05) over time.

Polymorphism in NEDD4L is associated with increased salt sensitivity, reduced levels of P-renin and increased levels of Nt-proANP.

Expression, transcription, and possible antagonistic interaction of the human Nedd4L gene variant: implications for essential hypertension.

Two polymorphisms in NEDD4L gene and essential hypertension in Chinese Hans - a population-based case-control study.

Physiological interaction between alpha-adducin and WNK1-NEDD4L pathways on sodium-related blood pressure regulation.

Suggestive linkage of ADHD to chromosome 18q22 in a young genetically isolated Dutch population.

A functional variant of NEDD4L is associated with hypertension, antihypertensive response, and orthostatic hypotension.

Genetic variation of NEDD4L is associated with essential hypertension in female Kazakh general population: a case-control study.

Human Nedd4L rs4149601 G allele generates evolutionary new isoform I with C2 domain.

[Association of the rs4149601 polymorphism of NEDD4L gene with obesity in Xinjiang Kazakh population].


 * is_associated_with_disease::Obesity
 * is_associated_with_disease::Essential hypertension