MTRR (gene)

Methionine synthase reductase also known as MSR is an is_associated_with::enzyme that in humans is encoded by the MTRR is_associated_with::gene.

Function
is_associated_with::Methionine is an essential is_associated_with::amino acid required for protein synthesis and is_associated_with::one-carbon metabolism. Its synthesis is catalyzed by the enzyme is_associated_with::methionine synthase. Methionine synthase eventually becomes inactive due to the oxidation of its cob(I)alamin cofactor. Methionine synthase reductase regenerates a functional methionine synthase via reductive methylation. It is a member of the ferredoxin-NADP(+) reductase (FNR) family of electron transferases.

Clinical significance
Patients of the cblE complementation group of disorders of folate/cobalamin metabolism which results in is_associated_with::homocystinuria are defective in reductive activation of methionine synthase.