AGPAT3

1-acyl-sn-glycerol-3-phosphate acyltransferase gamma is an is_associated_with::enzyme that in humans is encoded by the AGPAT3 is_associated_with::gene.

Model organisms
is_associated_with::Model organisms have been used in the study of AGPAT3 function. A conditional is_associated_with::knockout mouse line, called Agpat3tm1a(EUCOMM)Wtsi was generated as part of the is_associated_with::International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.

Male and female animals underwent a standardized is_associated_with::phenotypic screen to determine the effects of deletion. Twenty five tests were carried out on is_associated_with::mutant mice and one significant abnormality was observed. Few is_associated_with::homozygous is_associated_with::mutant animals survived until is_associated_with::weaning. The remaining tests were carried out on is_associated_with::heterozygous mutant adult mice; no additional significant abnormalities were observed in these.