BRAT1

BRCA1-associated ATM activator 1 is a is_associated_with::protein in humans that is encoded by the BRAT1 is_associated_with::gene.

Function
The protein encoded by this ubiquitously expressed gene interacts with the tumor suppressing is_associated_with::BRCA1 (breast cancer 1) protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of is_associated_with::cell cycle checkpoint signalling pathways that are required for cellular responses to is_associated_with::DNA damage such as is_associated_with::double-strand breaks that are induced by ionizing radiation and complexes with BRCA1 in the multi-protein complex BASC (BRAC1-associated genome surveillance complex). The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM.